Clinical trials: Choroidal Diseases
Choroideremia
An Open Label Clinical Trial of Retinal Gene Therapy for Choroideremia
A project has been developed in Edmonton, Alberta, Canada to enable male patients with choroideremia to access a clinical trial that replaces the defective gene with a normal copy.
- Trial name
- NCT02077361
- Testing
- rAAV2.REP1 vector
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- University of Alberta
Primary Open-angle Glaucoma
Multicenter Investigation of the Glaukos® Suprachoroidal Stent Model G3 In Conjunction With Cataract Surgery
Evaluate the safety and efficacy of the Glaukos® Suprachoroidal Stent Model G3 in conjunction with cataract surgery, compared to cataract surgery only, in subjects with mild to moderate primary open-angle glaucoma.
- Trial name
- NCT01461278
- Testing
- iStent supra, Cataract surgery
- Where
- United States
- Volunteers
- 505 people
- Sponsor
- Glaukos Corporation
Neovascular Age-related Macular Degeneration
Safety and Efficacy of ADVM-022 in Treatment-Experienced Patients With Neovascular Age-related Macular Degeneration [LUNA]
Neovascular or wet age-related macular degeneration (nAMD) is a degenerative ocular disease associated with the infiltration of abnormal blood vessels in the retina from the underlying choroid layer and is a leading cause of…
- Trial name
- NCT05536973
- Testing
- ADVM-022
- Where
- 39 sites in United States, France and 1 more
- Volunteers
- 69 people
- Sponsor
- Adverum Biotechnologies, Inc.
Choroideremia
"Natural History" Study of Choroideremia
The purpose of this study is to understand the rate of progression of all stages of choroideremia using a variety of assessments performed in the clinic including visual field measures, specialized photography of the eye and…
- Trial name
- NCT02994368
- Testing
- Observation
- Where
- 4 sites in United States, Canada
- Volunteers
- 57 people
- Sponsor
- 4D Molecular Therapeutics
Choroidal Retinal Neovascularization
Aflibercept Intravitreal Injection for Myopic Choroidal Neovascularization
The purpose of this study is to evaluate the clinical results of anti-VEGF intra-vitreal injections (IVT) in CNV secondary
- Trial name
- AflibxMyopia (NCT02033018)
- Testing
- Aflibercept Injection
- Where
- 2 sites in Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Instituto de Olhos de Goiania
Age-Related Macular Degeneration, Choroidal Neovascularization
Retinal Therapy Guided by 3D OCT Image Analysis
The main purpose is to find a better way to predict the timing of treatments given to patients with Wet Age-related macular degeneration using image analysis.
- Trial name
- NCT02308215
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Michael Abramoff
Neovascular Age-related Macular Degeneration
Study to Evaluate Suprachoroidally Administered CLS-AX in the Treatment of Neovascular Age-Related Macular Degeneration
Phase 2b, randomized, double-masked, parallel-group, active-controlled, multicenter, 36-week study designed to assess the safety and efficacy of suprachoroidally administered CLS-AX 1.0 mg with a flexible dosing regimen in…
- Trial name
- ODYSSEY (NCT05891548)
- Testing
- CLS-AX, Aflibercept
- Where
- 32 sites in United States
- Volunteers
- 60 people
- Sponsor
- Clearside Biomedical, Inc.
Neovascular (Wet) Age-related Macular Degeneration
A Study to Learn How Well Aflibercept Injected Into the Eye Works and How Safe it is When Given in Customized Treatment Intervals in Patients With an Eye Disease Called Neovascular Age-related Macular Degeneration After Start of Treatment
Researchers are looking for a better way to treat people who have neovascular (wet) age-related macular degeneration (nAMD or wet AMD).
- Trial name
- XPAND (NCT05473715)
- Testing
- Aflibercept(BAY86-5321, Eylea)
- Where
- 3 sites in Canada, United Kingdom
- Volunteers
- 3 people
- Sponsor
- Bayer
Pachychoroid Disease
Choroidal Venous Congestion Following Scleral Buckling - An Imaging Study
This study aims to understand how blood flow at the back of the eye changes over time after this surgery. By studying these changes, the investigators hope to gain insights that could help improve the understanding of other eye…
- Trial name
- SB (NCT07260097)
- Where
- Singapore
- Volunteers
- 50 people
- Sponsor
- Singapore National Eye Centre
Central Serous Chorioretinopathy, Irvine-Gass Syndrome
Results of Suprachoroidal Steroids Injections in Two Chorioretinal Diseases
Suprachoroidal injection is a safe way for intraocular drug delivery. It was used to treat various retinal conditions.
- Conditions
- Central Serous Chorioretinopathy, Irvine-Gass Syndrome, Pars Planitis, Cystoid Macular Edema
- Trial name
- NCT05337332
- Testing
- Triamcinolone Acetonide
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Benha University
Choroidal Neovascularization, Macular Degeneration
Combination Bevacizumab and Verteporfin (Two Different Sequences of Treatment)in Neovascular AMD
The purpose of this research study is to compare different timing therapies of Verteporfin with Bevacizumab to treat choroidal neovascularization (CNV) due to age-related macular degeneration (AMD).
- Trial name
- NCT00426998
- Testing
- Verteporfin, Bevacizumab
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Retinal Consultants Medical Group
Polypoidal Choroidal Vasculopathy
Study to Investigate the Efficacy, Safety and Durability of Faricimab in Caucasian Patients With Polypoidal Choroidal Vasculopathy (MONDEGO)
The goal of this clinical trial is to assess the efficacy, safety and durability of faricimab in caucasian patients with polypoidal choroidal vasculopathy (PCV).
- Trial name
- MONDEGO (NCT06709339)
- Testing
- Faricimab Injection [Vabysmo]
- Where
- 31 sites in Italy, Portugal and 2 more
- Volunteers
- 120 people
- Sponsor
- Association for Innovation and Biomedical Research on Light and Image
Choroidal Neovascularization, Retinal Pigment Epithelial Detachment
Triple Treatment for Detachment of Retinal Pigment Epithelium Secondary to Polypoidal Choroidal Vasculopathy
Study the effectiveness of the treatment detachment of retinal pigment epithelium secondary to polypoidal choroidal vasculopathy. Efficacy will be assessed by regression of polyp area after twelve months, compared to baseline.
- Trial name
- NCT01666236
- Testing
- Triple Therapy
- Where
- Brazil
- Sponsor
- Federal University of São Paulo
Angioid Streaks of Macula
Antiangiogenic Therapy of CNV Associated With Angioid Streaks
The purpose of this study is to determine the effectiveness of antiangiogenic therapy to choroidal neovascularization secondary to angioid streaks.
- Trial name
- COAST_UAasCNV (NCT04119219)
- Testing
- Intravitreal injection
- Where
- 3 sites in Ukraine
- Volunteers
- 100 people
- Sponsor
- The Filatov Institute of Eye Diseases and Tissue Therapy
Age-related Macular Degeneration, Choroidal Neovascularization
Randomized Study for Efficacy and Safety of Ranibizumab 0.5mg in Treat-extend and Monthly Regimens in Patients With nAMD
This study was designed to evaluate the efficacy and safety of two different regimens of 0.5 mg ranibizumab given as intravitreal injection in patients with neovascular age-related macular degeneration
- Trial name
- TREND (NCT01948830)
- Testing
- Ranibizumab 0.5mg
- Where
- 91 sites in Belgium, Chile and 17 more
- Volunteers
- 650 people
- Sponsor
- Novartis Pharmaceuticals
Vein Occlusion, Macular Degeneration Choroidal Neovascularization
Comparing Post-intravitreal Injection Pain Scores Using Loteprednol, Bromfenac Sodium, and Artificial Tears Over a 24-hour Period
The goal of this clinical trial is to learn how various topical drops (bromfenac, loteprednol, and artificial tears) fare in alleviating post-intravitreal injection pain.
- Conditions
- Vein Occlusion, Macular Degeneration Choroidal Neovascularization, Macular Edema, Diabetic Retinopathy
- Trial name
- NCT07090044
- Testing
- Bromfenac Sodium 0.07%, Loteprednol Etabonate 0.38% Ophthalmic Gel/Jelly, Propylene Glycol Preservative-free Artificial Tears
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Retina Research Institute, LLC
Myopia, Degenerative
Reduced-fluence Verteporfin Photodynamic Therapy Plus Ranibizumab for Choroidal Neovascularization in Pathologic Myopia
To demonstrate the efficacy of ranibizumab in combination with reduced-fluence verteporfin photodynamic therapy (RF-PDT) in patients with subfoveal choroidal neovascularization secondary to pathologic myopia (PM).
- Trial name
- NCT01968486
- Testing
- PDT standard fluence, ranibizumab, PDT reduced fluence, ranibizumab, ranibizumab
- Volunteers
- 60 people
- Sponsor
- University of Campania Luigi Vanvitelli
Choroidal Neovascularization, Macular Degeneration
Prospective Observational Study to Assess Effectiveness of Intravitreal Aflibercept in Patients With Wet Macular Degeneration in Greece
This is a prospective, observational, multi-center, study. The study will be conducted in approximately 12 ophthalmological clinics and practices throughout Greece.
- Trial name
- PERSEUS-GR (NCT02821247)
- Testing
- Aflibercept (Eylea, BAY86-5321)
- Where
- Greece
- Volunteers
- 119 people
- Sponsor
- Bayer
Pathologic Myopia
Antiangiogenic Therapy of Choroidal Neovascularisation Associated With Myopia
The purpose of this study is to determine the effectiveness of antiangiogenic therapy to choroidal neovascularization secondary to pathologic myopia.
- Trial name
- COAST_UAmCNV (NCT03963596)
- Testing
- Intravitreal injection
- Where
- 3 sites in Ukraine
- Volunteers
- 122 people
- Sponsor
- The Filatov Institute of Eye Diseases and Tissue Therapy
Macular Degeneration
Intravitreous Pegaptanib Sodium Injection in Patients With Exudative Age-Related Macular Degeneration (AMD)
To provide Pegaptanib sodium injection to patients with subfoveal choroidal neovascularization (CNV) secondary to AMD, who are unable to participate in any of the Sponsor's other clinical studies with this drug for AMD, until…
- Trial name
- NCT00088192
- Testing
- pegaptanib sodium
- Where
- 20 sites in United States
- Sponsor
- Eyetech Pharmaceuticals