Clinical trials: Chronic Arthritis
Systemic Vasculitis, Spondylarthropathies
Vaccination Against Herpes Zoster in Patients With Inflammatory Rheumatic Diseases
The purpose of HZ-REUMA study is explore vaccine response and protection against shingles (herpes zoster, HZ) after vaccination with two doses of Shingrix in immunosuppressed patients with inflammatory rheumatic diseases (IRD)…
- Conditions
- Systemic Vasculitis, Spondylarthropathies, Psoriatic Arthritis, Scleroderma
- Trial name
- HZ-REUMA (NCT06763783)
- Testing
- Shingrix, vaccination with 2 doses of Shingrix vaccine
- Where
- Sweden
- Volunteers
- 240 people
- Sponsor
- Region Skane
Osteoarthritis (OA) of the Knee, Knee Pain Arthritis
Neurolysis for the Treatment of Medial Chronic Knee Pain Due to Osteoarthritis
This study involves the use of sound waves to block pain signals caused by osteoarthritis of the knee. The sound waves are tightly focused on a specific area of the nerve.
- Conditions
- Osteoarthritis (OA) of the Knee, Knee Pain Arthritis, Chronic Knee Pain
- Trial name
- NCT07178951
- Testing
- Neurotomy of the medial sensory articular branches
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- FUSMobile Inc.
Knee Osteoarthritis, Knee Pain Chronic
Dorsal Root Ganglion Stimulation for the Treatment of Arthritic Knee Pain
Dorsal root ganglion stimulation (DRG-S) may be able to treat mechanical pain caused by tissue injury or damage such as trauma or arthritis in addition to pain caused by nerve dysfunction or injury.
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Knee Arthritis, Knee Arthropathy
- Trial name
- NCT05103527
- Testing
- Dorsal Root Ganglion Stimulation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Kenneth B Chapman
Chronic Osteoarthritis Pain, Chronic Low Back Pain
Study of PIPE-791 for Subjects With Chronic Osteoarthritis Pain or Chronic Low Back Pain
The primary goal of this clinical trial is to learn if PIPE-791 is safe and well-tolerated in adults with chronic osteoarthritis pain (COAP) or chronic low back pain (CLBP).
- Trial name
- NCT06810245
- Testing
- PIPE-791
- Where
- 5 sites in United States
- Volunteers
- 43 people
- Sponsor
- Contineum Therapeutics
Early Inflammatory Arthritis, Chronic Disease
Peer to Peer Mentoring: Facilitating Individuals With Early Inflammatory Arthritis to Manage Their Arthritis: Peer Mentoring Program
Inflammatory arthritis (IA) is a major cause of long-term disability. Peer support may be a solution to the common problem of delayed treatment.
- Trial name
- NCT01054131
- Testing
- peer support
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Diabetes, Hypertension
Exploring Folk Health Practices in Latinos With Chronic Medical Conditions
This study will explore how culture influences the use of folk healing practices and medical services in Latinos with chronic medical conditions.
- Conditions
- Diabetes, Hypertension, Asthma, Heart Disease
- Trial name
- NCT00224237
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Weill Medical College of Cornell University
Primary Immunodeficiency (PID), Congenital Bone Marrow Failure Syndromes
Data Collection Study of Patients With Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT With RIC
This is a data collection study that will examine the general diagnostic and treatment data associated with the reduced-intensity chemotherapy-based regimen paired with simple alemtuzumab dosing strata designed to prevented graft…
- Conditions
- Primary Immunodeficiency (PID), Congenital Bone Marrow Failure Syndromes, Inherited Metabolic Disorders (IMD), Hereditary Anemias
- Trial name
- PRO-RIC (NCT04528355)
- Testing
- data collection
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Paul Szabolcs
Fibromyalgia, Rheumatoid Arthritis
Pain Processing in Inflammatory and Non-Inflammatory Chronic Pain Syndromes
Fibromyalgia (FM) is a chronic musculoskeletal pain disorder that afflicts up to 4% of the general population. The evaluation of pain mechanisms in FM has shown predominant central abnormalities and therefore has been designated…
- Trial name
- NCT05277025
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Florida
Chronic Arthritis
Biomarkers in Chronic Arthritis
Use of genotyping for the optimization of treatment with biologics in chronic arthritis by looking for an association between certain alleles and response to treatment.
- Trial name
- NCT02909998
- Testing
- Blood sample
- Volunteers
- 379 people
- Sponsor
- University Hospital, Montpellier
Degenerative Disease, Oncology
Comprehensive Segmental Revision System
Clinical Data evaluation to document the performance and clinical outcomes of the Comprehensive Segmental Revision System.
- Conditions
- Degenerative Disease, Oncology, Revision Surgery, Trauma
- Trial name
- NCT03270982
- Testing
- Comprehensive SRS Replacement
- Where
- 4 sites in Canada, Denmark and 1 more
- Volunteers
- 105 people
- Sponsor
- Zimmer Biomet
Rheumatoid Arthritis, Systemic Lupus Erythematosus
Health Beliefs and Health Behaviors Among Minorities With Rheumatic Diseases
This study will explore the diverse health beliefs and behaviors among minority patients with rheumatic diseases. These diseases may cause joint pain, stiffness or swelling. Some can involve bones, muscles, tendons or ligaments.
- Conditions
- Rheumatoid Arthritis, Systemic Lupus Erythematosus, Arthritis
- Trial name
- NCT00069342
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Chronic Pain, Osteoarthritis of the Knee
Buprenorphine Transdermal System (BTDS) in Subjects w/Mod-sev Osteoarthritis (OA) Chronic Pain of Knee
The objective of this study is to determine the analgesic efficacy and safety of Buprenorphine Transdermal System (BTDS) 10 and 20 compared to placebo in opioid-naïve subjects with moderate to severe chronic pain due to…
- Trial name
- NCT00531427
- Testing
- Buprenorphine
- Where
- 87 sites in United States
- Volunteers
- 567 people
- Sponsor
- Purdue Pharma LP
Chronic Pain, Osteoarthritis
Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Pain Due to Osteoarthritis Taking WHO Step III Analgesics But Showing a Lack of Tolerability.
The main objective of the study is to evaluate the effectiveness, tolerability, and safety of tapentadol hydrochloride prolonged release (PR) in participants suffering from severe chronic pain due to osteoarthritis of the knee…
- Trial name
- NCT00982280
- Testing
- Tapentadol PR
- Where
- 24 sites in Australia, Denmark and 4 more
- Volunteers
- 82 people
- Sponsor
- Grünenthal GmbH
Chronic Pancreatitis, Inflammatory Bowel Diseases
Genomic Resources for Enhancing Available Therapies (GREAT1.0) Study
This is a prospective, descriptive, observational research study designed to observe and document the clinical practice by domain experts, and how the knowledge of new findings that are published in the medical literature affect…
- Conditions
- Chronic Pancreatitis, Inflammatory Bowel Diseases, Hepatitis, NASH - Nonalcoholic Steatohepatitis
- Trial name
- GREAT1 (NCT04306939)
- Testing
- venipuncture, Questionnaires, Additional Sample Collections
- Where
- United States
- Volunteers
- 120,000 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Anklyosing Spondylitis
16 Week Efficacy and 5 Year Long Term Efficacy, Safety and Tolerability of Secukinumab in Patients With Active Ankylosing Spondylitis
This study assessed the efficacy and safety of secukinumab in patients with active ankylosing spondylitis who were tolerant to or had an inadequate response to NSAIDs, DMARDs and / or TNFα inhibitor
- Trial name
- MEASURE2 (NCT01649375)
- Testing
- Secukinumab (75 mg), Secukinumab (150 mg)
- Where
- 53 sites in United States, Austria and 11 more
- Volunteers
- 219 people
- Sponsor
- Novartis Pharmaceuticals
Lupus or SLE, Spondyloarthritis
Evaluation of Plasma Vitamin C Levels in a Population of Chronic Rheumatism in Immuno-Rheumatology
Scurvy is an almost forgotten carential pathology, caused by a deep vitamin C (or ascorbic acid) deficiency, a priori exceptional in industrialized countries.
- Trial name
- VitCRIC (NCT05345899)
- Testing
- Evaluation of vitamin C level in plasma, Evaluation of quality of life
- Where
- France
- Volunteers
- 107 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Osteoarthritis of the Knee, Insomnia
Sleep, Pain and Inflammatory Processes in Older Adults With Osteoarthritis
The purpose if the study is to determine whether improving sleep, especially slow wave or "deep" sleep, in older adults with osteoarthritis (OA) and insomnia reduces pain sensitivity and inflammatory responses to pain, and…
- Conditions
- Osteoarthritis of the Knee, Insomnia, Knee Pain
- Trial name
- NCT01683799
- Testing
- Cognitive Behavioral Therapy for Insomnia
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Rochester
Gout; Hyperuricemia, Gout Flare
Developing A Gout Action Plan in Primary Care Setting in Singapore
The goal of this clinical trial is to develop a gout action plan in primary care setting in Singapore among adult patients with gout, and to learn if the gout action plan can improve gout control.
- Conditions
- Gout; Hyperuricemia, Gout Flare, Gout Chronic
- Trial name
- NCT07061587
- Testing
- Gout action plan
- Where
- Singapore
- Volunteers
- 72 people
- Sponsor
- SingHealth Polyclinics
Chronic Obstructive Pulmonary Disease, Arthritis
Modifying Exercise for the COPD Patient
This study will test whether using the Biodex BioStep Semi Recumbent Elliptical for the chronic obstructive pulmonary disease (COPD) patient with arthritic limitations will improve participation in a pulmonary rehab program…
- Conditions
- Chronic Obstructive Pulmonary Disease, Arthritis, Pain
- Trial name
- NCT02143206
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Angela N Fellner PhD CCRP
Inflammatory Disorder of Immune System, Spondylitis, Ankylosing
Effects of Phytocannabinoids on Immune Response and Autophagy During Chronic Immune-mediated Inflammatory Diseases
Cannabis, in addition to its psychotropic properties, could have anti-inflammatory and immunomodulatory effects. Phytocannabinoids (pCBs) are a group of molecules naturally secreted by the cannabis plant.
- Conditions
- Inflammatory Disorder of Immune System, Spondylitis, Ankylosing, Arthritis, Rheumatoid, Arthritis, Psoriatic
- Trial name
- pCB-IMIDs (NCT06842316)
- Testing
- 1 blood sample, 40 mL (collection during a blood test, part of the standard of care for this disease)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Régional d'Orléans