Clinical trials: Chronic Coronary Disease
COPD, Coronary Artery Calcification
Quebec Lung Cancer Screening PLUS Trial
Does an educational intervention for untreated COPD and cardiovascular disease which is integrated in an existing lung cancer screening program improve guideline concordant medication adherence at 12 months
- Trial name
- QLC+ (NCT05444062)
- Testing
- Educational material and treatment recommendations for patients, general practitioners and pharmacists
- Where
- Canada
- Volunteers
- 330 people
- Sponsor
- Nicole Ezer, MD, FRCPC, MPH
Atherosclerosis, Stroke
Vascular Inflammation Imaging Using Somatostatin Receptor Positron Emission Tomography
This VISION study aims to investigate the role of inflammation in atherosclerosis using 68Ga- DOTATATE PET, and to validate 68Ga-DOTATATE PET imaging for the detection and quantification of vascular inflammation in the aorta…
- Conditions
- Atherosclerosis, Stroke, Transient Ischemic Attack, Chronic Stable Angina
- Trial name
- VISION (NCT02021188)
- Where
- United Kingdom
- Volunteers
- 42 people
- Sponsor
- University of Cambridge
Heart Failure
Canadian e-Platform to Promote Behavioral Self-Management in Chronic Heart Failure: CHF-CePPORT
Chronic Heart Failure (CHF) is a growing public health issue in Canada. Hospital re-admission within 1-year after diagnosis is 25-40%, and the 5-year rate of CHF death is 50%.
- Trial name
- CHF-CePPORT (NCT01864369)
- Testing
- eCounseling + Usual Care
- Where
- 3 sites in Canada
- Volunteers
- 248 people
- Sponsor
- University Health Network, Toronto
Stable Angina Pectoris, Coronary Artery Disease
Efficacy and Safety of Aspirin in Patients With Chronic Coronary Syndromes Without Revascularization
The purpose of this study is to evaluate the efficacy and safety aspirin in patients with chronic coronary syndromes without revascularization.
- Conditions
- Stable Angina Pectoris, Coronary Artery Disease, Ischemic Heart Disease
- Trial name
- ASA-IN (NCT05347069)
- Testing
- Aspirin, No aspirin
- Where
- Japan
- Volunteers
- 2,890 people
- Sponsor
- Takeshi Morimoto
Cardiomyopathy, Heart Failure
International T1 Multicentre CMR Outcome Study
Myocardial fibrosis is the fundamental substrate for the development of heart failure. Cardiovascular magnetic resonance (CMR) allows non-invasive assessment of myocardial fibrosis based on late gadolinium enhancement (LGE) and…
- Conditions
- Cardiomyopathy, Heart Failure, Coronary Artery Disease, Chronic Kidney Diseases
- Trial name
- T1-CMR (NCT02407197)
- Where
- 4 sites in Australia, Germany and 1 more
- Volunteers
- 1,629 people
- Sponsor
- King's College London
Chronic Migraine, Headache
Comprehensive Approach to Lifestyle Modification in Chronic Migraine
Migraine is a highly prevalent neurological disorder and one of the leading causes of disability worldwide, substantially affecting quality of life and individuals during their most productive years.
- Trial name
- CALM-Migraine (NCT07802860)
- Testing
- Comprehensive Lifestyle Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Hacettepe University
Acute Coronary Syndrome, Chronic Coronary Syndrome
Common Femoral Vein-to-Artery Diameter Ratio for Detection of Elevated LVEDP
This prospective cross-sectional diagnostic accuracy study enrolled patients undergoing coronary angiography and left heart catheterization at Burapha University Hospital, Thailand.
- Conditions
- Acute Coronary Syndrome, Chronic Coronary Syndrome, Heart Failure
- Trial name
- NCT07866859
- Testing
- Ultrasound Measurement of Common Femoral Vein-to-Artery Diameter Ratio
- Where
- Thailand
- Volunteers
- 105 people
- Sponsor
- Burapha University
Pulmonary Disease, Chronic Obstructive
A Study to Assess the Effects of Repeat Doses of Fluticasone Furoate and GW642444M Combination in Healthy Subjects and in Subjects With Severe Impairment.
This study will assess the saftey of giving fluticasone furoate 200mcg/GW642444M 25mcg once daily for 7 days to patients with severe renal imparement.
- Trial name
- NCT01266980
- Testing
- Inhaled FF/ GW642444M (200/25mcg)
- Where
- Czechia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
COPD
Cardiac Effects of Spiolto®/Respimat® in Patients With Congestive Heart Failure and COPD
The aim of this study is to evaluate the pulmonary and cardiac effects of the LABA / LAMA combination Tiotropium / Olodaterol therapy in patients suffering from both congestive heart failure and chronic obstructive pulmonary…
- Trial name
- CREATES (NCT02812862)
- Testing
- Spiolto® Respimat® (Tiotropium / Olodaterol)
- Where
- Germany
- Sponsor
- RWTH Aachen University
Heart Failure, Reduced Ejection Fraction
Study on the Effects of Sacubitril/Valsartan on Physical Activity and Sleep in Heart Failure With Reduced Ejection Fraction Patients.
The purpose of this study was to investigate the effects of initiation of sacubitril/valsartan vs enalapril treatment on objective measures of both waking activity and sleep in subjects with heart failure with reduced ejection…
- Trial name
- AWAKE-HF (NCT02970669)
- Testing
- sacubitril/valsartan (LCZ696), enalapril
- Where
- 23 sites in United States
- Volunteers
- 140 people
- Sponsor
- Novartis Pharmaceuticals
Heart Failure
A Telerehabilitation Intervention for People With Heart Failure and Chronic Fatigue
This study compares the effectiveness of a 6-week Energy Conservation + Problem Solving Therapy Intervention to Health Education Intervention for reducing the fatigue impact and fatigue level and improving the level of…
- Trial name
- NCT03820674
- Testing
- Energy Conservation plus Problem Solving Therapy, Health Education Intervention
- Volunteers
- 23 people
- Sponsor
- East Carolina University
Refractory Heart Failure, Chronic Kidney Disease
The Role of Peritoneal Dialysis in Patients With Refractory Heart Failure and Chronic Kidney Disease
In patients with advanced heart failure (HF), systemic congestion is the main indication for hospitalization. Recent evidence has highlighted the role of fluid retention in the pathogenesis of renal dysfunction and subsequent…
- Trial name
- NCT01758627
- Testing
- Peritoneal dialysis (PD)
- Where
- South Korea
- Volunteers
- 7 people
- Sponsor
- Yonsei University
Oxygen Saturation and the Relationship to Other Cardiac Variables, Maintenance Hemodialysis
Hypoxemia in Maintenance Hemodialysis Patients
Previous research has shown that many patients with kidney failure undergoing chronic hemodialysis (HD) have a very low venous oxygen concentration, which may further decrease during dialysis treatments.
- Conditions
- Oxygen Saturation and the Relationship to Other Cardiac Variables, Maintenance Hemodialysis, Kidney Failure, Chronic
- Trial name
- NCT03045796
- Testing
- Oxygen Saturation measured by WristOx
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Chronic Respiratory Disease, COPD
The Effect of Spontaneous Respiration on Pulse-oximetry Measurements
This is a study designed to measure, characterize and describe changes on pulse-oxymetry values produced as a result of deep breaths in patients with stable chronic hypoxemic respiratory failure.
- Conditions
- Chronic Respiratory Disease, COPD, Interstitial Lung Disease
- Trial name
- NCT04139356
- Testing
- Deep breaths
- Where
- Mexico
- Volunteers
- 45 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Coronary Artery Disease, Chronic Coronary Syndrome
Artificial Intelligence-Driven Medipixel Fractional Flow Reserve Versus Invasive Fractional Flow Reserve-Guided PCI Trial (AIM-FFR Trial)
The AIM-FFR trial is a prospective, multi-center, open-label, randomized controlled, non-inferiority trial. The current trial will evaluate non-inferiority of MPFFR-guided PCI, compared with invasive FFR-guided PCI in patients…
- Conditions
- Coronary Artery Disease, Chronic Coronary Syndrome, Acute Coronary Syndrome
- Trial name
- AIM-FFR (NCT07329699)
- Testing
- MPFFR or Invasive FFR
- Where
- 23 sites in South Korea
- Volunteers
- 2,100 people
- Sponsor
- Samsung Medical Center
Diastolic Dysfunction, Heart Failure
Aerobic Versus Combined Exercise and Diastolic Dysfunction
Thirty-two stable patients with chronic heart failure participated in an exercise rehabilitation program. They randomly assigned to aerobic exercise (AER) or combined aerobic and strength training (COM).
- Trial name
- NCT04916184
- Testing
- aerobic exercise, combined exercise
- Where
- Greece
- Volunteers
- 32 people
- Sponsor
- Evangelismos Hospital
Heart Failure
The Gut Microbiome in Chronic Heart Failure
there are numerous studies, most of which are predominantly associative in nature, investigating the association between the gut microbiota and various pathologies.
- Trial name
- GMCHF (NCT06573892)
- Testing
- Probiotic
- Where
- Kazakhstan
- Volunteers
- 90 people
- Sponsor
- Nazarbayev University
Chronic Heart Failure
Nutritional Ketosis in Heart Failure
Chronic, ambulatory heart failure patients will be given ketone ester dietary supplementation to determine therapeutic efficacy, metabolic adaptation, pharmacokinetics, associated cognitive changes, and safety within this patient…
- Trial name
- INNKA-HF (NCT04370600)
- Testing
- beta hydroxybutyrate (BHB) ester
- Volunteers
- 16 people
- Sponsor
- Thomas Jefferson University
Congestive Heart Failure, Ischemic Cardiomyopathy
AutoLogous Human CArdiac-Derived Stem Cell to Treat Ischemic cArdiomyopathy (ALCADIA)
The aim of this study is to evaluate the safety and efficacy on the transplantation of autologous human cardiac-derived stem cells (hCSCs) with the controlled release of basic fibroblast growth factor (bFGF) to severe refractory…
- Conditions
- Congestive Heart Failure, Ischemic Cardiomyopathy, Ventricular Dysfunction
- Trial name
- ALCADIA (NCT00981006)
- Testing
- human cardiac stem cells
- Where
- 2 sites in Japan
- Volunteers
- 6 people
- Sponsor
- Naofumi Takehara
Pulmonary Disease, Chronic Obstructive
Interest of a 30 Minutes' Intermittent Work Exercise Test in Patients With Chronic Obstructive Pulmonary Disease: Cardiac and Pulmonary Functions
The aim of the study is to observe the ventilatory and cardiac function (included the pulmonary arterial pressure) during an intermittent work exercise test with high density work load.
- Trial name
- NCT00295113
- Testing
- EFR
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Strasbourg, France
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