Clinical trials: Chronic Hepatic
Cirrhosis, Liver, Acute-On-Chronic Liver Failure
20% Albumin vs. Balanced Salt Solution as Resuscitation Fluid in Cirrhosis With Sepsis Induced Hypotension
Patients with cirrhosis patients have a high incidence of sepsis which can trigger decompensation and may result in prolonged hospital stay and increased mortality.
- Conditions
- Cirrhosis, Liver, Acute-On-Chronic Liver Failure, Shock, Septic, Shock Hypovolemic
- Trial name
- NCT05441878
- Testing
- 20% albumin, Balanced salt solution
- Where
- India
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Morbidity
PPIs and In-Hospital Morbidity in Acute Variceal Bleeding With Chronic Liver Disease
With this study, the investigators pretend to describe intrahospital morbidity in patients living with cirrhosis (PLC) who present to the emergency department with variceal bleeding (VB).
- Trial name
- Liver-IMPACT (NCT06861478)
- Testing
- Omeprazole 40 mg IV, pantoprazole 40 mg iv
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Thrombocytopenia in Chronic Liver Disease Patients Undergoing Elective Invasive Surgery
The Phase III Clinical Study of Herombopag for the Treatment of Thrombocytopenia in Chronic Liver Disease Patients Undergoing Elective Invasive Surgery
This study includes Part A and Part B. Part A is a dose-finding study for subjects with chronic liver disease-related thrombocytopenia scheduled for elective surgery.
- Trial name
- NCT06507436
- Testing
- Herombopag tablets
- Where
- China
- Volunteers
- 127 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Liver Fibrosis, Liver Fibrosis in Chronic Hepatitis B
A Phase IIIc Clinical Study to Evaluate the Long-term Treatment of Hydronidone Capsules for Liver Fibrosis in Patients With Chronic Hepatitis B.
This study is conducted as a randomized, double-blind, placebo-controlled, multicenter clinical trial on a background of entecavir therapy.
- Trial name
- NCT07412236
- Testing
- Hydronidone (270mg)
- Where
- China
- Volunteers
- 1,208 people
- Sponsor
- Beijing Continent Pharmaceutical Co, Ltd.
Chronic Liver Disease
Effect of Perioperative Oral Rifaximin on Early Graft Dysfunction in Adult Living Donor Liver Transplant
Liver transplantation has been a lifesaving treatment for individuals with end stage liver disease and acute liver failure. However, initial poor function of a liver allograft after liver transplantation, termed early graft…
- Trial name
- NCT06743464
- Testing
- Rifaximin 550 MG, SOC
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Cirrhosis, Chronic Liver Disease
Real Time Elastography in Liver Fibrosis
AIM To evaluate the role of real time elastography (ARFI and Hitachi elastography) in noninvasive diagnosis of liver fibrosis in patients with chronic hepatitis
- Trial name
- RT-ELASTO (NCT01948687)
- Where
- 2 sites in Romania
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy Craiova
Allogene Transplantation, Chronic Liver Diseases Patients
Allogene MSCs Transplantation in Liver for Patients With Chronic Liver Diseases Through Portal Vein by Ultrasound Guiding
Allogene MSCs transplantation will be performed in patients with chronic liver diseases through portal vein by ultrasound guiding and therapeutic effects including short-term effects and long-term follow-up will be compared and…
- Conditions
- Allogene Transplantation, Chronic Liver Diseases Patients, Through Portal Vein by Ultrasound Guiding
- Trial name
- NCT01256138
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Sun Yat-sen University
Chronic Liver Disease, Hepatocellular Carcinoma (HCC)
Detection of Hepatocellular Carcinoma (HCC) With Octanoate Breath ID Test Compared to MRI
The Exalenz clinical investigation is a multicenter, non-randomized, study of the ¹³C-Octanoate Breath Test (OBT). The present study is a feasibility trial, which aims to evaluate the capability of the OBT measurement to…
- Trial name
- OBT for HCC (NCT01433016)
- Testing
- 13C Sodium Octanoate
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Meridian Bioscience, Inc.
Hepatic Encephalopathy, Acute-On-Chronic Liver Failure
Role of Bilirubin Molecular Species in Hepatic Encephalopathy and Acute-on-chronic Liver Failure
It has been identified that impaired liver function, as occurs in patients with liver cirrhosis, prevents proper conjugation of glucuronic acid with bilirubin; as a result, unconjugated bilirubin accumulates in the blood, and…
- Trial name
- NCT05566548
- Testing
- Liquid Chromatography-Mass Spectrometry Method to identify bilirubin molecular species
- Where
- Mexico
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medica Sur Clinic & Foundation
Acute on Chronic Liver Failure
Incidence And Outcome Of Paracentesis Induced Circulatory Dysfunction In Acute-On-Chronic Liver Failure.
All consecutive patients admitted in ILBS from MAY 2015 to DECEMBER 2016.ACLF (Acute on chronic Liver Failure). ACLF will be randomize into Group 1: MVP (Modest Volume Paracentesis) OF Less than 5 liters with IV albumin at a dose…
- Trial name
- NCT02467348
- Testing
- Albumin, Ascitic fluid
- Where
- India
- Volunteers
- 80 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Failure, Acute on Chronic, Hemostatic Disorder
A Prospective Study of Evaluation of Minor Bleeding and Utility of Bleeding Criteria in Acute-on-chronic Liver Failure Patients in China
Ineffective hemostasis or a paradoxical prothrombotic state of Acute-on-chronic liver disease (ACLF) has been well established. However, the minor and major bleeding events has not been described yet.
- Trial name
- NCT03281252
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Chronic Kidney Diseases, NAFLD
Chronic Kidney Disease and Non-alcoholic Fatty Liver Diseases
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. This disease reportedly affects up to 30% of the general population in Western countries, especially in patients with…
- Trial name
- NAFLD (NCT04779905)
- Testing
- urinary albumbin/creatinine ratio
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- Sohag University
Hepatitis C, Cirrhosis
Sofosbuvir and Ribavirin in Patients With Chronic HCV With Cirrhosis and Portal Hypertension With or Without Liver Decompensation
This study will evaluate the antiviral efficacy of combination therapy with sofosbuvir (SOF) plus ribavirin (RBV) for 48 weeks in adults with compensated and decompensated chronic hepatitis C virus (HCV) infection.
- Conditions
- Hepatitis C, Cirrhosis, Portal Hypertension, With or Without Liver Decompensation
- Trial name
- NCT01687257
- Testing
- SOF, RBV
- Where
- 9 sites in United States, Australia and 3 more
- Volunteers
- 50 people
- Sponsor
- Gilead Sciences
Acute on Chronic Liver Failure
Efficacy of Nonselective Beta Blocker vs Placebo in Patients With Acute-on-chronic Liver Failure With Small/ no Esophageal Varices
Acute on chronic liver failure patients with HVPG (Hepatic Venous Pressure Gradient) ≥ 12 mmHg + No/small esophageal varices who present to the Department of Hepatology at Institute of Liver and Billiary Sciences, who meet the…
- Trial name
- NCT02583698
- Testing
- Carvedilol
- Where
- India
- Volunteers
- 136 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Failure
Fecal Microbiota Transplantation for Liver Failure
To investigate the safety, adverse reactions and therapeutic effects of fecal microbiota transplantation on patients with liver failure;to investigate the effect of fecal microbiota transplantation on the intestinal microecology…
- Trial name
- NCT05170971
- Testing
- fecal microbiota transplantation
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ningbo Medical Center Lihuili Hospital
Chronic Kidney Disease, Hepatic Impairment
A Study to Learn About How BAY 3283142 Moves Into, Through, and Out of the Body After a Single Dose in Participants With Reduced Liver Function Compared to Participants With Normal Liver Function
Researchers are looking for a better way to treat people who have chronic kidney disease (CKD). CKD is a condition in which the kidneys' ability to work properly gradually decreases over time.
- Trial name
- NCT06402721
- Testing
- BAY3283142
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Bayer
Thrombocytopenia Associated With Liver Disease
Treatment of Thrombocytopenia in Patients With Chronic Liver Disease Undergoing an Elective Procedure
This is a global, multicenter, randomized, double-blind, placebo-controlled, parallel group study using avatrombopag to treat adults with thrombocytopenia associated with liver disease.
- Trial name
- NCT01976104
- Testing
- avatrombopag (lower baseline platelet count), avatrombopag (higher baseline platelet count)
- Where
- 120 sites in United States, Argentina and 15 more
- Volunteers
- 204 people
- Sponsor
- Eisai Inc.
Acute on Chronic Liver Failure
An Open-label Randomized Controlled Trial Comparing the Role of Therapeutic Plasma-exchange in Ameliorating Secondary Organ Dysfunctions in Patients With ACLF and Develop Biomarkers of Treatment Response
Rationale: Current understanding of the pathophysiology of ACLF suggests that unresolved injury, poor infection control, and liver regeneration result in persistent systemic inflammation and cytokine storm, which subsequently…
- Trial name
- NCT06276907
- Testing
- Plasma Exchange, Standard Medical Treatment
- Where
- India
- Volunteers
- 190 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Failure
Nomogram Analysis for HBV Related Acute-on-chronic Liver Failure
Acute-on-chronic liver failure (ACLF) is an acute deterioration of chronic liver diseases, which progresses rapidly, with a mortality rate of more than 50%.MELD score is used to evaluate the patients' condition.
- Trial name
- NCT03992898
- Testing
- No special intervention was suitable for this observational study
- Where
- China
- Volunteers
- 2,739 people
- Sponsor
- Sun Yat-sen University
Cirrhosis, Liver, Sepsis
Volume Resuscitation in Cirrhosis With Sepsis Induced Hypotension
In critically ill patients with liver disease like cirrhosis or ACLF, fluid therapy needs to be instituted after identification of patients who will be fluid responsive and initiate appropriate inotropes early to prevent the…
- Conditions
- Cirrhosis, Liver, Sepsis, Acute on Chronic Liver Failure
- Trial name
- NCT05059795
- Testing
- Albumin + electrolyte solution, POCUS guided fluid resuscitation
- Where
- 2 sites in India
- Volunteers
- 350 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh