Clinical trials: Chronic Arthritis
Knee Osteoarthritis, Knee Arthritis
Performance of MOTO Medial® Unicompartmental Knee Arthroplasty
This is a prospective, multi-center study, designed to assess mid-term performance of the MOTO Medial® Unicompartmental Knee Arthroplasty (UKA), with patient report outcomes, clinical findings and radiographic analysis.
- Conditions
- Knee Osteoarthritis, Knee Arthritis, Knee Pain Chronic
- Trial name
- NCT03211663
- Testing
- MOTO Medial® UKA
- Where
- 5 sites in United States
- Volunteers
- 269 people, healthy volunteers welcome
- Sponsor
- Medacta USA
Rheumatoid Arthritis, Fibromyalgia
Gut Microbiota: a Player in Chronic Pain in Patients With Rheumatoid Arthritis?
Although rheumatoid arthritis (RA) treatments are very effective in reducing inflammation, chronic pain persists in 20 to 30% of patients.
- Trial name
- MiSenDol (NCT05822856)
- Testing
- Blood sampling and others interventions
- Where
- France
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Rheumatoid Arthritis, Chronic Periodontitis
Estimation of Pentraxin3 and PGingivalis Levels in Patients With Knee Joint and Gum Diseases
Periodontitis and Rhematoid arthritis are chronic inflammatory diseases which share common risk factors The purpose of this study is to determine if Pentraxin 3 and Porphyromonas Gingivalis levels play an important role in the…
- Trial name
- EP3PGKG (NCT02503046)
- Testing
- Estimation of Pentraxin3, Estimation of P.Gingivalis levels
- Where
- India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Covid19, Rheumatic Fever
Impact of COVID-19 Pandemic and Social Distancing on Mental Health of Chronic Inflammatory Rheumatism Affected Patients
Recent studies have highlighted the consequences of COVID-19 pandemic and social distancing on mental health of individuals. The aim of this study is to evaluate those consequences within a sample of inflammatory chronic…
- Conditions
- Covid19, Rheumatic Fever, Mental Disorder
- Trial name
- EMOPTION (NCT04798053)
- Testing
- Questionnaire, blood sample and salivary sample
- Where
- 7 sites in France
- Volunteers
- 259 people
- Sponsor
- University Hospital, Bordeaux
Osteoarthitis, Fibromyalgia
Screening Anxiety and Depression Among Patients with Chronic Musculoskeletal Pain Within Physiotherapy Practices
This study will investigate whether physiotherapists can accurately identify symptoms of anxiety and of depression in patients with chronic musculoskeletal pain (primary aim).
- Conditions
- Osteoarthitis, Fibromyalgia, Rheumatoid Arthritis (RA, Low Back Pain
- Trial name
- NCT06785883
- Where
- Belgium
- Volunteers
- 750 people
- Sponsor
- KU Leuven
Chronic Knee Pain, Osteoarthritis
Genicular Embolization Using Doxycycline Sclerotherapy
The goal of this prospective case series is to develop an alternative pain management procedure for patients who are not surgical candidates.
- Trial name
- NCT07024654
- Testing
- Doxycycline Injection
- Sponsor
- Campbell Clinic
Calcium Pyrophosphate Deposition Disease
Tocilizumab in Chronic Inflammatory CPPD Disease
The aim of this clinical trial is to determine the efficacy of tocilizumab (an IL-6 inhibitor) in treatment-refractory chronic inflammatory forms of CPPD.
- Trial name
- TociCCAre (NCT07254637)
- Testing
- Tocilizumab
- Where
- 12 sites in France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Osteoarthritis of Knee, Central Sensitization
Duloxetine As an Analgesic in Patients Without Central Sensitivity After Same Sitting Bilateral Total Knee Arthroplasty
Analgesic effect of 20mg Duloxetine was evaluated at regular short term intervals in patients without central sensitivity and undergoing bilateral single sitting total knee arthroplasty for tricompartmental osteoarthritis using…
- Conditions
- Osteoarthritis of Knee, Central Sensitization, Central Sensitisation
- Trial name
- NCT06837012
- Testing
- Duloxetine - low dose
- Where
- India
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Orthopaedic Arthroscopy Knee and Shoulder Clinic
Spondylitis, Ankylosing
16-week Efficacy and 3-year Safety, Tolerability and Efficacy of Secukinumab in Active Ankylosing Spondylitis Patients
The purpose of this study was to generate 16-week efficacy data, as well as up to 3-year efficacy, safety and tolerability data in subjects with active AS despite current or previous NSAID, DMARD and/or anti-TNF therapy.
- Trial name
- MEASURE 3 (NCT02008916)
- Testing
- Secukinumab
- Where
- 57 sites in United States, Belgium and 8 more
- Volunteers
- 226 people
- Sponsor
- Novartis Pharmaceuticals
Chronic Pain, Lumbar Back Pain
Effectiveness of Acupuncture Clinical Pathway
The study will be described the development and implementation of the Clinical pathway (CPW) for acupuncture treatment in the management of patients with some chronic pain conditions.
- Conditions
- Chronic Pain, Lumbar Back Pain, Osteoarthritis, Knee, Headache
- Trial name
- ACUPATHWAY (NCT04490798)
- Testing
- Electroacupuncture
- Where
- Spain
- Volunteers
- 3,245 people
- Sponsor
- Hospital Son Llatzer
Foot Deformities, Pes Planus
The Relationship of the Medial Longitudinal Arch Height With Clinical Features of Knee Osteoarthritis
The goal of this observational study is to investigate the relationships between the medial longitudinal arch (MLA) height of the foot and clinical and radiological characteristics of knee osteoarthritis in adult patients 50 aged…
- Conditions
- Foot Deformities, Pes Planus, Pes Cavus, Knee Osteoarthritis
- Trial name
- NCT05656014
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Gazi University
Osteoarthritis, Knee
Study of StimRouter for Chronic Knee OA Pain
The goal of this study is to evaluate the use of StimRouter Neuromodulation System (StimRouter) in adult subjects with an established diagnosis of primary femorotibial osteoarthritis in the target knee (Kellgren-Lawrence ≥1) who…
- Trial name
- GLEAM (NCT05644639)
- Testing
- StimRouter Neuromodulation System
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Bioventus LLC
Arthritis
Comparing ASHC and CDSMP Outcomes In Arthritis
The arthritis-specific Arthritis Self Help Course (ASHC) and the more generic Chronic Disease Self Management Program (CDSMP) teach generalizable skills for managing arthritis and other chronic diseases.
- Trial name
- NCT00207441
- Testing
- Arthritis Self management program, Chronic Disease Self Management Program
- Where
- United States
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Osteoarthritis, Pain
A SAD Study to Evaluate the Safety, Tolerability and PK/PD of iN1011-N17 in Healthy Volunteers
A First-in-Human, Double-blind, Randomized, Placebo-controlled, Single Ascending Dose Study to Evaluate Safety, Tolerability, Pharmacokinetics/Pharmacodynamics of iN1011-N17 after Oral Administration in Healthy Volunteers.
- Conditions
- Osteoarthritis, Pain, Post Herpetic Neuralgia, Neuropathic Pain
- Trial name
- NCT05496205
- Testing
- iN1011-N17
- Where
- Australia
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- iN Therapeutics Co., Ltd.
Gout, Arthritis, Gouty
Phase 3 Evaluation of Efficacy and Safety of AR882 in Gout Patients (AR882-301)
This study will assess the serum uric acid lowering effect and safety of AR882 in gout patients at two doses compared to placebo over 12 months
- Conditions
- Gout, Arthritis, Gouty, Hyperuricemia, Gout Chronic
- Trial name
- NCT06846515
- Testing
- AR882 50 mg, AR882 75 mg
- Where
- 83 sites in United States
- Volunteers
- 866 people
- Sponsor
- Arthrosi Therapeutics
Arthritis;Lumbosacral, Osteo Arthritis Knee
Cooled RF Lesion MRI Characteristics
This Prospective, Single-center, Pilot Study will assist in gaining an understanding of the actual CRFA lesions in an in vivo situation in areas where CRFA is utilized as a standard of care treatment option for the relief of…
- Conditions
- Arthritis;Lumbosacral, Osteo Arthritis Knee, Sacroiliitis, Hip Osteoarthritis
- Trial name
- NCT03631030
- Testing
- Cooled radiofrequency ablation
- Where
- 2 sites in United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- International Spine, Pain and Performance Center
Osteoporosis, Osteoarthritis
The Effect of Exercise Training in the Community-dwelling Adults With Chronic Disorders
Previous studies have demonstrated that resistance training (RT) is beneficial to increase muscle strength, improve functional ability and the ability to rapidly produce force, known as the contractile rate of force development…
- Trial name
- NCT02017067
- Testing
- hydraulic resistance circuit training
- Where
- Taiwan
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
Rheumatoid Arthritis
Cognitive-Behavioral Therapy and Tai Chi Chih for Patients With Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic illness. Patients with RA often experience significant pain and depression. This study will evaluate two programs designed to improve the symptoms of RA: cognitive-behavioral therapy (CBT)…
- Trial name
- NCT00072657
- Testing
- Cognitive Behavioral Therapy, Tai Chi Chih, Health Education Seminar
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- University of California, Los Angeles
Osteoarthritis, Chronic Pain
A Study of Embeda (Kadian NT, ALO-01) in Subjects With Pain Due to Osteoarthritis of the Hip or Knee
The purpose of this study is to evaluate the efficacy of Kadian NT (ALO-01) compared with placebo for treating moderate to severe chronic pain over a 12 week period.
- Trial name
- NCT00420992
- Testing
- ALO-01 (Morphine Sulfate Plus Naltrexone Hydrochloride Extended Release)
- Where
- 81 sites in United States
- Volunteers
- 547 people
- Sponsor
- Pfizer
Osteoarthritis, Knee Osteoarthritis
Pain Management In Knee Osteoarthritis
In this study, it was aimed to investigate the effect of pain management education in individuals with knee osteoarthritis with chronic pain.
- Conditions
- Osteoarthritis, Knee Osteoarthritis, Pain, Chronic
- Trial name
- NCT05844319
- Testing
- tele-education
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Istanbul University