Clinical trials: Chronic Hepatic
Liver Disease Chronic
COVID-19 Vaccines in Patients With Chronic Liver Disease
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused pandemic since outbreak in 2020.Patients with chronic liver disease (CLD) are at higher risk of mortality and morbidity due to COVID-19.
- Trial name
- NCT05017805
- Testing
- COVID-19 Vaccines
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Beijing 302 Hospital
Chronic Liver Disease
Elastography in Chronic Liver Disease in Children
Chronic liver disease is a significant health issue among children and it can result in fibrosis, cirrhosis and liver failure. Since the prognosis and monitoring of these diseases are different from each other,, Conventional…
- Trial name
- NCT04774601
- Volunteers
- 50 people
- Sponsor
- Assiut University
Chronic Liver Disease
Study to Evaluate Efficacy, Safety and Tolerability of PENNEL Capsule in the Patients With Chronic Liver Disease
The test agent in this study is a product of biphenylmethyl dicarboxylate (BDD) with garlic oil. The two components were confirmed to have complementary effects because of different operational mechanism in animal experiments…
- Trial name
- NCT01393665
- Testing
- PENNEL capsule
- Where
- 2 sites in South Korea
- Volunteers
- 88 people
- Sponsor
- PharmaKing
Colon Disease
Safety, Efficacy and Tolerability of Bowel Preparation and Colonoscopy in Patient With CHD, CKD and CLD
Consecutive eligible patients will be enrolled and written informed consent will be obtained from all participants. Routine blood investigations will be sent.
- Trial name
- NCT06874036
- Testing
- Colonoscopy
- Where
- India
- Volunteers
- 74 people
- Sponsor
- Asian Institute of Gastroenterology, India
Advanced Chronic Liver Disease, Healthy Participants
A Study to Investigate the Pharmacokinetics of AZD2389 in Healthy Participants When Administered Alone and in Combination With Quinidine
The purpose of this study is to assess the pharmacokinetics (PK) and safety of AZD2389 when administered alone and in combination with quinidine in healthy participants.
- Trial name
- NCT06974565
- Testing
- AZD2389, Quinidine
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Liver Fibrosis, Cirrhosis
Fibroscan® and Its Dedicated Probes Efficiency in Obese Patients
The main objective of the study is to evaluate the diagnostic performance of the XL probe for estimating degree of liver fibrosis/cirrhosis in obese patients > 28 kg/m² with various liver diseases in patients with chronic liver…
- Trial name
- NCT00926224
- Testing
- FibroScan M and XL probes
- Where
- 5 sites in Canada
- Volunteers
- 300 people
- Sponsor
- Echosens
Hepatic Encephalopathy, Cirrhosis, Liver
Integrated Traditional Chinese and Clinical Medicine for Chronic Hepatitis B and Its Complication
Hepatic encephalopathy is the most common complication after TIPS, and hepatic encephalopathy occurs in almost all portosystemic shunts.
- Conditions
- Hepatic Encephalopathy, Cirrhosis, Liver, Portosystemic Shunt
- Trial name
- NCT05128305
- Testing
- traditional Chinese medicine1 and traditional Chinese medicine 2
- Where
- China
- Volunteers
- 276 people
- Sponsor
- Qianfoshan Hospital
Acute on Chronic Hepatic Failure, Liver Failure
A Trial of Ribavirin in Patients With ACLF Due to Hepatitis E Virus
The term Acute on chronic liver failure (ACLF) describes a clinical entity characterized by an acute and rapid deterioration of liver function in a patient with previously well-compensated liver disease owing to the effects of a…
- Conditions
- Acute on Chronic Hepatic Failure, Liver Failure, Hepatitis E Infection
- Trial name
- HEVRibavirin (NCT01698723)
- Testing
- Ribavirin
- Where
- 2 sites in India
- Volunteers
- 40 people
- Sponsor
- All India Institute of Medical Sciences
Chronic Liver Disease, Liver Fibrosis
Comparative Efficacy of Liver Fibrosis and Steatosis Assessment With Fibroscan and iLivTouch
This study is aimed to compare the results and operating characteristics of liver stiffness measurement with the use of Fibroscan (EchoSens, France) and iLivTouch (Wuxi Hisky Medical Technologies Co., China) in patients with…
- Conditions
- Chronic Liver Disease, Liver Fibrosis, Liver Steatoses
- Trial name
- OGIG-01-22-LF (NCT05224037)
- Testing
- iLivTouch
- Where
- Russia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Federal State Budgetary Scientific Institution
Family Members of the Patients
Effectiveness of Nurse-led Family Intervention on Stress, Engagement With Patient's Care and Satisfaction Among Primary Caregivers of Chronic Liver Disease Patients Admitted in High Dependency Unit of ILBS, New Delhi
Quasi experimental study to check the effectiveness of Nurse-led family Intervention on stress, engagement with patient care and satisfaction among primary caregivers of chronic liver disease patients admitted in high depency…
- Trial name
- NCT05073341
- Testing
- Nurse-led family intervention
- Where
- India
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Institute of Liver and Biliary Sciences, India
Hepatitis C, Hepatic Insufficiency
Study Evaluating the Safety of HCV-796 in Subjects With Liver Disease and in Healthy Adults
The purpose of this study is to assess the pharmacokinetics (PK) of HCV-796 in subjects with chronic hepatic impairment and in matched healthy adults.
- Trial name
- NCT00314054
- Testing
- HCV-796
- Where
- 3 sites in United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Metastatic Cancer, Congestive Heart Failure
Reducing Disparities in the Quality of Advance Care Planning for Older Adults
This study compares the effectiveness of two different approaches to advance care planning among older African Americans and older Whites living in the community.
- Conditions
- Metastatic Cancer, Congestive Heart Failure, Chronic Obstructive Pulmonary Disease, Parkinson Disease
- Trial name
- EQUALACP (NCT03516994)
- Testing
- Respecting Choices First Steps, Five Wishes Form
- Where
- 4 sites in United States
- Volunteers
- 790 people
- Sponsor
- Duke University
Compensated Advanced Chronic Liver Disease, Variceal Hemorrhage
Spleen Stiffness Combined With Liver Stiffness Measured by 2D-SWE for the Screening of High-risk Varices in Compensated Advanced Chronic Liver Disease (CHESS2004)
Variceal hemorrhage is the serious complication in patients with compensated advanced chronic liver disease (cACLD). To evaluate the bleeding risk of varices, esophagogastroduodenoscopy (EGD) should be performed.
- Trial name
- NCT04546360
- Testing
- Esophagogasrtoduodendoscopy, spleen stiffness measurement and liver stiffness measurement.
- Where
- 6 sites in China
- Volunteers
- 381 people
- Sponsor
- Hepatopancreatobiliary Surgery Institute of Gansu Province
Advanced Chronic Liver Disease, Portal Hypertension Related to Cirrhosis
Program to Avoid NSAIDs in Patients With Advanced Chronic Liver Disease
This study aims to implement measures to avoid the use of NSAIDs or metamizole in patients with advanced chronic liver disease (ACLD) scheduled for major surgery, which are contraindicated due to increased risk of renal…
- Trial name
- NCT07249294
- Testing
- Multidisciplinary support program
- Where
- Spain
- Volunteers
- 84 people
- Sponsor
- Parc de Salut Mar
Acute Liver Failure, Acute on Chronic Liver Failure (ACLF)
Continuous Renal Replacement Therapy Intensity in Hyperammonemia
Acute liver failure (ALF) and acute-on-chronic liver failure (ACLF) are life-threatening conditions often associated with hyperammonemia, hepatic encephalopathy, and multi-organ dysfunction.
- Conditions
- Acute Liver Failure, Acute on Chronic Liver Failure (ACLF), Acute Kidney Injury, Ammonia Metabolism
- Trial name
- CRITICAL (NCT06987604)
- Testing
- High-dose continuous renal replacement therapy, Conventional-dose continuous renal replacement therapy
- Where
- Brazil
- Volunteers
- 152 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Chronic Hepatitis B, Liver Fibrosis
MR Elastography for Assessing Liver Fibrosis in Chronic Hepatitis B
How to construct a non-invasive, accurate, and convenient method to evaluate the severity of liver fibrosis (LF) is an important general problem in the management of patients with chronic hepatitis B (CHB).
- Trial name
- NCT06779058
- Testing
- MRE, Liver biopsy
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Shengjing Hospital
Urea Cycle Disorder
Chronic Liver Disease in Urea Cycle Disorders
This is a pilot, cross-sectional study to assess liver stiffness and markers of hepatic injury, function, and fibrosis in patients with urea cycle disorders.
- Trial name
- NCT03721367
- Testing
- Diagnostic Ultrasound
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Baylor College of Medicine
Acute on Chronic Liver Failure
Efficacy of Albumin Therapy With Standard Medical Treatment (SMT) as Compared to Standard Medical Treatment (SMT) in Improving Patient Survival and Immune Modulation in Patients With Acute on Chronic Liver Failure (ASIA Trial).
The AIM of the study is to study the efficacy of intravenous albumin and standard medical treatment as compared to standard medical treatment alone in ameliorating/preventing SIRS and improving survival at 28 days .The project…
- Trial name
- NCT03754400
- Testing
- Albumin, Standard Medical Treatment
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Chronic Liver Disease, Fibrosis, Liver
Non Invasive Electrical Impedance Technology (EIT) for Diagnosing Liver Diseases Severity
The aims of this study are to assess the performance of the non-invasive Electrical Impedance Technology (EIT) in evaluating the liver fibrosis stage in patients with chronic liver diseases, in comparisons with a liver biopsy…
- Conditions
- Chronic Liver Disease, Fibrosis, Liver, Non-Alcoholic Fatty Liver Disease
- Trial name
- NCT03492879
- Testing
- EIT Technology
- Volunteers
- 210 people
- Sponsor
- Prof. Ziv Ben-Ari MD
Adenocarcinoma, Adenocystic Carcinoma
The Registry of Oncology Outcomes Associated With Testing and Treatment
This study is to collect and validate regulatory-grade real-world data (RWD) in oncology using the novel, Master Observational Trial construct. This data can be then used in real-world evidence (RWE) generation.
- Conditions
- Adenocarcinoma, Adenocystic Carcinoma, Anal Cancer, Appendix Cancer
- Trial name
- ROOT (NCT04028479)
- Testing
- Biomarker Testing (L), Systemic Treatment (T), Patient Reported Outcomes (P)
- Where
- 2 sites in United States
- Volunteers
- 167 people
- Sponsor
- Taproot Health