Clinical trials: Chronic Graft Vs. Host Disease, open to volunteers
GVHD (Acute or Chronic)
A Preliminary Clinical Study on the Efficacy of Cyclophosphamide and Sirolimus Combined With VIC-1911 in Preventing Graft-versus-Host Disease After Haploidentical Stem Cell Transplantation in Children
This study is a single arm, open label Phase Ib clinical trial, consisting of two parts: the first part is a safety introduction trial, and the second part is a dose escalation trial.
- Trial name
- GVHD (NCT07350057)
- Testing
- 1mg /kg VIC-1911
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Low Back Pain, Chronic
A Prospective Study to Evaluate the Efficacy of Iovera Lumbar Medial Branch Cryoneurolysis Versus Radiofrequency Ablation for the Treatment of Chronic Low Back Pain
A research study is being conducted to compare two treatments for long-term low back pain: One uses the iovera° system, which applies cold to certain nerves in the lower back.
- Trial name
- NCT07214844
- Testing
- Iovera Medial Branch Cryoneurolysis, Radiofrequency ablation (RFA)
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Montefiore Medical Center
Bronchiolitis Obliterable Syndrome
Longitudinal Pulmonary Chronic Graft-versus-host-disease (GvHD) Assessment in Hematopoietic Stem Cell Transplantation (HSCT) Patients
Prospective observational study on the clinical characteristics of pulmonary graft-versus-host disease in patients after hematopoietic stem cell transplantation.
- Trial name
- NCT07297303
- Where
- Taiwan
- Volunteers
- 600 people
- Sponsor
- National Taiwan University Hospital
Post-Surgical Pain, Chronic, Post-traumatic Pain, Chronic
Uncovering the Mechanism of Pain Relief by Peripheral Transcutaneous Magnetic Stimulation
This research aims to uncover the Mechanisms of pain relief through the FDA-cleared peripheral transcutaneous magnetic stimulation (pTMS) device by MagVenture.
- Trial name
- NCT07199361
- Testing
- Peripheral Transcutaneous Magnetic Stimulation from MagVenture
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Florida International University
Chronic Graft-Versus-Host Disease, Graft vs Host Disease
A Prospective Study of Madecassoside Tablets in Sclerotic Chronic Graft-versus-Host Disease After Allo-HSCT
Sclerotic chronic graft-versus-host disease (scl-cGVHD) is a severe subtype of chronic GVHD after allogeneic hematopoietic stem cell transplantation (allo-HSCT), characterized by skin sclerosis, fascial involvement, and…
- Trial name
- NCT07606703
- Testing
- Madecassoside Tablets, Standard Therapy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- WeiShi
Chronic Graft-versus-host Disease (cGVHD)
Ruxolitinib vs Prednisone as First-line Therapy for cGVHD Needing Systemic Therapy
Allogeneic transplant is potentially curative for hematological malignancies but its use is limited by the development of GVHD. Ruxolitinib now has FDA approval for treatment of chronic GVHD that has failed 1-2 prior lines of…
- Trial name
- NCT06660355
- Testing
- Ruxolitinib, Prednisone
- Where
- 6 sites in United States
- Volunteers
- 120 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Graft vs Host Disease, Mesenchymal Stem Cell Transplantation
Use of Bone Marrow Stem Cells (MesenCell) for the Treatment of Patients With Chronic Graft-versus-host Disease
The purpose of this Phase I clinical trial is to evaluate the safety and potential treatment response of bone marrow-derived mesenchymal stem cells (MesenCell) in adult patients with moderate or severe chronic graft-versus-host…
- Trial name
- NCT07826676
- Testing
- Mesenchymal Stem Cell Infusion
- Where
- 4 sites in Brazil
- Volunteers
- 20 people
- Sponsor
- Pontifícia Universidade Católica do Paraná
Autoimmune Diseases, Lupus Erythematosus, Systemic
Comparative Autoantibody and Immunologic Cell Marker Study
The purpose of this study is to compare immune phenotype, function, and specificity of B lymphocytes from different developmental stages in autoimmune patients to B cells from infectious disease patients and healthy controls.
- Conditions
- Autoimmune Diseases, Lupus Erythematosus, Systemic, Communicable Diseases
- Trial name
- NCT02422875
- Where
- 3 sites in United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Emory University
Kidney Diseases, Chronic Kidney Diseases
NAVIGATE Kidney: A Multi-level Intervention to Reduce Kidney Health Disparities
The overarching goal of this project is to refine and adapt previous work on the NAVIGATE-Kidney project for individuals with CKD.
- Trial name
- NAV-Kidney (NCT06810622)
- Testing
- Community health worker intervention, Standard Care (in control arm)
- Where
- 2 sites in United States
- Volunteers
- 448 people
- Sponsor
- University of Colorado, Denver
Graft vs. Host Disease, Chronic Graft vs. Host Disease
Study of Efficacy and Safety of Ruxolitinib in Chinese Participants With Corticosteroid-refractory Chronic Graft vs. Host Disease
The purpose of the study is to assess the efficacy and safety of ruxolitinib in Chinese adult and pediatric participants aged 12 years or older with corticosteroid-refractory chronic graft vs. host disease (SR-cGvHD).
- Conditions
- Graft vs. Host Disease, Chronic Graft vs. Host Disease, Corticosteroid-refractory Chronic Graft vs. Host Disease
- Trial name
- NCT06824103
- Testing
- Ruxolitinib
- Where
- 22 sites in China
- Volunteers
- 50 people
- Sponsor
- Novartis Pharmaceuticals
Chronic Neck Pain
Virtual Reality Program for Managing Chronic Neck Pain
The goal of this clinical trial is to find out if a virtual reality-based rehabilitation program developed by our team can help people with chronic neck pain.
- Trial name
- NCT07189052
- Testing
- Virtual Reality Rehabilitation, Conventional Rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Hacettepe University
Chronic Ocular Graft-versus-host Disease
A Study of Stem Cells Lenses in the coGVHD Subjects
This study is a single dose, Phase I study to evaluate the safety, tolerability, and preliminary effectiveness of Stem cells Lenses in the coGVHD Subjects. Three subject's enrollments are Expected.
- Trial name
- NCT06952114
- Testing
- Stem Cells Lenses
- Volunteers
- 6 people
- Sponsor
- Guangdong ProCapZoom Biosciences Co., Ltd.
Chronic Sinusitis, Acute Sinusitis
Efficacy of Bee Venom Phonophoresis in Treating Chronic Sinusitis:
This double-blind, randomized controlled trial (BEE-SONIC) aims to evaluate the efficacy of bee venom phonophoresis in the treatment of chronic sinusitis.
- Conditions
- Chronic Sinusitis, Acute Sinusitis, Rhinosinusitis
- Trial name
- BEE-SONIC (NCT07151313)
- Testing
- Bee Venom Phonophoresis, Standard Care (oral decongestants + saline nasal irrigation)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Sinai University
Chronic Graft-Versus-Host Disease
Establishment of Biomarker Panel For Forecasting Chronic Graft-Versus-Host Disease (cGVHD) After Allo-HSCT
This study is a single-center observational clinical study. Participants were enrolled as two cohorts of patients including discovery cohort and validation cohort.
- Trial name
- NCT07539220
- Testing
- Detection of Inflammatory Cytokine Levels in Peripheral Blood Serum
- Volunteers
- 1,500 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Chronic Granulomatous Disease (CGD), X-Linked Severe Combined Immune Deficiency (XSCID)
Evaluation of Patients With Immune Function Abnormalities
This study will evaluate patients with abnormal immune function that results in recurrent or unusual infections or chronic inflammation.
- Conditions
- Chronic Granulomatous Disease (CGD), X-Linked Severe Combined Immune Deficiency (XSCID), Leukocyte Adhesion Deficiency 1 (LAD), Graft Versus Host Disease (cGvHD)
- Trial name
- NCT00128973
- Where
- United States
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Acute Biphenotypic Leukemia, Acute Leukemia
Depletion of CD45RA Positive Naive T Cells for the Prevention of Graft Versus Host Disease in Older Patients Undergoing Allogeneic Hematopoietic Cell Transplantation for Acute Leukemia or Myelodysplastic Syndrome
This phase II trial tests how well removing CD45RA positive naive T cells works to prevent graft versus host disease in older patients undergoing standard of care allogeneic hematopoietic stem cell transplantation for the…
- Conditions
- Acute Biphenotypic Leukemia, Acute Leukemia, Acute Leukemia of Ambiguous Lineage, Acute Lymphoblastic Leukemia
- Trial name
- NCT07819396
- Testing
- Allogeneic CD34+-enriched and CD45RA-depleted PBSCs, Biospecimen Collection, Bone Marrow Aspiration
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Fred Hutchinson Cancer Center
Vulvovaginal Candidiasis
Effect of a Multi-strain Probiotic on Recurrent Vulvovaginal Candidiasis
This study evaluates the effect of a multi-strain probiotic on the risk of recurrence and severity of symptoms in females with recurrent vulvovaginal candidiasis (R-VVC).
- Trial name
- PROVELIA (NCT06480604)
- Testing
- Probiotic
- Where
- 6 sites in India
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- The Archer-Daniels-Midland Company
Hemolytic Anemia, Chronic, Liver Diseases
Predisposing Factors for Liver Diseases in Patients With Chronic Hemolytic Anemia
The goal of this observational study is to detect risk factors for liver affection in patients with chronic hemolytic anemias presented to the hematology unit.
- Trial name
- NCT06743854
- Volunteers
- 58 people
- Sponsor
- Assiut University
Gingivitis; Chronic
Effects of Using Miswak in Addition to Oral Hygiene Products in Patients With Gingivitis
This pilot study aims to evaluate the effects of miswak use on the oral biological environment by comparing biochemical parameters obtained from saliva and dental plaque samples collected from individuals who use miswak and…
- Trial name
- NCT07689786
- Testing
- Miswak, Toothpaste
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Hepatitis B Virus Infection, Children
Entecavir With or Without Pegylated Interferon α-2b in Children Aged 3-6 Years With Immune-Active Chronic Hepatitis B
This study aims to evaluate the efficacy and safety of entecavir monotherapy versus sequential entecavir plus pegylated interferon α-2b in achieving functional cure in immune-active, HBeAg-positive children aged 3-6 years with…
- Conditions
- Hepatitis B Virus Infection, Children, Chronic Hepatitis B
- Trial name
- NCT07345611
- Testing
- Entecavir, Entecavir + Pegylated interferon α-2b
- Volunteers
- 60 people
- Sponsor
- Qing-Lei Zeng