Clinical trials: Chronic Coronary Total Occlusions
Chronic Total Occlusions of Coronary Arteries
Randomized Comparison of Optimal Medical Therapy and Percutaneous Recanalization for Chronic Total Occlusion (COMET-CTO)
Several meta analysis comparing successful Percutaneous Coronary Intervention of Chronic Total Occlusion (PCI-CTO) with unsuccessful PCI-CTO showed that there is significant reduction in short-term and long-term mortality.
- Trial name
- NCT02964975
- Testing
- Percutaneous coronary intervention, Optimal medical therapy
- Where
- Serbia
- Volunteers
- 100 people
- Sponsor
- Clinical Centre of Serbia
Patients Who Are Scheduled to Undergo a PCI (Percutaneous Coronary Intervention) for CTO (Chronic Total Occlusion)
TIcaGrEloR and ABSORB Bioresorbable Vascular Scaffold Implantation for Recovery of Vascular Function After Successful Chronic Total Occlusion Recanalization
The study is a single-centre, randomized, active controlled, open label clinical trial. The primary hypothesis is that ticagrelor will show superiority over clopidogrel immediately after CTO-PCI (chronic total occlusion …
- Trial name
- TIGER-BVS (NCT02211066)
- Testing
- Clopidogrel, Ticagrelor
- Where
- 2 sites in Spain
- Volunteers
- 59 people
- Sponsor
- Hospital Clinic of Barcelona
Heart Function, Quality of Life
Functional and Clinical Benefits of PCI in Patients With CTO
The purpose of this study is to compare the diagnostic accuracy of hybrid imaging combining CTCA with low-dose stress-only SPECT vs.
- Trial name
- NCT01254253
- Testing
- Percutaneous coronary intervention, PCI
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Xijing Hospital
Chronic Total Occlusion of Coronary Artery
Evaluating the Use of the CapBuster System for the Crossing of CTO's in Coronary Arteries
Evaluate the safety and effectiveness of the CapBuster System medical device in crossing de novo or restenotic chronic total occlusions in coronary arteries
- Trial name
- NCT05733481
- Testing
- CapBuster System Medical Device for the Crossing of Chronic Total Occlusions in Coronary Arteries
- Volunteers
- 26 people
- Sponsor
- Praxis Medical Devices Ltd
Coronary Occlusion
Exercise in Patients With a Total Coronary Occlusion
A coronary chronic total occlusion refers to the long term complete blockage of a blood vessel supplying the heart. Exercise is beneficial for patients with heart problems, including people with narrowed blood vessels.
- Trial name
- EChO (NCT03993522)
- Testing
- Symptom limited cardiopulmonary exercise test & Sub-maximal cardiopulmonary exercise test
- Where
- United Kingdom
- Volunteers
- 4 people
- Sponsor
- University of Hull
Coronary Artery Disease, Myocardial Ischemia
BIOFLOW-III Belgium Satellite Registry
This registry is a clinical post-market evaluation of the Orsiro LESS in subjects requiring coronary revascularization with Drug Eluting Stents (DES).
- Trial name
- NCT01831336
- Where
- 8 sites in Belgium
- Volunteers
- 332 people
- Sponsor
- Biotronik Belgium NV
Coronary Artery Disease, Coronary Disease
Sapphire 3 CTO Study
A prospective, open label, multi-center, single arm, observational study designed to evaluate the acute safety and device performance of the Sapphire 3 0.85, 1.0 and 1.25mm diameter coronary dilatation catheter in predilatation…
- Conditions
- Coronary Artery Disease, Coronary Disease, Myocardial Ischemia, Heart Diseases
- Trial name
- NCT06358508
- Testing
- Sapphire 3 Coronary Dilatation Catheter
- Where
- 14 sites in United States, Spain
- Volunteers
- 170 people
- Sponsor
- OrbusNeich
Coronary Artery Disease
The Effect of GRAVITY on Physiological Measurements During Invasive Coronary Angiography and Intervention
This is a single centre observational study on the impact of change in patient position and hence gravity, on physiological measurements in coronary arteries.
- Trial name
- GRAVITY (NCT03097172)
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- Mid and South Essex NHS Foundation Trust
Coronary Occlusion
Single-Arm Study Evaluating Use of the CORA Catheters for the Crossing of Coronary Chronic Total Occlusions
The goal of this clinical trial is to evaluate the safety and effectiveness of the coraFlex, coraForce, and coraCross catheters for crossing chronic total occlusions of the coronary arteries.
- Trial name
- Cora CTO (NCT05848232)
- Testing
- coraFlex Catheter, coraForce Catheter, coraCross Catheter
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- ReFlow Medical, Inc.
Coronary Artery Disease (CAD), Chronic Total Occlusion of Coronary Artery
Predictors and Long-term Incidence of In-stent Restenosis After Chronic Total Occlusion Percutaneous Coronary Intervention
The goal of this clinical trial is to describe the long-term (≥ 3 years) patency of coronary artery stents following chronic total occlusion percutaneous coronary intervention (CTO PCI).
- Conditions
- Coronary Artery Disease (CAD), Chronic Total Occlusion of Coronary Artery, Chronic Total Occlusion (CTO)
- Trial name
- NCT07473596
- Testing
- chronic total occlusion percutaneous coronary intervention (CTO PCI), coronary computed tomography angiography, invasive coronary angiography
- Where
- Finland
- Volunteers
- 294 people
- Sponsor
- Lauri Mansikkaniemi
Coronary Atherosclerosis Due to Calcified Coronary Lesion, Chronic Total Occlusion of Coronary Artery
The XLIMUS-DES in Very Complex Lesions
Stent delivery failure occurs in 4% of all percutaneous coronary interventions (PCI) and >90% of these failures are due to vessel tortuosity and/or calcification.
- Trial name
- NCT02360020
- Testing
- XLimus
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Clinica Mediterranea
Coronary Artery Disease
GISSOC II: Sirolimus Eluting Stent Versus Bare Metal Stent in Chronic Total Coronary Occlusions
The objective of this study is to compare the Cypher Select-TM Sirolimus Eluting Stent (SES) with the SONIC-TM Bare Metal Stent (BMS) in the treatment of Chronic Total Occlusion lesions (CTO).
- Trial name
- NCT00220558
- Testing
- Coronary placement of bare metal stent vs. drug eluting stent
- Where
- 14 sites in Italy
- Volunteers
- 150 people
- Sponsor
- Società Italiana di Cardiologia Invasiva
Coronary Artery Obstructive Disease, Chronic Total Occlusion Lesions
Role of CT Scan for the Successful Recanalization of Chronic Total Occlusion; a Randomized Comparison Between 3D CT-guided PCI vs. Conventional Treatment (CT-CTO Trial)
The revascularization of chronic total occlusion of coronary arteries (CTO) is the most challenging procedure for the coronary intervention.
- Trial name
- NCT02037698
- Testing
- Pre-PCI coronary CT scan
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Yonsei University
Coronary Artery Disease, Total Occlusion of Coronary Artery
Drug-coated Balloon in de Novo Chronic Total Occlusions
The CTO-DENOVO study is a multicenter registry of consecutive patients with de novo coronary chronic total occlusions (CTO) undergoing successful CTO recanalization with the use of drug-coated balloon (DCB)-only strategy.
- Trial name
- CTO-DENOVO (NCT05977842)
- Testing
- CTO PCI using DCB-only strategy
- Where
- 35 sites in Austria, Belgium and 10 more
- Volunteers
- 309 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Coronary Artery Disease
Computed Tomography Angiography Prediction Score for Percutaneous Revascularization of Chronic Total Occlusions
Chronic total occlusions (CTO) are encountered in almost one-fourth of patients undergoing coronary angiography. The presence of an untreated CTO has been related to adverse clinical prognosis, both in stable angina and acute…
- Trial name
- CT-RECTOR (NCT02022878)
- Testing
- PCI of CTO
- Where
- 4 sites in Germany, Poland
- Volunteers
- 229 people
- Sponsor
- Kerckhoff Heart Center
Coronary Artery Disease, Coronary Artery Chronic Total Occlusion
The Asahi Intecc PTCA Chronic Total Occlusion Study
The primary objective of this trial is to evaluate confirmation of placement of any guidewire beyond the chronic total occlusion (CTO) in the true vessel lumen in patients in which at least one Asahi series of guidewires and/or…
- Trial name
- CTO-PCI (NCT02379923)
- Testing
- Crossing of Coronary Artery CTO
- Where
- 12 sites in United States
- Volunteers
- 163 people
- Sponsor
- Asahi Intecc USA Inc
Coronary Heart Disease, Chronic Total Occlusion of Coronary Artery
CTO Registry From Insight of IVUS in Fuwai Hospital
To evaluate the long-term outcome of chronic total occlusion (CTO) patients underwent contemporary percutaneous coronary intervention (PCI) techniques, we design this single-center, large-sample, prospective registry with…
- Conditions
- Coronary Heart Disease, Chronic Total Occlusion of Coronary Artery, Percutaneous Coronary Intervention, Intravascular Ultrasound
- Trial name
- FWCTO (NCT03461367)
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- China National Center for Cardiovascular Diseases
Chronic Total Occlusion, Coronary Artery Disease
Risk Factors and Outcomes in Coronary Chronic Total Occlusion
This study aims to assess the risk factors and evaluate the long-term outcomes of patients with coronary chronic total occlusion (CTO) treated with percutaneous coronary intervention or medical treatment.
- Trial name
- NCT06137521
- Testing
- Coronary angiography
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Ruijin Hospital
Chronic Total Occlusion of Coronary Artery, Microvascular Coronary Artery Disease
Microvascular Coronary Resistance and Absolute Coronary FLOW in Patients With Percutaneous Intervention of a Chronic Total Occlusion
It is an observational study which objective is to analyze, through a series of invasive parameters, the state of the coronary microvasculature immediately after the successful percutaneous coronary intervention of a chronic…
- Conditions
- Chronic Total Occlusion of Coronary Artery, Microvascular Coronary Artery Disease, Coronary; Ischemic, Coronary Microvascular Dysfunction
- Trial name
- FLOW-CTO (NCT05197361)
- Testing
- Invasive coronary physiology
- Where
- 4 sites in Spain
- Volunteers
- 34 people
- Sponsor
- Parc de Salut Mar
Percutaneous Coronary Intervention, Chronic Total Occlusion of Coronary Artery
Holo CTO Proctoring Study
Assess Microsoft HoloLens as an interactive communication device in remote proctoring, and enhancement of teamwork in complex CTO procedures
- Trial name
- NCT05377866
- Testing
- Remote proctoring using HoloLens
- Where
- Norway
- Volunteers
- 10 people
- Sponsor
- Sorlandet Hospital HF