Clinical trials: Chronic Back Pain
Lumbar Degenerative Disc Disease, Lower Back Pain
Human Autograft Mesenchymal Stem Cell Mediated Stabilization of The Degenerative Lumbar Spine
Investigate the potential of tissue grafting that includes human mesenchymal stem cells in the repair and potential stabilization of the degenerative Lumbar disk and facet joint denovo and at the time of surgical reconstruction.
- Conditions
- Lumbar Degenerative Disc Disease, Lower Back Pain, Chronic Lower Back Pain
- Trial name
- NCT02529566
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- The Foundation for Spinal Research, Education and Humanitarian Care, Inc.
Chronic Low Back Pain
Enso Pilot Study for Chronic Low Back Pain
Enso is a portable device for the treatment of chronic and acute types of musculoskeletal pain. This study is being designed as a single blind, sham-controlled randomized clinical trial.
- Trial name
- NCT03409783
- Testing
- ENSO Device
- Where
- 2 sites in United States
- Sponsor
- Thimble Bioelectronics, Inc.
Osteoarthritis, Low Back Pain
An Efficacy and Safety Study of Fentanyl Transdermal Patch in Filipino Participants With Osteoarthritis and Chronic Low Back Pain
The purpose of this study is to evaluate the efficacy and safety of fentanyl among Filipino participants with osteoarthritis (disorder which is seen mostly in older persons in which the joints become painful and stiff) and…
- Trial name
- NCT01795898
- Testing
- Fentanyl
- Where
- Philippines
- Volunteers
- 237 people
- Sponsor
- Janssen Pharmaceutica
Pain, Pain, Chronic
Long Term Use of a High Energy Pulsed Heating Device in the Management of Chronic Pain
The purpose of this study is to evaluate the Soovu Labs pain Relief System in a group of users that represent people most likely to purchase and use the units. This study is called an In Home Users Trial (IHUT).
- Conditions
- Pain, Pain, Chronic, Pain, Back
- Trial name
- NCT04407884
- Testing
- Soovu Labs Inc. Pain Relief System
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Soovu Labs Inc.
Chronic Pain
Study to Evaluate the Long-Term Safety of Hydrocodone Bitartrate Extended-Release Tablets (CEP-33237) in Patients Who Require Opioid Treatment for an Extended Period of Time
The primary objective of this study is to evaluate the safety of hydrocodone extended-release tablets when used over a 12-month period in patients with chronic pain, as assessed by adverse events, clinical laboratory results…
- Trial name
- NCT01223365
- Testing
- Hydrocodone ER
- Where
- 54 sites in United States
- Volunteers
- 330 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Chronic Low Back Pain, Lumbar Radiculopathy
Low-Dose Naltrexone and Acetaminophen Combination in the Treatment of Chronic Low Back Pain (ANODYNE-4)
Treatment of chronic low-back pain with low-dose naltrexone and acetaminophen combination: a small, randomized, double-Blind, and placebo-controlled clinical trial with an open-label extension for none-responders
- Trial name
- NCT03201393
- Testing
- Low-dose naltrexone and acetaminophen combination
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Allodynic Therapeutics, Inc
Chronic Pain
Spinal Cord Stimulation for Low Back Pain
The purpose of this study is to assess the acute and chronic effectiveness of the Advanced Bionics Precision(TM) Spinal Cord Stimulation System in subjects with failed back surgery syndrome and associated low back axial pain.
- Trial name
- NCT00205868
- Testing
- Precision Spinal Cord Stimulation System
- Where
- 30 sites in United States
- Volunteers
- 304 people
- Sponsor
- Boston Scientific Corporation
Low Back Pain
Safety, Effectiveness, and Impact on Quality of Life on Long-Term Administration of OROS Hydromorphone Slow-Release in Patients With Chronic Low Back Pain
The purpose of this open-label, extension study is to characterize the safety, effectiveness, and impact on quality of life measures of long-term repeated dosing of OROS hydromorphone slow release (8, 16, 32 and 64 mg tablets) in…
- Trial name
- NCT00411268
- Testing
- OROS hydromorphone HCI SR (slow release)
- Volunteers
- 207 people
- Sponsor
- Alza Corporation, DE, USA
Chronic Low-back Pain
ReActiv8 Stimulation Therapy vs Optimal Medical Management: A Randomized Evaluation
This study is a prospective, randomized study comparing ReActiv8 Therapy to Optimal Medical Management (OMM).
- Trial name
- RESTORE (NCT04803214)
- Testing
- ReActiv8
- Where
- 28 sites in United States
- Volunteers
- 203 people
- Sponsor
- Mainstay Medical
Chronic Low Back Pain (CLBP)
Clinical Investigation to Assess the Clinical Effect of the LumbaCure® Intervention on Patients Suffering From Chronic Low Back Pain
Low Back Pain (LBP) is one of the common causes of morbidity worldwide, with a one-month prevalence of 23.3 %. Number of people with LBP reached 577 million people in 2020.
- Trial name
- LumbaCure2302 (NCT06662032)
- Testing
- LumbaCure®, Rehab program
- Where
- 2 sites in Belgium
- Volunteers
- 50 people
- Sponsor
- Odix
Pain, Low Back Pain
Longterm Safety Study of BEMA Buprenorphine in Subjects With Chronic Pain
The purpose of this study is to determine whether BEMA Buprenorphine is safe in the treatment of chronic pain.
- Conditions
- Pain, Low Back Pain, Osteoarthritis, Neuropathic Pain
- Trial name
- NCT01298765
- Testing
- BEMA Buprenorphine
- Where
- 26 sites in United States
- Volunteers
- 302 people
- Sponsor
- BioDelivery Sciences International
Chronic Low Back Pain
Efficacy and Safety of Bicifadine in the Treatment of Chronic Low Back Pain
The primary objectives of this placebo-controlled clinical trial are to evaluate the analgesic efficacy and safety of bicifadine 200 mg BID compared with placebo in patients with moderate to severe chronic low back pain.
- Trial name
- NCT00295724
- Testing
- Bicifadine
- Sponsor
- DOV Pharmaceutical, Inc.
Myofascial Pain Syndrome - Lower Back, Myofascial Pain Syndrome - Neck
Low-Energy Ultrasound, Electrical and Magnetic Field Stimulation in Therapy-Resistant Myofascial Pain Syndrome
Sonodyn is an investigational device that within this clinical investigation is intended for use in patients suffering from low back pain, tension headache or neck pain, originating from therapy-resistant myofascial pain…
- Conditions
- Myofascial Pain Syndrome - Lower Back, Myofascial Pain Syndrome - Neck, Myofascial Pain Syndrome - Tension Headache
- Trial name
- NCT05851326
- Testing
- Active Sonodyn
- Where
- 6 sites in Austria, Switzerland
- Volunteers
- 126 people
- Sponsor
- Sobet AG
Failed Back Surgery Syndrome, Complex Regional Pain Syndrome (CRPS)
A Study to Confirm the Safety of High Frequency DRG Stimulator in Patients With Chronic Lower Limb Pain
This study is a prospective, single-arm, open label, single center pilot study to confirm the safety of a ultrahigh frequency DRG stimulator in patients with chronic lower limb pain. The actual trial length is 5 days.
- Trial name
- NCT03285113
- Testing
- GiMer Medical MN 1000 External Stimulator
- Where
- Taiwan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- GiMer Medical
Pain, Chronic Pain
Effect of Pulse Width With Spinal Cord Stimulation
The primary objective of this study is to assess the effects of varying pulse width in suprathreshold dorsal column stimulation in patients with low back pain.
- Conditions
- Pain, Chronic Pain, Back Pain
- Trial name
- NCT00399516
- Testing
- Precision
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Boston Scientific Corporation
Pain
Study of Embeda (Kadian NT, ALO-01) in Subjects With Chronic Moderate to Severe Nonmalignant Pain
Open-Label, Safety Study to evaluate the long-term safety of Kadian NT (ALO-01) administered for up to 12 months.
- Trial name
- NCT00415597
- Testing
- ALO-01 (Morphine Sulfate Plus Naltrexone Hydrochloride ER)
- Where
- 58 sites in United States
- Volunteers
- 467 people
- Sponsor
- Pfizer
Chronic Refractory Pain Associated With Failed Back Surgery Syndrome, Epidural Fibrosis, Peripheral Causalgia, Complex Regional Pain Syndrome
Restore Claims Characterization Study
The purpose of this study is to characterize the pain coverage capability of the RESTORE spinal cord stimulation (SCS) and assess health outcomes.
- Trial name
- NCT00200122
- Testing
- Spinal Cord Stimulation
- Where
- 8 sites in United States
- Volunteers
- 100 people
- Sponsor
- MedtronicNeuro
Pain, Low Back Pain
Longterm Safety Study of BEMA Buprenorphine in Subjects With Chronic Low Back Pain
This is an open label study of up to approximately 52 weeks duration to assess the safety and effectiveness of BEMA Buprenorphine in the management of moderate to severe chronic low back pain.
- Trial name
- NCT01431742
- Testing
- BEMA Buprenorphine
- Where
- United States
- Sponsor
- BioDelivery Sciences International
Osteoarthritis of the Knee, Chronic Lower Back Pain
A Study to Assess the Analgesic Efficacy of ASP7962 in Patients With Pain Due to Osteoarthritis of the Knee
The purpose of the study is to evaluate the analgesic efficacy of ASP7962 relative to placebo. This study will also evaluate the efficacy of ASP7962 relative to placebo on pain on walking, function and stiffness; the time course…
- Trial name
- OAK (NCT02611466)
- Testing
- ASP7962, Naproxen
- Where
- 34 sites in Belgium, Czechia and 4 more
- Volunteers
- 215 people
- Sponsor
- Astellas Pharma Europe B.V.
Chronic Low-back Pain, Vertebrogenic Pain Syndrome
Intracept Minimally-invasive PROcedure for VErtebrogenic Back Pain
Compile real-world outcomes of commercially approved Intracept™ Intraosseous Nerve Ablation Systems in the treatment of patients diagnosed with vertebrogenic pain.
- Trial name
- IMPROVE (NCT06827262)
- Testing
- Intracept™ Intraosseous Nerve Ablation
- Where
- 22 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- Boston Scientific Corporation