Clinical trials: Chronic Endometritis
Chronic Endometritis
Doxycycline and Progestin Therapy for Chronic Endometritis(CE) in Patients With Recurrent Reproductive Failure(RRF)
A Prospective Randomized Controlled Trial, the goal of this clinical trial is to evaluate the efficacy and safety of doxycycline alone versus doxycycline plus medroxyprogesterone acetate (MPA) in women with chronic endometritis…
- Trial name
- NCT07488949
- Testing
- Doxycycline combined with Medroxyprogesterone
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Fang Wang
Chronic Endometritis
Εffectiveness of Intrauterine Antibiotic Administration for Treatment of Chronic Endometritis
Chronic Endometritis (CE) is related to infertility and entails a challenging management. This study investigates the treatment of off-label intrauterine antibiotic infusion either separately or combined with oral antibiotic…
- Trial name
- NCT05205993
- Testing
- Intrauterine infusion, Oral administration
- Where
- Greece
- Volunteers
- 90 people
- Sponsor
- Genesis Athens Clinic
Chronic Endometritis, Uterus; Scar
Fertility Restoration Using Autologous Mesenchymal Stem Cells
Treatment of the patients with scarring and adhesions in the uterus resulting from caesarean section or chronic inflammation in the mucosa of the uterus and fallopian tubes and preventing the occurrence of these effects in the…
- Conditions
- Chronic Endometritis, Uterus; Scar, Uterine Synechiae, Fallopian Tube Obstruction
- Trial name
- NCT04432467
- Testing
- Autologous mesenchymal stem cells, standard treatment
- Where
- Belarus
- Volunteers
- 10 people
- Sponsor
- Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus
Endometritis, Infertility
Fertility Outcomes After Antibiotic Treatment In Women With Chronic Endometritis
Chronic endometritis (CE) is a long-lasting inflammation of the lining of the uterus. Many women with CE do not have symptoms, but the condition may affect fertility, embryo implantation, and pregnancy outcomes.
- Conditions
- Endometritis, Infertility, Hysteroscopy, Pregnancy Disease
- Trial name
- MORE (NCT07603492)
- Where
- 2 sites in Czechia
- Volunteers
- 100 people
- Sponsor
- Faculty Hospital Kralovske Vinohrady
Endometritis; Chronic, Subfertility
The FLORA-project: in Search for the Microbial Cause of Chronic Endometritis and the Most Appropriate Treatment to Obtain a Successful Pregnancy IVF/ICSI
Chronic endometritis is an inflammatory condition of the endometrium. This inflammation can negatively affect fertility and pregnancy. The pathology is frequently (+-10%) observed in women with fertility problems.
- Trial name
- FLORA (NCT05337072)
- Testing
- Microbiome study
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Chronic Endometritis
GnRH Agonist Pretreatment in Persistent Chronic Endometritis Undergoing FET
Women with PCE represent a treatment-resistant phenotype in whom the endometrial inflammatory and immune status remains abnormal despite antibiotic therapy.
- Trial name
- NCT07642700
- Testing
- Conventional estrogen-progesterone artificial cycle for endometrial preparation, GnRH agonist plus estrogen-progesterone for endometrial preparation
- Volunteers
- 150 people
- Sponsor
- Guoxia Yang
Non Specific Chronic Endometritis, Infertility, Female
Abundance of Lactobacillus in Endometrium Affected by Chronic Endometritis
Infertile women undergoing hysteroscopy for diagnostic or therapeutic indication are asked to donate a sample of endometrium. Endometrial samples of study participants are examined for signs of chronic endometritis by…
- Trial name
- endoMB (NCT04103242)
- Testing
- 16s rRNA gene sequencing
- Where
- Switzerland
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Minimally Invasive Surgical Procedures, Abnormal Uterine Bleeding, Unspecified
Cyclobenzaprine for Postoperative Pain in Minimally Invasive Hysterectomy
Typical postoperative pain control after minimally invasive hysterectomy includes ibuprofen, acetaminophen, and a short course of narcotics.
- Conditions
- Minimally Invasive Surgical Procedures, Abnormal Uterine Bleeding, Unspecified, Adenomyosis of Uterus, Fibroid Uterus
- Trial name
- NCT07664956
- Testing
- Cyclobenzaprine
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Christiana Care Health Services
Chronic Endometritis
Diagnosis of Chronic Endometritis in Endometrial Fluid Using Molecular Techniques to Improve the Outcomes of Assisted Reproductive Treatments
Chronic endometritis (CE) is a persistent inflammation of the endometrial lining caused by the infection of the uterine cavity mainly by bacterial pathogens.
- Trial name
- ChEndometritis (NCT03169621)
- Testing
- Endometrial Biopsy and endometrial fluid collection
- Where
- Spain
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Igenomix
Endometritis, IVF
Mid-Infrared Spectroscopy as a Real Time Diagnostic Tool for Chronic Endometritis
The Investigator propose to develop an in-vitro technique for the measurement and analysis of freshly excised biopsies during hysteroscopy procedure in patients with suspected Chronic Endometritis (CE) condition.
- Trial name
- NCT04197167
- Testing
- Hysteroscopy, Infrared Spectroscopy
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Hillel Yaffe Medical Center
Recurrent Implantation Failure, Recurrent Pregnancy Loss
Study of Endometrial Immune and Microbiological Modifications in Cases of Recurrent Implantation Failure and/or Recurrent Pregnancy Loss
The IMERR study aims to improve understanding of certain causes of infertility related to recurrent implantation failure (RIF) and/or recurrent pregnancy loss (RPL), conditions that affect many women undergoing assisted…
- Conditions
- Recurrent Implantation Failure, Recurrent Pregnancy Loss, Infertility, Female, Endometrial Diseases
- Trial name
- IMERR (NCT07265505)
- Testing
- Endometrial Biopsy, Vaginal Swab, Blood sample
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Endometritis
Intrauterine Antibiotic Infusion in Treating Chronic Endometritis and Restoring Reproductive Dynamics
Chronic Endometritis (CE) is related to infertility and entails a challenging management. This study investigates the treatment of off-label intrauterine antibiotic infusion (IAI) combined with oral antibiotic administration…
- Trial name
- NCT04447625
- Testing
- Oral antibiotic administration, Intrauterine antibiotic infusion
- Where
- Greece
- Volunteers
- 80 people
- Sponsor
- Genesis Athens Clinic
Chronic Endometritis, in Vitro Fertilization
Chronic Endometritis and IVF
Background: Embryo quality is known to be a very important determinant to predict the implantation and pregnancy rate in IVF patients, however, the role of uterine integrity or endometrial receptivity cannot be overlooked.
- Trial name
- CEIVF (NCT02646930)
- Testing
- Endometrial biopsy
- Where
- 2 sites in United States
- Volunteers
- 57 people
- Sponsor
- Duke University
Endometriosis, Pelvic Pain
Endometriosis and Chronic Endometritis
Pelvic endometriosis is a complex estrogen-dependent inflammatory syndrome of unknown etiology, altering the microenvironment of the peritoneal cavity and probably endometrial receptivity, and adversely affecting the…
- Conditions
- Endometriosis, Pelvic Pain, Infertility
- Trial name
- NCT05824507
- Testing
- Endometrial aspiration biopsies for CE diagnosis
- Where
- Poland
- Volunteers
- 64 people
- Sponsor
- Jagiellonian University
Chronic Endometritis
FuKe Qianjin Capsule Plus Antibiotics for Chronic Endometritis
This randomized, double-blind, single-dummy, multicenter clinical study, led by Principal Investigator Xue Fengxia at Tianjin Medical University General Hospital (sponsor and primary trial institution) and funded by Zhuzhou…
- Trial name
- FKQJCE (NCT07485842)
- Testing
- FuKe Qianjin Capsules
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Tianjin Medical University
Infertility, Endometritis
Chronic Endometritis in Patients With Recurrent Miscarriages or Repeated Implantation Failures in In-vitro Fertilization
Chronic endometritis is a persistent inflammation of the endometrium. Chronic endometritis is asymptomatic or little symptomatic.
- Conditions
- Infertility, Endometritis, Abortion, Spontaneous
- Trial name
- NCT01762098
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Clinique Ovo
Infertility Unexplained, Abnormal Uterine Bleeding
Diagnostics of Chronic Endometritis in Infertility
Chronic endometritis (CE) is characterized by the presence of atypical plasma cell infiltrates (CD138 positive) in the endometrial stroma.
- Conditions
- Infertility Unexplained, Abnormal Uterine Bleeding, Intrauterine Disorder
- Trial name
- NCT05946655
- Testing
- Ofloxacin + Metronidazole
- Where
- Poland
- Volunteers
- 102 people
- Sponsor
- Jagiellonian University
Infertility, Female, IVF
RCT to Assess the Impact of Microbiome Status in Infertile IVF Patients at Their First IVF/ICSI Cycle
Although the endometrium has been traditionally considered free of bacteria, recent studies have documented the presence of an endometrial microbiome.
- Trial name
- NCT04686357
- Testing
- EMMA/ALICE
- Volunteers
- 1,018 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Chronic Endometritis
Hysteroscopy for Chronic Endometritis: Diagnostic Performance and Observer Variability
This study investigates the role of hysteroscopy in diagnosing chronic endometritis (CE), a condition linked to female infertility but difficult to diagnose due to nonspecific symptoms.
- Trial name
- NCT06890754
- Testing
- Diagnostic hysteroscopy
- Where
- Tunisia
- Volunteers
- 70 people
- Sponsor
- Tunis University
IVF
Confounding Factors of Chronic Endometritis in Women With Reproductive Failure
The aim of the study is to investigate the confounding factors of chronic endometritis and therapeutic benefits of antibodies targeting plasma cells in women with reproductive failure.
- Trial name
- NCT05613049
- Where
- Hong Kong
- Volunteers
- 720 people
- Sponsor
- Chinese University of Hong Kong