Clinical trials: Chronic Graft-vs.-Host Disease
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia
Pentostatin and Lymphocyte Infusion in Preventing Graft Rejection in Patients Who Have Undergone Donor Stem Cell Transplant
This phase II trial studies pentostatin and donor lymphocyte infusion in preventing graft rejection in patients who have undergone donor stem cell transplant.
- Conditions
- Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Chronic Lymphocytic Leukemia, Chronic Myelogenous Leukemia, BCR-ABL1 Positive
- Trial name
- NCT00096161
- Testing
- Cyclosporine, Mycophenolate Mofetil, Pentostatin
- Where
- 5 sites in United States, Italy
- Volunteers
- 36 people
- Sponsor
- Fred Hutchinson Cancer Center
Low Back Pain, Mechanical, Biofeedback, Pain, Chronic, Low Back Pain
The Effects of Dynamic Neuromuscular Stabilization Exercises in Addition to Conventional Treatment on Functional Capacity, Core Stabilization Muscle Strength, and Balance in Female Patients With Chronic Low Back Pain
Low back pain, which is currently considered a public health problem, is commonly encountered. A significant proportion of low back pain cases is of mechanical origin.
- Trial name
- NCT07199842
- Testing
- Dynamic Neuromuscular Stabilization Exercises in Addition to Conventional Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Safiye Esin
Low Back Pain
Dose of Spinal Manipulation for Chronic Low Back Pain
This study will determine the number of visits to a chiropractor for spinal manipulation, light massage, and ultrasound necessary for optimal relief of chronic low back pain.
- Trial name
- NCT00376350
- Testing
- Spinal Manipulation, Light Massage, Pulsed Ultrasound
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of Western States
Dacryocystitis, Dacryocystitis; Chronic
Examination of Lacrimal Sac and Nasal Mucosa Preparations Taken in Dacryocystorhinostomy Surgery of Patients With Nasolacrimal Duct Obstruction and Comparison of Clinical Groups With Each Other
The goal of this observational study is to investigate etiology and pathogenesis of nasolacrimal duct obstruction and dacryocystitis in different adult clinic groups.
- Conditions
- Dacryocystitis, Dacryocystitis; Chronic, Dacryocystorhinostomy, Epiphora
- Trial name
- NCT06810089
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Uludag University
Graft Versus Host Disease
Study of First Line Treatment of Chronic Graft Versus Host Disease With the Association of Ciclosporine, Corticosteroids and Rituximab (Protocol R-GVHD)
The main objective of the study is to improve the response rate (complete and partial remission) at 12 months after diagnosis of chronic Chronic Graft Versus Host Disease (GVHD) and treatment with the combination of ciclosporine…
- Trial name
- R-GVHD (NCT01135641)
- Testing
- Rituximab, Ciclosporine, Corticosteroids
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Nantes University Hospital
Chronic Low Back Pain
Exposure Therapy and Safety-seeking Behavior in Chronic Low Back Pain
RATIONALE: Exposure in vivo therapy aims to reduce pain-related fear - a key maintaining factor of chronic low back pain- while increasing level of daily functioning, despite the pain.
- Trial name
- NCT01971151
- Testing
- Exposure therapy
- Where
- Netherlands
- Volunteers
- 6 people
- Sponsor
- Maastricht University Medical Center
Chronic Myeloproliferative Disorders, Graft Versus Host Disease
Cyclosporine Eye Drops in Preventing Graft-Versus-Host Disease of the Eye in Patients Who Have Undergone Donor Stem Cell Transplant for Hematologic Cancer or Bone Marrow Failure Disorder
RATIONALE: Cyclosporine eye drops may prevent graft-versus-host disease of the eye in patients who have undergone donor stem cell transplant for hematologic cancer or bone marrow failure disorder.
- Conditions
- Chronic Myeloproliferative Disorders, Graft Versus Host Disease, Leukemia, Lymphoma
- Trial name
- NCT00755040
- Testing
- cyclosporine ophthalmic emulsion
- Where
- 5 sites in United States
- Volunteers
- 164 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Graft Versus Host Disease
Hydroxychloroquine in Treating Patients With Newly Diagnosed Chronic Graft-Versus-Host Disease
RATIONALE: Hydroxychloroquine may decrease the immune response and be effective in treating chronic graft-versus-host disease. It is not yet known if standard therapy for graft-versus-host disease is more effective with or…
- Trial name
- NCT00031824
- Testing
- cyclosporine, hydroxychloroquine, prednisone
- Where
- 104 sites in United States, Australia and 4 more
- Volunteers
- 82 people
- Sponsor
- Children's Oncology Group
Chronic Graft vs. Host Disease, GVHD
Effects of Axatilimab on Skin in Chronic Graft-versus-Host Disease
Chronic graft-versus-host disease (cGVHD) is a condition that can develop after a stem cell transplant. It occurs when donor immune cells attack the body's tissues.
- Conditions
- Chronic Graft vs. Host Disease, GVHD, cGVHD, Graft Versus Host Disease in Skin
- Trial name
- NCT07728708
- Testing
- Axatilimab
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Northwestern University
Chronic Graft-versus-host-disease
A Study of Axatilimab at 3 Different Doses in Participants With Chronic Graft Versus Host Disease (cGVHD)
This is a Phase 2 study to evaluate the efficacy, safety, and tolerability of axatilimab at 3 different dose levels in participants with recurrent or refractory active chronic graft versus host disease (cGVHD) who have received…
- Trial name
- AGAVE-201 (NCT04710576)
- Testing
- Axatilimab
- Where
- 121 sites in United States, Australia and 14 more
- Volunteers
- 296 people
- Sponsor
- Syndax Pharmaceuticals
Cough
Study of the Safety and Effectiveness of BC1036 Capsules to Treat Frequent Long-Term Cough
The purpose of this study is to investigate the effect of BC1036 (theobromine) on cough-related quality of life and cough severity following 2 weeks' treatment.
- Trial name
- NCT01656668
- Testing
- BC1036
- Where
- 13 sites in United Kingdom
- Volunteers
- 288 people
- Sponsor
- Respicopea Limited
Chronic Graft-versus-host Disease
GRAVITAS-309: Itacitinib and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease
The purpose of this study is to assess the efficacy and safety of itacitinib in combination with corticosteroids as first-line treatment for moderate or severe chronic graft-versus-host disease (cGVHD).
- Trial name
- NCT03584516
- Testing
- Itacitinib, Methylprednisolone, Prednisone
- Where
- 133 sites in United States, Austria and 14 more
- Volunteers
- 155 people
- Sponsor
- Incyte Corporation
Sinusitis, Chronic, Asthma
Aggravated Airway Inflammation: Research on Genomics and Optimal Operative Treatment (AirGOs Operative)
This randomized study compares operative techniques in chronic rhinosinusitis with polyposis (CRSwNP) surgery. It aims to evaluate outcomes in asthma and CRSwNP, safety and costs.
- Conditions
- Sinusitis, Chronic, Asthma, Nasal Polyps, Aspirin Sensitivity
- Trial name
- NCT03704415
- Testing
- Extended endoscopic sinus surgery, Limited endoscopic sinus surgery
- Where
- 3 sites in Finland, Netherlands
- Volunteers
- 97 people
- Sponsor
- Helsinki University Central Hospital
Chronic Graft Versus Host Disease
Multiple Donor Treg DLI for Severe Refractory Chronic GVHD
This is a INTERVENTIONAL TRANSPLANTATION STUDY WITHOUT DRUGS. The INTERVENTION is represented by the INFUSION of DONOR T REGULATORY CELL-ENRICHED LYMPHOCYTES to PATIENTS suffering from REFRACTORY CHRONIC GVHD after ALLOGENEIC…
- Trial name
- TREG2015001 (NCT02749084)
- Testing
- T reg DLI
- Where
- Italy
- Volunteers
- 18 people
- Sponsor
- Mario Arpinati
Chronic, Infection
Pulpectomy of Primary Molars With Rotary Instrumentation Versus Manual Instrumentation
One of the major concerns in pediatric dentistry is premature loss of necrotic primary teeth which may cause a deleterious effect on the growth of the facial skeletal complex.
- Trial name
- NCT03964766
- Testing
- Rotary instrumentation, Hand instrumentation
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Cairo University
Gingivitis, Gingivitis; Chronic
A Multicentre Randomised Controlled Trial Evaluating the Efficacy of the SMILE™ Module for Improving Short-term Periodontal Outcomes, Compliance, and Acceptability Among Clinical Dental Students
This multicentre randomised controlled trial aims to evaluate the efficacy and safety of the SMILETM (Siwak Method for Integrated Lifestyle Enhancement) module in improving short-term periodontal outcomes, oral hygiene behaviour…
- Trial name
- SMILE (NCT07702383)
- Testing
- SMILE Module, Conventional Toothbrushing Module
- Where
- 4 sites in Malaysia
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Pulmonary Disease, Chronic Obstructive, Sexual Health
Impact of COPD on Sexual Health, Loneliness, and Well-being
Summary Person-centered care is a hot topic within healthcare, yet communication about patients' sexual health and intimacy issues remain too hot to handle within healthcare.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Sexual Health, Loneliness, Well-Being, Psychological
- Trial name
- NCT06240078
- Where
- Denmark
- Volunteers
- 521 people, healthy volunteers welcome
- Sponsor
- Vejle Hospital
Chronic Graft Versus Host Disease
Safety and Efficacy of Oral Belumosudil in Black or African American, American Indian or Alaska Native, and Native Hawaiian or Other Pacific Islander Male and Female Participants Aged 12 Years and Above With Chronic Graft Versus Host Disease (cGVHD) After At Least 2 Prior Lines of Systemic Therapy
The purpose of this study is to measure safety and efficacy of oral belumosudil in Black or African American, American Indian or Alaska Native, and Native Hawaiian or Other Pacific Islander male and female participants with cGVHD…
- Trial name
- NCT05567406
- Testing
- Belumosudil
- Sponsor
- Kadmon, a Sanofi Company
Cholecystitis, Chronic
Bikini Scarless Laparoscopic Cholecystectomy for Morbid Obesity as a Day Case.
Background: Bikini line laparoscopic cholecystectomy is a safe method, used as a scarless cosmetic port technique for gall bladder diseases in morbid obese patients as a day case.
- Trial name
- NCT04836598
- Testing
- laparoscopic cholecystectomy
- Where
- 4 sites in Egypt, Saudi Arabia
- Volunteers
- 3 people
- Sponsor
- Zagazig University
Chronic Wounds
P.E.M.F. Therapy of Chronic Wounds
To measure the effectiveness of pulsed electromagnetic fields (PEMF) as an adjunct wound care therapy.
- Trial name
- NCT05493943
- Testing
- Pulsed ElectroMagnetic Field (PEMF) therapy, Pulsed ElectroMagnetic (PEMF) therapy
- Volunteers
- 120 people
- Sponsor
- PEMF Systems, Inc.