Clinical trials: Chlorhexidine, open to volunteers
Alveolar Osteitis
Comparative Efficacy of Amoxicillin, Metronidazole, and Chlorhexidine in Preventing Alveolar Osteitis
This study will compare the effectiveness of amoxicillin, metronidazole, and chlorhexidine in preventing alveolar osteitis (dry socket) following lower third molar extraction.
- Trial name
- NCT07833176
- Testing
- Amoxicillin, Metronidazole, Chlorhexidine
- Where
- Pakistan
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Khyber Medical University Peshawar
Plaque, Dental, Antimicrobial
Anticariogenic Effect of Moringa Oleifera Mouthwash Compared to Chlorhexidine Mouthwash
Moringa oleifera (MO) is an extraordinary nutritious vegetable tree with high medicinal value for its antibacterial properties. Formulation of various natural dental remedies from this plant and their testing for their…
- Conditions
- Plaque, Dental, Antimicrobial, Mouthwash, Cytotoxicity
- Trial name
- NCT04575948
- Testing
- Moringa Oleifera, Chlorhexidine mouthwash, Base formula
- Volunteers
- 90 people
- Sponsor
- Misr International University
Infection, Pneumonia
Perioperative Respiratory Care and Outcomes for Patients Undergoing High Risk Abdominal Surgery
PENGUIN is a pragmatic multi-center trial investigating the effects of pre-operative mouthwash and perioperative oxygen on the incidences of pneumonia and surgical site infection (SSI) following major abdominal surgery.
- Conditions
- Infection, Pneumonia, Surgical Site Infection, Wound Infection
- Trial name
- PENGUIN (NCT04256798)
- Testing
- Chlorhexidine mouthwash, Oxygen
- Where
- 37 sites in Brazil, India and 3 more
- Volunteers
- 12,942 people
- Sponsor
- University of Birmingham
Periimplant Diseases, Dental Implant Failure
Microbiological Evaluation of the Effectiveness of Different Surface Decontamination Protocols for Dental Implants
The purpose of this prospective clinical study is to evaluate and compare the effectiveness of different cleaning (decontamination) methods for dental implants affected by peri-implantitis.
- Conditions
- Periimplant Diseases, Dental Implant Failure, Dental Implant Complications
- Trial name
- NCT07529444
- Testing
- Laser Photodynamic Therapy (PDT), GalvoSurge Electrolytic Cleaning, 0.2% Chlorhexidine Gluconate
- Where
- Croatia
- Volunteers
- 90 people
- Sponsor
- University of Zagreb
Hip Osteoarthritis, Avascular Necrosis of Femur Head
Influence of Antiseptic Washes on Wound Healing Complications After THA
The purpose of this research trial is to evaluate the effect of two types of washing solutions on wound healing after total hip replacement surgery.
- Trial name
- NCT07104084
- Testing
- lavage chlorhexidine, lavage povidone-iodine
- Where
- 2 sites in United States
- Volunteers
- 420 people
- Sponsor
- F. Johannes Plate
Periodontal Disease (PD), Cardio Vascular Disease
PMPR and Chlorhexidine on Periodontal Disease and Vascular Function
Gum inflammation is called gingivitis. Gum disease, known as periodontal disease, is a long-term inflammation of the gums and bone around teeth, leading to tooth loss.
- Conditions
- Periodontal Disease (PD), Cardio Vascular Disease, Oral-Systemic Link, Vascular Dysfunction
- Trial name
- CHX-PMPR-PERIV (NCT07311512)
- Testing
- Chlorhexidine (0.2%) mouthwash
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Mahdi Mutahar
HIV (Human Immunodeficiency Virus), HPV
Feasibility Study Comparing One vs Two Probes for TA Among Cervical Cancer Screen Positive WLWH in C1001P-CS5 Rwanda
Cervical cancer disproportionately affects women in low- and middle-income countries (LMICs), particularly women living with HIV (WLWH) who have a 6-fold increased risk of cervical cancer compared to women in the general…
- Conditions
- HIV (Human Immunodeficiency Virus), HPV, Cervical Precancer
- Trial name
- NCT07390916
- Testing
- Thermal ablation (TA) with 1 probe, Thermal ablation (TA) with 2 probes
- Where
- Rwanda
- Volunteers
- 300 people
- Sponsor
- Fred Hutchinson Cancer Center
Nosocomial Pneumonia, COPD Exacerbation
Role of Oral Care in Prevention of Nosocomial Pneumonia Among COPD Patients
Poor dental hygiene has been linked to respiratory pathogen colonization in ICU patients. Therefore, respiratory pathogens tend to colonize dental plaque and oral mucosa in these populations.
- Trial name
- NCT06691399
- Testing
- Oral care
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Colorectal Cancer, Surgical Site Infection
Chlorhexidine Gluconate Versus Saline for Flushing the Surgical Area During Colorectal Cancer Surgery
The aim of this study was to compare the effectiveness of chlorhexidine versus saline in flushing the surgical area during colorectal cancer surgery.
- Conditions
- Colorectal Cancer, Surgical Site Infection, Chlorhexidine, Complications
- Trial name
- NCT06869096
- Testing
- Intraoperative area irrigation
- Where
- China
- Volunteers
- 532 people
- Sponsor
- Nanchong Central Hospital
Oral Bacterial Colonization, Oral Hygiene
Effects of Three Oral Hygiene Protocols on Oral Bacteria in Intensive Care Patients
Patients in intensive care may develop changes in the bacteria found in their mouths. Some of these bacteria can cause infections, and patients who cannot clean their own teeth depend on staff to provide oral care.
- Trial name
- NCT07868549
- Testing
- Mechanical Oral Hygiene, Chlorhexidine, Hexetidine
- Where
- Croatia
- Volunteers
- 86 people
- Sponsor
- University of Zagreb
Plaque Induced Gingival Disease
Taste Acceptance and Effectiveness of Hyaluronic Acid and Chlorhexidine Mouthwashes in Children With Gingivitis
This randomized controlled clinical trial aims to compare the taste acceptance and clinical effectiveness of hyaluronic mouthwash and chlorhexidine mouthwash in children with plaque-induced gingivitis.
- Trial name
- NCT07662226
- Testing
- Hyaluronic Acid mouthwash, Chlorohexidine 0.12% mouthwash
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Neurogenic Bladder, Urinary Retention
Effect of Chlorhexidine Gluconate Bladder Instillations in Patients With Chronic Suprapubic Catheters on Unplanned Healthcare Encounters and Quality of Life
The goal of this clinical trial is to evaluate the feasibility and tolerability of 0.05% Chlorhexidine Gluconate (CGH) bladder instillations in an outpatient setting at the time of suprapubic catheter (SPC) exchange in patients…
- Trial name
- NCT06163469
- Testing
- Bladder instillation with Irrisept
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Yale University
Mouthwash, Chlorhexidine
Evaluation of the Anti-Plaque Effect of a Resveratrol-Based Mouthwash Using a 24-Hour Plaque Re-Growth
Dental plaque is a biofilm that accumulates on tooth surfaces and is a primary factor in the development of gingival inflammation.
- Conditions
- Mouthwash, Chlorhexidine, Biofilm Formation, Periodontal Health
- Trial name
- NCT07393802
- Testing
- Resveratrol-Based Mouthwash, Chlorhexidine Gluconate 0.12 % Mouthwash
- Where
- Iraq
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Pilonidal Disease
Effect of Antiseptic Irrigations With 0.05% Chlorhexidine Gluconate (Irrisept) Versus Normal Saline on Fasciocutaneous Flap-Based Closure of Pilonidal Disease
Pilonidal disease is a chronic condition that causes painful inflammation and infection near the top of the buttocks. Many patients require surgery, and one commonly used approach is a bilateral gluteal fasciocutaneous flap with…
- Trial name
- NCT07321704
- Testing
- Irrisept (0.05% chlorhexidine gluconate), Normal Saline
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Yosef Nasseri, MD
Pediatric Cancer
Care Bundle Containing Chlorhexidine Dressing on Port Catheter and Central Venous Catheters
In order to provide treatment in pediatric hematology-oncology patients, in some cases a central venous catheter is required in children.
- Trial name
- CHG-port (NCT06720064)
- Testing
- Chlorhexidine Dressing
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Dokuz Eylul University
Plaque Accumulation, Gingival Inflammation
Triphila Mouthwash Effect as Anti-plaque and Anti-gingivitis in Children
The study aim to to assess the antiplaque and antigingivitis efficacy of Triphala mouthwash versus chlorhexidine mouthwash among children.
- Trial name
- NCT07016659
- Testing
- 0.12% Chlorhexidine Mouthwash ( Hexitol ), Triphila mouthwash
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Cairo University
Halitosis, Mouth Disease
Efficacy of Resveratrol Containing Mouthwash in Reducing Halitosis Related Porphyrymonas Gingivalis.
The aim of the study: To assess the efficacy of antioxidant (resveratrol) mouthwash in reducing the level of p. gingivitis and oral malodor over 7 day period among undergraduate dental student patients from Mustansiriyah…
- Conditions
- Halitosis, Mouth Disease, Plaque Induced Gingival Disease, Bleeding Gum
- Trial name
- NCT06882564
- Testing
- resveratrol mouthwash, Chlorhexidine mouthwash (0.2%)
- Where
- Iraq
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Al-Mustansiriyah University
Dry Socket, Postoperative Infections
The Effect of Chlorhexidine + Hyaluronic Acid on Postoperative Wound Healing After Lower Third Molar Removal
Our aim is to evaluate chlorhexidine-hyaluronic acid containing gel on postoperative wound healing regarding impacted lower third molar surgery.
- Trial name
- NCT07044219
- Testing
- Third molar surgery
- Where
- Hungary
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Pecs
Carbapenemase-Producing Enterobacteriaceae (CPE), Healthcare-Associated Infections (HAIs)
Effect of Daily Chlorhexidine Bathing and Antibiotic/PPI Stewardship on Prevention of CPE Transmission and Infection
This multicenter, cluster-randomized crossover trial aims to evaluate the effectiveness and safety of a bundled intervention-including daily chlorhexidine bathing and targeted antimicrobial and proton pump inhibitor (PPI)…
- Trial name
- NCT07039955
- Testing
- Daily Chlorhexidine Bathing, Antimicrobial and PPI Stewardship Program, Standard Bathing
- Where
- 3 sites in South Korea
- Volunteers
- 5,760 people
- Sponsor
- Chuncheon Sacred Heart Hospital
Wound Healing, Alveolitis of Jaw
Effect of Curcumin Topical Spray on Wound Healing After Tooth Extraction
This randomized, single-blind, controlled clinical trial aims to evaluate the effects of a topical curcumin spray on post-extraction wound healing and postoperative symptoms in adults undergoing first molar extraction.
- Conditions
- Wound Healing, Alveolitis of Jaw, Tooth Extraction, Curcumin
- Trial name
- NCT07874789
- Testing
- Curcumin Topical Spray, Chlorhexidine Topical Spray
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Istanbul University