Clinical trials: Chronic Cerebrospinal Venous Insufficiency
Multiple Sclerosis
Endovascular Treatment for Chronic Cerebrospinal Venous Insufficiency (CCSVI)
The aim of this study is to assess the efficacy of endovascular treatment (balloon angioplasty and/or stenting) for the improvement of clinical symptoms in multiple sclerosis patients.
- Trial name
- NCT01264848
- Testing
- balloon angioplasty and/or stenting
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Euromedic Specialist Clinics, Poland
CCSVI, Chronic Cerebrospinal Venous Insufficiency
Multi-center Registry for CCSVI Testing and Treatment
Patients suspected of CCSVI (chronic cerebrospinal venous insufficiency) may be tested and if appropriate treated with catheter venoplasty by an interventional radiologist in their local community who has been credentialled…
- Conditions
- CCSVI, Chronic Cerebrospinal Venous Insufficiency, Venous Malformations of CNS Draining Veins
- Trial name
- CCSVI (NCT01205633)
- Testing
- venous angioplasty
- Where
- 9 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Hubbard Foundation
Multiple Sclerosis, Neurodegenerative Diseases
Observational Study of the Prevalence of CCSVI in Multiple Sclerosis and in Other Neurodegenerative Diseases
The presence of abnormalities in the cerebral venous circulation, defined as Chronic Cerebrospinal Venous Insufficiency (CCSVI), has recently been reported in patients with Multiple Sclerosis (MS), in healthy subjects and in…
- Trial name
- COSMO (NCT01384825)
- Where
- 43 sites in Italy, Romania
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Fondazione Italiana Sclerosi Multipla
Multiple Sclerosis
Study To Evaluate Treating Chronic Cerebrospinal Venous Insufficiency (CCSVI) in Multiple Sclerosis Patients
This is a single center, multispecialty, randomized double blind placebo control feasibility clinical trial. The purpose is to evaluate the safety, feasibility and efficacy of percutaneous transluminal angioplasty in treating…
- Trial name
- NCT01089686
- Testing
- Venoplasty
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Manish Mehta, MD
Ehlers Danlos Syndrome, External Hydrocephalus
Head Circumference Growth in Children With Ehlers-Danlos Syndrome Who Develop Dysautonomia Later in Life
It is known that 33-50% of Classic and Hypermobile Ehlers-Danlos Syndrome patients eventually develop dysautonomia, otherwise known as "POTS" (Postural Orthostatic Tachycardia Syndrome).
- Conditions
- Ehlers Danlos Syndrome, External Hydrocephalus, Dysautonomia, Postural Orthostatic Tachycardia Syndrome
- Trial name
- NCT01367977
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Genetic Disease Investigators
Ehlers-Danlos Syndrome, Multiple Sclerosis
Vascular Fundus Changes in Patients With High Probability of Chronic Cerebrospinal Venous Insufficiency (CCSVI)
The investigators propose that evidence of chronic cerebrospinal venous insufficiency (CCSVI) may be evident in the vasculature of the fundus.
- Trial name
- NCT01356134
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Genetic Disease Investigators
Multiple Sclerosis, Chronic Cerebrospinal Venous Insufficiency
Functional Changes Following Percutaneous Venoplasty in Multiple Sclerosis Patients
Multiple Sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) that often results in reduced muscle function which produces fatigue, weakness and a decline in daily mobility.
- Trial name
- NCT01555684
- Testing
- percutaneous venoplasty to alleviate chronic cerebrospinal venous insufficiency
- Where
- United Kingdom
- Sponsor
- University of Stirling
Multiple Sclerosis
Evaluation of Angioplasty in the Treatment of Chronic Cerebrospinal Venous Insufficiency (CCSVI) in Multiple Sclerosis
The study is being done to determine if venous angioplasty is an effective treatment for chronic cerebrospinal venous insufficiency (CCSVI).
- Trial name
- NCT01201707
- Testing
- Angioplasty, Observation
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- Community Care Physicians, P.C.
Clinically Isolated Syndrome (CIS), Multiple Sclerosis (MS)
Centralized Reading Assessment of Chronic CerebroSpinal Venous Insufficiency (CCSVI) in Patients With Multiple Sclerosis and Other Neurological Diseases
This a retrospective, blinded trial in which collaborators in Italy will review the doppler findings from the Combined Transcranial and Extracranial Venous Doppler (CTEVD) trial in an attempt to measure reproducibility.
- Conditions
- Clinically Isolated Syndrome (CIS), Multiple Sclerosis (MS), Other Neurological Disorders (OND), Healthy (HC)
- Trial name
- NCT02308579
- Volunteers
- 499 people
- Sponsor
- University at Buffalo
Multiple Sclerosis, Venous Insufficiency
BRAVE-DREAMS (BRAin VEnous DRainage Exploited Against Multiple Sclerosis)
To assess in a double blinded randomized control trial (RCT) study design safety and effectiveness of balloon angioplasty of the main extracranial and extravertebral veins in multiple sclerosis (MS) associated to chronic…
- Trial name
- BRAVE-DREAMS (NCT01371760)
- Testing
- Venous PTA, Catheter Venography
- Where
- 2 sites in Italy
- Volunteers
- 212 people
- Sponsor
- S. Anna Hospital
Multiple Sclerosis
Interventional Clinical Trial for CCSVI in Multiple Sclerosis Patients
To investigate the safety and tolerability of balloon venoplasty compared to sham in Multiple Sclerosis patients with Chronic Cerebrospinal Venous Insufficiency (CCSVI) as measured by adverse events occurring within 48 weeks of…
- Trial name
- NCT01864941
- Testing
- Catheter venography with balloon venoplasty, Catheter venography with balloon venoplasty and balloon
- Where
- 4 sites in Canada
- Volunteers
- 104 people
- Sponsor
- University of British Columbia
Chronic Cerebrospinal Venous Insufficiency
Doppler Sonography, MR Venography, Plethysmography for the Diagnosis of CCSVI
This study is aimed at evaluation of diagnostic value of Doppler sonography, MR venography and air-plethysmography for the assessment of abnormalities in the internal jugular veins, with catheter venography as the reference test.
- Trial name
- NCT01425554
- Testing
- Doppler sonography of internal jugular veins, Magnetic resonance venography of internal jugular veins, Air-plethysmography of the neck
- Where
- Poland
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Euromedic Specialist Clinics, Poland