Clinical trials: Cholesterol; Metabolic Disorder
Atherosclerosis, LDL-hypercholesterolemia
Effect of Mipomersen on LDL-Cholesterol Levels in Patients Treated by Regular Apheresis
Elevated LDL-cholesterol is a major risk factor for heart disease. In patients with heart disease LDL-cholesterol should be lowered to levels below 70 mg/dl to prevent progression of disease.
- Trial name
- MICA (NCT01598948)
- Testing
- mipomersen
- Where
- Germany
- Volunteers
- 17 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Type 1 Diabetes, Type 2 Diabetes
Nurse Telephone Management of Cholesterol in Diabetes
The current project is evaluating the effect of a nurse-administered phone care in diabetes to improve access to care and healthcare delivery.
- Trial name
- NATCHOS (NCT00950963)
- Testing
- Phone Counseling, Standard Clinical Care
- Where
- United States
- Volunteers
- 762 people
- Sponsor
- Denver Health and Hospital Authority
Healthy
Comparison of Colesevelam Hydrogen Chloride (HCl) Powder For Oral Suspension Versus Generic Cholestyramine Through Use of the Bile Acid Sequestrant Acceptability (BASA) Scale
The objective of this study is to compare the acceptability of Colesevelam HCl powder for oral suspension versus generic cholestyramine via the BASA scale, based upon an anticipated equivalent cholesterol lowering doses of each…
- Trial name
- NCT01122108
- Testing
- Cholestyramine, Colesevelam HCl
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Louisville Metabolic and Atherosclerosis Research Center
Dyslipidemia
A Study of the Kinetics of a 13C-Cholesterol Infusate in Healthy Male Subjects (0000-108)(COMPLETED)
This is a 2-part pilot study in healthy male subjects to evaluate plasma enrichment kinetics of [13C3,4]-cholesterol (Part I) and to assess the test-retest reproducibility (Part II) of Reverse Cholesterol Transport (RCT)…
- Trial name
- NCT01101763
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Mucopolysaccharidosis I, Mucopolysaccharidosis VI
Human Placental-Derived Stem Cell Transplantation
The purpose of this clinical trial is to investigate the safety of human placental-derived stem cells (HPDSC) given in conjunction with umbilical cord blood (UCB) stem cells in patients with various malignant or nonmalignant…
- Conditions
- Mucopolysaccharidosis I, Mucopolysaccharidosis VI, Adrenoleukodystrophy, Niemann-Pick Disease
- Trial name
- HPDSC (NCT01586455)
- Testing
- Human Placental Derived Stem Cell
- Where
- 3 sites in United States
- Volunteers
- 43 people
- Sponsor
- New York Medical College
Hypercholesterolemia, Mixed Dyslipidemia
Evaluation of Evolocumab (AMG 145) Efficacy in Diabetic Adults With Hypercholesterolemia/Mixed Dyslipidemia
The purpose of this study is to evaluate the effect of 12 weeks of subcutaneous evolocumab taken monthly compared with subcutaneous placebo taken monthly on low density lipoprotein cholesterol (LDL-C) in adults with type 2…
- Conditions
- Hypercholesterolemia, Mixed Dyslipidemia, Type 2 Diabetes
- Trial name
- BANTING (NCT02739984)
- Testing
- Evolocumab
- Where
- 66 sites in United States, Belgium and 5 more
- Volunteers
- 424 people
- Sponsor
- Amgen
HIV Infections, Lipodystrophy
Changing to Nonprotease Inhibitor Treatment to Improve Side Effects
The purpose of this study is to learn whether changing from a type of anti-HIV drug called a protease inhibitor (PI) to another type of anti-HIV drug will help to lower the amount of fats or sugars in the blood.
- Trial name
- NCT00021463
- Testing
- Abacavir sulfate, Lamivudine and Zidovudine, Abacavir sulfate, Efavirenz
- Where
- 11 sites in United States
- Volunteers
- 342 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Myocardial Infarction, Hypercholesterolemia
Alirocumab in Patients With Acute Myocardial Infarction
Phase IV investigator initiated clinical trial to study the effectiveness of alirocumab, an inhibitor of proprotein convertase subtilisin/kexin (PCSK9), versus placebo added to high-intensity statin (atorvastatin 80 mg) in…
- Trial name
- NCT02938949
- Testing
- alirocumab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Virginia Commonwealth University
Dyslipidemias
Effects of Statin Medications on Mental Processes, Behavior, and Serotonin Levels
Statins are cholesterol-lowering medications that are often prescribed for individuals with high cholesterol and who are at risk for heart disease.
- Trial name
- NCT00330980
- Testing
- 40 mg Pravastatin (Pravachol), 20 mg Simvastatin
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Familial Hypobetalipoproteinaemia - Heterozygous Form, Low-LDL-syndrome
Characterization of Two Novel Mutations in the Apob Gene
The pilot study has the target to evaluate the outcomes of two novel mutations in the gene of Apolipoprotein B (ApoB). ApoB is the main part of the low-density lipoprotein (LDL).
- Trial name
- NCT03963037
- Testing
- Blood draw
- Where
- Austria
- Volunteers
- 16 people
- Sponsor
- Medical University Innsbruck
Dyslipidemias
A Study Of The Efficacy Of Atorvastatin For Lowering Cholesterol In High-Risk Patients With High Cholesterol
The purpose of the study is to evaluate the effectiveness of atorvastatin in lowering cholesterol and getting these high risk patients to their goals of LDL <115 mg/dl across starting doses of 10 mg, 20 mg, or 40 mg with one step…
- Trial name
- NCT00644670
- Testing
- Atorvastatin
- Where
- 17 sites in Belgium
- Volunteers
- 232 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Hypercholesterolemia
How Cricket Powder Affects Gut Microbiome and Cholesterol Metabolism
Cardiovascular disease (CVD) is the leading cause of death worldwide, including in Thailand. One of the major risk factors for CVD is dyslipidemia, or abnormal levels of cholesterol and other fats in the blood.
- Trial name
- CricketOnME (NCT07009756)
- Testing
- Cricket Powder
- Where
- Thailand
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Macular Edema, Diabetes Mellitus
Laser and Antioxidant Treatment of Diabetic Macular Edema
This study will compare the side effects of two laser treatments for diabetic macular edema, a common condition in patients with diabetes.
- Trial name
- NCT00055042
- Testing
- Vitamin E
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Eye Institute (NEI)
Hypercholesterolemia
Efficacy of Sterol-Fortified Low Fat Soy Beverage on Cholesterol Metabolism, Inflammation and Oxidative Status in Humans - Study II
Hypercholesterolemia is a well-established risk factor for the development of atherosclerosis, a component of cardiovascular disease (CVD).
- Trial name
- NCT00923403
- Testing
- plant sterol enriched soymilk, control dairy milk
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
High Cholesterol, Diabetes
Complete Lifestyle Medicine Intervention Program
This project will use a mixed design and will be conducted at the West Parry Sound Health Centre. Based on similar studies there is an expected 10% drop-out rate so 20 participants per group will be invited to aim to have 15…
- Conditions
- High Cholesterol, Diabetes, Obesity, Hypertension
- Trial name
- CLIP (NCT06192251)
- Testing
- Lifestyle Medicine
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- Northern Ontario School of Medicine
Medication Adherence
Increasing Medication Adherence Through Physician Incentives and Messaging
The goal of this project is to increase patient adherence to medication using communications and incentives for physicians. The investigators are partnering with a health insurance company, Humana Inc, to design and implement an…
- Trial name
- NCT01603329
- Testing
- Increasing Medication Adherence through Physician Incentives and Messaging
- Where
- United States
- Volunteers
- 734 people
- Sponsor
- National Bureau of Economic Research, Inc.
Combined Hyperlipidemia
A Study to Evaluate Daily Pravastatin, Fenofibrate or Pravafen in the Treatment of Combined Hyperlipidemia
This is a multi-center, double blind, prospective, longitudinal, randomized, 12-week study with a 52-week open-label follow-up to evaluate the safety and efficacy of daily administration of Pravastatin 40 mg or Fenofibrate 160 mg…
- Trial name
- NCT00459745
- Testing
- Pravafen, Pravastatin, Fenofibrate
- Where
- 57 sites in United States
- Volunteers
- 481 people
- Sponsor
- Shionogi
Fasting, Fed
Development of the Leeds Food Preference Questionnaire in Spanish
The Leeds Food Preference Questionnaire (LFPQ) is a computer-based task used to measure reward responses and preferences for images of food.
- Trial name
- ES-LFPQ (NCT05837572)
- Testing
- Standardized meal
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Hypercholesterolemia
Coadministration of Ezetimibe and Atorvastatin in Patients With Primary Hypercholesterolemia (P05456)
Evaluate the safety of the long-term (1 year) coadministration of ezetimibe and atorvastatin in participants with hypercholesterolemia who have not reached low density lipoprotein (LDL)-cholesterol target with…
- Trial name
- NCT00654095
- Testing
- Ezetimibe, atorvastatin
- Volunteers
- 146 people
- Sponsor
- Organon and Co
Atherosclerotic Cardiovascular Disease, Familial Hypercholesterolemia
Trial to Evaluate the Effect of ALN-PCSSC Treatment on Low Density Lipoprotein Cholesterol (LDL-C)
This study is a Phase II, placebo-controlled, double-blind, randomized trial in 480 participants with atherosclerotic cardiovascular disease (ASCVD) or ASCVD-risk equivalents (for example, diabetes and familial…
- Conditions
- Atherosclerotic Cardiovascular Disease, Familial Hypercholesterolemia, Diabetes
- Trial name
- ORION-1 (NCT02597127)
- Testing
- ALN-PCSSC, Normal Saline
- Where
- 54 sites in United States, Canada and 3 more
- Volunteers
- 501 people
- Sponsor
- The Medicines Company
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