Clinical trials: Chronic Coronary Insufficiency
Type 2 Diabetes Mellitus, Chronic Kidney Disease
Extended Release Exenatide Versus Placebo In Diabetic Patients With Type 4 Cardiorenal Syndrome
Among adult individuals with type 2 diabetes mellitus and at risk for heart failure with impaired relaxation of the heart mildly reduced kidney filtration function (Type 4 cardiorenal syndrome) this trial will evaluate the…
- Conditions
- Type 2 Diabetes Mellitus, Chronic Kidney Disease, Left Ventricular Diastolic Dysfunction
- Trial name
- NCT02251431
- Testing
- BYDUREON
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Baylor Research Institute
Worsening Chronic Heart Failure, Chronic Kidney Disease
A Study to Learn How BAY94-8862 Moves Into, Through and Out of the Body, How Safe it is and How it Affects the Body in Adult Participants With Reduced Kidney Function and in Healthy Participants With Similar Age, Weight and Gender Distribution
Researchers are looking for a better way to treat people who have worsening of chronic heart failure, a long-term condition where the heart does not pump blood as well as it should.
- Trial name
- NCT04908436
- Testing
- Finerenone (BAY94-8862)
- Where
- Germany
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Bayer
Heart Failure, Chronic Obstructive Pulmonary Disease (COPD)
Epidemiological Cluster Evaluation in Patients Admitted to Internal Medicine, With at Least One of the Following Diagnoses: Heart Failure, COPD, Renal Failure. The FADOI IN-CluDiMI Study
Improved medical care has led to an increase in both the age and clinical complexity of patients admitted to Internal Medicine wards, characterized by multiple chronic diseases.
- Conditions
- Heart Failure, Chronic Obstructive Pulmonary Disease (COPD), Chronic Kidney Disease (CKD)
- Trial name
- IN-CluDiMI (NCT07660757)
- Where
- Italy
- Volunteers
- 4,500 people
- Sponsor
- Fadoi Foundation, Italy
Arthritis, Asthma
Mobility Assessment in Multi-morbidity
Multimorbidity (the presence of two or more coexisting long-term conditions) is a significant challenge facing the NHS, especially given UK's ageing population and the association with high levels of illness burden and healthcare…
- Conditions
- Arthritis, Asthma, Atrial Fibrillation, Bronchiectasis
- Trial name
- Multi-mobility (NCT06473168)
- Volunteers
- 55 people
- Sponsor
- Northumbria University
End Stage Renal Disease on Dialysis
pH, Hypoxia and Haemodialysis
End-stage renal disease typically requires haemodialysis to help replace kidney function. However, changes in oxygen uptake during haemodialysis have been linked to increased all-cause mortality.
- Trial name
- pHHd (NCT04501159)
- Testing
- blood sample pre, during and post HD, Non invasive cardiac output assessment
- Where
- 2 sites in United Kingdom
- Volunteers
- 100 people
- Sponsor
- Coventry University
Cardiomyopathy, Heart Failure
The Impact of Pomegranate Extract on Chronic Cardiomyopathy Complicated by Renal Insufficiency (ImPrOVE): a Pilot Study
This blinded, controlled study will examine the impact of pomegranate polyphenol extract (POMx, from Pom Wonderful, LLC), 1000mg on cardiomyopathy in subjects with chronic renal insufficiency.
- Trial name
- ImPrOVE (NCT01102140)
- Testing
- POMx, pomegranate polyphenol extract, Sugar Pill
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Jennifer Cowger , MD, MS
Coronary Heart Disease
Molecular Pathways Involved in Cardiac Remodeling in Patients With Chronic Heart Failure With Preserved Ejection Fraction by New Omics Technologies
Heart failure with preserved ejection fraction nowadays affects about half of all patients with heart failure. In the general population, the prevalence of this subclass of heart failure (HFpEF, ed.) increases as the age of…
- Trial name
- HFpEF (NCT05772754)
- Testing
- study of molecular and protein pathways
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Contrast Induced Nephropathy
PREdictive Value of COntrast voluMe to creatinINe Clearance Ratio
To determine a relatively safe contrast media volume to creatinine clearance cut-off value to avoid contrast-induced nephropathy in patients following coronary angiography
- Trial name
- PRECOMIN (NCT01400295)
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Guangdong Provincial People's Hospital
Hyperkalemia, Heart Failure
Evaluation of Patiromer in Heart Failure Patients
The purpose of this study was to assess the effects of patiromer on serum potassium participants with heart failure. This study also assessed the safety and tolerability of patiromer in participants with heart failure.
- Trial name
- PEARL-HF (NCT00868439)
- Testing
- patiromer
- Where
- 33 sites in United States, Czechia and 5 more
- Volunteers
- 120 people
- Sponsor
- Relypsa, Inc.
Kidney Diseases, Kidney Dysfunction
Music Therapy Intervention During Kidney Biopsy.
Kidney biopsy (KB) is an invasive procedure that is very useful in diagnosing kidney disease in both the native kidney and the transplanted kidney. Patients undergo KB can feel anxiety and pain.
- Conditions
- Kidney Diseases, Kidney Dysfunction, Kidney Disease, Chronic
- Trial name
- MTI-KB (NCT05119816)
- Testing
- music therapy intervention
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Blood Coagulation Disorders, Atrial Fibrillation
Left Atrial Appendage Occlusion vs. Usual Care in Patients With Atrial Fibrillation and Severe Chronic Kidney Disease
The purpose of this study is to evaluate the superiority of left atrial appendage occlusion in comparison to oral anticoagulation with a vitamin K antagonist (INR 2-3) related to the frequency of occurrence of at least one…
- Conditions
- Blood Coagulation Disorders, Atrial Fibrillation, Thrombosis of Left Atrial Appendage, Chronic Kidney Disease Stage 4
- Trial name
- WatchAFIB (NCT02039167)
- Testing
- Left atrial appendage occlusion
- Where
- 4 sites in Germany
- Volunteers
- 14 people
- Sponsor
- University of Magdeburg
Kidney Diseases, Diabetes Mellitus
Efficacy and Safety of Alprostadil Prevent Contrast Induced Nephropathy
The aim of this prospective, randomized, controlled study is to investigate the effect of pretreatment with intravenous Alprostadil on the incidence of CIN in a high-risk population of patients with both type 2 diabetes mellitus…
- Conditions
- Kidney Diseases, Diabetes Mellitus, Acute Kidney Injury, Kidney Failure, Chronic
- Trial name
- NCT01722513
- Testing
- Alprostadil ﹠control
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Shanghai 10th People's Hospital
Diabetes Mellitus, Congestive Heart Failure
Relative Impacts on Preventative Primary Care--a Longitudinal Evaluation of COVID-19:Phase 1
The goal of this observational study is to describe the impacts of COVID-19 on primary care chronic condition management in Canada within various patient populations.
- Conditions
- Diabetes Mellitus, Congestive Heart Failure, Chronic Kidney Diseases, Chronic Obstructive Pulmonary Disease
- Trial name
- RIPPLE-C (NCT05813652)
- Testing
- Pre-pandemic time period (Jun 22, 2018 to March 12, 2020), Peri-pandemic time period (March 13, 2020 to December 3, 2021)
- Where
- Canada
- Volunteers
- 919,928 people
- Sponsor
- McMaster University
Healthy Volunteers
Effect of AKB-6548 on Cardiac Repolarization Intervals in Healthy Volunteers
The main purpose of this study is to evaluate the effect of single oral therapeutic and supratherapeutic doses of AKB-6548 on the QT interval.
- Trial name
- NCT02062203
- Testing
- AKB-6548 (therapeutic dose), AKB-6548 (supratherapeutic dose), Moxifloxacin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Akebia Therapeutics
Cardiovascular Diseases, Heart Diseases
Role of Chronic Kidney Disease in Cardiovascular Disease
The purpose of this study is to determine how the progressive loss of kidney function influences cardiovascular disease.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Kidney Failure, Chronic
- Trial name
- NCT00069810
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Washington
Coronary Artery Disease, Chronic Renal Failure
Coronary Rotational Atherectomy Elective vs. Bailout in Severely Calcified Lesions and Chronic Renal Failure
The current role of the rotational atherectomy is for non-dilatable coronary lesions and for severely calcified lesions that may interfere with optimal stent expansion.
- Trial name
- CRATER (NCT05353946)
- Testing
- Percutaneous coronary intervention (PCI)
- Where
- Spain
- Volunteers
- 124 people
- Sponsor
- Guillermo Galeote; MD, PhD
Cancer, Chronic Liver Disease (CLD)
Identification of Patients With Advanced Chronic Diseases in Need of Palliative Care
Patients with advanced chronic diseases often have complex health needs and may benefit from palliative care. However, many of these patients are not identified early enough to receive appropriate palliative care interventions.
- Conditions
- Cancer, Chronic Liver Disease (CLD), Heart Failure Chronic, Chronic Kidney Disease (Stages 4 and 5)
- Trial name
- NECPAL_HUIL (NCT07387224)
- Where
- 2 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Infanta Leonor University Hospital
Cardiorenal Metabolic Syndrome, Atherosclerotic Cardiovascular Disease
Effect of Secukinumab on Cardiorenal Outcomes in Patients With Cardiorenal Metabolic Syndrome and Atherosclerotic Cardiovascular Disease
This is a prospective, randomized, open-label, parallel-controlled clinical trial to evaluate the efficacy and safety of targeted IL-17A inhibition with secukinumab on cardiovascular and renal endpoints in 100 patients with…
- Conditions
- Cardiorenal Metabolic Syndrome, Atherosclerotic Cardiovascular Disease, Chronic Kidney Disease, Coronary Artery Disease
- Trial name
- NCT07704190
- Testing
- Secukinumab (75 mg), Standard Medical Therapy
- Volunteers
- 100 people
- Sponsor
- Peking University Third Hospital
ESRD (End Stage Renal Disease), Dialysis
Laser Acupuncture for Fatigue in Hemodialysis Patients
The goal of this clinical trial is to learn if laser acupuncture (low-level laser therapy) works to treat fatigue and improve quality of life in adults with end-stage renal disease (ESRD) undergoing hemodialysis.
- Conditions
- ESRD (End Stage Renal Disease), Dialysis, Fatigue
- Trial name
- LA-HD-Fatigue (NCT07538310)
- Testing
- Low-Level Laser Acupuncture (LA)
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Taipei City Hospital
Coronary Disease, Myocardial Infarction
Chronical Illness-related Limitations of the Ability to Cope With Rising Temperatures, Third Wave
The CLIMATE-III Observational Study examines to what extent chronically ill patients experience adverse health effects because of heat and whether the patients' specific health behavior, somatosensory amplification, risk and…
- Conditions
- Coronary Disease, Myocardial Infarction, Heart Failure, Arrhythmias, Cardiac
- Trial name
- CLIMATE-III (NCT06890208)
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 176 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf