Clinical trials: Cholesterol Absorption
Cholesterol
A Research Study to Evaluate MK0653 (Ezetimibe) and Simvastatin, Given Together and Alone, on Intestinal Absorption of Cholesterol (0653-050)(COMPLETED)
To determine the effect of ezetimibe and simvastatin given together, and ezetimibe and simvastatin given alone on intestinal cholesterol absorption.
- Trial name
- NCT00652301
- Testing
- ezetimibe, simvastatin
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Organon and Co
Hypercholesterolemia, Coronary Artery Disease
Plaque REgression With Cholesterol Absorption Inhibitor or Synthesis Inhibitor Evaluated by IntraVascular UltraSound
The purpose of this study was to evaluate the difference in the effect of coronary plaque regression (as measured by intravascular ultrasound [IVUS] imaging) between cholesterol absorption inhibitor and cholesterol synthesis…
- Trial name
- PRECISE-IVUS (NCT01043380)
- Testing
- Combination therapy with Lipitor [Atorvastatin] and Zetia [Ezetimibe], Lipitor (Atorvastatin) monotherapy
- Where
- Japan
- Volunteers
- 245 people
- Sponsor
- Kumamoto University
Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus
Effect of Diabetes Mellitus on Cholesterol Metabolism
HMG CoA reductase inhibitors (statins) are commonly used to treat high cholesterol (HC) in both type 1 and type 2 diabetes mellitus (DM).
- Conditions
- Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Hypercholesterolemia
- Trial name
- NCT00879710
- Testing
- simvastatin or ezetimibe
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Medical College of Wisconsin
Mildly Hypercholesterolemic Subjects
Pilot Study in the Cholesterol Absorption Reduction After Consumption of Low-fat, Drinkable Fermented Milk Enriched With Plant Sterols
The objective of this study is to compare efficacy of a plant sterol enriched yogurt given at different moments of the day in lowering blood cholesterol of hypercholesterolemic.
- Trial name
- NCT01571869
- Testing
- 1- Low fat drinkable fermented dairy product enriched with 1.6g of plant sterol (as free equivalent) per unit, 2- Low fat drinkable fermented dairy product without plant sterols (control)
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Danone Global Research & Innovation Center
Hypercholesterolemia, Coronary Heart Disease
Comparison of Low and High Phytosterol Diets With Respect to Cholesterol Metabolism
The objective of this study is to compare cholesterol absorption and metabolism after feeding diets naturally low or high in phytosterols. All meals will be prepared in a metabolic kitchen and analyzed for phytosterols.
- Trial name
- Phyteaux-II (NCT00860509)
- Testing
- Low Phytosterol and High Phytosterol Diets
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Healthy
Intralumenal Effects on Cholesterol Absorption/Synthesis
The overall goal of this study is to better understand how cholesterol is absorbed and utilized in the body(metabolism) and how serum cholesterol affects the development of hardening of the arteries (atherosclerosis).
- Trial name
- NCT00328211
- Testing
- Bile Acids (Cholic, Ursodeoxycholic, Chenodeoxycholic), Sphingomyelin, C13 Stable isotope of Cholesterol
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Vitamin D Deficiency
Effect of an Inhibitor of Cholesterol Absorption on Vitamin D Levels
Double-blind randomized controlled trial to evaluate the serum levels of 25(OH)D after a single oral dose of cholecalciferol 50,000 IU plus ezetimibe or placebo.
- Trial name
- NCT02234544
- Testing
- Ezetimibe, Cholecalciferol
- Where
- Brazil
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Healthy
Characterization Of The Effect Of Food On Palbociclib (PD-0332991) Absorption
This study is intended to quantify the effect of food on the extent of absorption of palbociclib. The caloric content of the food and the time of the meals with respect to palbociclib administration may influence the capacity of…
- Trial name
- NCT01904747
- Testing
- Palbociclib administered Fasted, Palbociclib administered Fed high calorie, Palbociclib administered Fed low calorie
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Pfizer
Cholesterol Absorption
GPur- Luminating Oral Cholesterol Kinetics Pilot Study
In healthy subjects not receiving or requiring lipid lowering therapy and who do not have diabetes, the use of clinoptilolite (GPUR) will result in a reduction of absorbed dietary cholesterol observed over 6 days of therapy.
- Trial name
- GLOCK-pilot (NCT03090542)
- Testing
- clinoptilolite
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Canadian Collaborative Research Network
Ileostoma
Plant Stanol Ester Beverage and Ileostoma Patients
We aim to examine efficacy of a plant stanolester beverage to lower serum cholesterol and LDL-cholesterol levels, when given with or without a fatty acid preparation.
- Trial name
- STOMA (NCT00846937)
- Testing
- Plant stanolester and fatty acid
- Where
- Finland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Helsinki