Clinical trials: Chronic Asthma
Nasal Polyps, Asthma
Assessment of Oral and Nasal Breathing With Sensors Analyzing Algorithm
The goal of this observational study is to learn about the agreement between sensors analyzing algorithm and body plethysmography in measuring oral and nasal breathing in healthy adults, and in patients with chronic…
- Conditions
- Nasal Polyps, Asthma, COPD, Allergic Rhinitis
- Trial name
- NCT05869071
- Testing
- Sensor analyzing software (own development), Body plethysmograph
- Where
- Finland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Oulu University Hospital
Stroke (CVA) or TIA, Diabetes
Risk Factors, Costs, and Impacts of ED Boarding
The goal of this observational study is to learn about the risk factors, costs, and operational impacts of emergency department boarding (patients admitted to the hospital but remaining in the emergency department awaiting…
- Conditions
- Stroke (CVA) or TIA, Diabetes, Asthma (Diagnosis), COPD (Chronic Obstructive Pulmonary Disease)
- Trial name
- NCT07532564
- Where
- United States
- Volunteers
- 30,486 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Lung Cancer, Precancerous Condition
Studying Genes in Blood and Lung Fluid Samples From Patients With Chronic Obstructive Pulmonary Disease With or Without a Previous Diagnosis of Lung Cancer or With Asthma Treated With Budesonide and Formoterol
RATIONALE: Studying the genes expressed in samples of blood and lung fluid in the laboratory from patients receiving budesonide and formoterol may help doctors learn more about the effect of budesonide and formoterol on gene…
- Trial name
- NCT00569712
- Testing
- budesonide/formoterol fumarate dihydrate inhalation aerosol, DNA methylation analysis, comparative genomic hybridization
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- British Columbia Cancer Agency
Asthma
Study to Assess the Efficacy of a Single PBF-680 Oral Administration to Attenuate Adenosine 5'-Monophosphate Challenge-induced Airway Hyperresponsiveness in Mild-to-moderate Asthmatics
This is a single-center, double-blind, randomized trial utilizing a three-period, balanced block design, with each period comprising a unique study product administration.
- Trial name
- NCT01939587
- Testing
- PBF-680 5 mg, PBF-680 20 mg
- Where
- 2 sites in Spain
- Volunteers
- 21 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Study is Being Conducted in Healthy Volunteers
A Study to Assess How Much Drug Reaches the Blood When Given From Symbicort pMDI With Spacer Compared to That of Symbicort pMDI Without Spacer in Healthy Volunteers
This study will be conducted to establish the relative bioavailability of budesonide and formoterol delivered via Symbicort pressurized metered-dose inhaler (pMDI) with and without a spacer device.
- Trial name
- NCT02934607
- Testing
- Symbicort pMDI with spacer device, Symbicort pMDI without spacer device
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Asthma COPD
Oscillometry and Machine Learning Approaches
Unicentric retrospective study designed to analyses the performance of various machine learning approaches to predict patterns of chronic respiratory diseases such as asthma, based mainly on clinical information and respiratory…
- Trial name
- NCT07447596
- Testing
- 1
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Pulmonary Disease, Chronic Obstructive
An Investigation Of The Interaction Of GSK961081 With Inhaled Beta-Agonist And Anti-Muscarinic Drugs.
GSK961081 is a potent dual pharmacophore that demonstrates both antimuscarinic and beta-agonist pharmacology in preclinical studies, both pharmacologies being of long duration.
- Trial name
- NCT00674817
- Testing
- 400 microgrammes GSK961081, 1200 microgrammes GSK961081
- Where
- 4 sites in New Zealand, Thailand and 1 more
- Volunteers
- 45 people
- Sponsor
- Theravance Biopharma
Respiratory Tract Diseases, Pulmonary Disease, Chronic Obstructive
Feedback Reports and e-Learning in Primary Care Spirometry
Spirometry is a biomedical test to measure lung function in subject who (may) have a chronic respiratory condition. Performing the test requires a certain level of training and experience from the health care professional who…
- Conditions
- Respiratory Tract Diseases, Pulmonary Disease, Chronic Obstructive, Asthma
- Trial name
- FRESCO (NCT00962455)
- Testing
- e-learning & performance feedback, usual practice
- Where
- Netherlands
- Volunteers
- 1,135 people
- Sponsor
- Radboud University Medical Center
Asthma, Pulmonary Fibrosis
Segmental Bronchoalveolar Lavage
Bronchoalveolar lavage (BAL) is a diagnostic and therapeutic procedure conducted by placing a small fiberoptic scope into the lung of a patient, and injecting sterile water (saline) into the lung and removing the fluid.
- Trial name
- NCT00001618
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Respiratory Virus Infection, Stroke
Respiratory Virus Infections in Acutely Hospitalized Adult Patients With Pulmonary and Extrapulmonary Complications
Respiratory virus infections are one of the major causes of hospitalizations, and outbreaks of respiratory virus infection have led to severe economic loss.
- Conditions
- Respiratory Virus Infection, Stroke, Lung Disease, Acute Coronary Syndrome
- Trial name
- NCT03816059
- Testing
- Respiratory virus testing
- Where
- Hong Kong
- Volunteers
- 200 people
- Sponsor
- The University of Hong Kong
Asthma, COPD
The Clinical Value of the Nitric Oxide System Components in Asthma and COPD
It is planned to conduct a study of nitric oxide metabolites (nitrates and nitrites), L-arginine, arginase-1, and asymmetric dimethylarginine in patients with bronchial asthma and chronic obstructive pulmonary disease, followed…
- Trial name
- ASCONO (NCT04456491)
- Where
- Russia
- Volunteers
- 240 people
- Sponsor
- Ryazan State Medical University
Asthma
A Single Centre Study in Healthy Volunteers to Optimise the Rotacap Formulation and ROTAHALER Device for Delivery of Fluticasone Propionate/Salmeterol
The purpose of this study is to optimise the device and/or formulation of the Fluticasone propionate (FP)/salmeterol (SALM) unit dose powder inhaler (Rotahaler) to achieve drug delivery characteristics comparable to the…
- Trial name
- NCT01540708
- Testing
- SERETIDE Rotacaps, SERETIDE Diskus
- Where
- Australia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Asthma, Chronic Obstructive Pulmonary Disease
Analysis of Inhaled Corticoid Prescriptions in General Medicine
Chronic obstructive pulmonary disease (COPD) and asthma are frequent and disabling pathologies. The general practitioner is often at the front line vis-a-vis screening, diagnosis and treatment of these pathologies.
- Trial name
- COMEGE (NCT03179826)
- Where
- 2 sites in France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Montpellier
Asthma, COPD
The Effects of Broccoli Sprout Extract on Obstructive Lung Disease
The purpose of this study is to examine whether broccoli sprout extract can effect lung function measurements in individuals with asthma and COPD.
- Trial name
- NCT00994604
- Testing
- broccoli sprout extract
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Asthma, COPD
Novel Biomarkers in Chronic Airway Diseases
The purpose of this study is: To define The differences of bio-chemical phenotypes in chronic airway inflammatory diseases. To identify novel biomarkers in chronic airway inflammatory diseases as a screening, diagnostic, or…
- Trial name
- NCT00849836
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chonbuk National University
Infection, Heart Failure
Serum Potassium Prediction Using Machine Learning and Single-lead ECG
This is a retrospective study drawing on data from the Brigham and Women's Hospital Home Hospital Program's Database. Sociodemographic and clinical data from a training cohort were used to train a machine learning algorithm to…
- Conditions
- Infection, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT07493798
- Testing
- Potassium estimation algorithm
- Where
- 2 sites in United States
- Sponsor
- Brigham and Women's Hospital
Refractory Chronic Cough
Efficacy of Two Doses of Duloxetine and Amitriptyline in Subjects With Refractory Chronic Cough
This research study is evaluating the effectiveness of escalating doses of Amitriptyline and Duloxetine in reducing cough frequency in patients with refractory chronic cough (RCC)
- Trial name
- MACS-1 (NCT05110144)
- Testing
- Duloxetine 30 MG, Duloxetine 60 MG, Amitriptyline 25 MG
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Asthma (Diagnosis)
Chronic Effects of Photobiomodulation With an LED Vest on Functional Capacity, Inflammatory Markers, and Muscle Perfusion in Children With Asthma
Asthma is a chronic inflammatory disease of the airways that results in tissue remodeling, airflow limitation, and bronchial hyperresponsiveness.
- Trial name
- Asthma PBM (NCT07613671)
- Testing
- Photobiomodulation, Exercise
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Nove de Julho
Asthma (Diagnosis), COPD (Chronic Obstructive Pulmonary Disease)
Quantitative Chest CT and Multi-Omics to Distinguish Asthma From COPD and Predict Treatment Response
This study aims to improve the diagnosis and treatment prediction of asthma and chronic obstructive pulmonary disease (COPD) by combining quantitative chest computed tomography (CT) imaging with multi-omics data.
- Trial name
- CTOMICS (NCT07602192)
- Where
- 2 sites in South Korea
- Volunteers
- 200 people
- Sponsor
- Korea University Guro Hospital
Healthy Controls, Chronic Obstructive Pulmonary Disease
Number of Multiple Breath Washout Tests in Adults With Pulmonary Disease and Healthy Controls
The investigators aim to determine the optimal number of measurements required for multiple-breath-washout derived lung function parameters in adults with pulmonary disease as well as in healthy controls
- Conditions
- Healthy Controls, Chronic Obstructive Pulmonary Disease, Bronchial Asthma, Sarcoidosis
- Trial name
- NCT03176745
- Testing
- multiple breath washout
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Universitätsmedizin Mannheim