Clinical trials: Chloroquine
Malaria, Malaria Vivax
This is a Clinical Study to Assess Whether the Combination of SJ733 and Tafenoquine Will be a Safe and Rapidly Acting Anti-malarial for the Radical Cure of P. Vivax Malaria
The goal of this Phase 2b study is to examine the safety and efficacy of the combination of SJ733, an investigational agent, and tafenoquine for the radical cure of uncomplicated P.
- Conditions
- Malaria, Malaria Vivax, Radical Cure
- Trial name
- SJ733-2002 (NCT07430592)
- Testing
- CQ/TQ, SJ733 (3-day)/TQ, SJ733 (2-day ) /TQ
- Where
- Peru
- Volunteers
- 104 people
- Sponsor
- R. Kiplin Guy
COVID, COVID-19
Efficacy of Chloroquine or Hydroxychloroquine in Treating Pneumonia Caused by SARS-Cov-2 - COVID-19
Facing the challenge of finding an efficient treatment for COVID-19, the viral pneumonia caused by the Coronavirus SARS-Cov-2, this study intended to test if Chloroquine or Hydroxychloroquine, two drugs with strong in-vitro…
- Conditions
- COVID, COVID-19, SARS-CoV 2, Coronavirus
- Trial name
- NCT04420247
- Testing
- Chloroquine, Hydroxychloroquine, standard care
- Where
- Brazil
- Volunteers
- 142 people
- Sponsor
- Centro de Estudos e Pesquisa em Emergencias Medicas e Terapia Intensiva
Breast Cancer, Invasive Breast Cancer
A Phase 2 Randomized, Double-blind Trial Evaluating the Effects of Chloroquine in Breast Cancer
Chloroquine (CQ) is a well known, well tolerated medication that has been used for many years traditionally for arthritis, lupus, and malaria.
- Trial name
- CUBiC (NCT02333890)
- Testing
- Chloroquine
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Ottawa Hospital Research Institute
COVID-19
Chloroquine for Mild Symptomatic and Asymptomatic COVID-19
19 COVID (Coronavirus disease 2019 ) is a deadly viral disease that has been spreading around the world for several months, and is caused by a CORONA family virus (COVID-19).
- Trial name
- NCT04333628
- Testing
- chloroquine, standard care
- Where
- Israel
- Volunteers
- 5 people
- Sponsor
- HaEmek Medical Center, Israel
Influenza
The Chloroquine for Influenza Prevention Trial
A randomised controlled trial to determine the efficacy of chloroquine for the prevention of influenza
- Trial name
- CHIP (NCT01078779)
- Testing
- Chloroquine
- Where
- Singapore
- Volunteers
- 1,516 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Vivax Malaria
Study on the Treatment of Vivax Malaria
This is a randomised open label trial with follow up for 1 year. 660 adults and children above 6 months diagnosed with acute Plasmodium vivax will be randomised into 3 groups, either chloroquine, artesunate, or…
- Trial name
- VHX (NCT01074905)
- Testing
- Artesunate, Chloroquine, Chloroquine/Primaquine
- Where
- Thailand
- Volunteers
- 655 people
- Sponsor
- University of Oxford
Plasmodium Falciparum Infection
Safety and Efficacy of Sanaria's PfSPZ-CVac in Malian Adults
Single site, double-blinded, randomized, placebo-controlled clinical trial of PfSPZ-CVac safety, tolerability, immunogenicity and efficacy against naturally occurring malaria in malaria-exposed Malian adults.
- Trial name
- NCT02996695
- Testing
- Artesunate, Chloroquine, PfSPZ (NF54) Challenge
- Where
- Mali
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pancreatic Cancer
Adjuvant Effect of Chloroquine on Gemcitabine
The purpose of this study is to evaluate the safety by defining the maximum tolerated dose (MTD) of Choloroquine when combined with Gemcitabine, and to evaluate preliminary efficacy of combined systemic Gemcitabine and…
- Trial name
- NCT01777477
- Testing
- Chloroquine, Gemcitabine
- Where
- Switzerland
- Volunteers
- 9 people
- Sponsor
- University of Zurich
Methylene Blue, Chloroquine
BlueCQ Bioavailability
Bioavailability of methylene blue (MB) - comparison of an i.v. and two oral MB formulations - and influence of sustained release MB on chloroquine (CQ) concentrations in whole blood, plasma and urine.
- Conditions
- Methylene Blue, Chloroquine, Pharmacokinetics, Bioavailability
- Trial name
- NCT00176072
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Falciparum Malaria
A Three Day Trial of Azithromycin Plus Chloroquine for the Treatment of Uncomplicated Plasmodium Falciparum Malaria
The treatment of symptomatic, uncomplicated malaria caused by P. falciparum in adults.
- Trial name
- NCT00282919
- Testing
- Azithromycin plus chloroquine
- Where
- 2 sites in Colombia, India
- Volunteers
- 110 people
- Sponsor
- Pfizer
Malaria
A Phase 1 Study To Estimate The Relative Bioavailability Of Fixed Combination Tablets Of Azithromycin And Chloroquine Compared To Co-Administered Individual Tablets Of Azithromycin And Chloroquine
The primary objective is to estimate the relative bioavailability of fixed azithromycin / chloroquine combination tablets relative to co-administered individual tablets of azithromycin and chloroquine.
- Trial name
- AZCQ (NCT00844207)
- Testing
- Fixed combination of Azithromycin and Chloroquine, Azithromycin and Chloroquine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Pfizer
Malaria
Studies of AQ-13, a Candidate Aminoquinoline Antimalarial, in Comparison With Chloroquine
The purpose of this protocol is to perform Phase 1 (safety/toxicity and pharmacokinetic) Studies of an investigational aminoquinoline antimalarial (AQ-13) in human subjects.
- Trial name
- NCT00323375
- Testing
- AQ-13, Chloroquine (CQ) Treatment
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Tulane University Health Sciences Center
COVID
Zinc With Chloroquine/Hydroxychloroquine in Treatment of COVID-19
we want to investigate if zinc supplementation enhance the clinical efficacy of chloroquine in treatment of COVID-19.
- Trial name
- NCT04447534
- Testing
- Chloroquine or hydroxychloroquine, zinc
- Where
- Egypt
- Volunteers
- 191 people
- Sponsor
- Tanta University
Uncomplicated Falciparum Malaria
Trial of Artesunate Combination Therapy in Pakistan
This study is an evaluation of the benefit of adding artesunate to existing first and second line antimalarial therapies in Pakistan.
- Trial name
- NCT00959517
- Testing
- artesunate (AS), sulphadoxine-pyrimethamine (SP), Chloroquine (CQ)
- Where
- Pakistan
- Volunteers
- 588 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Pancreatic Cancer Metastatic, Pancreatic Adenocarcinoma Metastatic
The Seven Trial: Exploiting the Unfolded Protein Response
The goal of this investigator initiated interventional study is to improve the response to the anticancer treatments (chemotherapy) in people who have previously untreated metastatic pancreas cancer.
- Trial name
- NCT06076837
- Testing
- Botensilimab, Balstilimab, Chloroquine Phosphate
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- HonorHealth Research Institute
Dengue
The Effect of Chloroquine in the Treatment of Patients With Dengue
The objective of this study was to evaluate the effect of chloroquine in the treatment of patients with dengue.
- Trial name
- NCT00849602
- Testing
- Chloroquine
- Where
- Brazil
- Volunteers
- 132 people
- Sponsor
- University of Sao Paulo
Malaria
Plasmodium Vivax Efficacy Trial in Cruzeiro do Sul, Acre, Brazil
Background: The World Health Organization recommends that antimalarial treatment policies be evaluated every few years to check their efficacy. P.
- Trial name
- NCT02043652
- Testing
- Chloroquine, Primaquine
- Where
- Brazil
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Glioblastoma Multiforme
Chloroquine for Treatment of Glioblastoma Multiforme
Chloroquine is a strong lysosomotropic and DNA-intercalating agent in experimental studies (Neurosurgical Focus 14(2): February, 2003) and an open-label clinical trial the investigators have demonstrated a strong adjuvant effect…
- Trial name
- NCT00224978
- Testing
- Chloroquine
- Where
- Mexico
- Sponsor
- National Institute of Neurology and Neurosurgery, Mexico
Malaria, Falciparum
Chloroquine and Amodiaquine for Treatment of Malaria in Children
This study will evaluate the efficacy of the treatment recommended by the National Malaria Programme in Guinea-Bissau as compared to a higher dose of chloroquine and to another anti-malarial drug, amodiaquine.
- Trial name
- NCT00137514
- Testing
- chloroquine, amodiaquine
- Where
- Guinea-Bissau
- Volunteers
- 720 people
- Sponsor
- Bandim Health Project
COVID-19
Azithromycin in Hospitalized COVID-19 Patients
The present study is a randomized, double-blind, controlled, clinical trial, with the approval of the ethics committee will be conducted on patients who have a positive test confirming COVID-19 in Shahid Modarres Medical…
- Trial name
- AIC (NCT04359316)
- Testing
- Hydroxychloroquine, Azithromycin
- Where
- Iran
- Volunteers
- 40 people
- Sponsor
- Shahid Beheshti University of Medical Sciences