Clinical trials: Chronic Disease Lung
Chronic Pancreatitis, Inflammatory Bowel Diseases
Genomic Resources for Enhancing Available Therapies (GREAT1.0) Study
This is a prospective, descriptive, observational research study designed to observe and document the clinical practice by domain experts, and how the knowledge of new findings that are published in the medical literature affect…
- Conditions
- Chronic Pancreatitis, Inflammatory Bowel Diseases, Hepatitis, NASH - Nonalcoholic Steatohepatitis
- Trial name
- GREAT1 (NCT04306939)
- Testing
- venipuncture, Questionnaires, Additional Sample Collections
- Where
- United States
- Volunteers
- 120,000 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
COPD, Asthma
A Study Into Airways Disease Case Finding and Management
Chronic Obstructive Pulmonary Disease (COPD) is a disease of the lungs which is generally caused by smoking tobacco. It is a largely preventable disease that causes severe and irreversible damage to the lungs.
- Trial name
- ASSIST (NCT03355677)
- Testing
- Case finding Clinic, At Risk Case Clinics, Usual Care
- Where
- United Kingdom
- Volunteers
- 327 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Acute Rejection (AR) of Transplanted Kidney, Chronic Allograft Nephropathy (CAN)
Proteogenomic Monitoring and Assessment of Kidney Transplant Recipients
Chronic Allograft Nephropathy (CAN)/Interstitial fibrosis and Tubular Atrophy (IFTA) is responsible for most kidney transplant failures. CAN/IFTA on a 3 month kidney biopsy strongly predicts graft survival long term.
- Conditions
- Acute Rejection (AR) of Transplanted Kidney, Chronic Allograft Nephropathy (CAN), Interstitial Fibrosis (IF), Tubular Atrophy (TA)
- Trial name
- Mini-Kidney (NCT01531257)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Northwestern University
COVID-19, Virus Diseases
Bacillus Calmette-guérin Vaccination to Prevent COVID-19
Based on findings of the interim analysis of the ACTIVATE study showing 53% decrease of the incidence of all new infections with BCG vaccination, a new trial is designed aiming to validate if BCG can protect against COVID-19…
- Conditions
- COVID-19, Virus Diseases, Corona Virus Infection, Coronary Heart Disease
- Trial name
- ACTIVATEII (NCT04414267)
- Testing
- BCG vaccine
- Where
- 15 sites in Greece
- Volunteers
- 301 people, healthy volunteers welcome
- Sponsor
- Hellenic Institute for the Study of Sepsis
Organic, Including Symptomatic, Mental Disorders, Substance Use
Exploring the Comorbidity Between Mental Disorders and General Medical Conditions
Mental disorders have been shown to be associated with a number of general medical conditions (also referred to as somatic or physical conditions).
- Conditions
- Organic, Including Symptomatic, Mental Disorders, Substance Use, Schizophrenia, Mood [Affective] Disorders
- Trial name
- COMO-GMC (NCT03847753)
- Testing
- Organic Disorders, Substance Use Disorders, Schizophrenia Disorders
- Volunteers
- 5,940,299 people
- Sponsor
- University of Aarhus
Chronic Obstructive Pulmonary Disease
Exacerbation Study
This study compares indacaterol with tiotropium in terms of bronchodilation over 52 weeks
- Trial name
- INVIGORATE (NCT00845728)
- Testing
- Indacaterol 150 µg, Tiotropium
- Where
- 423 sites in Argentina, Australia and 38 more
- Volunteers
- 3,439 people
- Sponsor
- Novartis Pharmaceuticals
Spirometry, Qadriceps Muscle
The Effect of Orally Administered L- Arginine on Quadriceps Strenght in Healthy Smokers
The study will investigate changes in certain locomotor parameters as early predictors of disease in smokers who are prone to develop chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT04643600
- Testing
- L-Arginine, 500 Mg Oral Capsule
- Where
- Croatia
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Goranka Radmilović
Chronic Obstructive Pulmonary Disease
Effects of Rehabilitation on Muscle Fibre Composition and Capillaries in Chronic Obstructive Pulmonary Disease (COPD) Patients
Pulmonary rehabilitation has been established as an evidence-based and recommended therapy in patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT01715337
- Testing
- pulmonary rehabilitation
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Schön Klinik Berchtesgadener Land
Chronic Obstructive Pulmonary Disease (COPD), Asthma
Combined Bio- and Neuro- Feedback vs. Varenicline Use for Smoking Cessation
This study will develop and experimentally test the efficiency of a neurofeedback training protocol vs. varenicline use for smoking cessation.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Asthma, Smoking
- Trial name
- NCT02991781
- Testing
- Biofeedback and Neurofeedback Training, Varenicline use for smoking cessation, Passive Control
- Where
- 3 sites in Bulgaria, Cyprus and 1 more
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Chronic Obstructive Pulmonary Disease, Nocturnal Desaturation
The International Nocturnal Oxygen (INOX) Trial
This multicenter randomized placebo controlled trial aims to determine if in patients with COPD not qualifying for LTOT but presenting significant nocturnal arterial oxygen desaturation, whether nocturnal oxygen therapy provided…
- Trial name
- INOX (NCT01044628)
- Testing
- Concentrator
- Where
- 28 sites in Canada, France and 2 more
- Volunteers
- 243 people
- Sponsor
- Laval University
Chronic Obstructive Pulmonary Disease, Emphysema or COPD
The Effect of Treatment of Emphysema With Endobronchial Valves on the Diaphragm Mobility
In some patients with chronic obstructive pulmonary disease (COPD) the breathlessness is caused by hyperinflation of the lungs. This causes difficulty breathing air out and makes it harder to breath in new air and limits the…
- Trial name
- NCT06163131
- Where
- Denmark
- Volunteers
- 35 people
- Sponsor
- Aarhus University Hospital
Chronic Obstructive Pulmonary Disease
Efficacy of Respiratory Physiotherapy Treatment in Chronic Obstructive Disease.
To test the effectiveness of a respiratory physiotherapy treatment plan in patients who have been diagnosed with chronic obstructive pulmonary disease, comparing with two randomized groups, for the performance of different…
- Trial name
- NCT07204431
- Testing
- the PowerBreathe and PEP Therosold tools group.
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Universidad Católica de Ávila
Asthma, COPD
Blood Collection From Individuals With Lung Disease for Genetic Studies
This is a research study where researchers are collecting blood to evaluate the genetic characteristics of individuals with chronic lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), interstitial lung…
- Conditions
- Asthma, COPD, Interstitial Lung Disease, Cystic Fibrosis
- Trial name
- NCT00362739
- Where
- United States
- Volunteers
- 3,087 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Central Serous Chorioretinopathy
Eplerenone for the Treatment of Central Serous Chorioretinopathy
To test the effect oral eplerenone versus placebo in patients with central serious chorioretinopathy .
- Trial name
- NCT01990677
- Testing
- 25mg Eplerenone
- Where
- 10 sites in United States
- Volunteers
- 108 people
- Sponsor
- Wills Eye
Chronic Obstructive Pulmonary Disease (COPD), Acute Exacerbation of COPD
Remote Monitoring of COPD Patients Experiencing an Acute Exacerbation Through Health Evaluations Using Wearable Mobile Technology
Chronic obstructive pulmonary disease (COPD) causes about 3 million deaths annually and significantly burdens healthcare systems, costing the EU 38.6 billion euros, largely due to frequent hospitalizations triggered by acute…
- Trial name
- COPD-BREATHE (NCT06890767)
- Testing
- Wearable mobile device, CAT Questionnaire, DHRQ Questionnaire
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- David Ruttens
COPD, Healthy
The Effectiveness of Dual-task Exercises in Individuals With COPD
The goal of this clinical trial is to evaluate the effect of dual-task performance on motor and cognitive functions and to determine the effect of dual-task exercises given together with the pulmonary rehabilitation program on…
- Trial name
- NCT05930158
- Testing
- Dual Task Exercises, Pulmonary Rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Marmara University
Respiratory Diseases, Chronic and Acute Respiratory Failure
Validation of a Simulated Clinical Evaluation of Ventilators
The purpose of this study is to evaluate the ability of a device reproducing patients' respiratory characteristics to select in-VITRO the most appropriate ventilator for a given pathology.
- Trial name
- SIMULVENTI (NCT01113255)
- Testing
- bench-evaluation, of three ventilators
- Where
- France
- Volunteers
- 54 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COPD
Human Safety of Capsaicin Inhalation Challenge Testing for Young and Older Men
In 2004, the investigators initiated a human Capsaicin inhalation experiment under an Investigational New Drug (IND) protocol approved by the FDA (IND 69,642) and the subject safety procedures instituted and approved by the…
- Trial name
- Capsaicin (NCT01621685)
- Testing
- biological/vaccine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Chronic Thrombo-embolic Pulmonary Hypertension and Pulmonary Arterial Hypertension
Determinants of Right Heart Remodeling in Patients With CTEPH or PAH
Right heart failure is the main cause of morbi-mortality in patients with pulmonary hypertension (PH), including patients of chronic thrombo-embolic pulmonary hypertension (CTEPH) or pulmonary arterial hypertension (PAH)…
- Trial name
- PRINCEPT (NCT03205085)
- Testing
- magnetic resonance imaging, 2D and 3D trans-thoracic echocardiography, Blood samples
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Pulmonary Disease, Chronic Obstructive
Personalized Prediction Strategy for Acute Exacerbation of Chronic Obstructive Pulmonary Disease
This is a 3-year longitudinal study designed to establish a personalized prediction and prevention system for acute exacerbations of chronic obstructive pulmonary disease (AECOPD).
- Trial name
- NCT03240315
- Where
- China
- Volunteers
- 442 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
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