Clinical trials: Chronic Depressive Disorder
Mental Illness Persistent, Chronic Disease
Reverse Colocated Integrated Care Intervention Among Persons With Severe Persistent Mental Illness at US-Mexico Border
This study evaluated whether patients with severe and persistent mental illness (SPMI) who received coordinated co-located behavioral health and primary care services were more likely to improve health outcomes after 12 months…
- Conditions
- Mental Illness Persistent, Chronic Disease, Hypertension, Diabetes
- Trial name
- NCT03881657
- Testing
- Reverse Colocated Integrated Care, Usual Care
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- Health Resources in Action, Inc.
Major Depressive Disorder
Treatment for Chronic Depression
The purpose of this study is to test the clinical efficacy of two psychotherapies for early onset chronic major depression, including Behavioral Activation (Jacobson et al., 2001), and an integrated version of Behavioral…
- Trial name
- NCT00204152
- Testing
- (Condition 1) Behavioral Activation; (Condition 2) Behavioral Activation and Stress Innoculation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Chicago
Depression, End Stage Renal Disease
A Trial of Sertraline vs. CBT for End-stage Renal Disease Patients With Depression {ASCEND}
Patients whose kidneys fail generally require dialysis treatments to sustain life. The ability of patients to make major adjustments in their lives for dialysis is hampered by depression that affects almost one-quarter of such…
- Trial name
- ASCEND (NCT02358343)
- Testing
- Engagement Interview, Cognitive Behavioral Therapy, Antidepressant Drug Therapy
- Where
- 3 sites in United States
- Volunteers
- 184 people
- Sponsor
- University of Washington
Major Depressive Disorder
Combining Medications to Enhance Depression Outcomes
This study will compare whether a combination of antidepressant medications is better than one antidepressant medication alone when given as initial treatment for people with chronic or recurrent major depressive disorder.
- Trial name
- CO-MED (NCT00590863)
- Testing
- Escitalopram + Bupropion SR, Venlafaxine XR + Mirtazapine
- Where
- 15 sites in United States
- Volunteers
- 665 people
- Sponsor
- National Institute of Mental Health (NIMH)
Major Depression
Cognitive Behavioral Treatments for Depression in Chronic Illness
Duke University Medical Center in collaboration with Glendale Adventist Medical Center propose a randomized clinical trial of conventional cognitive behavior therapy (CCBT) vs.
- Trial name
- NCT01208428
- Testing
- Conventional cognitive behavioral therapy, Religious cognitive behavioral therapy
- Where
- 2 sites in United States
- Volunteers
- 132 people
- Sponsor
- Duke University
Chronic Pain, Depression, Anxiety
Evaluating the Psychophysiological Effects of a Smartphone-Based Mindfulness Task
The aim of the present study is to evaluate the psychophysiological effects of a smart phone based mindfulness meditation app (MMA) for individuals with clinically significant symptoms of major depression and/or anxiety, or…
- Trial name
- NCT03296007
- Testing
- Mindfulness Meditation
- Where
- Canada
- Volunteers
- 2,016 people, healthy volunteers welcome
- Sponsor
- York University
Coccyx Injuries, Pain, Chronic
The Relationship of Disability With Depression, Anxiety and Sleep Quality in Patients With Coccygodynia
Pain of the sacrococcygeal region is called coccygodynia This painful clinical picture, which causes a decrease in the quality of life, also causes disability.
- Conditions
- Coccyx Injuries, Pain, Chronic, Anxiety, Depression
- Trial name
- NCT05047380
- Testing
- Owstery Disability Scale for disability Beck Depression Scale, Beck Anxiety Scale for psychological evaluation, VAS for pain, Pittsburgh Sleep Quality Scale for sleep quality
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Cumhuriyet University
Pain, Chronic, Depressive Symptoms
Pain Reduction Through Empowered Recovery (PRIME) Study
Chronic pain and depression or low mood are often experience by women who age with or into disabilities. Due to various factors women with disabilities often experience this cycle of pain and depression.
- Conditions
- Pain, Chronic, Depressive Symptoms, Depression, Disability Physical
- Trial name
- PRIME (NCT05619510)
- Testing
- PRIME Intervention
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Johns Hopkins University
Chronic Obstructive Pulmonary Disease, Exercise
Mind-Body Walking Exercise for Chronic Obstructive Pulmonary Disease
Mind-body exercise improves symptom of negative moods, dyspnea and quality of life in chronic diseases, but these improvements for chronic obstructive pulmonary disease (COPD) are unproven.
- Conditions
- Chronic Obstructive Pulmonary Disease, Exercise, Anxiety, Depression
- Trial name
- NCT03388489
- Testing
- Mind-Body Walking
- Volunteers
- 84 people
- Sponsor
- National Taiwan University Hospital
Anxiety Depression, Post Traumatic Stress Disorder
Neuropsychological Sequelae and Long COVID-19 Fatigue
An association of fatigue with post-viral neuropsychological disturbs has been reported. Among patients hospitalized with COVID-19 there is an increased incidence of anxiety and depression symptoms.
- Conditions
- Anxiety Depression, Post Traumatic Stress Disorder, Mental Fatigue, COVID-19
- Trial name
- PostCoV2Psy (NCT05323318)
- Testing
- Neuropsychological Sequelae
- Where
- 6 sites in Portugal
- Volunteers
- 200 people
- Sponsor
- Centro Hospitalar Universitario do Algarve
Inflamation, Hemodialysis
Effect of Sertraline on Inflammation in Hemodialysis Patients with Depression: a Randomized Controlled Trial
Depression is a common mental health condition among patients undergoing hemodialysis and is associated with a lower quality of life, poor treatment adherence, and worse overall health outcomes.
- Conditions
- Inflamation, Hemodialysis, End Stage Renal Disease on Hemodialysis (Diagnosis)
- Trial name
- NCT06840379
- Testing
- Sertraline (Oral Antidepressant)
- Where
- Pakistan
- Volunteers
- 62 people
- Sponsor
- Nishtar Medical University
Tinnitus, Depression
Home-based Transcranial Electrical Stimulation (TES) in Patients With Chronic Tinnitus
The investigators applied home-based transcranial electrical stimulation (TES) for neuromodulative treatment in patients with intractable chronic tinnitus.
- Conditions
- Tinnitus, Depression, Depressive Disorder, Hearing Disorders
- Trial name
- NCT05189587
- Testing
- transcranial electrical stimulation (TES)
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Hematoma, Subdural, Chronic, Hematoma, Subdural, Intracranial
Covers to Improve Esthetic Outcome After Surgery for Chronic Subdural Hematoma
The clinical-functional result after frontal and parietal burr-hole trepanation for the treatment of chronic subdural hematoma (cSDH) is effective with regards to control of the hematoma and regression of symptoms (headache…
- Conditions
- Hematoma, Subdural, Chronic, Hematoma, Subdural, Intracranial, Haematoma;Subdural;Traumatic
- Trial name
- CORRECT-SCAR (NCT03755349)
- Testing
- Placement of burr-hole covers, No placement of burr-hole covers
- Where
- Switzerland
- Volunteers
- 83 people
- Sponsor
- University of Zurich
Chronic Pain, Chronic Pain Syndrome
Outcomes Mandate National Integration With Cannabis as Medicine
This will be a multistate, multicenter clinical study to determine the efficacy and safety of medical cannabis for a wide variety of chronic medical conditions.
- Conditions
- Chronic Pain, Chronic Pain Syndrome, Chronic Pain Due to Injury, Chronic Pain Due to Trauma
- Trial name
- OMNI-Can (NCT03944447)
- Testing
- Cannabis, Medical, RYAH-Medtech Inhaler
- Where
- 17 sites in United States
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- OMNI Medical Services, LLC
COPD, Anxiety State
Assessment of Stress Levels and Depressive and Anxiety Symptoms in Patients With COPD
The aim of the study was to assess the levels of depression, anxiety and stress in patients with COPD qualified for In-hospital pulmonary rehabilitation program
- Conditions
- COPD, Anxiety State, Stress, Depressive Symptoms
- Trial name
- NCT04726917
- Testing
- Pulmonary rehabilitation
- Where
- Poland
- Volunteers
- 51 people
- Sponsor
- The Opole University of Technology
Major Depressive Disorder, Chronic Major Depression, Recurrent
Establishing Multimodal Brain Biomarkers for Treatment Selection in Depression
The purpose of the study is to identify brain biomarkers and characteristics that predict individual responses to treatment of major depression with the antidepressant drug sertraline (tradename Zoloft), a common selective…
- Trial name
- Re-EMBARC (NCT05892744)
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Texas at Austin
Chronic Illness, Chronic Pain
Treating Comorbid Depression During Care Transitions Using Relational Agents
Depression is common among individuals with chronic illness such as chronic heart failure (CHF) or chronic obstructive pulmonary disease (COPD) and is a strong predictor of poor clinical outcomes and high rates of avoidable…
- Conditions
- Chronic Illness, Chronic Pain, Depression, Comorbid Depression
- Trial name
- RA-CBT (NCT02845102)
- Testing
- Pre-Post Feasibility
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Comorbidity, Depressive Symptoms
Community Assets Supporting Transitions (CAST)
The aim of this study is to test a support program for older adults with symptoms of depression and other chronic health problems after they are discharged home from hospital.
- Trial name
- CAST (NCT03157999)
- Testing
- Intervention group (CAST)
- Where
- 4 sites in Canada
- Volunteers
- 127 people
- Sponsor
- McMaster University
Mastectomy, Pain, Acute
Stellate Ganglion Block for Prevention of Post Mastectomy Depression
Complications after mastectomy include chronic pain and depression.
- Conditions
- Mastectomy, Pain, Acute, Pain, Chronic
- Trial name
- SGB (NCT06263907)
- Testing
- Stellate gangalion block
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Mansoura University
Radiation Toxicity, Chemotherapeutic Toxicity
Patients Referred to the Chronic Pain Unit for Palliative Treatment With Ozone Therapy Between 2022 and 2025
The main objective of this study is to analyze the impact on the health-related quality of life of patients with refractory symptoms, who have been referred to the HUGCDN Chronic Pain Unit for adjuvant palliative treatment with…
- Conditions
- Radiation Toxicity, Chemotherapeutic Toxicity, Chemotherapy-induced Peripheral Neuropathy, Delayed Wound Healing
- Trial name
- EPOOzo (NCT05417737)
- Testing
- Ozone therapy
- Where
- Spain
- Volunteers
- 105 people
- Sponsor
- Bernardino Clavo, MD, PhD