Clinical trials: Chronic End Stage Renal Failure
End Stage Renal Disease
24 Hour Use of the Wearable Artificial Kidney
This is a prospective, interventional study designed to provide preliminary data on the human use of the WAK. Up to 10 subjects currently receiving intermittent hemodialysis (HD) treatment three times per week for end-stage renal…
- Trial name
- WAK US 1 (NCT02280005)
- Testing
- WAK Treatment
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Blood Purification Technologies, Inc.
Iron Deficiency Anemia (IDA), ESRD (End Stage Renal Disease)
Management of Iron Deficiency Anemia in Hemodialysis Patients
The aim of this interventional study is to assess the effectiveness of oral lactoferrin in improving hemoglobin levels and correcting iron deficiency anemia in patients with end-stage renal disease (ESRD) on dialysis and also…
- Trial name
- NCT07706582
- Testing
- Lactoferrin, IV iron sucrose
- Where
- Egypt
- Volunteers
- 108 people
- Sponsor
- Beni-Suef University
End Stage Renal Disease, Malnutrition
The Effect of Intradialytic Parenteral Nutrition on Nutritional Status and Quality of Life in Hemodialysis Patients
Protein-energy wasting (PEW), a hypercatabolic state characterized by loss of muscle mass and fuel reserves, is highly prevalent in hemodialysis patients.
- Conditions
- End Stage Renal Disease, Malnutrition, Sarcopenia, Hemodialysis Complication
- Trial name
- NCT04094038
- Testing
- Olimel N12, Glucose IV
- Where
- 2 sites in Netherlands
- Volunteers
- 166 people
- Sponsor
- Erasmus Medical Center
Chronic Renal Failure, Hemodialysis
Nicotinamide Versus Sevelamer Hydrochloride on Phosphatemia Control on Chronic Hemodialysed Patients
The comparison between nicotinamide and sevelamer aims to demonstrate, in chronic hemodialysed patients, the non-inferiority of nicotinamide in terms of control of the phosphatemia.
- Trial name
- NICOREN (NCT01011699)
- Testing
- nicotinamide, sevelamer, cinacalcet
- Where
- 18 sites in France
- Volunteers
- 176 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
End-stage Renal Disease
Effects of Strict Volume Control in Hypertensive Hemodialysis Patients on Cardiac Structure and Chronic Inflammation
This study aims mainly to investigate the effects of two approaches to control blood pressure in hypertensive hemodialysis patients; using antihypertensive drugs versus strict volume control (by strict dietary salt restriction…
- Trial name
- NCT00307463
- Testing
- strict volume control policy, antihypertensive drugs administration
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 258 people
- Sponsor
- Ege University
Transplant; Failure, Kidney, Renal Disease, End Stage
Oral Paricalcitol in Kidney Transplant Recipients
This study is being done to find out whether patients who receive a kidney transplant can benefit from taking the medication paricalcitol (trade name Zemplar®) as compared to kidney transplant recipients not taking this…
- Conditions
- Transplant; Failure, Kidney, Renal Disease, End Stage, Hyperparathyroidism, Secondary
- Trial name
- NCT00587158
- Testing
- Paricalcitol, Corticosteroid Avoidance Immune Suppression Protocol
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
ESRD, Hemodialysis
The Evaluation of the DIMI RRT System In-Center to Demonstrate Safety and Usability in the Home Environment
This is a prospective, multicenter, open label, non-randomized, cross-over study. Subjects will be enrolled in the trial for approximately 18 weeks and will use the DIMI RRT System for their dialysis treatments for all study…
- Trial name
- NCT04868643
- Testing
- The DIMI Renal Replacement Therapy (RRT) System
- Sponsor
- Dialco Medical Inc.
Kidney Failure, Chronic, Neuromuscular Blockade
Efficacy and Safety of Sugammadex in Renal Diseased Patients
The purpose of this study is to determine whether sugammadex reverses a profound neuromuscular blockade induced by rocuronium in patients with end-stage renal disease just as effectively and safely as it does in patients with…
- Trial name
- NCT01785758
- Testing
- Sugammadex (4 mg/Kg)
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of São Paulo
Renal Insuffiency, Kidney Transplantation
Pre-emptive Kidney Transplantation Quality of Life
The main objective is to assess the psychological impact of pre-emptive kidney transplantation on patients' quality of life taking into account psychological adjustment (response shift), compared to patients who have experienced…
- Trial name
- PreKiTQoL (NCT02154815)
- Testing
- Questionnaires : Patient-Reported Outcomes
- Where
- 5 sites in France
- Volunteers
- 390 people
- Sponsor
- Nantes University Hospital
End-stage Kidney Disease, CD4 T Cells
Effects of High Cut-off (HCO) Hemodialysis on Central Memory CD4+ T and Treg Cells in Patients With End-stage Kidney Disease
In this study, the investigators will evaluate whether CD4+ TCM producing effector cytokines can be distinguished on the basis of their expression of the IL-7 receptor alpha-chain (CD127).
- Conditions
- End-stage Kidney Disease, CD4 T Cells, Central Memory T Cells, Regulatory T Cells
- Trial name
- NCT01103076
- Testing
- Polyamide HD membrane
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier du Centre du Valais
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, End Stage Renal Disease
Maintaining or Stopping Immunosuppressive Therapy in Patients With ANCA Vasculitis and End-stage Renal Disease
This prospective randomized trial aims to evaluate the feasibility, risk and benefit of the discontinuation of immunosuppressive maintenance treatments in AAV (Antineutrophil Cytoplasmic Autoantibodies (ANCA)-associated…
- Trial name
- MASTER-ANCA (NCT03323476)
- Testing
- Discontinuation (or not initiation) of Immunosuppressive Therapy, Maintenance (or initiation) of immunosuppressive treatment: Imurel®, Mabthera®,Cellcept®, Cortancyl®
- Where
- 57 sites in France
- Volunteers
- 136 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Low-Level Light Therapy, Renal Insufficiency, Chronic
Effects of Low Level Laser Therapy on Functional Capacity and DNA Damage of Patients With Chronic Kidney Failure
This study aims to verify the effects of low level laser therapy (LLLT) on functional capacity, DNA damage, lower limbs muscle strength, quadriceps muscle architecture, muscle pain and perception of lower limb fatigue…
- Conditions
- Low-Level Light Therapy, Renal Insufficiency, Chronic, Renal Dialysis, Clinical Trial
- Trial name
- NCT03250715
- Testing
- Low Level Laser Therapy
- Where
- Brazil
- Volunteers
- 28 people
- Sponsor
- Federal University of Health Science of Porto Alegre
End Stage Kidney Disease
Effect of 25-hydroxyvitamin D and a Structured Exercise Program on Dialysis Patients
This study aims to examine the effect of 25 hydroxyvitamin D supplementation and a structured exercise program on the exercise capacity and quality of life of haemodialysis patients with 25 hydroxyvitamin D insufficiency.
- Trial name
- NCT00798993
- Testing
- Structured Exercise program, Cholecalciferol (25-Hydroxyvitamin D), Usual exercise
- Where
- Australia
- Volunteers
- 19 people
- Sponsor
- Sir Charles Gairdner Hospital
End-Stage Renal Disease, Kidney Failure
Treatment of Children With Kidney Transplants by Injection of CD4+CD25+FoxP3+ T Cells to Prevent Organ Rejection
T regulatory cells (T regs) are responsible for immune tolerance in solid organ transplant patients. This study will evaluate the treatment of children with kidney transplants either with Campath and other immune system…
- Trial name
- NCT01446484
- Testing
- CD4+CD25+CD127lowFoxP3+ T regulatory cells injection, Alemtuzumab, Mycophenolate mofetil
- Where
- 2 sites in Russia
- Volunteers
- 30 people
- Sponsor
- Pirogov Russian National Research Medical University
End Stage Renal Disease
Multicentre, Open Label, Randomized, Two-arm, Parallel-group Study to Assess Efficacy and Safety of ENVARSUS® Compared With Tacrolimus Used as Per Current Clinical Practice in the Initial Maintenance Setting in de Novo Kidney Transplant Patients
The purpose of the study is to compare tacrolimus dosing of the new Envarsus®-based immunosuppressive regimen with current clinical practice (Prograf or Advagraf) over 6 months following de novo renal transplantation in a…
- Trial name
- STEADY (NCT02432833)
- Testing
- ENVARSUS®, PROGRAF®, ADVAGRAF®
- Where
- Italy
- Volunteers
- 428 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Chronic Kidney Failure
BCD to Measure the ED95 of Remimazolam-Assisted Sedation in Arteriovenous Fistula Creation Surgery
This study intends to measure the ED95 of remimazolam-assisted sedation in arteriovenous fistula creation by BCD.
- Trial name
- BCD (NCT06998732)
- Testing
- remimazolam sedation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sir Run Run Shaw Hospital
End Stage Renal Disease
Protein Supplementation in Dialysis Patients
The mortality rate in chronic hemodialysis (CHD) patients remains excessively high and approaches 21% per year. Among the many factors that adversely affects patient outcome is uremic malnutrition, a unique form of deranged…
- Trial name
- NCT00367198
- Testing
- Pro-Stat
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Renal Insufficiency, Kidney Disease
A Study to Evaluate the Pharmacokinetics Of Sativex® in Subjects With Severe Renal Impairment or End Stage Renal Disease, Compared to Matched Subjects With Normal Renal Function.
The study aims to determine the pharmacokinetic (PK) profile of a single oromucosal dose of Sativex® (i.e. how the body absorbs, distributes, metabolises and excretes the drug) when subjects have severe renal impairment or end…
- Trial name
- NCT02325024
- Testing
- Sativex
- Volunteers
- healthy volunteers welcome
- Sponsor
- GW Pharmaceuticals Ltd
End Stage Renal Disease
Triferic AVNU Infusion Via Freedom Pump During Hemodialysis
The main purpose of this study is to evaluate the delivery of Triferic AVNU intravenously using the Freedom Pump-20 during hemodialysis into the pre-dialyzer and post-dialyzer blood lines.
- Trial name
- NCT04689932
- Testing
- Triferic AVNU
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Rockwell Medical Technologies, Inc.
Hyperphosphatemia, End-stage Renal Disease
Trial of a New Formulation of KRX-0502 (Ferric Citrate) in Patients With End-Stage Renal Disease
The objective of this study is to see if KRX-0502 (ferric citrate) is safe and effective as a dietary phosphate binder in controlling and managing serum phosphorus levels in patients with end-stage renal disease (ESRD).
- Conditions
- Hyperphosphatemia, End-stage Renal Disease, Renal Failure Chronic Requiring Hemodialysis
- Trial name
- NCT00967993
- Testing
- ferric citrate
- Where
- 3 sites in Israel
- Volunteers
- 22 people
- Sponsor
- Keryx Biopharmaceuticals