Clinical trials: Chronic Consciousness Disorders
Minimally Conscious State, Vegetative State
Further Psychometric Data for the Reliability and the Diagnostic Validity of CRS-R
This study aims to provide, in a large sample, further psychometric data as regards the internal consistency, the test-retest reliability and the diagnostic validity of the Coma Recovery Scale-Revised (CRS-R).
- Trial name
- NCT03126929
- Testing
- Coma Recovery Scale-Revised and Glasgow Coma Scale
- Volunteers
- 169 people
- Sponsor
- Hangzhou Normal University
Minimally Conscious State
Therapeutic Effects of Animal-assisted Therapy for Patients in a Minimally Conscious State
The aim of this study is to investigate the effects of animal-assisted occupational therapy on patient's consciousness, measured via the achievement of predefined, patient-specific goals.
- Trial name
- MCS Therapy (NCT03910959)
- Testing
- Animal-assisted therapy, Conventional therapy
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Basel
Disorder of Consciousness, Vegetative State
The Use of LIFUP in Chronic Disorders of Consciousness
When patients survive a severe brain injury but fail to fully recover, they often enter a Disorder of Consciousness (DoC) --that is, a set of related conditions of decreased awareness and arousal including the Vegetative State…
- Conditions
- Disorder of Consciousness, Vegetative State, Minimally Conscious State, Minimally Conscious State Plus
- Trial name
- NCT04921683
- Testing
- BX Pulsar 1002 (LIFUP) Low intensity Focused Ultrasound Pulsation
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Disorders of Consciousness
mindBEAGLE: Unlocking Functional Communication for Patients With Disorders of Consciousness
The goal of this clinical trial is to test how effective the mindBEAGLE device is in allowing people who are unconscious (due to a brain injury or other condition) to communicate using brain waves to answer Yes/No questions.
- Trial name
- NCT06426602
- Testing
- mindBEAGLE daily device use
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Amy Wagner
Minimally Conscious States Due to Traumatic Brain Injury, Persistently Vegetative States Due to Traumatic Brain Injury
Vagus Nerve Stimulation to Augment Recovery From Minimally Conscious or Persistently Vegetative States After Traumatic Brain Injury
Traumatic brain injury has a high morbidity and mortality in both civilian and military populations. Blast and other mechanisms of traumatic brain injury damage the brain by causing neurons to disconnect and atrophy.
- Trial name
- NCT01260090
- Testing
- Vagus nerve stimulation;, No stimulation
- Where
- United States
- Sponsor
- VA New York Harbor Healthcare System
Vegetative State, Minimally Conscious State
Fronto-parietal tDCS in Severely Brain Injured Patients With Disorders of Consciousness
Previous studies showed that anodal transcranial direct current stimulation (tDCS) transiently improves performance of memory and attention.
- Conditions
- Vegetative State, Minimally Conscious State, Disorders of Consciousness
- Trial name
- NCT02626403
- Testing
- Anodal tDCS
- Where
- Belgium
- Volunteers
- 46 people
- Sponsor
- University of Liege
Disorder of Consciousness
Apomorphine in Severe Brain-injured Patients
Background: Patients who survive severe brain injury may develop chronic disorders of consciousness (DoC). Treating these patients to improve recovery is extremely challenging because of scarce and inefficient therapeutical…
- Trial name
- APODoC (NCT05213169)
- Testing
- Apomorphine Hydrochloride 5mg/ml, Sodium chloride 9mg/ml
- Where
- 4 sites in Belgium, Spain
- Volunteers
- 48 people
- Sponsor
- University of Liege
Chronic Vegetative State
The Impact of RPh201 on CVS Patients: Clinical and fMRI Measurements
The investigators are studying the impact of RPh201 on chronic vegetative patients. RPh201 has been reported to induce neuronal regeneration in animal models.
- Trial name
- CVS (NCT01417299)
- Testing
- RPh201, saline
- Sponsor
- Hadassah Medical Organization
Coma
Longitudinal Study of the Default-mode Network Connectivity in Brain Injured Patients Recovering From Coma
Several studies in healthy volunteers have suggested that the synchronized functional connectivity in the DMN (Deafult-Mode Network) would sustain the mental content at rest, and when required, a switch in the activity between…
- Trial name
- ACI-Coma (NCT01620957)
- Where
- France
- Volunteers
- 43 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Conscious Sedation
Magnesium Sulphate Versus Fentanyl for Conscious Sedation in CSDH
The investigators hypothesize that magnesium sulphate owing to its analgesic and sedative properties is not inferior to fentanyl in providing conscious sedation as adjuvants to propofol and local injection of lidocaine in…
- Trial name
- CSDH (NCT03548493)
- Testing
- Magnesium sulphate, Fentanyl, Propofol
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Kasr El Aini Hospital
Disorder of Consciousness, Minimally Conscious State
Two Intensities of Transcranial Direct Current Stimulation to Improve Consciousness in Severely Brain Injured Patients
Limited treatments are available to improve consciousness in severely brain injured patients. Transcranial Direct Current stimulation (tDCS) is one of the few therapeutics that showed evidence of efficacy to increase level of…
- Conditions
- Disorder of Consciousness, Minimally Conscious State, Vegetative State, Cognitive Impairment
- Trial name
- STIMCOM (NCT03007784)
- Testing
- transcranial direct current stimulation (tDCS) / Comparison of current intensities
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Disorders of Consciousness, Minimally Conscious State
Aiming for a Better Understanding and Improvement of the Diagnosis and Prognosis of Patients With Disorders of Consciousness Through Multimodal Observations
Improved treatment of severe brain injuries has resulted in increased survival rates. While some of these patients regain consciousness after a transient state of coma, others may develop a disorder of consciousness (DoC).
- Conditions
- Disorders of Consciousness, Minimally Conscious State, Unresponsive Wakefulness Syndrome, Caregivers
- Trial name
- PerBrain (NCT04798456)
- Testing
- Coma scales, Imaging, electrophysiology, body signals, and brain stimulation, Questionnaires
- Where
- 4 sites in France, Germany and 2 more
- Volunteers
- 150 people
- Sponsor
- Paris Brain Institute (ICM)
Chronic Disease
Resting Metabolic Rate in Chronic Bed-Ridden Patients
Research objective: to measure resting metabolic rate (REE) in long term, bed ridden, chronically ill patients and to compare their measured energy needs to standard REE equations
- Trial name
- RMR (NCT01069380)
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Reuth Rehabilitation Hospital
Trauma, Nervous System, Brain Trauma
Characterization of the Sleep-Wake Cycle in Traumatic Brain Injury Patients with a Disorder of Consciousness
Each year in France, 160,000 peoples suffer from a mild or severe traumatic brain injury (TBI). Sleep plays a crucial role in the process of brain plasticity, which is essential for neurological and cognitive recovery.
- Trial name
- SLEEPDOC (NCT06766513)
- Testing
- Actimetry, Subjective assessments, questionnaire
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hospices Civils de Lyon
Depression Chronic, Depressed
Evaluation of Dalia Solution For Depressed Patient
The goal of this superiority clinical investigation, prospective, multicenter, controlled, randomized, open-label is to evaluate the clinical impact of the Dalia medical telemonitoring device on the management of depressive…
- Conditions
- Depression Chronic, Depressed, Depressed Mood, Depression and Quality of Life
- Trial name
- DaliaMonitorin (NCT07211984)
- Testing
- Dalia Monitoring, Conventional healthcare
- Where
- France
- Volunteers
- 644 people
- Sponsor
- Dalia Care
Consciousness Disorder
Detection of Arousal With Facial Micro-expression in Severe Brain-damaged Patient
Severe brain injuries lead to disorders of consciousness after coma. During this awakening period, detection of arousal is critical to the adaptation of medical strategy, but global paralysis, including facial expression, make…
- Trial name
- DAME (NCT03023657)
- Testing
- Detection of arousal
- Where
- 2 sites in France
- Volunteers
- 3 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Postural Orthostatic Tachycardia Syndrome, Chronic Orthostatic Intolerance
Using Mirabegron to Increase BP in Patients With POTS
This is a pilot dose-finding study to test the hypothesis that mirabegron increases systolic blood pressure (BP), prevents syncope/presyncope, and improves the quality of life (QOL), functional capacity, chest pain, and…
- Conditions
- Postural Orthostatic Tachycardia Syndrome, Chronic Orthostatic Intolerance, Syncope
- Trial name
- RAISE-BP (NCT06133075)
- Testing
- Mirabegron 50 MG, Mirabegron 25 MG
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cedars-Sinai Medical Center
Syncope, Arrest
Urgent Medical and Surgical Conditions During Flights
The aim of this study is to evaluate the incidence and status of urgent medical conditions. After defining the urgent situations, the investigators will evaluate the adequacy of the standard medical kits and trainings.
- Conditions
- Syncope, Arrest, Vertigo, Pain
- Trial name
- NCT02457455
- Where
- Turkey (Türkiye)
- Volunteers
- 1,312 people
- Sponsor
- Antalya Training and Research Hospital
Chronic and Severe Post-coma Disorders of Consciousness (Permanent Vegetative State, Minimally Conscious State)
Study of Conscious Behavior Under Low-frequency Deep Brain Stimulation in Chronic and Severe Post-coma Disorders of Consciousness
Chronic post-coma consciousness impairment is a severe handicap. Preliminary studies suggest that deep brain stimulation of the thalamic-tegmental reticular system could improve consciousness disorders, and facilitate the…
- Trial name
- Post-coma DBS (NCT01718249)
- Testing
- Implantable neurostimulation system
- Where
- France
- Volunteers
- 5 people
- Sponsor
- University Hospital, Clermont-Ferrand
Minimally Conscious State, TBI
Transcranial Direct Current Stimulation Effects in Patients With Chronic Consciousness Disorders
Chronic consciousness disorders have high level of impact on public health and its costs.
- Trial name
- NCT02288533
- Testing
- real-tDCS
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- University Hospital of Ferrara