Clinical trials: Chronic Disease Lung
Cough
The Utility of feNO in the Differential Diagnosis of Chronic Cough
In this study the investigators wish to explore the difference in 24 hr. cough counts measured using the Hull Automated Cough Counter (HACC), from baseline and after two weeks treatment with either montelukast or prednisolone in…
- Trial name
- TUF (NCT02479074)
- Testing
- Montelukast (High FeNO group), Prednisolon, Montelukast (High FeNO), Montelukast (Low FeNO group)
- Where
- United Kingdom
- Volunteers
- 49 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Pulmonary Disease, Chronic Obstructive
Influence Of Salmeterol Xinafoate/Fluticasone Propionate (50/500 µg BID) On The Course Of The Disease And Exacerbation Frequency In COPD Patients Gold Stage III And IV
This is a 12 month randomized, open-label, parallel-group study to obtain data on the frequency and variability of exacerbations in severe and very severe Chronic Obstructive Pulmonary Disease (COPD) patients (Global Initiative…
- Trial name
- NCT00527826
- Testing
- Salmeterol / Fluticasone (50/500 µg) BID fixed combination, Salmeterol / Fluticasone (50/500 µg) BID separate Inhalers
- Where
- 23 sites in Germany
- Volunteers
- 214 people
- Sponsor
- GlaxoSmithKline
Respiration Disorders
To Identify if a COPD Self-management App Can Safety and Appropriately Identify When Patients Are Not on the Best Medication Plan for Their COPD Symptoms and Support Their COPD Management.
Although COPD cannot be cured, managing COPD can help reduce symptoms control, slows progression of the disease, and may improve the quality of life.
- Trial name
- mySmartCOPD (NCT07797985)
- Testing
- MMH-LAB1 app
- Where
- United Kingdom
- Volunteers
- 746 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Post-acute COVID-19 Syndrome
SENSING-AI Cohort for Long COVID Patients
The prospective study will focus on the collection of biometric and psychometric data from a limited population for 1 month with the aim of complementing the SENSING-AI retrospective cohort.
- Trial name
- SENSING-AI (NCT05204615)
- Testing
- Collection of clinical, psychometric and biometric data
- Where
- 2 sites in Spain
- Volunteers
- 10 people
- Sponsor
- Adhera Health, Inc.
Cystic Fibrosis, Chronic Pancreatitis
Study to Evaluate Symptoms of Exocrine Pancreatic Insufficiency in Adult Participants With Cystic Fibrosis or Chronic Pancreatitis Treated With Creon
Exocrine pancreatic insufficiency (EPI) is a condition that is caused by the inadequate pancreatic enzymes needed for normal digestion and is commonly associated with a wide range of chronic diseases, including cystic fibrosis…
- Trial name
- NCT05069597
- Testing
- CREON
- Where
- 21 sites in United States
- Volunteers
- 30 people
- Sponsor
- AbbVie
Tracheomalacia, Tracheobronchomalacia
Tracheal Mechanics During Bronchoscopy
The main purpose of this study is use a new type of measurement to help decide what kind of therapy would help people with a collapsing windpipe or tracheomalacia.
- Trial name
- NCT00536315
- Where
- United States
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Chronic Obstructive Pulmonary Disease
A Crossover Study to Determine the 24 Hour Lung Function Profile of Indacaterol in Patients With Moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD)
This study was conducted to provide detailed information on the efficacy of indacaterol in terms of its effect on spirometry assessed forced expiratory volume in 1 second (FEV1) over a 24 hour time period.
- Trial name
- NCT00622635
- Testing
- Indacaterol 300 μg, Salmeterol 50 μg
- Where
- 14 sites in United States, Belgium and 1 more
- Volunteers
- 68 people
- Sponsor
- Novartis Pharmaceuticals
Long COVID, Cardiorespiratory Fitness
Nitrite Supplementation in Long COVID Patients
Potential benefits of a nitrate-rich juice supplement to improve skeletal muscle function and associated physical capacity will be studied in patients with Long COVID.
- Trial name
- NCT05618574
- Testing
- 140 ml per day of Beet-It nitrate beverage (James White Drinks Ltd., Ipswich, UK)
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- VA Office of Research and Development
Chronic Obstructive Pulmonary Disease
Randomized Trial of Physical Activity Self-Management Intervention for Patients With COPD
Chronic obstructive pulmonary disease (COPD) is a common condition associated with major disability. There is strong evidence that pulmonary rehabilitation (PR) improves outcomes and is cost saving, but fewer than 2% of patients…
- Trial name
- COPD-SMART (NCT01108991)
- Testing
- Physical activity self-management, COPD education + Usual care
- Where
- United States
- Volunteers
- 325 people
- Sponsor
- The University of Texas Health Science Center at Tyler
Pulmonary Disease, Chronic Obstructive
Impact of Feedback on Physical Activity and Health-related Outcomes During Pulmonary Rehabilitation in COPD
The aim of this study is to investigate whether providing feedback on physical activity (PA) levels to patients with Chronic Obstructive Pulmonary Disease (COPD) is feasible and enhances daily PA and health-related outcomes…
- Trial name
- NCT02725931
- Testing
- Pulmonary rehabilitation (PR) plus PA-focused intervention
- Volunteers
- 20 people
- Sponsor
- Aveiro University
Chronic Obstructive Pulmoriary Disease (COPD), Asthma
Clinical Study on the Treatment of Chronic Airway Diseases (Asthma, Chronic Obstructive Pulmonary Disease) with Shu Fei Tie
Conduct a multi-center, large-sample, randomized controlled clinical study of "winter disease being cared in summer" with Shu Fei Tie prevent recurrence of Asthma and COPD, scientifically evaluate the clinical efficacy and safety…
- Trial name
- NCT06691802
- Testing
- Shu Fei Tie
- Where
- China
- Volunteers
- 2,312 people
- Sponsor
- Henan University of Traditional Chinese Medicine
Pulmonary Disease, Chronic Obstructive
A Study to Evaluate the Effect of Umeclidinium (UMEC) as Combination Therapy in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
This is a multicenter, randomized, double-blind, parallel-group study to evaluate the efficacy and safety of the addition of UMEC (62.5 microgram[mcg]) when administered once-daily via dry powder inhaler (DPI) to Inhaled…
- Trial name
- NCT02257372
- Testing
- UMEC DPI, ICS/LABA medication, Albuterol/salbutamol Metered Dose Inhaler (MDI)
- Where
- 28 sites in Czechia, Germany and 2 more
- Volunteers
- 236 people
- Sponsor
- GlaxoSmithKline
Parkinson Disease, COPD
The ADAPT-study: Measuring Physical Performance Using Wearable Sensors in Parkinson's Disease and COPD (ADAPT)
The aim of this study is to investigate whether a smartwatch can measure the physical capacity of patients with Parkinson's Disease and COPD in the physiotherapy practice and at home.
- Trial name
- ADAPT (NCT05756075)
- Testing
- Aerobic exercise training
- Where
- 28 sites in Netherlands
- Volunteers
- 154 people
- Sponsor
- Radboud University Medical Center
Long COVID, Post Acute Sequelae of COVID-19
PET Imaging of Cyclooxygenase-1 in Participants With Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)
Background: SARS-CoV-2 is the virus that causes COVID-19. Some people who recover from COVID-19 have long-term symptoms that affect the brain.
- Trial name
- NCT06920628
- Testing
- 11C-PS13
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Chronic Obstructive Pulmonary Disease (COPD), Asthma
Mitigating Chronic Respiratory Disease Through the Lens of Multimorbidity (MARES3)
The investigators aim to investigate how individuals attending primary healthcare (PHC) services in Brazil for treatment of non-communicable diseases (NCDs), identified there as having abnormal spirometry or as being at high risk…
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Asthma, Preserved Ratio Impaired Spirometry (PRISM)
- Trial name
- NCT07134855
- Where
- 2 sites in Brazil
- Volunteers
- 473 people
- Sponsor
- University College, London
Pulmonary Disease, Chronic Obstructive, Airflow Obstruction, Chronic
Non-invasive Ventilation System in Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD)
When using the Breathe Technologies Ventilation System during simulated activities of daily living (ADLs), Subjects with moderate-to-severe chronic obstructive pulmonary Disease (COPD) will be comfortable and report acceptability.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Airflow Obstruction, Chronic, Chronic Obstructive Airway Disease, Chronic Obstructive Lung Disease
- Trial name
- PRIDE (NCT01355978)
- Testing
- Noninvasive Open Ventilation System
- Where
- 3 sites in United States
- Volunteers
- 22 people
- Sponsor
- Breathe Technologies, Inc.
COPD, Smoking
Defective FGFR2 Signaling in the Small Airway Basal Progenitor Cells in COPD
Early changes associated with the development of smoking-induced diseases, e.g., COPD and lung cancer (the two commonest causes of death in U.S.) are often characterized by abnormal airway epithelial differentiation.
- Conditions
- COPD, Smoking, Lung Disorder
- Trial name
- NCT02341326
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Cystic Fibrosis, Burkholderia Infection
A Study of OligoG in Cystic Fibrosis Subjects With Burkholderia Spp. Infection
The purpose of the study is to assess the efficacy of Alginate oligosaccharide (OligoG) dry powder for inhalation in cystic fibrosis (CF) patients with a Burkholderia spp. infection.
- Trial name
- SMR-2591 (NCT02453789)
- Testing
- Alginate oligosaccharide
- Where
- 2 sites in Germany
- Volunteers
- 15 people
- Sponsor
- AlgiPharma AS
Chronic Obstructive Pulmonary Disease (COPD)
Single Dose Lipopolysaccharide (LPS) Study In Healthy Volunteers
A single dose study with the inhaled anti-inflammatory agent PF-03715455 to establish if it has anti-inflammatory activity following a challenge with LPS.
- Trial name
- NCT01314885
- Testing
- PF-03715455, PH-797804
- Where
- 2 sites in United Kingdom
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Pfizer
Pulmonary Disease, Chronic Obstructive
Repeat Dose Study in Male Healthy Volunteer Smokers
This is a 4 to 6 week study to look at the safety and PK profile of SB656933 in healthy male smokers
- Trial name
- NCT00615576
- Testing
- SB-656933
- Where
- United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
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