Clinical trials: Cholesterol, LDL
Hyperlipidemia
Effect Of Capros Supplementation On Cardiovascular Disease Risk Factors In Humans
The hypothesis of this study is that the natural supplement Capros will decrease LDL levels, platelet aggregation, and serum concentrations of high sensitivity C-reactive protein in humans at risk for cardiovascular disease.
- Trial name
- Capros (NCT01858376)
- Testing
- Capros dietary supplement
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Chandan K Sen
Hypertriglyceridemia
Effect of Fish Oil on Plasma Triglycerides in Adults
The purpose of this small, short pilot study is to determine the feasibility (e.g., recruitment, dose acceptance, retention) of a future longer trial comparing the effects of two types of omega-3 fats from fish oil on plasma…
- Trial name
- NCT00804427
- Testing
- Fish oil (90% triglycerides), Fish oil (60% triglycerides), Fish oil (ethyl esters)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Stanford University
Mildly Hypercholesterolemic Subjects
Effect of the Consumption of a Fermented Milk Enriched With Plant Sterols (France)
The purpose of this study is to investigate the effect on cholesterolemia profile of a low fat fermented milk enriched with plant sterol after 3 and 6 weeks of daily consumption in mildly hypercholesterolemic people treated or…
- Trial name
- NCT01574469
- Testing
- 1-Low fat fermented dairy product enriched with plant sterol esters (0,8 g equivalent as free sterols) (test), 2-Low fat fermented dairy product (control)
- Where
- France
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- Danone Global Research & Innovation Center
Diabetes Mellitus, Type 1, Hyperlipidemias
Efficacy of Colesevelam in Subjects With Type 1 Diabetes Mellitus
This is a prospective, randomized, double blind, parallel, placebo controlled clinical trial evaluating the efficacy of colesevelam HCl in reducing LDL in subjects with type 1 diabetes mellitus over a 12 week treatment period.
- Trial name
- NCT00938405
- Testing
- Colesevelam HCl
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Cardiovascular Diseases
Study of the Effectiveness and Safety of Niaspan ® in the Treatment of Lipid Abnormalities in Latin America
Post-Marketing Observational study of Niaspan® tablet in accordance with each country regulations. This study will be conducted in a prospective, single-arm, multi-center format.
- Trial name
- NCT01200160
- Testing
- Niacin
- Where
- 22 sites in Colombia, Mexico and 1 more
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Abbott
Hypercholesterol
Rye Bread Trial; Antioxidative and Cholesterol Lowering Effects
The purpose of this study is to investigate the antioxidative effects of alkylresorcinols (AR), originating from the rye fiber, on serum LDL particles and the use of AR or it's metabolites as biomarkers for rye fiber intake and…
- Trial name
- Rye-2008 (NCT01084226)
- Testing
- Rye-2008
- Where
- Finland
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Primary Hypercholesterolemia or Combined Hyperlipidemia Characterized by Elevated LDL-C
Pharmacokinetics and Pharmacodynamics Study
The purpose of this study is to compare the pharmacokinetics and pharmacodynamics behavior of the two formulation of QLC7401 injection to further evaluate the effect of the production site change.
- Trial name
- NCT07074236
- Testing
- QLC7401 injection, RBD7022 injection
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Dyslipidemias, LDL Hyperlipoproteinemia
Red Rice Yeast in Low-density Lipoprotein (LDL) Lowering: an Efficacy Study
Red yeast rice is a source of active compounds in reducing LDL levels with practically no side effects. Molval Fort is a natural product available in the Lebanese market with a combination of red yeast rice extracts, EPA/DHA and…
- Trial name
- NCT03607383
- Testing
- Red Rice Yeast Extract, Statin
- Where
- Lebanon
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Saint-Joseph University
Hypercholesterolemia, Dyslipidemia
Pharmacokinetic And Pharmacodynamic Study Of A Single-Dose Of PF-04950615 (RN316) In Combination With Atorvastatin
The primary objective of this study is to evaluate the pharmacokinetics and pharmacodynamics of a single dose of PF-04950615 (RN316) in volunteers on stable doses of atorvastatin.
- Trial name
- NCT01163851
- Testing
- 4 mg/kg, 0.5 mg/kg
- Where
- 5 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Pfizer
Rheumatoid Arthritis, Cardiovascular Disease
Low Density Lipoprotein Cholesterol (CLDL) as a Cardiovascular Disease Risk Factor in Rheumatoid Arthritis
The investigators hypothesize that cLDL levels are elevated in RA patients and represents an important mechanism for accelerated atherosclerosis leading to excess cardiovascular disease (CVD) in rheumatoid arthritis (RA)…
- Trial name
- cLDL in RA (NCT01105715)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Hyperlipidemias
A Study to Evaluate SGB-3403 in Healthy Volunteers and Subjects With Elevated Low-Density Lipoprotein Cholesterol (LDL-C)
This study is a randomized, double-blind, placebo-controlled, single ascending dose (SAD) and multiple ascending doses (MAD) of SGB-3403 when single administered subcutaneously to healthy volunteers and multiple administered…
- Trial name
- NCT06239714
- Testing
- SGB-3403, Atorvastatin
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Suzhou Sanegene Bio Inc.
Healthy
Effectiveness of a Vitamin Mineral Supplement
The goal of the study is to evaluate the effectiveness of a new one-a-day Cooper complete vitamin supplement with or without a combined omega-3 fatty acid supplement on selected clinical risk factor measures.
- Trial name
- Omega-3 (NCT00153764)
- Testing
- Cooper Complete One-A-Day Vitamin Supplement
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- The Cooper Institute
Familial Hypercholesterolemia
Relationships Between Plasma PCSK9 Levels, LDL-cholesterol Concentrations and Lipoprotein (a) Levels in Familial Hypercholesterolemia
Familial hypercholesterolemia (FH) is an autosomal codominant single gene disorder caused by mutations in the LDL receptor gene (LDLR) that disrupt the normal clearance of LDL particles from the plasma.
- Trial name
- NCT02225340
- Where
- Canada
- Volunteers
- 348 people, healthy volunteers welcome
- Sponsor
- Laval University
Gut Microbiome, Cholesterol, LDL
Corn and Heart Health Study
The purpose of this study is to investigate the effects of 3 different corn flours: (1) whole grain corn flour, (2) 50% refined corn flour + 50% corn bran derived from whole corn meal, and (3) refined corn flour, on…
- Conditions
- Gut Microbiome, Cholesterol, LDL, Cholesterol, HDL
- Trial name
- CHS (NCT03967990)
- Testing
- Refined cornmeal flour, 50/50 refined cornmeal-bran mix, Whole grain cornmeal flour
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Hypercholesterolemia
Effect of Red Yeast Rice, Phytosterols and L-tyrosol on Lipid Profile and Endothelial Function
A large body of evidence confirm the cholesterol lowering effect of red yeast rice, phytosterols and L-tyrosol. Because their mechanisms of action mime the ones of chemical statins and cholesterol absorption inhibitors, it is…
- Trial name
- NCT03065491
- Testing
- Combined nutraceutical
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Bologna
Hypercholesterolemia
Effect of Alirocumab on Lipid Metabolism in Adults With Elevated LDL-Cholesterol
Primary Objective: To assess the effects of subcutaneous (SC) doses of alirocumab on the elimination (measured by Fractional Clearance Rate (FCR)) of apolipoprotein B (apoB) in low density lipoprotein (LDL) in adults with mildly…
- Trial name
- NCT01959971
- Testing
- alirocumab
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sanofi
Dyslipidemia, Healthy Volunteers
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of TAP311 in Healthy Subjects and Dyslipidemic Patients
This study will assess the safety, tolerability, and effect of TAP311 on blood lipids in healthy subjects and in patients who have dyslipidemia.
- Trial name
- NCT01487460
- Testing
- TAP311
- Where
- United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Dyslipidemia
A Study to Assess the Effect of AZD0780 on the Pharmacokinetics of Rosuvastatin.
The purpose of the study is to assess the effect of AZD0780 on the pharmacokinetics of rosuvastatin, and to assess the safety and tolerability of AZD0780 single dose, in healthy participants administered alone and in combination…
- Trial name
- NCT05787002
- Testing
- AZD0780, Rosuvastatin
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
LDL-cholesterol Level 130-159mg/dL
The Effectiveness of Plant Stanols as Ester on Change in Blood Cholesterol Level
The purpose of randomized, double-blind, placebo-controlled study was to determine whether yoghurt drink containing 2g plant stanols (3.4g as plant stanol esters) is effective in the control of blood cholesterol level in subjects…
- Trial name
- NCT02779673
- Testing
- Yoghurt drink containing plant stanol as esters, Yoghurt drink without plant stanol as esters
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Hypercholesterolemia, Hyperlipidemias
Independent Effects of High-cholesterol (High-egg) and High-saturated Fat Diets on LDL-cholesterol
This study will comprise a randomized controlled, counter-balanced, cross-over trial to evaluate the independent effects of a high cholesterol (high egg), low saturated fat diet and a high saturated fat, low cholesterol diet on…
- Conditions
- Hypercholesterolemia, Hyperlipidemias, Physical Inactivity, Diet, Healthy
- Trial name
- NCT05267522
- Testing
- Egg diet, Egg-free Diet, Control Diet
- Where
- Australia
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of South Australia