Clinical trials: Chronic
Chronic Rhinosinusitis (Diagnosis)
Silver Nanoparticle Investigation for Treating Chronic Sinusitis
Chronic rhinosinusitis is a highly prevalent disease resulting in high economic burden. Effective therapeutic options are needed. Rhinosinusitis-related biofilms are a likely contributor to recalcitrant disease.
- Trial name
- SNITCH (NCT03243201)
- Testing
- Colloidal silver nanoparticles, Purified Water
- Volunteers
- healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Chronic Low Back Pain (CLBP)
Impairment Based Treatment Versus Modified Functional Restoration Program in Chronic Low Back Pain Patients
The aim of this feasibility study is to evaluate the practicality of conducting a future randomized controlled trial comparing two rehabilitation approaches for older adults with degenerative chronic low back pain…
- Trial name
- FIRM-CLBP (NCT07699419)
- Testing
- Impairment-based trearment, Modified Functional restoration program
- Where
- Egypt
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Cairo University
Chronic Kidney Disease Requiring Chronic Dialysis
Activation of the Contact System and the Immune System in Patients With Chronic Kidney Disease.
Patients with end-stage renal disease undergoing hemodialysis (HD) are burdened with extremely high mortality rates (15% per year) and during the early stage (≤120days) the mortality rate is even higher (27% per year).
- Trial name
- AKIM-CKD (NCT05266092)
- Testing
- Observational study
- Where
- Denmark
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Nasal Polyps, Chronic Sinusitis
Wound Healing After Endoscopic Sinus Surgery
This study aims to determine the effect of Thymoquinone (0.5%) and olive oil ointment on Wound healing after Endoscopic sinus surgery.
- Trial name
- NCT06070311
- Testing
- Thymoquinone (0.5%) and Olive oil ointment
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Atopic Dermatitis, Psoriasis
Identification of Cutaneous and Blood Biomarkers Predictive of Response to Systemic Treatments During Chronic Inflammatory Skin Diseases
Chronic inflammatory skin diseases constitute a heterogeneous group of pathologies. They affect the skin but also other organs (joints, lungs, muscles, etc.). Their prognosis and response to treatments is extremely variable.
- Conditions
- Atopic Dermatitis, Psoriasis, Hidradenitis Suppurativa, Lichen Planus
- Trial name
- ImmuneSkinBank (NCT06599411)
- Testing
- Sampling
- Where
- France
- Volunteers
- 830 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetes Mellitus, Type II
Jordan Diabetes Microclinic Project
The purpose of the study is to provide participants in economically depressed areas of Jordan essential knowledge, practical skills, and intimate support groups-called microclinics-for managing their diabetes.
- Trial name
- NCT01596244
- Testing
- Microclinic
- Where
- 2 sites in Jordan
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Microclinic International
Chronic Prostatitis With Chronic Pelvic Pain Syndrome
Chronic Prostatitis/Chronic Pelvic Pain Syndrome Patients
Chronic prostatitis/chronic pelvic pain syndrome (CPPS) is a common health problem among men and can cause severe quality of life.
- Trial name
- NCT06016595
- Testing
- Chronic prostatitis/chronic pelvic pain syndrome
- Where
- Turkey (Türkiye)
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Hisar Intercontinental Hospital
Chronic Obstructive Pulmonary Disease (COPD)
Educational Interventions for Chronic Obstructive Pulmonary Disease (COPD) Self-management in Ethno-cultural Communities
Goal: The main goal of this study is to develop and validate educational materials that aim to improve self-management knowledge and practices about COPD among patients in Mandarin and Cantonese-speaking communities in the…
- Trial name
- COPD (NCT01474707)
- Testing
- Group one, Group two, Group three
- Where
- 2 sites in Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Cough
The Safety, Tolerability, PK and PD of GSK2339345 in Healthy Subjects
This is a First Time in Human (FTIH) study for the sodium channel inhibitor, GSK2339345. The study is split into two parts. Part A will assess the safety and tolerability of the new drug.
- Trial name
- FTIH (NCT01494636)
- Testing
- GSK2339345 (solution), GSK2339345 (nebulised), Lidocaine
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Pulp Necroses, Apical Periodontitis
Transplantation of Allogeneic MSC in Patients With Pulp Necrosis and Chronic Apical Periodontitis
The purpose of the study is to evaluate the effect of Mesenchymal Stromal Cell (MSC) implantation on pulp and periapical regeneration of immature teeth with pulp necrosis and chronic apical periodontitis.
- Trial name
- MSC (NCT04545307)
- Testing
- Allogenic transplant of BM-MSC in a root canal from patients with immature apexes and pulpar necrosis and apical periodontitis
- Where
- Venezuela
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Universidad Central de Venezuela
Hepatitis B, Chronic Hepatitis B
Study of the Relative Oral Bioavailability of AL-3778 Tablets and Drug Interaction With Entecavir or Tenofovir Disoproxil Fumarate in Healthy Volunteers
This is an open-label, randomized, multi-part study to evaluate the relative oral bioavailability of a tablet formulation of AL-3778 (formerly NVR 3-778) administered under fasted and fed conditions (Parts 1 and 2) and the…
- Conditions
- Hepatitis B, Chronic Hepatitis B, Viral Hepatitis B
- Trial name
- NCT03032536
- Testing
- AL-3778, Entecavir, Tenofovir disoproxil fumarate
- Where
- 2 sites in New Zealand
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Alios Biopharma Inc.
Chronic Obstructive Pulmonary Disease
A Study to Assess Safety, Tolerability and Pharmacokinetics of of AZD6553 in Healthy Volunteers and Patients With Chronic Obstructive Pulmonary Disease (COPD)
AZD6553 is a new drug being developed as a possible treatment for patients with chronic obstructive pulmonary disease (COPD). COPD refers to chronic bronchitis and emphysema, a pair of two commonly co-existing diseases of the…
- Trial name
- NCT01068184
- Testing
- AZD6553
- Where
- United Kingdom
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Concussion, Mild
The Combined Effect of Chronic Cannabis Use and Subconcussive Head Impacts on Brain Health
The purpose of this pilot study is to better understand the effects of chronic cannabis (THC) use on the neural responses to subconcussive head impacts, as a form of repetitive soccer headings.
- Trial name
- NCT04641832
- Testing
- Soccer heading
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Indiana University
COVID-19
Impact of Long COVID-19 on the Health and Quality of Life of Military Personnel (Active or Retired) and Their Families
Severe and sometimes irreversible sequelae are observed in people who have developed a severe form of COVID-19 (pulmonary, cardiovascular, renal, neurological sequelae among others).
- Trial name
- IMP@LA (NCT05200832)
- Testing
- Online questionnaire, Semi-structured interview
- Where
- France
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Sleep Patterns
Mayo Clinic Family Medicine Resident Wellness Study
The objectives of this study are to better understand the association between sleep characteristics (sleep disruptions and deprivations) during overnight shifts and mental fatigue among medical residents, and to explore the…
- Trial name
- NCT05148221
- Testing
- Questionnaires, Actigraph and activPAL devices
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
COPD (Chronic Obstructive Pulmonary Disease), Rhinovirus Infection
Using Multiomics to Define Mechanisms of Rhinovirus-induced Chronic Obstructive Pulmonary Disease Exacerbations to Develop Novel Therapies and Therapeutic Targets
The goal of this study is to examine exacerbations of chronic obstructive pulmonary disease (COPD) caused by a common cold virus called rhinovirus, to identify new treatments.
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Rhinovirus Infection, Exacerbation of COPD
- Trial name
- MRVCOPD (NCT07112235)
- Testing
- Rhinovirus-A16
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Chronic Musculoskeletal Pain, Clinical Communication
Development and Evaluation of an Educational Program for the Management of Chronic Musculoskeletal Pain
A controlled randomized study will be conducted to assess the effectiveness of the educational program before and after its implementation.
- Trial name
- NCT06653114
- Testing
- Education in Chronic Musculoskeletal Pain, Education in Communication Skills
- Where
- Greece
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Chronic Pain
Defense Health Agency- Development of a Medical Device Utilizing an EEG-Based Algorithm for the Objective Quantification of Pain
PainQx, with the support of the Department of Defense (Contract #W81XWH-21-C-0034), is conducting a study to collect electroencephalography (EEG) data from people with chronic pain in order to develop algorithms than will…
- Trial name
- PQXDOD1 (NCT05215184)
- Testing
- Zeto WR19 EEG Recording
- Where
- 5 sites in United States
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- PainQx, Inc
IBD and Renal Involement, Chronic Kidney Disease
Renal Dysfunction in Patients With Inflammatory Bowel Disease and the General Population (NEPHRO-IBD)
The NEPHRO-IBD study is a multicenter prospective observational study designed to evaluate the prevalence of renal dysfunction and renal complications in adult patients with inflammatory bowel disease (IBD) compared with…
- Conditions
- IBD and Renal Involement, Chronic Kidney Disease, Inflamatory Bowel Disease (Crohn's and Ulcerative Colitis)
- Trial name
- NEPHRO-IBD (NCT07593352)
- Testing
- Prospective assessment of the prevalence of kidney disease and/or renal complications in patients with IBD/the general population based on routine laboratory test and abdominal ultrasound.
- Where
- Poland
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Państwowy Instytut Medyczny Ministerstwa Spraw Wewnętrznych i Administracji
Pulmonary Disease, Chronic Obstructive
Evaluation of COPD (Chronic Obstructive Pulmonary Disease) to Longitudinally Identify Predictive Surrogate Endpoints
This is a 3 year longitudinal study to identify novel endpoints and compare these with standard measures such as forced expiratory volume in 1 second (FEV1) for their ability to measure and predict COPD (Chronic Obstructive…
- Trial name
- ECLIPSE (NCT00292552)
- Testing
- Novel endpoint determination
- Where
- 44 sites in United States, Bulgaria and 10 more
- Volunteers
- 2,747 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
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