Clinical trials: Cholera
Diarrhea, Cholera
Randomized Controlled Trial of Killed Oral Cholera Vaccine in Kolkata
The primary purpose of this study is to estimate the efficacy of a two-dose regimen of the oral killed bivalent cholera vaccine when administered to individual residing in a cholera-endemic area in India.
- Conditions
- Diarrhea, Cholera, Vibrio Infections
- Trial name
- NCT00289224
- Testing
- bivalent killed whole cell oral cholera vaccine
- Where
- India
- Volunteers
- 69,329 people, healthy volunteers welcome
- Sponsor
- International Vaccine Institute
Cholera, Vibrio Cholerae Infection
Effect of Extended Dose Intervals on the Immune Response to Oral Cholera Vaccine
Cholera is a life-threatening disease if prompt actions are not taken. The most recent estimates of the global burden of cholera estimate that there are more than 1.3 billion people at risk.
- Trial name
- NCT03373669
- Testing
- Oral Cholera Vaccine, Adjusted Dose Oral Cholera Vaccine
- Where
- Zambia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Cholera (Disorder)
VAXCHORA Pediatric Study to Assess Safety and Immunogenicity
VAXCHORA (Cholera Vaccine, Live, Oral) is a vaccine indicated for active immunization against disease caused by Vibrio cholerae serogroup O1.
- Trial name
- NCT03220737
- Testing
- VAXCHORA (Cholera Vaccine, Live, Oral)
- Where
- 10 sites in United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Bavarian Nordic
Diarrhea, Cholera
PK Study of iOWH032 in Adult Male/Female Healthy Volunteers & Adult Males With Cholera
This study will assess if the pharmacokinetics, safety and tolerability of iOWH032 are grossly different in 1) Bangladeshi healthy population and 2) Bangladeshi cholera patients. This is not a hypothesis-driven research study.
- Trial name
- PISCES (NCT01823939)
- Testing
- iOWH032
- Where
- Bangladesh
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- PATH
Enterotoxigenic Escherichia Coli Infection, Diarrhea
Study Confirming A Human Challenge Model and Investigating The Safety Of VLA1701
This is a single-center, double-blind, placebo-controlled, Phase II vaccination and challenge study designed to confirm a human challenge model with E. coli strain LSN03-016011/A.
- Trial name
- NCT03576183
- Testing
- VLA1701, Challenge Strain
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Valneva Austria GmbH
Cholera
A Study of Two Doses of Oral Cholera Vaccine (Shanchol™) in Subjects Aged 1 Year and Older in Dominican Republic
The aim of the study is to generate safety and immunogenicity data with Shanchol in The Philippines Objectives: To describe the safety after each dose of Shanchol vaccine.
- Trial name
- NCT02434822
- Testing
- Shanchol™: Oral Cholera Vaccine Killed Bivalent (O1 and O139) Whole Cell
- Where
- Dominican Republic
- Volunteers
- 336 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Cholera
Safety and Immunogenicity of a New Formulation of a Bivalent Killed, Whole-Cell Oral Cholera Vaccine
The purpose of this study is to evaluate the safety and immunogenicity of a new formulation of a locally-produced bivalent, (O-1 and O-139) killed whole cell oral cholera vaccine among Vietnamese adults.
- Trial name
- NCT00128011
- Testing
- killed oral cholera vaccine
- Where
- Vietnam
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- International Vaccine Institute
Cholera
Safety and Immunogenicity of Oral Cholera Vaccine in Kolkata
The purpose of the study is to confirm the safety and immunogenicity of the oral killed bivalent cholera vaccine in adult and pediatric volunteers in Eastern Kolkata, West Bengal, India.
- Trial name
- NCT00119197
- Testing
- killed whole cell oral cholera vaccine, Heat Killed E. coli
- Where
- India
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- International Vaccine Institute
Vaccine-Preventable Diseases, Typhoid Fever
Immune Response Elicited by Concomitant Administration of Oral Typhoid Fever (Vivotif®) and Cholera (Dukoral®) Vaccines
The goal of this clinical trial is to explore the coadministration of oral typhoid fever (Vivotif®) and cholera (Dukoral®) vaccines in healthy volunteers aged 18-65 years.
- Conditions
- Vaccine-Preventable Diseases, Typhoid Fever, Cholera
- Trial name
- NCT06104345
- Testing
- Oral typhoid fever vaccine, Oral cholera vaccine
- Where
- Finland
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Vibrio Cholerae
A Study to Evaluate Safety and Immunogenicity of the Bivalent Killed Whole Cell Oral Cholera Vaccine in Adults and Children
The purpose of this study is to determine whether the killed bivalent (O1 and O139)whole cell oral cholera vaccine(Shanchol™) is safe and effective in the treatment of Vibrio cholerae.
- Trial name
- NCT00760825
- Testing
- killed bivalent (O1 and O139)whole cell oral cholera vaccine
- Where
- India
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- International Vaccine Institute
Cholera
Immunity to Human Cholera in Bangladesh
Cholera is a severe diarrhea illness caused by bacteria. The purpose of this study is to better understand how the immune systems of people in Dhaka, Bangladesh, fight infection with cholera.
- Trial name
- NCT00401934
- Where
- Bangladesh
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cholera
Introduction of Cholera Vaccine in Bangladesh
The purpose of this study is to conduct and evaluate the feasibility and effectiveness of a mass cholera vaccination program to reduce diarrhea due to Vibrio cholerae in a high incidence urban area.
- Trial name
- ICVB (NCT01339845)
- Testing
- ShanChol, Vaccine and behaviour
- Where
- Bangladesh
- Volunteers
- 240,000 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Cholera, Diarrhea
Safety and Immunogenicity of Peru-15 Vaccine When Given With Measles Vaccine in Healthy Indian and Bangladeshi Infants
The purpose of this study is to confirm the safety and immunogenicity of Peru-15 vaccine in infants when given simultaneously with measles vaccine.
- Conditions
- Cholera, Diarrhea, Vibrio Infections
- Trial name
- NCT00624975
- Testing
- Peru-15 Vaccine
- Where
- 2 sites in Bangladesh, India
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- International Vaccine Institute
Cholera
A Study of Live Oral Cholera Vaccine, PXVX200 in Healthy Older Adults
Demonstrate that the vaccine offers protection based on antibody levels in older adults and is similar to antibody levels in adults aged 18-45 following vaccination with PXVX0200.
- Trial name
- NCT02100631
- Testing
- PXVX0200
- Where
- 16 sites in United States
- Volunteers
- 398 people, healthy volunteers welcome
- Sponsor
- Bavarian Nordic
Cholera
Cholera Vaccine Investment Strategy in Bangladesh
To evaluate the preventive impact, demand, acceptability, uptake, feasibility, and cost-effectiveness of a two-dose regimen of the OCV Shanchol in children living in urban slums in Bangladesh, Investigators will conduct a…
- Trial name
- CVIS (NCT02727855)
- Testing
- Shanchol
- Where
- Bangladesh
- Volunteers
- 75,170 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Gastroenteritis Escherichia Coli
Safety and Immunogenicity of Peru-15-pCTB in Healthy Adult Subjects
Enterotoxigenic Escherichia (E.) coli (ETEC) bacteria are the main cause of traveler's diarrhea and are significant pathogens affecting children and elderly individuals of developing countries.
- Trial name
- NCT00654108
- Testing
- Ciprofloxacin, Peru-15-pCTB, Sodium bicarbonate/Ascorbic Acid/Aspartame Buffer
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cholera, Diarrhoea
Study of Alternative Vaccination Schedule of Oral Cholera Vaccine
The absence of a boosting response after a 14 day interval with the two-dose regimen of the modified killed oral cholera vaccine raises the possibility that a longer dosing interval may be required to observe a boost in the…
- Conditions
- Cholera, Diarrhoea, Vibrio Infection
- Trial name
- NCT01233362
- Testing
- Modified killed oral cholera vaccine at 14 day interval, Modified killed oral cholera vaccine at 28 day interval
- Where
- India
- Volunteers
- 386 people, healthy volunteers welcome
- Sponsor
- International Vaccine Institute
Cholera
PXVX0200 (CVD103-HgR) vs Shanchol in Mali
To compare the ability of a single dose of PXVX0200 at two different dose levels, to placebo to elicit a significant antibody response 14 days after vaccination, compared to baseline.
- Trial name
- NCT02145377
- Testing
- PXVX0200 10E8, PXVX0200 10E9, Shanchol
- Where
- Mali
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Cholera
A Study of Two Doses of Oral Cholera Vaccine (Shanchol™) in Subjects Aged 1 Year and Older in the Philippines
The aim of the study is to generate safety and immunogenicity data with Oral Cholera Vaccine (Shanchol™) in The Philippines Objectives: To describe the safety after each dose of Shanchol vaccine.
- Trial name
- NCT01949675
- Testing
- Shanchol™: Oral Cholera Vaccine Killed Bivalent (O1 and O139) Whole Cell
- Where
- 2 sites in Philippines
- Volunteers
- 336 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Infection
Effect of Milk on the Vaccination Response
Rationale: Oral vaccination is known to induce a systemic immune response as well as an immune response in mucosal tissues, and can therefore serve as a model to study systemic and mucosal immunity.
- Trial name
- MOSAIC-2 (NCT02924246)
- Testing
- cholera vaccination, raw milk, pasteurized milk
- Where
- Netherlands
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- NIZO Food Research