Clinical trials: Chronic Functional Constipation
Chronic Idiopathic Constipation
SP-304 Dose Ranging Study in Patients With Chronic Idiopathic Constipation
This is a Phase 2a, randomized, double-blind, placebo-controlled, 14-day repeat oral, dose ranging study to determine the safety, pharmacokinetics (PK) and pharmacodynamics (PD) effects of SP-304 in patients with chronic…
- Trial name
- CIC (NCT01053962)
- Testing
- SP-304 0.3 mg, SP-304 1.0 mg, SP-304 3.0 mg
- Where
- 14 sites in United States
- Volunteers
- 84 people
- Sponsor
- Bausch Health Americas, Inc.
Constipation - Functional, Constipation-predominant Irritable Bowel Syndrome
MOWOOT Device Treatment for Adults With Chronic Constipation
The primary objective is to compare the effectiveness of the experimental Intermittent Colonic Exoperistalsis (ICE) treatment with MOWOOT, with the active control of trans-anal irrigation (TAI) as standard-of-care.
- Conditions
- Constipation - Functional, Constipation-predominant Irritable Bowel Syndrome, Constipation Chronic Idiopathic, Constipation; Neurogenic
- Trial name
- MOTACC (NCT04666155)
- Testing
- Intermittent Colonic Exoperistalsis with MOWOOT device, Standard of care with Trans-Anal Irrigation
- Where
- 3 sites in United Kingdom
- Volunteers
- 86 people
- Sponsor
- usMIMA S.L.
Constipation - Functional, Constipation
The ReVo Study: Low-volume vs High-volume Rectal Irrigation
Rectal irrigation, which is the introduction of warm tap water through the anal canal into the rectum to initiate defaecation, is recommended to be considered in patients with chronic constipation, which is refractory to…
- Conditions
- Constipation - Functional, Constipation, Constipation by Outlet Obstruction, Defecation Disorder
- Trial name
- ReVo (NCT06100055)
- Testing
- Rectal Irrigation
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Constipation - Functional
Efficacy and Safety of PEG 3350 for Treatment of Chronic Constipation
The aim of this study is to determine the efficacy and safety of PEG 3350 (polyethylene glycol 3350) for short-term treatment of chronic constipation in adults.
- Trial name
- NCT03957668
- Testing
- PEG 3350, Lactulose
- Where
- 3 sites in Indonesia
- Volunteers
- 184 people
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Chronic Constipation, Methanogenesis
Effect of Lubiprostone on Methanogenesis and Bowel Function in Chronic Constipation.
Lubiprostone, a chloride channel activator, has been shown to improve symptoms of chronic constipation, largely by enhancing chloride-rich intestinal fluid secretion.
- Trial name
- NCT01190020
- Testing
- Lubiprostone, Lubiprostone Control
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Augusta University
Chronic Idiopathic Constipation
A Exploratory Study of KWA-0711 in Patients With Chronic Idiopathic Constipation (CIC)
The purpose of this study is to evaluate the efficacy and safety of KWA-0711 in Chronic Idiopathic Constipation (CIC) patients.
- Trial name
- NCT01600001
- Testing
- KWA-0711
- Where
- Japan
- Volunteers
- 75 people
- Sponsor
- Kissei Pharmaceutical Co., Ltd.
Bladder Dysfunction, Bowel Dysfunction
Comparison of Transcutaneous Electrical Nerve Stimulation and Manual Therapy in Children With Cerebral Palsy
There are many studies in the literature on healthy children with lower urinary tract dysfunction (LUTD), but there are limited number of studies in children with cerebral palsy (CP) with LUTD.
- Conditions
- Bladder Dysfunction, Bowel Dysfunction, Cerebral Palsy, Neurogenic Bladder
- Trial name
- NCT05351138
- Testing
- TENS, Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Bahçeşehir University
Mollii Suit, Cerebral Palsy
Effects of Mollii Suit in Children With Non-Ambule Cerebral Palsy
The aim of our study is to examine the effectiveness of the Mollii Suit application on gross motor function, spasticity, postural control, upper extremity skills, selective motor control, daily living activities, quality of life…
- Trial name
- NCT06259864
- Testing
- EXOPULSE Mollii Suit method
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Kırıkkale University
Chronic Constipation
Physiotherapeutic Intervention in Children With Chronic Functional Constipation
The purpose of this study is to determine whether physiotherapy is effective in the treatment of the chronic functional constipation in children.
- Trial name
- NCT00906971
- Testing
- diaphragmatic breathing, isometric training of the abdominal muscles and abdominal massage
- Where
- Brazil
- Volunteers
- 72 people
- Sponsor
- Universidade Federal de Pernambuco
Constipation
The Efficacy and Safety Study of Electro-acupuncture for Severe Chronic Functional Constipation
The main purpose of this study is to evaluate efficacy of electro-acupuncture for severe functional constipation compared with sham acupuncture, used as placebo; the secondary purpose is to evaluate the safety and post-treatment…
- Trial name
- NCT01726504
- Testing
- electro-acupuncture
- Where
- China
- Volunteers
- 1,075 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Gut Microbiome, Gastrointestinal Microbiome
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.
- Conditions
- Gut Microbiome, Gastrointestinal Microbiome, Autism, Autism Spectrum Disorder
- Trial name
- NCT04031469
- Testing
- There is no intervention in this study
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- ProgenaBiome
Functional Constipation, Fecal Impaction
Comparison of Efficacy & Tolerability Of PEG 4000 Versus PEG 3350+ Electrolytes for Pediatric Fecal Disimpaction
Childhood constipation is a common but serious gastrointestinal disorder prevalent worldwide. In 90-95% of children, it is of functional origin.
- Conditions
- Functional Constipation, Fecal Impaction, Constipation - Functional, Constipation Chronic Idiopathic
- Trial name
- NCT06349031
- Testing
- Administration of Polyethylene Glycol (PEG) 4000 as per treatment allocation to participants, Administration of Polyethylene Glycol (PEG) 3350 + Electrolyte as per treatment allocation to participants
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Medical Sciences and SUM Hospital
Constipation
Levofloxacin in the Treatment of Chronic Functional Constipation Associated With PIB(Peristaltic Contraction-Inhibiting Bacterium) Infection
Constipation, a prevalent clinical condition, significantly impacts patients' quality of life, yet relevant clinical trial technical guidelines have yet to be issued domestically.
- Trial name
- NCT06571097
- Testing
- Levofloxacin
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Haifeng Lan
Constipation
Efficacy and Tolerability of Cassia Fistula Plus Senna Alexandrina Miller (Sugar Free) in the Chronic Functional Constipation (CFC).
Primary Objective: To evaluate the clinical efficacy of Naturetti (jelly sugar free) To test medication on subjects who suffer chronic functional constipation in 30 days use.
- Trial name
- NCT00931853
- Testing
- SENNA+CASSIA(Naturetti)
- Where
- Brazil
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Sanofi
Chronic Functional Constipation
The Efficacy of Long-Course Treatment Using Vibrating Capsules for Chronic Constipation
This is a single-center trial. It enrolled nine 18- to 85-year-old patients with chronic constipation to evaluate the efficacy of long-course treatment by using vibrating capsule (VC).
- Trial name
- NCT06553664
- Testing
- Treat with Vibrabot capsules for at least 7 weeks
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Other Constipation, Irritable Bowel Syndrome
Intestinal Microecology in Chronic Constipation
The purpose of this study is to determine whether the bacteria normally present in the bowels are different in people with constipation and to see what effect the treatment with the Food and Drug Administration (FDA) - approved…
- Trial name
- NCT00934479
- Testing
- Lubiprostone
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Chronic Constipation
Administration of a Natural Molecular Complex in Functional Chronic Constipation
This is a multi-center, randomized, double-blinded placebo controlled trial to evaluate the efficacy and safety of the substance-based medical device (Sollievo Fisiolax) in the treatment of Chronic Constipation.
- Trial name
- NCT05192317
- Testing
- Sollievo Fisiolax
- Where
- 2 sites in Italy
- Volunteers
- 86 people
- Sponsor
- Aboca Spa Societa' Agricola
Constipation - Functional
HyGIeaCare Procedure for Chronic Constipation
To assess the safety and clinical effectiveness of using the FDA cleared HyGIeaCare System to relieve constipation in patients not responding to standard laxative treatment.
- Trial name
- NCT03335969
- Testing
- colon irrigation
- Where
- United States
- Sponsor
- HyGIeaCare, Inc.
Chronic Constipation
Study to Evaluate the Effects of RM-131 in Patients With Chronic Constipation
The purpose of this study is to evaluate safety and tolerability as well as the effects of RM-131 on colonic motor and sensory effects in patients with chronic constipation.
- Trial name
- NCT02137642
- Testing
- RM-131
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Motus Therapeutics, Inc.
Inflammatory Bowel Diseases, Irritable Bowel Syndrome
Fecal Calprotectin Collection Protocol
The primary objective is to obtain stool samples from subjects diagnosed with , and displaying signs and/or symptoms of IBD and/or IBS will be evaluated in this study.
- Conditions
- Inflammatory Bowel Diseases, Irritable Bowel Syndrome, Ulcerative Colitis, Crohn Disease
- Trial name
- CALFE (NCT03143517)
- Testing
- Stool collection
- Where
- 13 sites in United States
- Volunteers
- 240 people
- Sponsor
- DiaSorin Inc.