Clinical trials: Cholesterol
Cholesterol
A Research Study to Evaluate MK0653 (Ezetimibe) and Simvastatin, Given Together and Alone, on Intestinal Absorption of Cholesterol (0653-050)(COMPLETED)
To determine the effect of ezetimibe and simvastatin given together, and ezetimibe and simvastatin given alone on intestinal cholesterol absorption.
- Trial name
- NCT00652301
- Testing
- ezetimibe, simvastatin
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Organon and Co
Hypercholesterolemia
Efficacy and Safety of HEP-40 Chitosan for Mild to Moderately Elevated Cholesterol
Chitosan is a natural product that is produced commercially through the deacetylation of chitin, which is found in the exoskeleton of crustaceans. It has been suggested that chitosan has a lipid-lowering effect.
- Trial name
- HEP-40 (NCT00454831)
- Testing
- HEP-40 chitosan
- Where
- Canada
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- DNP Canada
Hypercholesterolemia
Effect of the Molecular Weight of Oat β-glucan on Its Ability to Lower Serum Cholesterol
The purposes of this study were: 1. To determine if a breakfast cereal containing 3g of high molecular weight oat beta-glucan fiber would lower low-density lipoprotein (LDL) - cholesterol (the "bad" cholesterol) compared to a…
- Trial name
- Bluebird (NCT00981981)
- Testing
- Wheat bran, 3g high MW, 4g medium MW
- Where
- 5 sites in Australia, Canada and 1 more
- Volunteers
- 367 people, healthy volunteers welcome
- Sponsor
- Glycemic Index Laboratories, Inc
Heart Failure, High Blood Pressure
BVA-200 vs BVA-100 Validation Study
The proposed study is a prospective, observational, investigator and patient blinded study comparing the results of blood volume measurement using the FDA-cleared Daxor BVA-100 device to the Daxor BVA-200 device.
- Conditions
- Heart Failure, High Blood Pressure, High Cholesterol, Anemia
- Trial name
- NCT06227819
- Testing
- BVA-200
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Daxor Corporation
ASCVD, LDL-C
Test 2 Treat: Can we Improve the Testing and Treatment of High Cholesterol in Patients Who Have Been Hospitalized for a Cardiac Event by Providing Education to Doctors and Patients?
The goal of this implementation trial is to learn if providing education to doctors and patients who have had a heart event works to prevent future heart problems. The main questions it aims to answer are: 1.
- Trial name
- T2T (NCT06471036)
- Testing
- Care Champion Intervention
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Duke University
Hyper-Alimentation, Healthy
How Does 4 Weeks of Increased Fast Food Intake Affect Metabolism?
Objective: To study the effect of fast food-based hyper-alimentation on liver enzymes and hepatic triglyceride content (HTGC)and metabolism. Design: Prospective interventional study with parallel control group.
- Trial name
- NCT00826631
- Testing
- Fast food arm
- Where
- Sweden
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Hospital, Linkoeping
Familial Hypercholesterolemia, Nutrition, Healthy
Unravelling the Impact of Diet on Cardiovascular Health in Heterozygous Familial Hypercholesterolemia.
The investigators will first conduct a fully controlled dietary randomized crossover trial (RCT) including 50 adults with HeFH to investigate the impact of a whole food plant-based (WFPB) diet low in red and processed meats and…
- Conditions
- Familial Hypercholesterolemia, Nutrition, Healthy, Cholesterol, Elevated, Cholesterol; Metabolic Disorder
- Trial name
- FH-Diet (NCT05181553)
- Testing
- Whole-food plant based diet (WFPB diet), Standard North American diet (SAD diet)
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Laval University
Hypercholesterolemia, Myopathy
DNA Diagnostic System for Statin Safety and Efficacy
Lipitor®, Zocor®, and Crestor® are statin drugs commonly taken to lower cholesterol and prevent heart disease. Statins lower cholesterol by different amounts in different patients and sometimes statins cause muscle pain, cramps…
- Trial name
- SIM (NCT00767130)
- Where
- 3 sites in United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Genomas, Inc
Hypercholesterolemia
Evaluating the Efficacy of AI-Guided (GenAIS TM) vs. Standard Physician-Guided Dietary Supplement Prescriptions for Lowering LDL Cholesterol in Hypercholesterolemic Patients
The trial compared AI-guided and standard physician-guided dietary supplement (DS) prescriptions for lowering LDL cholesterol (LDL-C) in hypercholesterolemic patients.
- Trial name
- NCT06448234
- Testing
- Standart supplementation therapy group, AI-guided supplementation therapy group
- Where
- Russia
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- S.LAB (SOLOWAYS)
Cholesterol Lowering
Influence of Polyglucosamine L112 on Serum Surrogate Markers of Cholesterol Absorption
Obesity is widespread and the number of overweight people has tripled from 1975 to 2016. According to the WHO (World Health Organisation), 1.9 billion adults worldwide are overweight, of which 650 million are obese.
- Trial name
- NCT05038436
- Testing
- Polyglucosamine L112
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Certmedica International GmbH
Healthy
Study of Acute Effects of Sn-1 and Sn-3 Palmitic Acid-rich or Stearic Acid-rich Fats on Metabolic Markers
To determine the effect of degree of fat saturation on postprandial lipemia, haemostatic and inflammatory markers, gut hormone concentrations, satiety perceptions, and insulinemic responses in healthy adult subjects.
- Trial name
- NCT01428960
- Testing
- Palm Mid Fraction, Shea Butter, High Oleic Sunflower Oil
- Where
- Malaysia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Malaysia Palm Oil Board
Dyslipidemia, Diabetes
Meta-analyses of the Effect of Important Food Sources of Sugars on Cardiometabolic Risk Factors
Fructose-containing sugars have been implicated in the epidemics of obesity, diabetes and related cardiometabolic disorders. This view is supported by lower quality evidence from ecological observations, animal models, and select…
- Conditions
- Dyslipidemia, Diabetes, Prediabetes, Dysglycemia
- Trial name
- NCT02716870
- Testing
- Fructose-containing Sugars
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Cholesterol, HDL
Prospective Randomized Clinical Trial Evaluating the Impact of Vinegar on High Density Lipoprotein
This is a double-blinded randomized placebo controlled prospective clinical trial evaluating the impact of apple cider vinegar on serum HDL.
- Trial name
- NCT00755924
- Testing
- Vinegar
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
Dyslipidemia
A Study to Investigate the Pharmacokinetics, Safety, Tolerability, and Efficacy of AZD0780 With Ezetimibe Combinations in Healthy Adults With Elevated LDL-C.
The main aim of this study is to assess the effects of AZD0780 when added on top of ezetimibe or ezetimibe and rosuvastatin or ezetimibe and bempedoic acid.
- Trial name
- NCT06742853
- Testing
- AZD0780, Ezetimibe, Rosuvastatin
- Where
- 3 sites in United States, United Kingdom
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Chronic Arsenic Poisoning
Vitamin E Level in Buccal Cells of Arsenicosis Patients
To understand the pathogenesis of chronic arsenic toxicity, the investigators need to know the levels of vitamin E in patients chronically exposed to high concentration of arsenic and if changes are found, what happens when…
- Trial name
- NCT01743066
- Testing
- Vitamin E
- Where
- Bangladesh
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Cholesterol (Total and HDL), Exercise
Step-Aerobics Versus Core Exercise for Non-HDL Cholesterol Reduction in Sedentary/Obesity Women
This study investigated the effects of a step-aerobics program versus a core exercise program on serum non-HDL-C levels and other cardiometabolic parameters in sedentary women with overweight/obesity.
- Trial name
- NCT07703202
- Testing
- Intervention 1: Step-Aerobics Program, Intervention 2: Core Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Muğla Sıtkı Koçman University
Cardiovascular Diseases, Cognition
Acute Impact of Whey Protein-enriched Milk Fat Globule Membrane Supplementation on Postprandial Markers of Heart and Brain Health
In a single-blind, randomised, placebo-controlled crossover manner, this study aims to assess the impact of a high-fat mixed meal containing a whey protein (WP)-enriched milk fat globule membrane (MFGM) powdered ingredient on…
- Conditions
- Cardiovascular Diseases, Cognition, Overweight or Obesity, Postmenopausal Women
- Trial name
- NCT06953232
- Testing
- Whey protein-enriched milk fat globule membrane supplement, Whey protein-based supplement
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Hypercholesterolemia, Hypertriglyceridemia
Beef in an Optimal Lean Diet (BOLD) Effects on Cardiovascular Disease (CVD) Risk
The study is designed to assess the effects of a heart-healthy diet that includes lean beef as the primary source of high quality protein on risk factors for cardiovascular disease.
- Trial name
- BOLD (NCT00937898)
- Testing
- BOLD+ Diet, BOLD diet
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Penn State University
Lipid Metabolism, Glucose Metabolism
Effects of Beta-glucan From Barley and Oats on Glucose and Lipid Metabolism, and Satiety
The interventional study will evaluate the effects of a regularly consumption of barley and oat flakes in crude and roasted form on the glucose and lipid metabolism as well as the postprandial saturation.
- Conditions
- Lipid Metabolism, Glucose Metabolism, Satiety
- Trial name
- gLUCAn (NCT03648112)
- Testing
- Intervention 1, Intervention 2, Intervention 3
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Jena
Intestinal Cholesterol Absorption
Algae and Cholesterol Absorption
The primary objective of this study is to investigate the effects of wakame and spirulina consumption on intestinal cholesterol absorption.
- Trial name
- NCT03380611
- Testing
- Wakame, Spirulina, Control
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center