Clinical trials: Chronic Cough
Asthma
Biological Monitoring of Nano Sized Particles in the Airways of Asthmatic Children
Background Ambient airborne particulate material (PM) is defined according the aerodynamic diameter into coarse, fine, and ultrafine or "nano" sized particles ranging between 2.5-10 µm (coarse), <2.5 µm (fine), and <0.1 µm…
- Trial name
- EHF (NCT01754948)
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Gastroesophageal Reflux, Regurgitation
Prospective, Comparative, Randomized, Controlled Trial on the Efficacy of the Treatment of Gastroesophageal Reflux Infant With Magnesium Alginate
The results on the efficacy of the formulations based on alginic acid are controversial. Corvaglia et al demonstrated a significant reduction in reflux episodes in preterm infants by evaluation with pH-impedance analysis.
- Conditions
- Gastroesophageal Reflux, Regurgitation, Vomiting, Chronic Cough
- Trial name
- NCT01858584
- Testing
- Gastrotuss, thickened milk
- Where
- Italy
- Volunteers
- 75 people
- Sponsor
- Federico II University
Pulmonary Disease, Chronic Obstructive, Asthma
Evaluation of Spirometry Expert Support in General Practice
More and more general practitioners (GPs) use spirometry in their practices. At this time, there is sufficient reason to presume that, after a single postgraduate training program without any further support, most GPs have…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Asthma, Cough, Dyspnea
- Trial name
- NCT00131157
- Testing
- expert support for interpretation of spirometry
- Where
- Netherlands
- Volunteers
- 39 people
- Sponsor
- Radboud University Medical Center
Chronic Cough
A Study of Gefapixant (MK-7264) in Adult Participants With Chronic Cough (MK-7264-027)
The main objectives of this study will be to evaluate the efficacy of gefapixant in reducing cough frequency as measured over a 24-hour period at Week 12, and to evaluate the safety and tolerability of gefapixant.
- Trial name
- NCT03449134
- Testing
- Gefapixant
- Where
- 156 sites in United States, Argentina and 15 more
- Volunteers
- 732 people
- Sponsor
- Merck Sharp & Dohme LLC
Chronic Obstructive Pulmonary Disease, Asthma
Novel Endpoints in Cough Challenge Testing
The sensitivity of a person's cough reflex can be measured by getting them to breathe in (inhale) irritant chemicals. There are different methods by which subjects are asked to inhale these chemicals, either by taking one deep…
- Conditions
- Chronic Obstructive Pulmonary Disease, Asthma, Healthy, Chronic Cough
- Trial name
- NEAT (NCT01566968)
- Testing
- Cough challenge test, 24 hour ambulatory cough recording, Cough quality of life questionnaire
- Where
- United Kingdom
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Manchester University NHS Foundation Trust
Cough, COPD
Cough Monitoring in COPD
This is an observational study designed to learn about symptoms of cough and how changes in cough may be associated with the beginning of a COPD exacerbation (acute worsening of symptoms.
- Conditions
- Cough, COPD, COPD Exacerbation
- Trial name
- NCT07098793
- Testing
- Cough monitoring
- Where
- United Kingdom
- Volunteers
- 39 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Extraesophageal Reflux, Laryngopharyngeal Reflux
Comprehensive Analysis of the Swallowing Mechanism Using High-resolution Manometry With Impedance
The aim of this project is to perform a detailed evaluation of upper esophageal sphincter function and the swallowing mechanism in patients with swallowing disorders or suspected extraesophageal reflux using high-resolution…
- Conditions
- Extraesophageal Reflux, Laryngopharyngeal Reflux, Dysphagia, Chronic Cough
- Trial name
- NCT07365046
- Testing
- High resolution oesophageal manometry with impedance, 24-hour pH metry
- Where
- Czechia
- Volunteers
- 160 people
- Sponsor
- University Hospital Ostrava
Chronic Obstructive Pulmonary Disease
Erdosteine (Erdotin) Versus Standard Care Plus Placebo on Erdosteine for Treatment of Cough in Acute Exacerbations of Chronic Obstructive Pulmonary Disease (COPD)
This is a parallel group, double-blind, placebo controlled, multi-centre, randomised trial. 60 patients to be included who are adult patients admitted to hospital with a clinical diagnosis of acute exacerbation of Chronic…
- Trial name
- NCT01176318
- Testing
- Erdosteine
- Where
- United Kingdom
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Chronic Cough
A Study to Assess the Efficacy of Gefapixant (MK-7264/AF-219), in Participants With Chronic Cough (MK-7264-006)
This is a randomised, double-blind, placebo-controlled, crossover, single centre study of gefapixant (AF-219/MK-7264) in participants with idiopathic or treatment resistant chronic cough designed to evaluate the effectiveness of…
- Trial name
- EPICC (NCT01432730)
- Testing
- Gefapixant
- Volunteers
- 24 people
- Sponsor
- Afferent Pharmaceuticals, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Interstitial Lung Disease
Gabapentin vs. Benzonatate vs. Standard of Care for Cough in ILD
Absence of a clear standard of care and approved drug for chronic cough, the commonest symptom in ILD, calls for further research in this area.
- Trial name
- GAZEBO-ILD (NCT07859839)
- Testing
- Gabapentin, Benzonatate 200 mg, Standard of care treatment for ILD
- Where
- India
- Volunteers
- 177 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Chronic Obstructive Pulmonary Disease, Chronic Cough
Study of AffloVest in At-Risk Respiratory Patients During COVID-19 Pandemic
The purpose of the study is to investigate the addition of high frequency chest wall oscillation (HFCWO) therapy to the prescribed care regimen to support the diaphragm during airway clearance among post-COVID patients with COPD…
- Conditions
- Chronic Obstructive Pulmonary Disease, Chronic Cough, Covid19
- Trial name
- NCT04654481
- Testing
- HCFWO, Standard Care Plus Monitoring
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cough, Refractory Chronic Cough
A 2x2 Factorial, Randomized, Open-label Trial to Evaluate Neuromodulators and Cough Control Therapy in Patients With Refractory or Unexplained Chronic Cough
The FORTITUDE trial will provide head-to-head evidence on the benefits and harms of two commonly prescribed neuromodulators (low-dose morphine and pregabalin), the effectiveness of a virtual cough control therapy, exploratory…
- Conditions
- Cough, Refractory Chronic Cough, Unexplained Chronic Cough, Cough Hypersensitivity Syndrome
- Trial name
- FORTITUDE (NCT07288528)
- Testing
- Morphine Sulphate, Morphine Sulphate + Cough Control Therapy, Pregabalin
- Where
- 5 sites in Canada
- Volunteers
- 124 people
- Sponsor
- McMaster University
Postoperative Cough, Thoracoscopy
Effects of Vagus Nerve Pulmonary Branch Block on Postoperative Cough After VATS Lung Resection
Postoperative cough after pulmonary resection is a common issue seen after thoracic surgeries, hindering patients' recovery and affecting their postoperative quality of life.
- Conditions
- Postoperative Cough, Thoracoscopy, Pulmonary Resection, Vagus
- Trial name
- NCT06500949
- Testing
- Vagus Nerve Pulmonary Branch Block, Vagus Nerve Pulmonary Branch Injection
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Chronic Cough, Video-assisted Thoracoscopic Surgery (VATS)
A Prospective, Randomized, Double-blind Study on the Effects of Different Anesthesia Strategies on Postoperative Cough in Patients Undergoing Video-assisted Thoracoscopic Surgery.
This study aims to systematically evaluate the effects of different anesthesia methods on postoperative chronic cough in lung cancer patients undergoing video-assisted thoracoscopic lung resection (VATS), and to clarify the…
- Trial name
- Chronic cough (NCT07190664)
- Testing
- Patients were randomly grouped
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University Union Hospital
Refractory Chronic Cough
An 8-Week Refractory Chronic Cough Study (MK-7264-021)
This was an 8-week randomized, parallel, double-blind, placebo-controlled study of gefapixant (AF-219) in participants with refractory chronic cough.
- Trial name
- NCT02612623
- Testing
- Gefapixant
- Where
- 10 sites in United States
- Volunteers
- 24 people
- Sponsor
- Afferent Pharmaceuticals, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis (IPF)-Related Chronic Cough Reduction With Nalbuphine Extended-Release (NAL ER) Tablets
The primary purpose is to evaluate the safety and efficacy of NAL ER for the treatment of chronic cough in participants with Idiopathic Pulmonary Fibrosis (IPF).
- Trial name
- OCEAN-1 (NCT07671911)
- Testing
- NAL ER
- Where
- 22 sites in United States
- Volunteers
- 306 people
- Sponsor
- Trevi Therapeutics
Endometriosis Related Pain, Overactive Bladder
Study on the Safety of BAY1817080, How it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Drug in Participants With Impaired Liver Function or Normal Liver Function
BAY1817080 is currently under clinical development to treat pain related to unexplained chronic cough or chronic cough not affected by a treatment (refractory and/or unexplained chronic cough, RUCC), or a condition where the…
- Conditions
- Endometriosis Related Pain, Overactive Bladder, Diabetic Neuropathic Pain, Refractory or Unexplained Chronic Cough
- Trial name
- NCT04454424
- Testing
- BAY1817080, Midazolam
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- Bayer
Cough, Refractory Chronic Cough
A 52-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough
This is a randomized, double-blind, placebo-controlled, parallel-arm, Phase 3 study of BLU-5937 in participants with Refractory Chronic Cough (RCC).
- Trial name
- CALM-1 (NCT05599191)
- Testing
- BLU-5937
- Where
- 200 sites in United States, Argentina and 13 more
- Volunteers
- 957 people
- Sponsor
- Bellus Health Inc. - a GSK company
Cough
Study of the Safety and Effectiveness of BC1036 Capsules to Treat Frequent Long-Term Cough
The purpose of this study is to investigate the effect of BC1036 (theobromine) on cough-related quality of life and cough severity following 2 weeks' treatment.
- Trial name
- NCT01656668
- Testing
- BC1036
- Where
- 13 sites in United Kingdom
- Volunteers
- 288 people
- Sponsor
- Respicopea Limited
Chronic Refractory Cough
A Dose-ranging Study of Orvepitant in Patients With Chronic Refractory Cough
The purpose of this study is to determine the effectiveness of three doses of orvepitant, taken once a day, in the treatment of chronic refractory cough.
- Trial name
- NCT02993822
- Testing
- Orvepitant Maleate
- Where
- 66 sites in United States, Canada and 1 more
- Volunteers
- 315 people
- Sponsor
- Nerre Therapeutics Ltd.