Clinical trials: Cholesterol, HDL
Chronic Hepatitis C Viral Infection
Do Low High Density Lipoprotein (HDL) Levels Predict Treatment Outcome in Patients With Chronic Hepatitis C Viral Infection?
The working hypothesis is that the low HDL serum level predict favorable response to anti viral treatment in chronic HCV (genotype 1) viral infection. This might be used to improve the rate of sustained virologic response.
- Trial name
- NCT01159613
- Testing
- Responders, Non Responders
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Ziv Hospital
Metabolic Syndrome X
A Mechanistic Study of the Effects of LY518674 on High-Density Lipoprotein Cholesterol (HDL-C) Metabolism
Agents that increase HDL-C via reverse cholesterol transport could provide a new therapeutic option for the prevention of atherosclerotic cardiovascular disease.
- Trial name
- NCT00327002
- Testing
- LY518674
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pennsylvania
Healthy Volunteers
Genetic and Metabolism of Post-prandial HDL Particles
Reverse cholesterol transport (RCT) pathway explains the anti-atherosclerosis role of HDL. Post prandial hypertriglyceridemia is highly predictive of atherosclerosis.
- Trial name
- HDL-PP (NCT03109067)
- Testing
- Standardized meal
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Atherosclerosis
Comparative Study of the Effect of Ezetimibe Versus Extended-Release Niacin on Atherosclerosis
Recent evidence on the use of statin therapy indicates the potential for ultra-low levels of low-density lipoprotein (LDL-C) to provide greater protection from recurrent coronary heart disease (CHD) events.
- Trial name
- NCT00397657
- Testing
- extended release niacin, ezetimibe
- Where
- 2 sites in United States
- Volunteers
- 400 people
- Sponsor
- Walter Reed Army Medical Center
Type 2 Diabetes
The Effects of Dapagliflozin on HDL Particles Subtypes and Reverse Cholesterol Transport in Type 2 Diabetic Patients
In Phase 2b/3 clinical trials, Dapagliflozin has been shown to raise HDL cholesterol levels by about 4 mg/dl (1 mmol/l), which is generally considered a clinically-meaningful change.
- Trial name
- DAPA-HDL (NCT02327039)
- Testing
- Dapagliflozin
- Where
- Italy
- Volunteers
- 33 people
- Sponsor
- University of Padova
HDL Cholesterol
Crossover of Higher Dose Statins in Patients With Low High-density Lipoproteins Cholesterol (HDLc)
Summary: Background: There is a lot of interest in the function and role of HDL to prevent and mitigate atherosclerosis in patients who are at or near LDLc targets.
- Trial name
- NCT00736463
- Testing
- Simvastatin, Atorvastatin 80 mg
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Oregon Health and Science University
Type 2 Diabetes
Effects of Peanut and Peanut Butter Consumption on Blood Lipids and Glycemic Control in Adults With Type 2 Diabetes
Peanuts and peanut butter contain high levels of monounsaturated fat (MUFA), arginine, fiber, phytosterols, resveratrol and vitamin E that have the potential to reduce cardiovascular disease (CVD) risk through improved blood…
- Trial name
- NCT00937222
- Testing
- Peanuts and peanut butter
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Loma Linda University
Cholesterol, HDL, Lipid Metabolism, Inborn Errors
Mendelian Reverse Cholesterol Transport Study
The purpose of this study is to investigate the use of radiolabeled particulate cholesterol administered intravenously in association with albumin, as a method to study reverse cholesterol transport (RCT) in people carrying…
- Conditions
- Cholesterol, HDL, Lipid Metabolism, Inborn Errors, Tangier Disease, LCAT Deficiency
- Trial name
- NCT01782027
- Testing
- 3H-cholesterol bound to albumin
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Hyperlipidemia
Safety and Benefit of MBX-8025 With and Without Commonly Used Statins in Moderately Overweight Patients With High Cholesterol
A Multicenter Randomized, Double-Blind, Placebo-Controlled Study to evaluate the efficacy, safety and tolerability of MBX-8025, a novel PPAR-d agonist to treat hyperlipidemia, insulin resistance and obesity in overweight…
- Trial name
- MBX-8025 (NCT00701883)
- Testing
- MBX-8025, Atorvastatin
- Where
- 28 sites in United States
- Volunteers
- 183 people
- Sponsor
- Gilead Sciences
Hyperlipidemias, Hypertension
The Effect of Farlong® NotoGinseng™ (Ginseng Plus®) on Cholesterol and Blood Pressure
In this randomized, placebo-controlled, double-blind parallel study in human participants with elevated LDL-C and elevated BP described here, the clinical benefits of Farlong NotoGinseng™ (Farlong Ginseng Plus® Panax Notoginseng…
- Trial name
- NCT04069715
- Testing
- Farlong NotoGinseng™ (Farlong Ginseng Plus® Panax Notoginseng extract)
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- LongStar HealthPro, Inc. DBA Farlong Pharmaceutical
Morbid Obesity
Bariatric Surgery and HDL-cholesterol
Objective: to assess the effect of gastric bypass on HDL-cholesterol concentration and its Apolipoprotein A4 content at 1 year following bariatric surgery in comparison with a hypocaloric diet.
- Trial name
- NCT01707771
- Testing
- Roux-en-Y gastric bypass, diet and lifestyle modifications
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Catholic University of the Sacred Heart
Cholesterol (Total and HDL), Exercise
Step-Aerobics Versus Core Exercise for Non-HDL Cholesterol Reduction in Sedentary/Obesity Women
This study investigated the effects of a step-aerobics program versus a core exercise program on serum non-HDL-C levels and other cardiometabolic parameters in sedentary women with overweight/obesity.
- Trial name
- NCT07703202
- Testing
- Intervention 1: Step-Aerobics Program, Intervention 2: Core Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Muğla Sıtkı Koçman University
Dyslipidemias, Hypercholesterolemia
Dachundou No Sugar Added Soymilk for Lipid Modulation
Cardiovascular disease is one of the leading causes of death worldwide, and high cholesterol is a major risk factor. Diet is known to play an important role in managing blood lipids.
- Conditions
- Dyslipidemias, Hypercholesterolemia, Cardiovascular Diseases
- Trial name
- DNS Soymilk (NCT07175766)
- Testing
- Dachundou No Sugar Added Soymilk
- Where
- Taiwan
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Taiwan Sport University
Coronary Disease, Hypolipoproteinemia
Exercise Versus Niacin in Patients With Coronary Artery Disease (CAD) and Low High-Density Lipoproteins (HDL)
The investigators want to study the relative effects of physical exercise vs. extended-release niacin (lipid-lowering drug) in patients with coronary heart disease and low HDL cholesterol ("good cholesterol") on lipid profile…
- Trial name
- NCT00298909
- Testing
- physical exercise, niaspan (extended-release niacin), niacin
- Where
- Germany
- Volunteers
- 48 people
- Sponsor
- University of Leipzig
Metabolic Syndrome
Pioglitazone vs Placebo in Combination With Niacin Extended Release on Low HDL
We will test our primary hypothesis that combining niacin extended release (niacin-ER), at a daily dosage of up to 2.0 g with pioglitazone, at a daily dosage of 45 mg will result in a 12% greater increase in HDL-C when compared…
- Trial name
- NCT00300365
- Testing
- Pioglitazone, Niacin ER, Aspirin
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Pennsylvania
Cardiovascular Disease
Clinical Study to Assess High-DHA Fish Oil on Biomarkers of Cardiovascular Disease Risk in Adults on Statin Therapy
The objective of this study is to determine the acute and chronic [4-week] effects of a high-DHA fish oil supplement on fasting and post-prandial (post-meal) biomarkers of cardiovascular disease risk, in adults on Statin therapy.
- Trial name
- NCT01690312
- Testing
- Fish Oil
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- Nutrasource Pharmaceutical and Nutraceutical Services, Inc.
Cardiovascular Disease
Effects of Almonds on Cardiovascular Risk Factors
The purpose of this research is to build the evidence base for approval of FDA health claims related to almonds and cardiovascular disease.
- Trial name
- ALD (NCT01101230)
- Testing
- Almonds
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Penn State University
Inflammatory Arthritis, Cardiovascular Risk Factor
Pharmacist CVD Intervention for Patients With Inflammatory Arthritis
Cardiovascular disease (CVD) (disease of the heart and blood vessels) is one of the leading causes of death and disability in Canada today. The majority of CVD cases are caused by factors that can be controlled.
- Conditions
- Inflammatory Arthritis, Cardiovascular Risk Factor, Rheumatoid Arthritis, Ankylosing Spondylitis
- Trial name
- RxIALTA (NCT03152396)
- Testing
- CV risk assessment and modification of global risk
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Epidemiology Coordinating and Research Centre, Canada
Dyslipidemia, Menopause
Dose-response Study of Carduus Marianus in Centesimal Scale for Dyslipidemia in Climacteric Overweighed or Obese Women.
Metabolic disorders including hypercholesterolemia and hypertriglyceridemia are present in climacteric women. Carduus marianus is a homeopathic medicine that traditionally has been used for hepatic diseases.
- Conditions
- Dyslipidemia, Menopause, Obesity
- Trial name
- NCT02775448
- Testing
- Carduus marianus 6cH, Carduus marianus 12cH, Carduus marianus 30cH
- Where
- Mexico
- Volunteers
- 62 people
- Sponsor
- Hospital Nacional Homeopático, Mexico
Cardiovascular Diseases, Lipid Disorder
SRMA of the Effect of Soy Milk vs Cow's Milk on Cardiometabolic Outcomes
Dairy consumption has shown associations with decreased incidence of cardiometabolic diseases. With the growing interest in plant-based eating, and the mounting evidence for the cardiovascular benefits of plant forward diets…
- Conditions
- Cardiovascular Diseases, Lipid Disorder, Metabolic Disease, Non-Alcoholic Fatty Liver Disease
- Trial name
- NCT05637866
- Testing
- Soy milk
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto