Clinical trials: Chloride Disorder
Severe Trauma Patients, Acute Kidney Injury
Plasmalyte Versus Saline in Trauma Patients
Fluid resuscitation remains the cornerstone for the care of severe trauma patients to compensate for blood loss, to compensate for capillary leak induced by systemic inflammation but also to prevent the detrimental consequences…
- Trial name
- ASTRAU (NCT03630224)
- Testing
- Plasmalyte Viaflo, NaCl 0.9%
- Where
- France
- Volunteers
- 365 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Vertigo
Evaluation of Aminobutyric Acid, Glutamic Acid, Calcium, Thiamine, Pyridoxine and Cyanocobalamin as Therapy for Vertigo
The goal of this clinical trial is to assess the efficacy and safety of a combination of aminobutyric acid, glutamic acid, calcium, thiamine, pyridoxine and cyanocobalamin as adjuvant therapy for vertigo comparatively to ginger…
- Trial name
- NCT05221892
- Testing
- Gamma-aminobutyric acid tartarate, glutamic acid, dibasic calcium phosphate, thiamine nitrate, pyridoxine chloride and cyanocobalamin, Ginger
- Where
- Brazil
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- Fundação Educacional Serra dos Órgãos
Fibromyalgia, Fibromyalgia Syndrome
Effect of Transdermal Magnesium Chloride on Quality of Life in Patients With Fibromyalgia
In this pilot study we propose to gather preliminary data on whether transdermal magnesium chloride can improve quality of life in patients with fibromyalgia. Forty women with fibromyalgia will be enrolled in this study.
- Trial name
- NCT01968772
- Testing
- Transdermal Magnesium Chloride
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Contact Allergy, Neuropathic Pain
Intranasal Neurostimulation for the Treatment of Neurosensory Abnormalities in CL Wearers (INTAC)
To find out if the use of an intranasal tear neurostimulator (ITN), may be useful in decreasing the pain symptoms felt by patients who experience contact lens discomfort.
- Trial name
- INTAC (NCT04240587)
- Testing
- TrueTear™ intranasal neurostimulator (ITN)
- Where
- United States
- Sponsor
- Tufts Medical Center
Metastatic Cancer, Prostate Cancer
Strontium Compared With Radiation Therapy in Treating Patients With Hormone-Refractory Prostate Cancer With Painful Bone Metastases
RATIONALE: Radiolabeled monoclonal antibodies can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. This may be an effective treatment for prostate cancer.
- Trial name
- NCT00002503
- Testing
- strontium chloride Sr 89
- Where
- 21 sites in Belgium, Denmark and 7 more
- Volunteers
- 204 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Vascular Function, Healthy
Effects of Sodium Chloride or Its Substitute Salt Potassium Chloride on Vascular Function
This is a prospective, monocentric, randomized trial to investigate how sodium chloride or its substitute potassium chloride acutely affects vascular function by ingestion via a salted soup.
- Conditions
- Vascular Function, Healthy, Diabetes
- Trial name
- ESCAPE-SALT (NCT05970601)
- Testing
- Soup
- Where
- Germany
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Prof. Dr. med. Johannes Stegbauer
Nephropathy
Effect of Hypertonic Sodium Chloride on Urinary Biomarkers in Healthy Subjects and Patients With Chronic Kidney Disease
Patients with chronic kidney disease (CKD) have a defect in the tubular reabsorption of sodium, and therefore the ability to excrete a sodium load is diminished compared to healthy subjects.
- Trial name
- CASE (NCT01623661)
- Testing
- hypertonic saline
- Where
- Denmark
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Regional Hospital Holstebro
Neurogenic Bladder, Spina Bifida
Comparing Urinary Tract Infections in Children With Spina Bifida Using Two Types of Catheters for Catheterization
The primary aim of this study was to determine if using the SpeediCath hydrophilic catheter would reduce the incidence of symptomatic urinary tract infections (UTI)in children with spina bifida who perform clean intermittent…
- Trial name
- NCT01263392
- Testing
- Intermittent catheterization
- Where
- 4 sites in Canada
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Allergic Rhinitis
Impact of Carrier Solutions for House Dust Mite Allergen on Allergic Reactions
Single-blind, within-block randomized, clean-air-controlled study to assess the effect of lactose and sodium chloride particles in patients with allergic rhinitis on nasal symptoms when challenged in the Fraunhofer Allergen…
- Trial name
- SIMBA (NCT05245175)
- Testing
- Sodium chloride particles, Lactose particles, Clean air
- Where
- Germany
- Volunteers
- 19 people
- Sponsor
- Fraunhofer-Institute of Toxicology and Experimental Medicine
Kidney Failure, Acute
Preventing Acute Renal Failure After Cardiac Surgery in High Risk Patients Using Sodium Bicarbonate Therapy
The purpose of this study is to determine whether sodium bicarbonate is effective in reducing kidney injury that may occur during cardiac surgery.
- Trial name
- PARACHUTE (NCT00522756)
- Testing
- Sodium bicarbonate, Sodium chloride
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Chronic Obstructive Pulmonary Disease
Study of Trospium Chloride Inhalation Powder (TrIP) in Patients With Chronic Obstructive Pulmonary Disease
To assess the effect of a single dose of TrIP on pulmonary function in patients with COPD
- Trial name
- NCT00465959
- Testing
- trospium chloride inhalation powder (TrIP)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Inverse Psoriasis, Sebopsoriasis
Efficacy of Aerosal® in the Treatment of Inverse Psoriasis and Sebopsoriasis
The purpose of this study is to evaluate the efficacy of Aerosal® compared to placebo in the prognosis of inverse psoriasis or sebopsoriasis present for at least one year
- Trial name
- NCT01574872
- Testing
- Halotherapy
- Where
- Italy
- Sponsor
- Tecno Sun SRL
Bronchial Hyperreactivity, Abnormal Respiratory Airway Resistance
Diagnostic Utility of Different Airway Resistance Assessment Techniques in the Methacholine Challenge Test
The aim of the study is to compare standard spirometric evaluation of methacholine challenge test with plethysmographic, interrupter technique and forced oscillation technique (FOT) evaluation of the airways resistance.
- Trial name
- NCT02343419
- Testing
- Methacholine Challenge Test
- Where
- Poland
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Pharyngitis Acute, Gingivitis
Salivary Drug Concentration Exploratory Study of Cetylpyridinium Chloride Buccal Tablets
The study is a single-arm, open-label study to explore the salivary concentration of Cetylpyridinium Chloride Buccal Tablets after single-dose administration in Healthy Subjects
- Trial name
- NCT05802628
- Testing
- Cetylpyridinium Chloride Buccal Tablets
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Patients Undergoing Cardiothoracic Surgery
Limiting IV Chloride to Reduce AKI After Cardiac Surgery
This primary aim of this study is to test the impact of a strategy of perioperative chloride-restriction through intravenous (IV) fluid therapy on the incidence of acute kidney injury after cardiac surgery.
- Trial name
- LICRA (NCT02020538)
- Testing
- Low-chloride perioperative intravenous fluid strategy, High-chloride perioperative intravenous fluid strategy
- Where
- Australia
- Volunteers
- 1,298 people
- Sponsor
- Bayside Health
Corneal Edema
Hyper-CL™ Lens (Hyper Osmotic Contact Lens) In Subjects Suffering From Corneal Edema
The Hyper-CL™ lenses are indicated for therapeutic use as a bandage to protect the corneal surface and to relieve corneal pain in the treatment of acute or chronic ocular pathologies, such as bullous keratopathy, corneal…
- Trial name
- NCT01890252
- Testing
- Hyper CL, saline solution
- Where
- Israel
- Volunteers
- 9 people
- Sponsor
- Eye-yon Medical
Periodontal Diseases, Diabetes Mellitus Type 2
Microbiological Effect of 0.12% Chlorhexidine Digluconate and 0.05% Cetylpyridinium Chloride vs Probiotics (Lactobacillus Reuteri Prodentis) on Porphyromonas Gingivalis.
This randomized non-inferiority clinical trial aims to evaluate the microbiological effect of 0.12% chlorhexidine and 0.05% cetylpyridinium vs.
- Trial name
- NCT07489924
- Testing
- Mouthwash with chlorhexidine and cetylpyridine chloride, Probiotic (Lactobacillus reuteri Prodentis
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- Universidad de Colima
Asthma
Efficacy (Bronchoprotection) and Safety of Orally Inhaled BI 1744 CL in Patients With Intermittent Asthma
The primary objective of this study is to assess the efficacy (bronchoprotection) and safety of single doses of BI 1744 CL inhalation solution (2, 5, 10 and 20 mcg) delivered via the Respimat® inhaler, in patients with…
- Trial name
- NCT00928668
- Testing
- Olodaterol (BI1744CL)
- Where
- 4 sites in Canada
- Volunteers
- 32 people
- Sponsor
- Boehringer Ingelheim
Prostate Cancer, Castration-resistant Prostate Cancer
A Biomarker Study of Standard-of-care Radium-223 Chloride for Metastatic Castration-resistant Prostate Cancer
The purpose of this study is to look for markers of how Ra-223 improves the lives of men with prostate cancer. This study makes use of Ra-223 in the standard FDA-approved way, but adds non-standard testing in an attempt to gain…
- Conditions
- Prostate Cancer, Castration-resistant Prostate Cancer, Castration-resistant Prostate Cancer Metastatic to Bone
- Trial name
- NCT02346526
- Testing
- Blood Tests, CT scan, FACBC PET/MRI in a subset of participants
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Massachusetts General Hospital
Fuchs' Endothelial Dystrophy, Corneal Edema
ODM 5 in the Treatment of Corneal Edematous Fuchs' Endothelial Dystrophy
Clinical observation to confirm the clinical safety and efficacy of ODM 5 in the treatment of corneal edema caused by Fuchs' endothelial dystrophy.
- Trial name
- NCT02332109
- Testing
- ODM 5
- Where
- 4 sites in Germany
- Volunteers
- 29 people
- Sponsor
- TRB Chemedica AG