Clinical trials: Chronic Arthritis
Juvenile Idiopathic Arthritis, Persistent Knee Arthritis
Genicular Nerve Block in Juvenile Idiopathic Arthritis
N=104 juvenile idiopathic arthritis patients diagnosed after ILAR criteria with unilateral persistent knee arthritis. They will be randomly assigned into two groups; group 1 will receive genicular nerve block, group 2…
- Conditions
- Juvenile Idiopathic Arthritis, Persistent Knee Arthritis, no Intra-articular Injection in the Last 3 Months, no Other Cause for Chronic Kneearthritis
- Trial name
- NCT04687930
- Testing
- genicular nerve block, intra-articular steroid injection
- Where
- Egypt
- Volunteers
- 104 people
- Sponsor
- Sohag University
Chronic Pain, Osteo Arthritis Knee
rTMS for Relieving Chronic OA Pain
In this study the investigators aim to examine the effects of Transcranial Magnetic Stimulation (TMS) on hippocampal network connectivity and pain levels in individuals with pain due to knee osteoarthritis.
- Trial name
- NCT05097729
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Sponsor
- Northwestern University
Anterior Uveitis, Arthritis, Juvenile Idiopathic
Human Anti-Tac (Daclizumab) to Treat Juvenile Idiopathic Arthritis (JIA)-Associated Uveitis
This study will examine the safety and effectiveness of a monoclonal antibody called humanized anti-Tac (HAT, also called daclizumab) to treat children and adolescents with uveitis (chronic inflammatory eye disease) associated…
- Conditions
- Anterior Uveitis, Arthritis, Juvenile Idiopathic, Iritis, Immunosuppression
- Trial name
- NCT00130637
- Testing
- Daclizumab
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- National Eye Institute (NEI)
Lipedema, Knee Osteoarthritis
The Effect of Lipedema on Knee Osteoarthritis
This study will be one of the few to examine the effect of lipedema on knee osteoarthritis in a comparative manner with a control group within the same osteoarthritis context.
- Conditions
- Lipedema, Knee Osteoarthritis, Knee Acute and Chronic Pain, Knee
- Trial name
- NCT07575555
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Izmir Democracy University
Back Pain, Osteoarthritis
Strategies for Prescribing Analgesics Comparative Effectiveness Trial
Chronic musculoskeletal pain conditions are among the most prevalent conditions in VA primary care. Over the past two decades, improved clinical attention to pain has been associated with exponentially greater use of long-term…
- Trial name
- SPACE (NCT01583985)
- Testing
- Opioid-intensive prescribing strategy, Opioid-avoidant prescribing strategy
- Where
- United States
- Volunteers
- 265 people
- Sponsor
- VA Office of Research and Development
Osteoarthritis, Knee, Knee Pain Chronic
Finding the Optimal Aim of Correction in Opening Wedge High Tibial Osteotomy
The purpose of this RCT is to investigate whether high tibial osteotomy using 3D printed patient specific guides aiming at 55% correction is non-inferior to aiming at 62%.
- Conditions
- Osteoarthritis, Knee, Knee Pain Chronic, Arthralgia
- Trial name
- NCT06134050
- Testing
- Procedure: HTO using PSI aiming at 55% correction, Procedure: HTO using PSI aiming at 62% correction
- Volunteers
- 70 people
- Sponsor
- Vestre Viken Hospital Trust
Anklyosing Spondylitis
16 Week Efficacy and 5 Year Long Term Efficacy, Safety and Tolerability of Secukinumab in Patients With Active Ankylosing Spondylitis
This study assessed the efficacy and safety of secukinumab in patients with active ankylosing spondylitis who were tolerant to or had an inadequate response to NSAIDs, DMARDs and / or TNFα inhibitor
- Trial name
- MEASURE2 (NCT01649375)
- Testing
- Secukinumab (75 mg), Secukinumab (150 mg)
- Where
- 53 sites in United States, Austria and 11 more
- Volunteers
- 219 people
- Sponsor
- Novartis Pharmaceuticals
Cerebral Palsy, Spina Bifida
A Peer E-mentoring Intervention to Improve Employment
Despite the strong business case of hiring people with disabilities, a significant proportion of youth with disabilities leave high school and neither work nor continue their education and are unprepared to meet the demands of a…
- Conditions
- Cerebral Palsy, Spina Bifida, Juvenile Arthritis, Spinal Cord Injury
- Trial name
- NCT02522507
- Testing
- Empowering youth towards employment
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Chronic Pain
Effectiveness, Safety, and Tolerability Study of Oxymorphone Immediate Release (IR) Oral Liquid in Opioid Tolerant Pediatric Subjects
The purpose of this study is to evaluate the effectiveness, tolerability, and safety of oxymorphone immediate release (IR) oral liquid as an analgesic in pediatric subjects having severe to moderate chronic pain.
- Trial name
- NCT01206907
- Testing
- oxymorphone IR
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Chronic Pain, Juvenile Idiopathic Arthritis
Turkish Validity and Reliability of Pain Catastrophizing Scale-Child (PCS-C)
Perception of chronic pain and related disability; occurs through the interaction of physiological and psychological processes. Pain catastrophizing is a cognitive attribution style characterized by a negative mindset and…
- Trial name
- NCT05436301
- Testing
- Pain Catastrophizing Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Arthritis of the Knee
Dosing of Intra-articular Triamcinolone Hexacetonide for Knee Synovitis in Chronic Polyarthritis
This prospective randomised controlled single blind trial comparing the relapse rate in 6 months for 20 mg versus 40 mg intraarticular triamcinolone hexacetonide (Lederspan®) for knee synovitis in patients with rheumatoid…
- Trial name
- NCT02437461
- Testing
- Triamcinolone hexacetonide
- Where
- Sweden
- Volunteers
- 159 people
- Sponsor
- Uppsala University
Osteoarthritis Knees Both, Pain, Chronic
Investigation of the Effectiveness of a Structured Squat-based Program in Knee Osteoarthritis Rehabilitation
The main purpose of the study is to examine the effect of squat-based exercise approach in individuals with knee osteoarthritis.
- Conditions
- Osteoarthritis Knees Both, Pain, Chronic, Walking, Difficulty
- Trial name
- NCT04588558
- Testing
- Flywheel exercise, Home exercise, Electrotherapy group
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Istanbul Medipol University Hospital
Hip Osteoarthritis, Hip Pain Chronic
Fast Track Total Hip Arthroplasty vs Standard Care
Fast-track total hip arthroplasty (THA) is a well-established concept including optimized logistics and evidence-based treatment, focusing on minimizing surgical stress and improved post-operative recovery.
- Trial name
- FastTrack-H (NCT04211987)
- Testing
- fast track care protocol, standard care protocol
- Where
- Italy
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Istituto Ortopedico Rizzoli
Pain Syndrome, Pain, Chronic
Validity, Reliability and Responsiveness of Pain Sensitization Questionnaire
The aim of this study was to translate the Pain Sensitivity Questionnaire, which was developed to determine the level of pain sensitivity of individuals, to Turkish and to evaluate the validity and reliability of the Turkish…
- Conditions
- Pain Syndrome, Pain, Chronic, Knee Osteoarthritis
- Trial name
- NCT04162730
- Testing
- Pressure pain threshold and behavioural data
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Acibadem University
Chronic Pain, Osteoarthritis, Knee
Embo Registry; National Registry for Artery Embolization
Embo Registry is a retrospective and prospective observational study to evaluate real world effectiveness and the use of Artery Embolization as a treatment for chronic pain with patients that have osteoarthritis and localized…
- Conditions
- Chronic Pain, Osteoarthritis, Knee, Osteoarthritis Thumb, Osteoarthritis Shoulder
- Trial name
- NCT06477965
- Testing
- Artery Embolization
- Where
- 2 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Vascular Solutions of North Carolina
Gout, Chronic Kidney Disease (CKD)
A Phase 4 Safety and Efficacy Study to Evaluate Lesinurad 200 mg in Participants With Gout and Renal Impairment
This study evaluates the safety and efficacy of lesinurad administered with an XOI versus a placebo plus an XOI in gout participants who have moderate renal impairment and who are not at target level of serum urate (sUA).
- Trial name
- NCT03226899
- Testing
- Lesinurad, XOI, colchicine
- Where
- 116 sites in United States, Czechia and 2 more
- Volunteers
- 242 people
- Sponsor
- Ironwood Pharmaceuticals, Inc.
Pain, Low Back Pain
Longterm Safety Study of BEMA Buprenorphine in Subjects With Chronic Pain
The purpose of this study is to determine whether BEMA Buprenorphine is safe in the treatment of chronic pain.
- Conditions
- Pain, Low Back Pain, Osteoarthritis, Neuropathic Pain
- Trial name
- NCT01298765
- Testing
- BEMA Buprenorphine
- Where
- 26 sites in United States
- Volunteers
- 302 people
- Sponsor
- BioDelivery Sciences International
Arthritis
Comparing ASHC and CDSMP Outcomes In Arthritis
The arthritis-specific Arthritis Self Help Course (ASHC) and the more generic Chronic Disease Self Management Program (CDSMP) teach generalizable skills for managing arthritis and other chronic diseases.
- Trial name
- NCT00207441
- Testing
- Arthritis Self management program, Chronic Disease Self Management Program
- Where
- United States
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Knee Osteoarthritis
Effectiveness of Exercise Plus Pain Neuroscience Education on Brain Function in Knee Osteoarthritis
A three-arm randomized controlled trial will be conducted. Fifty-nine participants with KOA will be recruited in a 1:1:1 ratio. Assessor, and statistician will be blinded to group allocation.
- Trial name
- NCT06482970
- Testing
- Neuromuscular exercise plus pain neuroscience education, Neuromuscular exercise
- Volunteers
- 57 people
- Sponsor
- Universidad Santo Tomas, Chile
Chronic Pain, PERIPHERAL NEUROPATHY
Prospective Case Series Evaluating 6-Month and 12-Month Outcomes After Cryoneurolysis for Chronic Pain
To prospectively describe patient-centered and health utilization outcomes through 12 months after cryoneurolysis performed as routine clinical care for chronic pain at Yale.
- Conditions
- Chronic Pain, PERIPHERAL NEUROPATHY, Occipital Neuralgia, Chronic Hip Pain
- Trial name
- NCT07639060
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Yale University