Clinical trials: Cholesterol Absorption
Mildly Hypercholesterolemic Subjects
Effect of the Consumption of a Fermented Milk Enriched With Plant Sterols (France)
The purpose of this study is to investigate the effect on cholesterolemia profile of a low fat fermented milk enriched with plant sterol after 3 and 6 weeks of daily consumption in mildly hypercholesterolemic people treated or…
- Trial name
- NCT01574469
- Testing
- 1-Low fat fermented dairy product enriched with plant sterol esters (0,8 g equivalent as free sterols) (test), 2-Low fat fermented dairy product (control)
- Where
- France
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- Danone Global Research & Innovation Center
Cardiometabolic Risk
Impact of Milk Polar Lipids on Lipids Digestion, Absorption and Metabolism
Polar lipids have a specific chemical structure: they are an essential component of human cell membranes, play a major role in the nervous system and also influence the metabolic pathways including the cholesterol metabolism.
- Trial name
- VALOBAB-D (NCT02146339)
- Testing
- Cheese n°1- cheese n°2 - cheese n°3, Cheese n°1- cheese n°3 - cheese n°2, cheese n°2 - cheese n°1- cheese n°3
- Where
- 2 sites in France
- Volunteers
- 4 people
- Sponsor
- Hospices Civils de Lyon
Intestinal Cholesterol Absorption
Algae and Cholesterol Absorption
The primary objective of this study is to investigate the effects of wakame and spirulina consumption on intestinal cholesterol absorption.
- Trial name
- NCT03380611
- Testing
- Wakame, Spirulina, Control
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Coronary Heart Disease
Efficacy of Sterol Enhanced Soy Beverage on Cholesterol Metabolism, Inflammation and Oxidative Status in Humans
It is becoming increasingly clear that North Americans prefer dietary approaches to enhance health in favour of pharmaceutical approaches.
- Trial name
- NCT00924391
- Testing
- phytosterol enhanced soy based beverage, 1% milk
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Healthy Participants
GPR146 and Cholesterol Metabolism
Blood cholesterol balance is regulated by an interplay between the small intestine and the liver. Recently, a new protein (cholesin) was discovered, which is secreted by intestinal cells after dietary cholesterol intake.
- Trial name
- GPR146 (NCT07142317)
- Testing
- Cholesterol-poor, plant sterol-poor shake, Cholesterol-rich, plant sterol-poor shake, Cholesterol-rich, plant sterol-rich shake
- Where
- Netherlands
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Hypercholesterolemia
Effects of Ezetimibe on the Absorption of Oxidized Cholesterol
The purpose of this study is to test the effects of Zetia™ (ezetimibe) 10 milligrams (mg) on the absorption of oxysterol into the blood following a meal containing oxysterol.
- Trial name
- NCT00794677
- Testing
- ezetimibe
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Hypercholesterolemia
Effectiveness of Treatment of Hypercholesterolemia With Rosuvastatin and Ezetimibe
The aim of the study is to demonstrate, whether the time of day of administration of the study drug (containing rosuvastatin and ezetimibe) has an impact on the effectiveness of lipid-lowering therapy.
- Trial name
- ROSEZE (NCT02772640)
- Testing
- Rosuvastatin and Ezetimibe morning or evening administration
- Where
- Poland
- Volunteers
- 83 people
- Sponsor
- Collegium Medicum w Bydgoszczy
Coronary Heart Disease, Cardiovascular Disease
Physiological Study of Human Cholesterol Metabolism and Excretion
The underlying hypothesis is that whole body cholesterol - including cholesterol present in tissues that cannot be measured by standard blood tests - is related to heart disease risk.
- Conditions
- Coronary Heart Disease, Cardiovascular Disease, Dyslipidemia, Disorder of Cholesterol Metabolism
- Trial name
- NCT01603758
- Testing
- Ezetimibe
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Richard E. Ostlund Jr., MD
Hypercholesterolemia, Coronary Heart Disease
Phytosterols, Ezetimibe, and Cholesterol Metabolism
Phytosterols and ezetimibe each reduce intestinal cholesterol absorption by 30-55% but appear to have different mechanisms of action.
- Trial name
- Phyteaux-III (NCT00863265)
- Testing
- Ezetimibe, Phytosterols + ezetimibe
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Primary Hypercholesterolemia
A 4-week, Randomized, Placebo-Controlled, Double-Blind, Efficacy and Safety Study of HS-25 in Adults With Primary Hypercholesterolemia
To determine the efficacy of HS-25 (5, 10, 20 or 30 mg) in reducing low density lipoprotein-cholesterol (LDL-C) levels after a 4-week period of treatment in adults with primary hypercholesterolemia.
- Trial name
- NCT02087917
- Testing
- HS-25
- Where
- 27 sites in United States
- Volunteers
- 376 people
- Sponsor
- Zhejiang Hisun Pharmaceutical Co. Ltd.
Cholesterol Lowering
Influence of Polyglucosamine L112 on Serum Surrogate Markers of Cholesterol Absorption
Obesity is widespread and the number of overweight people has tripled from 1975 to 2016. According to the WHO (World Health Organisation), 1.9 billion adults worldwide are overweight, of which 650 million are obese.
- Trial name
- NCT05038436
- Testing
- Polyglucosamine L112
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Certmedica International GmbH
Cholesterol Absorption Inhibition
Cholesterol Absorption Inhibition Study
Rationale: Consuming Plant Sterols (PS) fortified foods is widely accepted as easy to apply, life-style change to combat modestly elevated plasma cholesterol concentrations.
- Trial name
- CASTELL (NCT01138787)
- Testing
- Reference spread, Test spread
- Where
- Netherlands
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Unilever R&D
Hypercholesterolemia
Effect of Plant Stanols on Cholesterol Absorption
This study aims to measure the effect of three different doses of plant stanols in margarine on the cholesterol absorption efficiency in subjects with mildly to moderately increased serum LDL cholesterol concentrations
- Trial name
- DOSE (NCT00441857)
- Testing
- plant stanol consumption
- Where
- Finland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Oy Foodfiles Ltd
Lipoidosis
SCH-58235 (Ezetimibe) to Treat Homozygous Sitosterolemia
This study will test the safety and effectiveness of SCH-58235 (Ezetimibe) in lowering sitosterol, plant sterol and cholesterol blood levels in patients with homozygous sitosterolemia when added to the patients' current treatment…
- Trial name
- NCT00045812
- Testing
- SCH-58235
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Heart Diseases, Metabolism, Inborn Errors
Higher-Dose Ezetimibe to Treat Homozygous Sitosterolemia
This study will test the safety and effectiveness of 40 mg of ezetimibe (Zetia ) daily in lowering blood levels of cholesterol and of the plant sterols sitosterol and campesterol in patients with homozygous sitosterolemia, an…
- Trial name
- NCT00099996
- Testing
- SCH-58235, Ezetimibe
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Dyslipidemia
A Study to Investigate the Pharmacokinetics, Safety, Tolerability, and Efficacy of AZD0780 With Ezetimibe Combinations in Healthy Adults With Elevated LDL-C.
The main aim of this study is to assess the effects of AZD0780 when added on top of ezetimibe or ezetimibe and rosuvastatin or ezetimibe and bempedoic acid.
- Trial name
- NCT06742853
- Testing
- AZD0780, Ezetimibe, Rosuvastatin
- Where
- 3 sites in United States, United Kingdom
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Hypercholesterolemia, Coronary Heart Disease
Addition of Phytosterols to a Low Phytosterol Diet
Studies have shown that phytosterols will lower LDL cholesterol. Typical diets can contain between 250 to 500 mg of naturally-occurring phytosterols.
- Trial name
- phyteaux-I (NCT00860054)
- Testing
- Different amount of phytosterols are added into diets
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Healthy Volunteers
Evaluation Of The Potential Effect That The Administration Of Food Or Antacid Medication May Have In The Oral Absorption Of Dacomitinib (PF-00299804)
Evaluation of the potential effect that the administration of food or antacid medication may have in the oral absorption of dacomitinib relative to the administration of dacomitinib in absence of food or antacid medication
- Trial name
- NCT01702506
- Testing
- dacomitinib fasted, dacomitinib fed, dacomitinib+antacid
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pfizer
Metabolic Syndrome X
Effects of Selective Inhibition of Cholesterol Absorption With Ezetimibe on Intestinal Cholesterol Homeostasis in Dyslipidemic Men With Insulin-resistance - a Pilot Study
Ezetimibe has been shown to inhibit cholesterol absorption and several lines of evidence from in vitro systems and animal models suggest that this effect is associated with an increase in low-density lipoprotein (LDL) receptor…
- Trial name
- EZEmRNA (NCT01849068)
- Testing
- Ezetimibe
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Laval University
Cardiovascular Disease
Impact of Buttermilk on Cholesterol Concentration and Homeostasis
The role of low-density lipoprotein cholesterol (LDL-C) in the pathogenesis of cardiovascular disease (CVD) and the clinical benefit of lowering LDL-C in high-risk patients have both been well established.
- Trial name
- BMILK (NCT01248026)
- Testing
- Buttermilk
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Laval University