Clinical trials: Chronic Encephalopathy
CTE, TBI (Traumatic Brain Injury)
Traumatic Brain Injury and Risk for Chronic Traumatic Encephalopathy
This project was designed to determine brain imaging patterns using 2-(1-{6-[(2-fluorine 18-labeled fluoroethyl)methylamino]-2-naphthyl}ethylidene)malononitrile ([F-18]FDDNP) with positron emission tomography (PET) in…
- Trial name
- NCT02003183
- Testing
- [F-18]FDDNP
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of California, Los Angeles
Inherited Mitochondrial Disease, Including Leigh Syndrome
Open-Label, Dose-Escalating Study Assessing Safety, Tolerability, Efficacy, of RP103 in Mitochondrial Disease
To evaluate safety, tolerability and efficacy of cysteamine bitartrate delayed-release capsules (RP103) administered at a target maintenance dose of 1.3 g/m²/day in two divided doses, every 12 hours, for up to 6 months in…
- Trial name
- MITO-001 (NCT02023866)
- Testing
- Cysteamine Bitartrate
- Where
- 5 sites in United States
- Volunteers
- 36 people
- Sponsor
- Amgen
Alzheimer's Disease (AD), Parkinson's Disease (PD)
Evaluation of [18F]MNI-777 PET as a Marker of Tau Pathology in Subjects With Tauopathies Compared to Healthy Subjects
The goal of this study is to assess [18F]MNI-777 PET imaging as a tool to detect tau pathology in the brain of individuals who carry a clinical diagnosis of a tauopathy, including: Alzheimer's Disease (AD),Parkinson's disease…
- Conditions
- Alzheimer's Disease (AD), Parkinson's Disease (PD), Chronic Traumatic Encephalopathy (CTE), Progressive Supranuclear Palsy (PSP)
- Trial name
- NCT02103894
- Testing
- [18F]T807 ([18F]MNI-777)
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Molecular NeuroImaging
Cirrhosis, Hepatic Encephalopathy
Brain Energy Metabolism in Patients With Chronic Liver Disease and Impaired Central Nervous System
The purpose of the current study is to look into the pathogenesis of a severe medical condition causing acute episodes on the central nervous system as seen in majority of patients with liver cirrhosis.
- Trial name
- NCT00424957
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Liver Cirrhosis, Cognitive Dysfunction
The Liver Cirrhosis Cognitive Decline Scale (LiCCoS)
The goal of this observational study is to develop and test a new questionnaire called the Liver Cirrhosis Cognitive Decline Scale (LiCCoS) for adults with liver cirrhosis.
- Conditions
- Liver Cirrhosis, Cognitive Dysfunction, Hepatic Encephalopathy, Neurocognitive Disorders
- Trial name
- LiCCoS (NCT07418008)
- Where
- India
- Volunteers
- 230 people
- Sponsor
- University of Malaya
Hepatic Encephalopathy
RICE Trial: Rifaximin In Chronic Hepatic Encephalopathy - A Randomized, Controlled Trial
The purpose of this study is to compare the effectiveness of three different treatments for hepatic encephalopathy.
- Trial name
- NCT00364689
- Testing
- Rifaximin, Lactulose
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Miami
End-stage Liver Disease (ESLD), Cirrhosis, Liver
RTX001 Autologous Engineered Macrophages for Liver Cirrhosis
The purpose of this study is to assess the safety and efficacy of RTX001 in patients with end-stage liver disease. This study is the first time RTX001, a macrophage cell therapy engineered to have an anti-inflammatory and…
- Conditions
- End-stage Liver Disease (ESLD), Cirrhosis, Liver, Cirrhosis, Decompensated, Liver Diseases
- Trial name
- EMERALD (NCT06823713)
- Testing
- RTX001
- Where
- 15 sites in Spain, United Kingdom
- Volunteers
- 30 people
- Sponsor
- Resolution Therapeutics Limited
Hepatic Encephalopathy, Acute-On-Chronic Liver Failure
PEG3350 in ACLF With Hepatic Encephalopathy
it is a single blind randomised control study which aims to study the effect of PEG3350 in resolution of overt hepatic encephalopathy in patients of acute on chronic liver failure.
- Trial name
- NCT03987893
- Testing
- PEG-3350 with Electolytes, Lactulose
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
MELAS Syndrome, Lebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus)
A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)
This is a parallel arm non-randomized dose-escalation, open-label basket exploratory phase 1 clinical trial where Mitochondrial encephalopathy, lactic acidosis, stroke-like episodes (MELAS) and Leber's hereditary optic…
- Trial name
- NCT06792500
- Testing
- Glycerol Tributyrate
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- George Washington University
Chronic Liver Disease, Hepatic Encephalopathy
Effect of Probiotics in Treatment of Minimal Hepatic Encephalopathy (MHE) and Health Related Quality of Life
This study is a randomized, open, parallel group, active comparator, single center trial. Objectives of the study are hereby given below: To study the health related quality of life (HRQOL) in patients with chronic liver disease.
- Trial name
- MHE (NCT01008293)
- Testing
- VSL#3, Lactulose
- Where
- India
- Volunteers
- 120 people
- Sponsor
- CD Pharma India Pvt. Ltd.
Alzheimer Disease, Alzheimer Dementia
Alzheimer's Autism and Cognitive Impairment Stem Cell Treatment Study
The purpose of the study is to evaluate the use of autologous Bone Marrow Derived Stem Cells (BMSC) as a means to improve cognitive impairment as occurs in Alzheimer's Disease and other dementias and to improve behavior and…
- Conditions
- Alzheimer Disease, Alzheimer Dementia, Vascular Dementia, Lewy Body Disease
- Trial name
- ACIST (NCT03724136)
- Testing
- Intravenous Bone Marrow Stem Cell (BMSC) Fraction, Intranasal Topical Bone Marrow Stem Cell (BMSC) Fraction, Near Infrared Light
- Where
- 3 sites in United States, United Arab Emirates
- Volunteers
- 100 people
- Sponsor
- MD Stem Cells
Chronic Traumatic Encephalopathy
Pilot Study Evaluating brainQuant's Ability to Detect Alterations in White Matter in Diffusion MRI, Indicative of Post-traumatic Lesions
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease described in boxing, but also in contact sports such as American football.
- Trial name
- BQ TC-foot (NCT07302503)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Strasbourg, France
Hepatic Encephalopathy, Acute-On-Chronic Liver Failure
Intravenous BCAA for HE in ACLF (BCAA-HE-ACLF)
This multi-centric study analyses the effect of intravenous branched-chain amino acids (BCAA) on overt HE in patients with ACLF.
- Trial name
- NCT05700695
- Testing
- Branch Chain Amino Acid, Lactulose
- Where
- India
- Volunteers
- 114 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Hepatic Encephalopathy, HE
Hepatic Encephalopathy: Lactulose or Polyethylene Glycol (H.E.L.P.)
The purpose of this study is to evaluate whether the use of polyethylene glycol is superior and more safe in treating hepatic encephalopathy compared to lactulose and also to determine if treatment with polyethylene glycol will…
- Conditions
- Hepatic Encephalopathy, HE, Cirrhosis, Altered Mental Status
- Trial name
- HELP (NCT01923376)
- Testing
- Lactulose, Polyethylene Glycol 3350
- Where
- United States
- Sponsor
- New York Presbyterian Brooklyn Methodist Hospital
Cerebral Palsy, Stroke
Spinal Stimulation and Mobility Devices
This research study will combine non-invasive spinal stimulation with an ankle exoskeleton to examine the acute impact of the stimulation on gait in children with cerebral palsy.
- Conditions
- Cerebral Palsy, Stroke, Premature Birth, Hypoxic-Ischemic Encephalopathy
- Trial name
- NCT05520359
- Testing
- Mobility Device, Spinal Stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Washington
Acute Disseminated Encephalomyelitis, Encephalomyelitis
The Aim of the Present Study is to Determine Outcome Predictors in Children Who Were Diagnosed as Acute Disseminated Encephalomyelitis (ADEM).
The aim of the present study is to determine outcome predictors in children who were diagnosed as acute disseminated encephalomyelitis (ADEM).
- Conditions
- Acute Disseminated Encephalomyelitis, Encephalomyelitis, Encephalopathy
- Trial name
- ADEM disease (NCT07540182)
- Volunteers
- 25 people
- Sponsor
- Assiut University
Hepatic Encephalopathy, Minimal Hepatic Encephalopathy
A Study of MHE in Patients With Liver Diseases
The study analyzes the diagnostic efficacy of neurophysiological tests and blood biomarkers on MHE, predicts risk factors on the development of OHE and investigate the mortality of MHE in patients with cirrhosis and acute on…
- Conditions
- Hepatic Encephalopathy, Minimal Hepatic Encephalopathy, Overt Hepatic Encephalopathy
- Trial name
- NCT04058327
- Testing
- neurophysiological tests, blood biomarkers.
- Where
- China
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Qin Ning
Chronic Traumatic Encephalopathy
Post-Concussion Syndrome in Professional Athletes: A Multidisciplinary Study
to examine the relationship between repeated concussions and late decline of brain function. In addition, all participants agreeing to participate in the study will be asked to will their brains to The Krembil Neuroscience Centre…
- Trial name
- NCT03218332
- Testing
- Biomarkers for detecting possible CTE invivo
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Liver Cirrhosis
Study in Patients With Decompensated Liver Cirrhosis
OPAL is a multicenter observational study, following the natural disease trajectory of participants who have permanent damage to their liver caused by scarring, sometimes also referred to as liver cirrhosis.
- Trial name
- OPAL (NCT06380335)
- Where
- 12 sites in Spain, United Kingdom
- Volunteers
- 24 people
- Sponsor
- Resolution Therapeutics Limited
Spastic Diplegia
Early Intensive Exercise to Improve Walking in Children With Spastic Diplegia
This is a randomized controlled trial comparing 3 months of intensive leg exercise to standard physiotherapy care for the improvement of motor function in the legs in young children with spastic diplegia.
- Trial name
- NCT03166293
- Testing
- Intensive leg training with a physical therapist
- Where
- 2 sites in Canada
- Volunteers
- 4 people
- Sponsor
- University of Alberta