Clinical trials: Chronic Fatigue Syndrome (CFS)
Chronic Fatigue Syndrome
Cytokine Inhibition in Chronic Fatigue Syndrome Patients
Rationale: Chronic fatigue syndrome (CFS) is a medically unexplained syndrome for which no somatic or pharmacological treatment has been proven effective.
- Trial name
- CiCFS (NCT02108210)
- Testing
- Anakinra
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Myalgic Encephalomyelitis, Chronic Fatigue Syndrome
Cardiovascular Analysis of PEM
The purpose of this study is to examine cardiopulmonary function in Chronic Fatigue Syndrome (CFS) patients and determine how it relates to the common symptom of Post-exertional malaise (PEM).
- Trial name
- NCT04740736
- Testing
- Saline Infusion
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Irritable Bowel, Fibromyalgia
Psychiatric Disorders and Functional Somatic Disorders
The objectives of this study are: Firstly, to investigate the association between psychiatric disorders and functional somatic disorder (FSD).
- Conditions
- Irritable Bowel, Fibromyalgia, Chronic Fatigue Syndrome, Bodily Distress Syndrome
- Trial name
- NCT06006715
- Volunteers
- 7,493 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Chronic Fatigue Syndrome
Exploring Worry in CFS/ME
This study will be building on the findings of Kalfas et al 2022 paper exploring the prevalence of generalised worry in patients with Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS) before and after Cognitive…
- Trial name
- NCT06011135
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- King's College London
Myalgic Encephalomyelitis, Chronic Fatigue Syndrome
Analysis of Post-exertional Malaise Using a Two-day CPET in People With ME/CFS
This study aims to collect and identify key outcome measures or disease parameters in ME/CFS that are altered during elevated symptoms relative to baseline by gathering information before and after symptom provocation using a…
- Trial name
- NCT04026425
- Testing
- Two-day cardiopulmonary exercise test
- Where
- 3 sites in United States
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Ithaca College
Mental Fatigue, Fatigue
Effect of Ginko and Cistanche Against Fatigue Symptoms
To evaluate the efficacy of Nutrilite® ginkgo biloba cistanche tablets in relieving the symptoms of chronic fatigue syndrome(CFS), the investigators randomly recruit189 subjects with CFS, aged 35-60 yrs.
- Conditions
- Mental Fatigue, Fatigue, Chronic Fatigue Syndrome
- Trial name
- GkoCist (NCT02807649)
- Testing
- Experimental: Nutrilite® Low dose, Experimental: Nutrilite® High dose
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Access Business Group
Chronic Fatigue Syndrome, Fibromyalgia
Proteomics of Cerebrospinal Fluid in Chronic Fatigue Syndrome
The purpose of this study is: 1. To identify specific set of proteins in the cerebrospinal fluid (fluid surrounding the brain and the spinal cord), that are believed to be seen in Chronic fatigue syndrome (CFS) patients, but not…
- Conditions
- Chronic Fatigue Syndrome, Fibromyalgia, Gulf War Illness, Multiple Chemical Sensitivity
- Trial name
- NCT00810329
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Depressive Disorder, Fatigue Syndrome, Chronic
Glucocorticoid Effects on Cellular Cytokine Release
A variety of hormones and immune system processes are responsible for how the body responds to illness. This study concentrates on how the hormone cortisol effects the release of immune system factors called cytokines.
- Conditions
- Depressive Disorder, Fatigue Syndrome, Chronic, Fibromyalgia, Healthy
- Trial name
- NCT00001415
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Myalgic Encephalomyelitis
Long-term Sequelae of COVID-19 (Myalgic Encephalomyelitis): An International Cross-Sectional Study
The term recovery from COVID-19 caused by SARS-CoV-2 is unverified because the infection leaves many symptoms due to permanent effects on multiple organs; The primary objective of this research is to understand acute and chronic…
- Trial name
- ME (NCT05059184)
- Testing
- This is an observational cross-sectional study, there is no need for intervention
- Where
- Egypt
- Volunteers
- 2,450 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Chronic Fatigue Syndrome, Cognitive Impairments
Efficacy and Safety of Lisdexamfetamine Dimesylate in Adults With Chronic Fatigue Syndrome
Over the past decade, the Rochester Center for Behavioral Medicine (RCBM) has evaluated many patients with attention deficit hyperactivity disorder (ADHD).
- Trial name
- NCT01071044
- Testing
- Lisdexamfetamine Dimesylate
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Rochester Center for Behavioral Medicine
Chronic Fatigue Syndrome
Efficacy of Web-based Cognitive Behavioural Treatment for Adolescents With Chronic Fatigue Syndrome
The aim of this study is to determine the efficacy of FITNET (web-based cognitive behavioural treatment) for adolescents with Chronic Fatigue Syndrome (CFS) in The Netherlands.
- Trial name
- FitNet (NCT00893438)
- Testing
- FitNet treatment, Usual care
- Where
- 2 sites in Netherlands
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Chronic Fatigue Syndrome, Fibromyalgia
Central Mechanisms of Chronic Pain and Fatigue Subtitle: Functional Imaging of Brain and Spinal Cord
Chronic pain and fatigue are characterized by peripheral and central mechanisms including low pain thresholds, temporal summation, peripheral and central sensitization.
- Trial name
- NCT03075254
- Testing
- A Peltier for Sensory testing, functional magnetic resonance imaging for Brain Neuroimaging, fMRI for Spinal Cord Neuroimaging
- Where
- United States
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- University of Florida
Myalgic Encephalomyelitis, Chronic Fatigue Syndrome
Autoimmunity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
This study investigates whether there is an immune response directed against gut microbes or food and parts of the body in severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) patients.
- Trial name
- NCT03254823
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Chronic Fatigue Syndrome
Efficacy and Safety of Fermented Velvet Antler Extract on Fatigue Recovery After Exercise
The investigators performed a 12-week, randomized, double-blind, placebo-controlled human trial to evaluate the efficacy and safety of Fermented Velvet Antler extract on fatigue recovery after exercise.
- Trial name
- NCT01689467
- Testing
- Fermented Velvet Antler extract
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chonbuk National University Hospital
Chronic Fatigue Syndrome
Noradrenergic and Stress-Related Etiologies of Chronic Fatigue Syndrome
The objective of this study is to measure sympathetic nervous system function and stress responses in patients with clinically documented and self-reported chronic fatigue that is worsened by stress, compared to healthy controls.
- Trial name
- NCT03029377
- Testing
- Posture Study, Autonomic Function Tests, and a Stress Test
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Fibromyalgia, Chronic Fatigue Syndrome
Tracking Peripheral Immune Cell Infiltration of the Brain in Central Inflammatory Disorders Using [Zr-89]Oxinate-4-labeled Leukocytes.
This study will use brain Positron Emission Tomography/ Magnetic Resonance Imaging (PET/MRI) and an investigational radioactive drug called [Zr-89]oxine to track the location of white blood cells (also called leukocytes) in the…
- Conditions
- Fibromyalgia, Chronic Fatigue Syndrome, Multiple Sclerosis, Healthy
- Trial name
- NCT03807973
- Testing
- [Zr-89]Oxine-labeled leukocytes PET/MRI
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Chronic Fatigue Syndrome
Epstein-Barr Virus as a Possible Cause for Chronic Fatigue Syndrome
The purpose of this study is to understand what causes a continuing fatigue for a long time with a number of symptoms occurring at the same time (Chronic Fatigue Syndrome-CFS).
- Trial name
- NCT00433355
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Mississippi Medical Center
Fibromyalgia, Irritable Bowel Syndrome
Observational Study of Control Participants for the MAPP Research Network
The Control Study for the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network has been established to focus on a broader approach to the study of Interstitial Cystitis (IC)/Painful Bladder…
- Conditions
- Fibromyalgia, Irritable Bowel Syndrome, Fatigue Syndrome, Chronic
- Trial name
- MAPP-Control (NCT01098292)
- Where
- 8 sites in United States
- Volunteers
- 615 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Gastrointestinal Diseases, Chronic Pain
Web-Based Survey of Pain, Stress and Complementary and Alternative Medicine
The investigators are inviting people with fibromyalgia, IBS, interstitial cystitis, chronic pain, and other chronic and recurring conditions to sign up and participate in a year-long Internet-based survey to study the…
- Conditions
- Gastrointestinal Diseases, Chronic Pain, Stress, Anxiety
- Trial name
- PROCAIM (NCT00740233)
- Volunteers
- 2,300 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Long COVID, PTLDs
A Prospective Study to Evaluate the Role of T-Cell Dysfunction in Patients Who Present Symptoms Associated With Long COVID, Lyme Disease and Myalic Encephalomyelitis / Chronic Fatigue Syndrome Using the Vira Immune Fluorospot T Cell Assay
This is a longitudinal observational study recruiting individuals that have attended three clinical sites with symptoms associated with a diagnosis of long COVID, PTLDS or ME/CFS.
- Conditions
- Long COVID, PTLDs, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) (ICD-10 G93.3)
- Trial name
- NCT06731179
- Where
- 3 sites in United Kingdom
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- ViraxBio Labs