Clinical trials: Chronic Headache
Chronic Cluster Headache
SPG Neurostimulation in Cluster Patients
We hypothesized that LF stimulation of the SPG would increase parasympathetic outflow, activate sensory afferents and provoke a cluster-like attack.
- Trial name
- NCT02510729
- Testing
- Neurostimulation
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Danish Headache Center
Migraine
Occipital Nerve Stimulation in the Treatment of Migraine
The objective of this proof-of-concept study is to generate initial safety and effectiveness data for the neuro-modulation stimulation (NMS) E-Box in patients with chronic migraine in an acute setting.
- Trial name
- Verona (NCT01855672)
- Testing
- Stimulation of the Occipital Nerves
- Where
- 4 sites in United States
- Volunteers
- 1 people
- Sponsor
- Ethicon, Inc.
Migraine, Chronic Migraine
Neuroimaging Studies of Chronic Primary Headaches Using Positron Emission Tomography and Magnetic Resonance Imaging
Investigators hypothesize that chronic primary headaches are accompanied by a discrete pattern of brain metabolism and activity involving brain structures related to the development of acute exacerbations as well as pain…
- Trial name
- NCT01741246
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Post Traumatic Headache, Chronic Daily Headache
Yoga Training for Returning Veterans With Headache
The objective of the study is to evaluate the efficacy of a yoga treatment for veterans with mild post-traumatic and chronic tension-type headaches.
- Trial name
- NCT01993069
- Testing
- Iyengar-based Yoga Training
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Los Angeles
Migraine Headache
Effectiveness and Acceptability of MINDFULNESS by Smartphone, for Patients with Chronic Migraine and Medication Overuse
Chronic Migraine is a disabling condition that affects the 2% of migraine population. It is often associated with medication overuse that makes this condition very difficult to treat.
- Trial name
- ChroMig-Smart (NCT04389372)
- Testing
- Mindfulness
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Post-COVID-19 Syndrome
Biomarker Analysis in Post-COVID Patients
Headache is one of the most common neurological manifestations of COVID-19. However, it is unclear whether chronic headache after the initial diagnosis, is associated with ongoing damage of the central nervous system.
- Trial name
- NCT05836428
- Testing
- no intervention
- Where
- Germany
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Migraine
Efficacy of Anti-IL-6 Treatments on Migraine in Patients Treated With Anti-IL-6 for a Rheumatological Condition
Migraine affects approximately 15% of the global population. Its prevalence doubles or even triples in individuals with chronic inflammatory conditions, such as chronic inflammatory rheumatic diseases (34%), multiple sclerosis…
- Trial name
- RHUMIL-6 (NCT07598045)
- Testing
- Migraine assessement, Patient Global Impression of Change
- Where
- France
- Volunteers
- 320 people
- Sponsor
- University Hospital, Clermont-Ferrand
Primary Headache Disorders, Tension Headache
Pericranial and General Sensitivity in Patients With Primary Headache
Primary headaches such as migraine and tension type headache are among the most common neurological disorders and frequently cause significant disability and reduced quality of life.
- Conditions
- Primary Headache Disorders, Tension Headache, Tension-type Headache, Migraine
- Trial name
- HEAD-TMD (NCT07514208)
- Testing
- Pericranial Tenderness Assessment, Pressure Pain Threshold Assessment, Temporomandibular Disorder Assessment
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Chronic Migraine
Non-Invasive Neurostimulation for the Prevention of Chronic Migraine
The purpose of this multi-center, prospective, double-blind, randomized, sham-controlled pilot study is to study feasibility and collect preliminary clinical data related to the safety and clinical benefits of daily use of…
- Trial name
- NCT01667250
- Testing
- GammaCore Active Device
- Where
- 6 sites in United States
- Volunteers
- 59 people
- Sponsor
- ElectroCore INC
Chronic Pain Syndrome, Chronic Daily Headache
Offset Analgesia as a Measure of Central Sensitization in Children
Pediatric chronic pain disorders are common and consequential in Western societies, occurring in 25-80% of population-based samples with a median prevalence of 11-38% and significant pain-related disability in 3-5% of these…
- Conditions
- Chronic Pain Syndrome, Chronic Daily Headache, Functional Abdominal Pain Syndrome, Musculoskeletal Pain Disorder
- Trial name
- NCT03445403
- Testing
- Offset analgesia
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Migraine
Enfacement Illusion and Chronic Migraine Pain
The concept of body image can be described as "the intentional content of consciousness comprising perceptions, attitudes and beliefs relating to one's body".
- Trial name
- NCT04904458
- Testing
- Experimental group ("enfacement illusion"), Control Group (Pleasant virtual environment exposure)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Depression, Headaches Chronic
CBT Depression Intervention for Co-Occurring Chronic Headache
Having co-occurring depression and chronic headaches is challenging and can greatly impact one's professional, personal, family, and social life.
- Conditions
- Depression, Headaches Chronic, Migraine Disorders
- Trial name
- NCT02870725
- Testing
- CBT Individual Psychotherapy
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- University of Georgia
Chronic Pain, Abdominal Pain
Internet Intervention for Adolescents With Chronic Pain
The purpose of this study is to evaluate the efficacy of a web-based (i.e., internet) behavioral program to reduce pain and improve functioning in children and adolescents with chronic pain.
- Conditions
- Chronic Pain, Abdominal Pain, Headache
- Trial name
- NCT01316471
- Testing
- Online Behavioral Intervention, Education: Online Patient Education
- Where
- United States
- Volunteers
- 273 people
- Sponsor
- Seattle Children's Hospital
Delirium, Confusion
Improving Safety of Diagnosis and Therapy in the Inpatient Setting
To improve the safety of diagnosis and therapy for a set of conditions and undifferentiated symptoms for hospitalized patients, the investigators will employ a set of methods and tools from the disciplines of systems engineering…
- Conditions
- Delirium, Confusion, Mental Status Change, Back Pain
- Trial name
- PSLL2-0 (NCT04393909)
- Testing
- Diagnostic Uncertainty Educational Curriculum, Diagnostic Timeout, Patient Diagnostic (Dx) Questionnaire
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- Brigham and Women's Hospital
Post Stroke, Post-Traumatic Headache
Aerobic Exercise and Transcranial Low Laser Therapy in Patients With Central Nervous System Injury
Objective of this protocol will be to evaluate the parameters related to the function of the musculoskeletal and cardiorespiratory system, through a rehabilitation and training program for people with acquired central nervous…
- Conditions
- Post Stroke, Post-Traumatic Headache, Spinal Injuries, Cerebral Palsy, Spastic
- Trial name
- NCT03751306
- Testing
- Transcranial Photobiomodulation, Cardiorespiratory Rehabilitation
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- Universidade do Vale do Paraíba
Chronic Migraine, Insomnia
Efficacy of Behavioral Insomnia Treatment for Chronic Migraine
The purpose of this study is to test the efficacy of a brief behavioral insomnia intervention in reducing headache frequency and severity among patients with chronic migraine and insomnia.
- Trial name
- NCT01314651
- Testing
- Stimulus Control and Sleep Restriction, Lifestyle Modification
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Daniel Riche
Chronic Migraine, Headache, Temporomandibular Joint Dysfunction
The Effect of Accompanying Temporomandibular Joint Dysfunction in Patients With Chronic Migraine
The aim of this clinical study to evaluate the effect of temporomandibular joint dysfunction accompanying patients with chronic migraine on pain, quality of life, sleep and functionality.
- Conditions
- Chronic Migraine, Headache, Temporomandibular Joint Dysfunction, Chronic Pain, Quality of Life
- Trial name
- NCT05381129
- Testing
- Detection of Pain, Quality of Life, Sleep and Functioning, Temporomandibular joint dysfunction
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Istanbul University - Cerrahpasa
Posttraumatic Headache, Combat Disorders
Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin
The purpose of this study is to determine if prazosin is more effective than placebo in decreasing frequency, severity, disability, and other negative effects of headaches related to mild traumatic brain injury in Service Members…
- Conditions
- Posttraumatic Headache, Combat Disorders, Post Concussion Syndrome, Headache
- Trial name
- NCT02266329
- Testing
- prazosin hydrochloride
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- VA Office of Research and Development
Chronic Migraine Headache
The Neuroanatomical and Psychological Correlates of Suggestibility in Patients With Non-Responsive Chronic Migraine
Chronic migraine is a disabling neurovascular disorder and one of the leading causes of years lived with disability worldwide. Population-based studies report a worrying level of resistance to currently available treatments in…
- Trial name
- SIGMA (NCT07617441)
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Istituto per la Ricerca e l'Innovazione Biomedica
Migraine Disorders
BOTOX® Prophylaxis in Patients With Chronic Migraine
This is a post authorization observational study to monitor the utilization practices and describe the safety profile of BOTOX® in clinical practice for the prophylactic treatment of headaches in adult patients with chronic…
- Trial name
- NCT01432379
- Testing
- botulinum toxin Type A
- Where
- 4 sites in Germany, Spain and 2 more
- Volunteers
- 1,168 people
- Sponsor
- Allergan