Clinical trials: Cholesteatoma
Tympanomastoid Surgery, Cochlear Implant
Great Auricular Nerve Block for Children Undergoing Tympanomastoid Surgery
The investigators goal is to determine the efficacy and duration of analgesia with the addition of Clonidine, an alpha-2 agonist, to local anesthetic blockade using bupivacaine, of the great auricular nerve in children undergoing…
- Conditions
- Tympanomastoid Surgery, Cochlear Implant, Mastoidectomy, Cholesteatoma
- Trial name
- NCT01638052
- Testing
- 0.25% Bupivacaine + Clonidine
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Cholesteatoma of Attic, Cholesteatoma, Middle Ear
Impact of Mastoid Condition on Results of Endoscopic Management of Cholesteatoma
The goal of this interventional study is to learn about the effect of mastoid process status and the method of ossicular reconstruction on the results of the procedure transcanal endoscopic management of patients with localized…
- Trial name
- NCT06246682
- Testing
- Transcanal Endoscopic removal of atticoantral cholesteatoma
- Where
- Egypt
- Volunteers
- 25 people
- Sponsor
- Sohag University
Paediatric Cholesteatoma
Radical Mastoidectomy Versus Mastoid Oblitration in Pediatric Population
Chronic otitis media (COM) has a significant impact on health issues since prehistoric time. It is a global disease, seen in all the continents of world having different environmental and socioeconomic background.
- Trial name
- NCT05584891
- Testing
- mastoidectomy and mastoid oblitration
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Chronic Otitis Media
Retrospective Health Care Utilisation and Current Quality of Life in Adults With Chronic Otitis Media Who Had a Middle Ear Surgery
The objective of this multicentre study is to evaluate the standard of care of participants diagnosed with Chronic Otitis Media that have already gone through a first middle ear surgery but still have at least a moderate hearing…
- Trial name
- NCT04864912
- Testing
- Questionnaires and survey
- Where
- 6 sites in France, Germany and 1 more
- Volunteers
- 69 people
- Sponsor
- Cochlear
Cholesteatoma, Middle Ear
Level of Middle Cranial Fossa Dura in Patients With Cholesteatoma
Cholesteatoma is a destructive lesion that progressively expands in the middle ear, mastoid or petrous bone and leads to destruction of the nearby structures.
- Trial name
- NCT04551612
- Testing
- Multislice computed tomography temporal bone
- Volunteers
- 80 people
- Sponsor
- Assiut University
CerebroSpinal Fluid (CSF) Leak, Chronic Otitis Media
Cone Beam CT for Diagnosis of Select Otorhinolaryngology (ENT) Indications at Lower Dose
The study objective is to compare the CBCT images generated by the CS 9300 to those generated by conventional CT.
- Conditions
- CerebroSpinal Fluid (CSF) Leak, Chronic Otitis Media, Otospongiosis, Otosclerosis
- Trial name
- CBCT-ENT (NCT01855425)
- Testing
- Radiation
- Where
- 3 sites in United States, Belgium and 1 more
- Volunteers
- 96 people
- Sponsor
- Carestream Health, Inc.
Otitis Media, Suppurative Chronic, Cholesteatoma
Chronic Suppurative Otitis Media Microbiology
This study is planned to reveal the microbiological agents and drug sensitivities to these agents in patients diagnosed with chronic suppurative otitis media who complain of ear discharge.
- Conditions
- Otitis Media, Suppurative Chronic, Cholesteatoma, Microbial Colonization
- Trial name
- NCT06424704
- Testing
- Microbiological culture
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Selcuk University
Cholesteatoma
Outcomes of Mastoid Obliteration Canal Wall Down Tympanomastoidectomy in Cholesteatoma Surgery
Randomised study to evaluate the outcomes of mastoid cavity obliteration by muscle versus bone in canal wall down tympanomastoidectomy in cholesteatoma surgery
- Trial name
- NCT06268938
- Testing
- Canal wall down tympanomastoidectomy
- Where
- 2 sites in Egypt
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Assiut University
Otitis Media Chronic, Cholesteatoma
The Serum Sclerostin Levels in Cholesteatoma Patients
The aim of this study is to investigate the levels of sclerostin in patients with cholesteatoma. So far, there is no study showing the levels of sclerostin in cholesteatoma.
- Trial name
- NCT03954288
- Testing
- serum for sclerostin ELISA test
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Abant Izzet Baysal University
Cholesteatoma
Detection of Cholesteatoma Using Diffusion Magnetic Resonance Imaging
Cholesteatoma is a retraction pocket lined with squamous epithelium lined with keratin debris occurring within pneumatized spaces of the temporal bone.
- Trial name
- NCT03305796
- Testing
- Diffusion magnetic resonance imaging
- Volunteers
- 30 people
- Sponsor
- Assiut University
Identification of Residual Cholesteatoma After Microscopic Mastoidectomy With and Without Check Endocscopy
Comparison of Outcomes of Microscopic Mastoidectomy With and Without Check Endoscopy
PROJECT SUMMARY Cholesteatoma is a serious otological condition that remains a serious problem and poses a great challenge to otolaryngologists around the globe.
- Trial name
- NCT07896200
- Testing
- Mastoidectomy with and without check endoscopy for cholesteatoma surgery
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Sheikh Zayed Federal Postgraduate Medical Institute
Cholesteatoma, Middle Ear
Evolution of Surgery for Middle-ear Cholesteatoma After the Introduction of Exclusive Endoscopic Ear Surgery
This retrospective observational study describes the evolution of surgical management of middle-ear cholesteatoma at Nice University Hospital over a 12-year period (January 2012 to December 2023), following the introduction of…
- Trial name
- NCT07723547
- Testing
- Cholesteatoma surgery without exclusive endoscopic technique
- Where
- France
- Volunteers
- 443 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Imaging of Bony Structures of the Head (Various Conditions), Hearing Loss
MRI-based Synthetic CT Images of the Head and Neck
In case of surgical procedures in the head and neck region, MRI in combination with CT of the bone is often the standard modality to visualise bony landmarks for planning, navigation and risk assessment.
- Conditions
- Imaging of Bony Structures of the Head (Various Conditions), Hearing Loss, Cholesteatoma, Sinusitis
- Trial name
- NCT06016335
- Testing
- CT scan, MRI scan, Synthetic CT scan
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Amsterdam UMC, location VUmc
Cholesteatoma
Short- and Medium-term Evaluation of Mastoid Filling Using Bioactive Glass"
Adult patients referred to the ENT surgery department of the Hospices Civils de Lyon with cholesteatoma that had never been operated on.
- Trial name
- GLASS-BONA (NCT05921643)
- Testing
- verre bioactif 45S5 GlassBONE, verre bioactif S53P4 Bonalive
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Cholesteatoma
Endoscopic Transcanal Tympanoplasty With Attico-antrostomy Versus Endoscopic-assisted Canal Wall up Mastoidectomy in Management of Localized Cholesteatoma: A Randomized Clinical Trial
the main objective of the study is to compare endoscopic transcanal tympanoplasty with attico-antrostomy with endoscopic assisted canal wall up mastoidectomy in treatment of limited attic cholesteatoma.
- Trial name
- NCT04959539
- Testing
- endoscopic transcanal tympanoplasty with attico-antrostomy, endoscopic assisted canal wall up mastoidectomy
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Mansoura University
Middle Ear Cholesteatoma
How Long Must the MRI Follow-up Last to Safely Identify Middle Ear Residual Cholesteatoma
Previous studies demonstrated the high diagnostic value of non-echoplanar diffusion weighted magnetic resonance imaging (non-EP DWI) for residual cholesteatoma.
- Trial name
- NCT04489550
- Where
- France
- Volunteers
- 17 people
- Sponsor
- University Hospital, Montpellier
Hearing Loss, Sensorineural, Hearing Loss, Conductive
Wide Frequency Band Test of Hearing in Veterans
The accurate assessment of auditory status is critical for planning treatment for Veterans with hearing loss to include medical and audiological management.
- Conditions
- Hearing Loss, Sensorineural, Hearing Loss, Conductive, Hearing Loss, Mixed Conductive-Sensorineural, Otosclerosis
- Trial name
- CWTBAFV (NCT02019888)
- Where
- 2 sites in United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Otitis Media Chronic, Temporal Bone
Efficacy of Platelet- and Extracellular Vesicle-rich Plasma in Chronic Postsurgical Temporal Bone Inflammations
This clinical study evaluates the efficacy of the autologous blood-derived product called platelet- and extracellular vesicle-rich plasma (PVRP) for the treatment of chronically inflamed post-surgical temporal bone cavities.
- Trial name
- PvRP-ear (NCT04281901)
- Testing
- Platelet- and extracellular vesicle-rich plasma, Standard conservative treatment
- Where
- Slovenia
- Volunteers
- 25 people
- Sponsor
- University Medical Centre Ljubljana
Endoscopy; Microscopy; Ear Surgery; Cholesteatoma; Clinical Effect
Comparison of Clinical Effect Between Endoscopic and Microscopic Ear Surgery of Cholesteatoma: A Multicenter Retrospective Observational Study
Background: Cholesteatoma is a potentially life-threatening inflammatory lesion that causes hearing loss, ear discharge, and ear pain, and serious complications.
- Trial name
- NCT05182268
- Testing
- endoscopic ear surgery, microscopic ear surgery
- Volunteers
- 186 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Cholesteatoma
Diffusion Weighted MRI Accuracy in Cholesteatoma Localization
Magnetic resonance imaging of the middle ear has an increasing place in the therapeutic strategy in otology and especially for cholesteatoma.
- Trial name
- CHOLEMRI (NCT03915392)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Strasbourg, France