Clinical trials: Chlorhexidine
Carbapenemase-Producing Enterobacteriaceae (CPE), Healthcare-Associated Infections (HAIs)
Effect of Daily Chlorhexidine Bathing and Antibiotic/PPI Stewardship on Prevention of CPE Transmission and Infection
This multicenter, cluster-randomized crossover trial aims to evaluate the effectiveness and safety of a bundled intervention-including daily chlorhexidine bathing and targeted antimicrobial and proton pump inhibitor (PPI)…
- Trial name
- NCT07039955
- Testing
- Daily Chlorhexidine Bathing, Antimicrobial and PPI Stewardship Program, Standard Bathing
- Where
- 3 sites in South Korea
- Volunteers
- 5,760 people
- Sponsor
- Chuncheon Sacred Heart Hospital
Periimplant Diseases, Dental Implant Failure
Microbiological Evaluation of the Effectiveness of Different Surface Decontamination Protocols for Dental Implants
The purpose of this prospective clinical study is to evaluate and compare the effectiveness of different cleaning (decontamination) methods for dental implants affected by peri-implantitis.
- Conditions
- Periimplant Diseases, Dental Implant Failure, Dental Implant Complications
- Trial name
- NCT07529444
- Testing
- Laser Photodynamic Therapy (PDT), GalvoSurge Electrolytic Cleaning, 0.2% Chlorhexidine Gluconate
- Where
- Croatia
- Volunteers
- 90 people
- Sponsor
- University of Zagreb
Root Canal Infection
Comparison of Effectiveness of Disinfectants
This is a comparative experimental study to compare the efficacy of chemical disinfection agents , sodium hypochlorite and chlorhexidine gluconate in decontaminating gutta percha cones
- Trial name
- NCT06811779
- Testing
- Sodium Hypochlorite, Chlorhexidine
- Where
- Pakistan
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Armed Forces Institute of Dentistry, Pakistan
Palatal Donor Site Wound Healing, Periodontal Plastic Surgery
MOUTHRİNSES AND PALATAL DONOR SİTE HEALİNG AFTER FREE GİNGİVAL GRAFT
This single-blind randomized controlled clinical trial aimed to compare the effects of hypochlorous acid, hyaluronic acid, and chlorhexidine mouthrinses on palatal donor site healing following free gingival graft surgery.
- Trial name
- NCT07689695
- Testing
- Hypochlorous Acid, Hyaluronic Acid (HA), Chlorhexidine gluconate 0.2%
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Yuzuncu Yil University
Orthopedic Surgery
Efficacy of CHX Cloths Versus CHX Soaps for Bathes Before Orthopedic Surgery
Surgical site infections (SSI) in orthopedic surgery are rare events but associated with great morbidity as well as a significant additional cost.
- Trial name
- POL (NCT05120739)
- Testing
- 2% CHX cloths
- Where
- France
- Volunteers
- 64 people
- Sponsor
- University Hospital, Grenoble
Peri-implant Mucositis
Efficacy of a Xanthan-based Chlorhexidine Gel in the Treatment of Peri-implant Mucositis
The peri-implant mucositis is an inflammatory and reversible lesion that surrounds the peri-implant mucosa without loss of supporting bone, clinically characterized by bleeding on gentle probing.
- Trial name
- NCT07047261
- Testing
- Adjunctive use of Xanthan-Chlorexidine based gel
- Where
- Italy
- Volunteers
- 182 people
- Sponsor
- University of Turin, Italy
Neonatal Sepsis
Chlorhexidine Gluconate and Alcohol Hand Rubbing on Healthcare-associated Infection
This study aims to compare of effect of chlorhexidine gluconate and alcohol hand rubbing on healthcare-associated infection (HCAI) in neonatal intensive care unit at Alexandria University Children Hospital.
- Trial name
- NCT07421323
- Testing
- Alcohol hand rub group, Chlorhexidine hand rub
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Alexandria University
Bone Resorption, Bacteria Caused Disease
0.2% Chx Gel vs Implant Bacterial Contamination
The objective of this human randomized, double blind, placebo-control (RDBPC) study is to evaluate the efficacy of a 0.2% chlorhexidine (CHX) gel on reducing bacterial load and peri-implant inflammation at implant-abutment…
- Trial name
- NCT03431766
- Testing
- 0.20% chlorhexidine gel
- Where
- Italy
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Mouthwashes, Chlorhexidine
Effects of Two Daily CHX Mouthrinses on Plaque, Gingivitis and Staining
Τhe aim of this randomized clinical trial was to investigate the efficacy of two daily mouth rinses containing CHX and different combinations of H2O2 and CPC, when used adjunctive to mechanical oral hygiene, and compare them with…
- Conditions
- Mouthwashes, Chlorhexidine, Dental Plaque, Gingival and Periodontal Disease
- Trial name
- NCT07351370
- Testing
- chlorhexidine/ cetylpyridinium chloride/ hydrogen peroxide mouthwash, Chlorhexidine/ cetylpyridinium chloride
- Where
- Greece
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Dental School
Surgical Site Infection, Cesarean Section; Infection
Aqueous vs Alcohol Chlorhexidine Skin Preparation for Prevention of Cesarean Section Wound Infections
This will be a single-center randomized control trial comparing the efficacy of two different formulations of Chlorhexidine surgical skin preparation in preventing cesarean section wound infections.
- Trial name
- NCT05920122
- Testing
- 2% Chlorhexidine gluconate with 70% alcohol, 4% Chlorhexidine Gluconate aqueous solution
- Where
- United States
- Volunteers
- 1,398 people, healthy volunteers welcome
- Sponsor
- Hyagriv Simhan
Dental Caries
Antibacterial Effect of Nano Silver Fluoride vs Chlorhexidine on Occlusal Carious Molars Treated With Partial Caries Removal Technique
The teeth of the patients that meet inclusion criteria will be anesthetized, isolated with a rubber dam. Cavity opened using conventional high-speed rotary instruments.
- Trial name
- NCT03186261
- Testing
- Nano silver fluoride solution, Cavity Cleanser
- Where
- Egypt
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Cairo University
One-Piece Dental Implant, Bone-Level Implant
Inflammatory Biomarkers, Microbial Findings, and Clinical Characteristics Before and After Treatment of Peri-Implant Mucositis Around One-Piece and Two-Piece Dental Implants
The goal of this clinical study was to learn whether the design of a dental implant affects how the gums around it respond to treatment of peri-implant mucositis, an early and reversible inflammation of the soft tissue around a…
- Conditions
- One-Piece Dental Implant, Bone-Level Implant, Two-Piece Dental Implant, Nonsurgical Mechanical Debridement
- Trial name
- 1PvsBL (NCT07892313)
- Testing
- Nonsurgical Mechanical Debridement With 1% Chlorhexidine Gel
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Cuneyt Asim Aral
Periodontitis, Premature Birth of Newborn
Feasibility and Acceptability of Use of Daily Oral Rinse in Pregnant Women in Rural Nepal
In Nepal, investigators are conducting a cohort study to estimate the relationship between signs of periodontal disease in pregnant women and preterm delivery.
- Trial name
- NCT02788786
- Testing
- Chlorhexidine, Cetylpyridinium chloride, Salt and Water
- Where
- Nepal
- Volunteers
- 175 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Effects of Topical Chlorhexidine and Benzidine Spray
To Evaluate the Effect of Chlorhexidine-benzidamine Administration
The use of laryngeal mask (LMA) for the purpose of providing airway safety of patients is a common method in general anesthesia practice.
- Trial name
- NCT03253497
- Testing
- Chlorobenzene Liquid
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Peri-Implantitis
Surgical Protocol for Peri-implantitis Treatment-2
Peri-implant diseases are common post-restorative complications in implant rehabilitations and they occur with an incidence of 12-43%.
- Trial name
- NCT03977285
- Testing
- chlorhexidine
- Where
- Italy
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Università Vita-Salute San Raffaele
Surgical Site Infection
Study of Chlorhexidine Gluconate as a Preoperative Antisepsis
The purpose of this study is to determine which drug (chlorhexidine gluconate vs. povidone iodine) as a preoperative antisepsis in clean-contaminated abdominal surgery (liver, hepatobiliary, small or large bowel, stomach) is…
- Trial name
- CHG (NCT01495117)
- Testing
- Povidone-Iodine, Chlorhexidine gluconate
- Where
- South Korea
- Volunteers
- 534 people
- Sponsor
- Seung Duk Lee
Skin Coverage
Evaluation 2% Chlorhexidine Gluconate
Medline 2% CHG cloth (Active) - A single cloth from the pack was used per treatment area. The investigational test article was applied topically by vigorously scrubbing the skin in a back and forth motion for three minutes (and…
- Trial name
- NCT03326726
- Testing
- 2% CHG
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medline Industries
Surgical Site Infection
Chlorhexidine Cloths to Reduce Surgical Site Infection in Cesarean Deliveries
Pregnancy-associated infection represents a major cause of maternal morbidity and mortality. Cesarean delivery is the most common major surgical procedure and is associated with a rate of surgical site infection (SSI) that is…
- Trial name
- NCT04202471
- Testing
- Chlorhexidine Cloth
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwell Health
Neonatal Infections
Neonatal Package Study in Rural District of Pakistan
Neonatal mortality has been a notable health issue in Pakistan. Considering the importance of the issue and well recognized interventions the investigators are proposing a randomized controlled trial in a rural district of…
- Trial name
- NCT02279381
- Testing
- Chlorhexidine, Kangaroo Mother Care, Essential Neonatal Care
- Where
- Pakistan
- Volunteers
- 1,450 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Chlorhexidine, Intensive Care
Detection of Chlorhexidine in Tracheal Secretions After Routine Oral Care With Chlorhexidine Gluconate
Recent meta-analysis have suggested that the safety of oral care with chlorhexidine in patients under mechanical ventilation could be questionable.
- Trial name
- NCT02583321
- Testing
- Endotracheal tubes not allowing SSD, Endotracheal tubes allowing SSD
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Centre Hospitalier Departemental Vendee