Clinical trials: Chronic Disease of Cardiovascular System
Decompensated Chronic Heart Failure
Observational Study Designed to Detect Decompensation of Congestive Heart Failure (dCHF) Using a Non-Invasive Wearable Device
This is a prospective, observational pilot study designed to develop a mathematical algorithm capable of predicting decompensation of congestive heart failure (dCHF) using physiologic data collected from a non-invasive wearable…
- Trial name
- NCT07350759
- Testing
- wearable ring device with multiple embedded sensors to detect heart rate, SVO2, respiratory rate, heart rate variability and a number of other related physiologic parameters
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- CHFDX,Inc.
Coronary Artery Disease, Chronic Total Occlusions
Prognostic Impact of Chronic Total Occlusions
The purpose of this study is to determine the prognostic impact of the presence of chronic total occlusions (CTO) of the coronary arteries in patients undergoing coronary angiography and PCI.
- Trial name
- NCT02084888
- Where
- Sweden
- Volunteers
- 91,154 people
- Sponsor
- Sahlgrenska University Hospital
Heart Failure, Heart Failure With Preserved Ejection Fraction (HFPEF)
Sodium-Glucose Cotransporter 2 Inhibitor Use in a National Heart Failure Telemonitoring Program
This observational cohort study evaluates temporal trends and determinants of sodium-glucose cotransporter 2 inhibitor (SGLT2i) prescriptions among adults with chronic heart failure enrolled in a nationwide remote monitoring…
- Conditions
- Heart Failure, Heart Failure With Preserved Ejection Fraction (HFPEF), Heart Failure With Reduced Ejection Fraction, Heart Failure With Mildly Reduced Ejection Fraction (HFmrEF)
- Trial name
- REMOTE-HF (NCT07022379)
- Testing
- SGLT2 Inhibitor Use
- Where
- France
- Volunteers
- 13,660 people
- Sponsor
- Satelia
Chronic Venous Disease
Surface NeuroMuscular Electrical Stimulation in the Treatment of Chronic Venous Leg Ulcers
This study aims to determine if the use of surface neuromuscular electrical stimulation, applied to various motor points on the lower limb to elicit muscle contraction when combined with compression bandaging accelerates the rate…
- Trial name
- NCT01801891
- Testing
- VASGARD stimulator, Compression bandaging
- Where
- 2 sites in Ireland
- Volunteers
- 25 people
- Sponsor
- Professor Stewart Walsh
Sialorrhea
Open-Label and Single-Arm Study of MYOBLOC® in the Treatment of Troublesome Sialorrhea in Adults
Multicenter, open-label, outpatient study of the safety and effectiveness of repeated doses of MYOBLOC over a 1-year duration in adult subjects with troublesome sialorrhea.
- Trial name
- OPTIMYST (NCT02610868)
- Testing
- MYOBLOC
- Where
- 35 sites in United States, Belarus and 1 more
- Volunteers
- 187 people
- Sponsor
- Solstice Neurosciences, LLC, a subsidiary of US WorldMeds, LLC
Graft Rejection
Efficacy and Safety of Everolimus in Recipients of Heart Transplants to Prevent Acute and Chronic Rejection
This trial was to examine the impact of everolimus and reduced dose of cyclosporine on efficacy and safety compared to mycophenolate mofetil and a standard dose of cyclosporine in heart transplant recipients.
- Trial name
- NCT00300274
- Testing
- everolimus, mycophenolate mofetil, cyclosporine
- Where
- 64 sites in United States, Argentina and 13 more
- Volunteers
- 721 people
- Sponsor
- Novartis Pharmaceuticals
Chronic Obstructive Pulmonary Disease
Effects of Long Acting Bronchodilators on CARDiac Autonomic Control in Chronic Obstructive Pulmonary Disease (COPD)
The aim of this interventional, randomized, double-blind, monocentric, cross-over study is to quantify the possible deleterious effect on the cardiac autonomic nervous system control of two long-acting anticholinergic…
- Trial name
- LAB-Card (NCT02872090)
- Testing
- Indacaterol, Glycopyrronium, Tiotropium
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Chronic Disease, Diabetes
Pragmatic Randomized Control Trial of Telehealth vs Standard Care in Follow-up of Patients With Chronic Conditions
The Norwegian health authorities has initiated a three-year trial of telehealth solutions as part of the treatment of patients with chronic illness in the period 2018-2021.
- Conditions
- Chronic Disease, Diabetes, Vascular Diseases, Chronic Lung Disease
- Trial name
- MAO (NCT04142710)
- Testing
- Telemedicine: tablet and possibly tools to perform measurements
- Where
- 9 sites in Norway
- Volunteers
- 732 people
- Sponsor
- University of Oslo
CTEPH, Pulmonary Embolism
Symptom-related Screening for Early Detection of CTEPH.
Routine screening for Chronic thromboembolic pulmonary hypertension (CTEPH) i after PE is not supported by current evidence and guidelines.
- Conditions
- CTEPH, Pulmonary Embolism, Symptoms and Signs, Dyspnea
- Trial name
- NCT03953560
- Testing
- dyspnea grade ≥ II according NYHA-WHO
- Where
- 16 sites in Spain
- Volunteers
- 646 people
- Sponsor
- Luis Jara-Palomares, MD
Stroke, Hemiparesis
Efficacy of a Combined Transcranial Direct Current Stimulation and Virtual Reality Intervention
Rehabilitation options for stroke survivors who present severe hemiparesis in chronic stages are limited and may end in compensation techniques that involve the use of the less affected arm to achieve some degree of functional…
- Conditions
- Stroke, Hemiparesis, Chronic Stroke, Upper Limb Injury
- Trial name
- REACT01 (NCT03528018)
- Testing
- REACt system, Physical therapy
- Where
- Spain
- Volunteers
- 14 people
- Sponsor
- Hospitales Nisa
Stroke
High Intensity Interval Training in Chronic Stroke Patients
Stroke is a global health-care problem that is common, serious and disabling. In most countries, stroke is second or third most common cause of death and one of the main causes of acquired adult disability.
- Trial name
- NCT01777113
- Testing
- High intensity aerobic training, High Intensity Strength Training, Mixed Training
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Universita di Verona
Heart Failure, Congestive
Ursodeoxycholic Acid in Chronic Heart Failure
This is a double-blind, placebo-controlled, cross-over study evaluating the effects of UDCA on peripheral blood flow and immune function in patients with stable chronic heart failure (CHF).
- Trial name
- NCT00285597
- Testing
- Ursodeoxycholic Acid
- Where
- United Kingdom
- Sponsor
- National Heart and Lung Institute
Hypertension
The Standardized Management of Hypertension in Rural Shaanxi
The purpose of the study is to build a prevention and management system of hypertension in rural Shaanxi, China, which tries to use the standardized and economical methods to improve the outcome of chronic cardiovascular diseases.
- Trial name
- NCT04371874
- Testing
- Hydrochlorothiazide, Captopril, Nitrendipine, Aspirin
- Where
- China
- Volunteers
- 1,210 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Heart Failure
The Effects of Self-monitoring With a Mobile Application in Heart Failure
In the United States, about 40 percent of heart failure (HF) patients are readmitted within 1-year following their first admission for HF and hospitalization accounts for approximately 70 percent of the costs of HF management.
- Trial name
- NCT03149510
- Testing
- Mobile Application
- Where
- 2 sites in United States
- Volunteers
- 83 people
- Sponsor
- University of Michigan
Venous Leg Ulcer
A Multicentre European Study to Evaluate Granulox® Used in the Treatment Pathway of Predominantly Chronic Venous Leg Ulcers (VLUs).
The investigation is designed as an open label, randomized, prospective, assessor blinded, multi centre investigation. 254 evaluable subjects will be randomized to either standard of care group or standard of care with Granulox…
- Trial name
- Granulox01 (NCT04181320)
- Testing
- Venous Leg Ulcer Standard of Care with Granulox
- Where
- 27 sites in Croatia, Czechia and 5 more
- Volunteers
- 128 people
- Sponsor
- Molnlycke Health Care AB
Chronic Subdural Hematoma, Subdural Drain
The Effect of Subdural Drain Placement After Burr Hole Evacuation of Chronic Subdural Haematomas on Recurrence: a Prospective Randomised-controlled Multi-centre Study
This is a prospective randomised-controlled multi-centre trial based in Hong Kong to determine whether temporary subdural drain placement after burr hole evacuation of a chronic subdural haematoma can reduce the risk of…
- Trial name
- NCT01785797
- Testing
- Silicon subdural drain placement after burr hole evacuation of chronic subdural hematoma
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Kwong Wah Hospital
Neutropenia
A Study of Mavorixafor in Participants With Congenital and Acquired Primary Autoimmune and Idiopathic Chronic Neutropenic Disorders Who Are Experiencing Recurrent and/or Serious Infections
The purpose of this study is to demonstrate the efficacy and evaluate the safety and tolerability of mavorixafor in participants with congenital or acquired primary autoimmune and idiopathic chronic neutropenic disorders who are…
- Trial name
- NCT06056297
- Testing
- Mavorixafor
- Where
- 114 sites in United States, Argentina and 23 more
- Volunteers
- 176 people
- Sponsor
- X4 Pharmaceuticals
End Stage Renal Failure, Hemodialysis
Effect of Missed Dialysis Sessions on Short Term Cardiovascular Events
the effect of missed hemodialysis sessions on the occurrence of short-term cardiovascular events in patients with end-stage renal disease receiving maintenance hemodialysis.
- Trial name
- NCT07455799
- Testing
- Electrocardiography (ECG) and Echocardiography (ECHO)
- Where
- Egypt
- Volunteers
- 225 people
- Sponsor
- Assiut University
COVID-19, Vaccine Adverse Reaction
National Vaccine Adverse Event Reporting Survey and Etiology
If your serious vaccine-induced adverse event has been entered in the CDC Vaccine Adverse Event Reporting System (VAERS) we are interested in enrolling you for this study in order to log your symptoms.
- Conditions
- COVID-19, Vaccine Adverse Reaction, Vaccine Reaction, Vaccine or Biological Substance, Unspecified Causing Adverse Effects in Therapeutic Use
- Trial name
- NVAERS (NCT05095844)
- Testing
- vaccinated
- Where
- United States
- Volunteers
- 100,000 people
- Sponsor
- Neuroganics LLC
Cardio-Renal Syndrome, Coronary Angiography
Risk Factors and Prognosis of Adverse Cardiovascular and Kidney Events After Coronary Intervention
As a single center, retrospective observation study in Guangdong Institute of Cardiovascular Diseases, this study included the main study population of patients who underwent coronary angiography and / or coronary intervention…
- Conditions
- Cardio-Renal Syndrome, Coronary Angiography, Coronary Artery Disease, Kidney Diseases
- Trial name
- NCT04407936
- Where
- China
- Volunteers
- 88,938 people
- Sponsor
- Guangdong Provincial People's Hospital
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