Clinical trials: Chronic Disease of Cardiovascular System
Stroke
Augmentation of Locomotor Adaptation Post-Stroke
This project will evaluate two different methods of normalizing the center of mass acceleration (COMa) in individuals post-stroke, specifically focusing on rates and pattern of recovery to analyze walking-specific adaptations as…
- Trial name
- NCT02892084
- Testing
- tDCS
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Stroke
Circuit Class Training vs. Individual, Task Specific Training in Chronic Stroke Patient
Due to minimal volitional activation of the impaired arm, these individuals are less able to engage in activities of daily living (ADL's). Moreover, simultaneous use of the hand and arm are needed throughout ADL's.
- Trial name
- NCT05059704
- Testing
- Circuit Class Training, Individual Task specific training
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Lymphoma
Bortezomib and Rituximab in Treating Patients With Relapsed or Refractory B-Cell Non-Hodgkin's Lymphoma
RATIONALE: Bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as rituximab, can block cancer growth in different ways.
- Trial name
- NCT00265928
- Testing
- bortezomib, rituximab, antibody therapy
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Virginia
Hypertension, Cognitive Decline
The Influence of Tai Chi Practice on Blood Pressure and Brain Health Among Older Adults With Hypertension (ACTION)
High blood pressure and poor cognitive function are two common health problems among older adults in the United States. They are also closely related because high blood pressure may lead to negative changes in brain structure and…
- Trial name
- ACTION (NCT04384263)
- Testing
- Tai Chi
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Connecticut
Chronic Myeloproliferative Disorders, Leukemia
Fludarabine, Cyclophosphamide, and Total-Body Irradiation in Treating Patients Who Are Undergoing a Donor Bone Marrow Transplant for Hematologic Cancer
RATIONALE: Giving low doses of chemotherapy, such as fludarabine and cyclophosphamide, and radiation therapy before a donor bone marrow transplant helps stop the growth of cancer cells.
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00134004
- Testing
- cyclophosphamide, fludarabine phosphate, mycophenolate mofetil
- Where
- 3 sites in United States
- Volunteers
- 210 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Cardiovascular Diseases, End Stage Renal Disease
Modulation of Inflammation by Medium Cut Off Membranes
This study examines whether medium-cut off dialysis results in improved blood purification of large middle molecules e.g. inflammatory molecules compared to hemodialysis (HD) treatments with conventional high-flux dialyzers.
- Trial name
- MCO-IF (NCT03270371)
- Testing
- Medium cut off dialysis, Standard High Flux Dialyzer
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Technical University of Munich
Heart Failure, Volume Overload
Assessment of ProEnkephalin to Detect Acute Kidney Injury (AKI)
Researchers are observing the values of proEnkephalin (PENK) via a blood draw in hospitalized patients that are volume overloaded requiring diuresis.
- Conditions
- Heart Failure, Volume Overload, Decompensated Heart Failure, Systolic Heart Failure
- Trial name
- NCT04019314
- Testing
- Blood Collection, Blood Volume Analysis
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Cerebrovascular Accident, Chronic Obstructive Pulmonary Disease
Tocilizumab for the Treatment of Cytokine Release Syndrome in Patients With COVID-19 (SARS-CoV-2 Infection)
This phase III trial compares the effect of adding tocilizumab to standard of care versus standard of care alone in treating cytokine release syndrome (CRS) in patients with SARS-CoV-2 infection.
- Conditions
- Cerebrovascular Accident, Chronic Obstructive Pulmonary Disease, Chronic Renal Failure, Coronary Artery Disease
- Trial name
- NCT04361552
- Testing
- Best Practice, Tocilizumab
- Where
- United States
- Sponsor
- Emory University
Uremia; Chronic, Cardiovascular Diseases (CVD)
Prevention and Management of Cardiovascular and Cerebrovascular Complications in Maintenance Hemodialysis (MHD) Patients
Background and Purpose: This clinical study aims to explore and validate two innovative treatment strategies to address two major challenges faced by patients on maintenance hemodialysis (uremia): the high incidence of…
- Conditions
- Uremia; Chronic, Cardiovascular Diseases (CVD), Cerebrovascular Disorders, Intradialytic Hypotension
- Trial name
- NCT07335471
- Testing
- Continuous High-Glucose Infusion and Regular Hemoperfusion in Maintenance Hemodialysis
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Suzhou Municipal Hospital of Anhui Province
Heart Failure, Congestive
Effect of 48 Hours of Treatment With the Natural Peptide-Hormone GLP-1 in Patients With Chronic Heart Failure
The purpose of this study is to determine whether 48 hours of glucagon-like-peptide-1 (GLP-1) infusion can improve heart function and alter substrate metabolism in non-diabetic patients with heart failure.
- Trial name
- NCT00264199
- Testing
- GLP-1
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Aarhus University Hospital Skejby
Cardiovascular Disease (CVD), Chronic Obstructive Pulmonary Disease (COPD)
Towards Personalized Nutrition With SCAPIS2-HOME
The Swedish CardioPulmonary bioImage Study (SCAPIS) is a nationwide, open-access, population-based cohort in Sweden designed to study cardiovascular disease and chronic obstructive pulmonary disease.
- Trial name
- NCT06992921
- Testing
- Dietary intervention
- Where
- 2 sites in Sweden
- Volunteers
- 1,641 people, healthy volunteers welcome
- Sponsor
- Chalmers University of Technology
Reperfusion Injury After Pulmonary Thromboendarterektomy
High PEEP Application Following Pulmonary Thromboendarterectomy; Does it Have Any Impact on Outcome?
Investigation of the effect of intraoperative lung protection high PEEP maneuver on ischemic reperfusion injury in patients undergoing pulmonary endarterectomy.
- Trial name
- NCT03806504
- Testing
- PEEP, control group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Chronic Heart Failure With Low Ejection Fraction
ContriBution of Digital RemOte MoniToring to IMPROVing The Effectiveness of Treatment in Patients With Chronic Heart Failure With Low Ejection Fraction
BOT-IMPROVE-HF is a two-center, parallel group study designed to evaluate the efficacy of up-titration of heart failure treatment using digital remote monitoring after hospitalization due to heart failure decompensation.
- Trial name
- BOT-IMPROVE-HF (NCT06304753)
- Testing
- Telebot
- Where
- 2 sites in Russia
- Volunteers
- 66 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Breast Cancer, Chronic Myeloproliferative Disorders
Lactobacillus in Preventing Infection in Patients Undergoing a Donor Stem Cell Transplant for Hematologic Cancer or Myelodysplastic Syndrome
RATIONALE: Probiotics, such as Lactobacillus, may be effective in preventing infections in patients with suppressed immune systems.
- Conditions
- Breast Cancer, Chronic Myeloproliferative Disorders, Leukemia, Lymphoma
- Trial name
- NCT00946283
- Testing
- Lactobacillus rhamnosus GG
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Rutgers, The State University of New Jersey
B-Cell Prolymphocytic Leukemia, Hypodiploidy
Autologous Peripheral Blood Stem Cell Transplant Followed by Donor Bone Marrow Transplant in Treating Patients With High-Risk Hodgkin Lymphoma, Non-Hodgkin Lymphoma, Multiple Myeloma, or Chronic Lymphocytic Leukemia
This phase II trial studies autologous peripheral blood stem cell transplant followed by donor bone marrow transplant in treating patients with high-risk Hodgkin lymphoma, non-Hodgkin lymphoma, multiple myeloma, or chronic…
- Conditions
- B-Cell Prolymphocytic Leukemia, Hypodiploidy, Loss of Chromosome 17p, Plasma Cell Leukemia
- Trial name
- NCT01008462
- Testing
- Allogeneic Bone Marrow Transplantation, Allogeneic Hematopoietic Stem Cell Transplantation, Autologous Hematopoietic Stem Cell Transplantation
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Fred Hutchinson Cancer Center
Cardiorenal Syndrome
Levosimendan Versus Dobutamine for Renal Function in Heart Failure
Although inotropes have a favorable effect on central hemodynamics in patients with heart failure, their effect on renal hemodynamics is incompletely defined.
- Trial name
- ELDOR (NCT02133105)
- Testing
- Levosimendan, Dobutamine
- Where
- Sweden
- Volunteers
- 33 people
- Sponsor
- Göteborg University
Coronary Artery Disease
A Trial to Evaluate Efficacy of Heart-protecting Musk Pill
Title: A randomized, double-blind, multi-centered, placebo-controlled trial to examine effects of of Heart-protecting Musk Pill on clinical outcomes in patients with chronic stable coronary artery disease Objective: To examine…
- Trial name
- NCT01897805
- Testing
- Heart-protecting Musk Pill
- Where
- 98 sites in China
- Volunteers
- 2,700 people
- Sponsor
- Shanghai Hutchison Pharmaceuticals Limited
Chronic Thromboembolic Pulmonary Hypertension
Identification of Criteria of the Success of the Endarterectomy in Chronic Pulmonary Post Embolic Hypertension
In order to improve effectiveness of the surgical operation thanks to a reduction in the rate of failure, this study will allow us to identify predictive angiographic and CT finding of surgical failure, starting from standardized…
- Trial name
- ETHAPE (NCT00657722)
- Testing
- Angiography and Computed Tomography
- Where
- 2 sites in France
- Volunteers
- 249 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Stable Angina, Unstable Angina
The Role of Alcohol Consumption in the Aetiology of Different Cardiovascular Disease Phenotypes: a CALIBER Study
The association between alcohol consumption and cardiovascular disease (CVD) has mostly been examined using broad endpoints or cause-specific mortality.
- Conditions
- Chronic Stable Angina, Unstable Angina, Coronary Heart Disease Not Otherwise Specified, Acute Myocardial Infarction
- Trial name
- NCT01864031
- Where
- United Kingdom
- Volunteers
- 2,240,000 people
- Sponsor
- University College, London
Heart Failure, Chronic Obstructive Airway Disease
A Comparison of the Effect of Carvedilol and Metoprolol on Airways Tone in Patients With Heart Failure
This study looks at the effect of two drugs (carvedilol and metoprolol) which are used for patients with CHF (chronic heart failure).
- Trial name
- NCT00384566
- Testing
- Carvedilol, Metoprolol
- Where
- Australia
- Sponsor
- The Alfred
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