Clinical trials: Chronic Cough (CC)
Chronic Cough (CC), Upper Airway Cough Syndrome
Inhaled vs Intranasal Corticosteroids for Chronic Cough in Upper Airway Cough Syndrome
Chronic cough - a cough lasting eight weeks or longer - is one of the most common reasons people see a lung specialist. It can disturb sleep, make conversation difficult, and reduce quality of life.
- Conditions
- Chronic Cough (CC), Upper Airway Cough Syndrome, Chronic Rhinitis
- Trial name
- NCT07777796
- Testing
- Budesonide (400μg/d), Mometasone Furoate 50mcg Nasal Spray
- Where
- Poland
- Volunteers
- 56 people
- Sponsor
- Silesian University of Medicine
Chronic Cough (CC), Laryngeal Disease
Efficacy of Intramuscular Steroid Injection for Chronic Cough.
The primary goal of this study is to test the hypothesis that injecting steroid intramuscularly is an effective treatment for unexplained chronic cough.
- Conditions
- Chronic Cough (CC), Laryngeal Disease, Coughing
- Trial name
- NCT06634823
- Testing
- Triamcinolone Acetonide Injectable Suspension, Saline injection
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Medical University of South Carolina
Chronic Cough (CC)
China Chronic Cough Registry: a Multicenter, Prospective, Observational Study
The aim is to establish a national clinical database and biobanks for chronic coughers. Through real-world chronic cough case registry and follow-up studies, we will explore the clinical phenotypes and molecular subtypes of…
- Trial name
- NCT06862362
- Where
- China
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Chronic Cough (CC), Asthma
The Safety, Feasibility, and Repeatability of Inhaled ATP Cough Challenges
The inhalation of adenosine 5'-triphosphate (ATP) to evoke cough (ATP cough challenge) is becoming increasingly used as a tool to measure cough hypersensitivity in patients with chronic cough.
- Trial name
- NCT07085975
- Testing
- Adenosine 5'-triphosphate
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- McMaster University
Chronic Cough (CC)
Investigating the Role of ATP Production by Airway Epithelium in Patients With Refractory and Unexplained Chronic Cough (RCC/UCC).
Chronic cough is a common troublesome symptom which has a global prevalence of approximately 10%, but with wide variations across continents.
- Trial name
- APEC (NCT06600646)
- Testing
- Bronchoscopy
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McMaster University
Chronic Cough (CC), Refractory Chronic Cough
Mechanisms of Change in Behavioral Cough Suppression Therapy for Refractory Chronic Cough
This study is testing new ways to help people who have chronic cough that has not improved with typical treatments. One approach is called behavioral cough suppression (BCS) therapy, which teaches people techniques to stop…
- Conditions
- Chronic Cough (CC), Refractory Chronic Cough, Unexplained Chronic Cough
- Trial name
- CoughLESS (NCT06960759)
- Testing
- BCS+inactive, BCS+active
- Where
- 3 sites in United States
- Volunteers
- 135 people
- Sponsor
- University of Montana
Chronic Cough (CC), Gastroesophageal Reflux (GER)
Impact of Gastroesophageal Reflux and Aspiration on Airway Inflammation and Microbiome in Children With Chronic Cough
Using an active cohort of children in whom Airway and gastrointestinal endoscopy will be performed, investigators will conduct a chart review to obtain relevant clinical data and the investigators will use an aliquot of airway…
- Trial name
- NCT02797756
- Testing
- Esophago-gastro-duodenoscopy (EGD) with biopsy, Esophageal Impedance Monitoring (EIM)
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- NYU Langone Health
Chronic Cough (CC), Healthy Adult Participants
Impact of Refractory Chronic Cough on Activities of Daily Living and Response to Acute High-intensity Exercise
Chronic cough is a common and debilitating condition that affects up to 10% of the global population. The health impact of chronic cough is multifaceted and manifests both physical and psychological symptoms including syncope…
- Trial name
- NCT06766175
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Asthma, Chronic Obstructive Pulmonary Disease (COPD)
Canadian Consortium on Airway Mucus Occlusions in Asthma, COPD and Chronic Cough
Chronic lung diseases affect one in five Canadians, causing symptoms such as cough, breathlessness, and wheeze. Despite advancements in medical care, these conditions not only impact individuals and their close circles but also…
- Conditions
- Asthma, Chronic Obstructive Pulmonary Disease (COPD), Chronic Cough (CC)
- Trial name
- CANMuc (NCT06858748)
- Testing
- Observational
- Where
- 7 sites in Canada
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- McMaster University
Chronic Cough
Analysis of the Reliability and Validity of the Chinese Version of CC-QoL
At present, there is no research scale designed for the quality of life of children with chronic cough in China, most of them use the cough scale designed for adults to evaluate the quality of life of children.
- Trial name
- NCT05362097
- Testing
- The reliability and validity of the Chinese version of CC-QoL
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Chronic Cough (CC)
Wenjuanxing-Based Multidimensional Etiologic Screening and Clinical Validation of Chronic Cough in Children
Chronic cough is a common and burdensome condition in children, with complex and overlapping etiologies that often lead to delayed diagnosis, misdiagnosis, and inappropriate treatment.
- Trial name
- NCT07306637
- Testing
- No intervention (observational study)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai Children's Medical Center