Clinical trials: Choroid Diseases
Plexus Choroideus, Metabolic Syndrome
Choroid Plexus Dysfunction in Neurological Diseases
Cerebral folate deficiency (CFD), a partially treatable condition defined by a low folate cerebrospinal fluid (CSF) concentration, can be linked to genetic defects of folate metabolism or be secondary to various diseases without…
- Trial name
- PLEXFOLD (NCT06403189)
- Testing
- Biologic samples and MRI
- Where
- 2 sites in France
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Choroidal Neovascularization, Macular Degeneration
Reduced Fluence Visudyne-Anti-VEGF-Dexamethasone In Combination for AMD Lesions (RADICAL)
The objective of this study is to determine if combination therapy (reduced-fluence Visudyne followed by Lucentis [within 2 hours] or either of two regimens of reduced-fluence Visudyne followed by Lucentis-Dexamethasone triple…
- Trial name
- RADICAL (NCT00492284)
- Testing
- verteporfin, ranibizumab, dexamethasone
- Where
- 26 sites in United States, Canada
- Volunteers
- 162 people
- Sponsor
- QLT Inc.
Retinitis Pigmentosa, Choroideremia
Pilot Study of a Suprachoroidal Retinal Prosthesis
This study will be an initial proof of concept study, to evaluate safety and efficacy of a prototype suprachoroidal retinal implant
- Trial name
- NCT01603576
- Testing
- Prototype wide view suprachoroidal retinal prosthesis
- Where
- 2 sites in Australia
- Volunteers
- 3 people
- Sponsor
- Center for Eye Research Australia
Intraocular Melanoma, Melanoma (Skin)
Vaccine Therapy in Treating Patients With Metastatic Melanoma
RATIONALE: Vaccines made from a person's white blood cells mixed with tumor proteins may help the body build an effective immune response to kill melanoma cells.
- Trial name
- NCT00334776
- Testing
- MART-1 antigen, gp100:209-217(210M) peptide vaccine, therapeutic autologous dendritic cells
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- University of Southern California
Paediatric Hydrocephalus
Efficacy of Combined Endoscopic Third Ventriculostomy and Choroid Plexus Cauterization in Treatment of Hydrocephalus
Hydrocephalus remains one of the most common conditions encountered in neurosurgery, traditionally managed by ventriculoperitoneal (VP) shunting.
- Trial name
- NCT07735936
- Testing
- Combined endoscopic third ventriculostomy & coroid plexus cauterization
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Assiut University
Choroidal Neovascularization
Study on the Biomarkers of Anti-VEGF Treatment for Choroidal Neovascularization
Choroidal neovascularization (CNV), also known as subretinal neovascularization, is a proliferative change from choroidal capillaries that has become one of the most important causes of blindness worldwide.
- Trial name
- NCT06243406
- Testing
- Intravitreal injection of anti-VEGF
- Volunteers
- 80 people
- Sponsor
- Beijing Hospital
Wet Macular Degeneration
Pilot Study of Ranibizumab With and Without Ketorolac Eyedrops for Exudative Age-related Macular Degeneration
The addition of an anti-inflammatory agent could be a valid option for controlling choroidal neovascularization, as simply inhibiting VEGF addresses neither the multifactorial pathogenesis of choroidal neovascularization nor the…
- Trial name
- NCT02060604
- Testing
- Ketorolac + Ranibizumab, Ranibizumab
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Università degli Studi di Brescia
Traumatic Brain Injury, Pediatric
Age Related Thresholds for Management of Severe Head Injury in Paediatrics: An Extension of STARSHIP
Traumatic brain injury in children can cause serious and long-lasting neuro-disability. However, there is still limited evidence about the best ways to treat children with severe brain injury in intensive care.
- Conditions
- Traumatic Brain Injury, Pediatric, Cerebral Perfusion Pressure, Cerebral Autoregulation
- Trial name
- ARTSHIP (NCT07834476)
- Where
- United Kingdom
- Volunteers
- 450 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma
Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck Cancer
Bevacizumab may reduce CNS side effects caused by radiation therapy. This randomized phase II trial is studying how well bevacizumab works in reducing CNS side effects in patients who have undergone radiation therapy to the brain…
- Conditions
- Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma, Adult Anaplastic Meningioma, Adult Anaplastic Oligodendroglioma
- Trial name
- NCT00492089
- Testing
- bevacizumab, magnetic resonance imaging, quality-of-life assessment
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- National Cancer Institute (NCI)
Central Nervous System Tumor, Pediatric
Genetic Study of Brain Tumors in Young Children
RATIONALE: Genetic studies may help in understanding the genetic processes involved in the development of some types of cancer. PURPOSE: Genetic study to understand how genes may be involved in the development of brain tumors in…
- Trial name
- NCT00010101
- Where
- 4 sites in United States
- Volunteers
- 38 people
- Sponsor
- Pediatric Brain Tumor Consortium
Pediatric Brain Tumors, Glioma
AI-Assisted MRI Molecular Subtyping in Pediatric Brain Tumors
This multicenter observational cohort study aims to develop and validate an artificial intelligence (AI)-assisted diagnostic system for preoperative molecular subtyping of pediatric brain tumors using routine magnetic resonance…
- Conditions
- Pediatric Brain Tumors, Glioma, Medulloblastoma, Ependymoma
- Trial name
- NCT07703605
- Volunteers
- 1,400 people
- Sponsor
- Huashan Hospital
Anaplastic Astrocytoma, Diffuse Brainstem Glioma
Testing Cerebrospinal Fluid for Cell-free Tumor DNA in Children, Adolescents, and Young Adults With Brain Tumors
Recent advances in technology have allowed for the detection of cell-free DNA (cfDNA). cfDNA is tumor DNA that can be found in the fluid that surrounds the brain and spinal cord (called cerebrospinal fluid or CSF) and in the…
- Conditions
- Anaplastic Astrocytoma, Diffuse Brainstem Glioma, Glioblastoma Multiforme, High-grade Astrocytoma NOS
- Trial name
- NCT05934630
- Where
- 10 sites in United States, Canada
- Volunteers
- 57 people
- Sponsor
- Pediatric Brain Tumor Consortium
Childhood Burkitt Lymphoma, Childhood Central Nervous System Germ Cell Tumor
Ispinesib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Lymphoma
This phase I trial is studying the side effects and best dose of ispinesib in treating young patients with relapsed or refractory solid tumors or lymphoma.
- Conditions
- Childhood Burkitt Lymphoma, Childhood Central Nervous System Germ Cell Tumor, Childhood Choroid Plexus Tumor, Childhood Craniopharyngioma
- Trial name
- NCT00363272
- Testing
- ispinesib, laboratory biomarker analysis, pharmacological study
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Chorioretinitis
Antiangiogenic Therapy of Choroidal Neovascularisation Associated With Central Chorioretinitis
The purpose of this study is to determine the effectiveness of antiangiogenic therapy to choroidal neovascularization secondary to central chorioretinitis.
- Trial name
- COAST_UAcCNV (NCT04245072)
- Testing
- Intravitreal injection, Fluorescent angiography, Visometry
- Where
- 3 sites in Ukraine
- Volunteers
- 100 people
- Sponsor
- The Filatov Institute of Eye Diseases and Tissue Therapy
Macular Edema, Retinal Vein Occlusion
The Use of Suprachoroidal Triamcinolone Acetonide to Treat Macular Edema in Retinal Vein Occlusion
This prospective non-randomized open-label interventional study aimed to evaluate feasibility in regard to potential efficacy and safety of triamcinolone acetonide (TA) injected in the suprachoroidal space (SCS) as a promising…
- Trial name
- NCT05038072
- Testing
- suprachoroidal injection of Triamcinolone Acetonide.
- Where
- Syria
- Volunteers
- 16 people
- Sponsor
- Damascus University
Age Related Macular Degeneration, Diabetic Retinopathy
Effect of Video Viewing on Intravitreal Injection Experience
Study Objective The goal of this clinical trial is to evaluate whether viewing a procedural video can improve the patient experience and reduce the incidence and severity of subconjunctival hemorrhage in individuals undergoing…
- Conditions
- Age Related Macular Degeneration, Diabetic Retinopathy, Choroidal Neovascularization, Retinal Vein Occlusion
- Trial name
- NCT07002372
- Testing
- Procedure video viewing
- Where
- China
- Volunteers
- 182 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Age Related Macular Degeneration, Choroidal Neovascularization
Sensitivity of the Home Macular Perimeter (HMP)
estimate the sensitivity of the HMP test in identifying visual field functional defects in subjects with CNV secondary to AMD
- Trial name
- HMP (NCT00604071)
- Where
- 10 sites in United States
- Volunteers
- 99 people
- Sponsor
- Notal Vision Ltd.
Choroidal Neovascularization
Genetic Factors of Idiopathic Polypoidal Vasculopathies in the ATM Gene (Ataxia Telangiectasia Mutated)
Polypoidal choriodal vasculopathy (PCV) is an ophthalmologic disease, characterized by vascular abnormalities of the walls of small choroidal vessels, reproducing the specific aspect of polyps (cluster aspect).
- Trial name
- ATM (NCT02857894)
- Where
- France
- Volunteers
- 7 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Myopia
Effects of 650nm Low Energy Light on Human Retina and Choroid Microcirculation
This project is a single-center, prospective, self-controlled clinical study. It intends to select patients with simple medium and low degree myopia as subjects, and apply 650nm low-energy red light irradiation to the retina to…
- Trial name
- NCT04604405
- Testing
- photobiomodulation
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Central South University
Clinical and Nutritional Safety.
Oat Products in the Treatment of Coeliac Disease in Children
In many Northern European countries oat-based products have been used in the dieto-therapy of coeliac disease for many years. The purpose of this study is to evaluate clinical tolerance and liking of gluten-free products…
- Trial name
- NCT00808301
- Testing
- Gluten-free products
- Where
- 7 sites in Italy
- Volunteers
- 300 people
- Sponsor
- Heinz Italia SpA