Clinical trials: Chronic Hypertension
Chronic Kidney Diseases, Hypertension
Phase 2b Study of KBP-5074 in Subjects With Uncontrolled Hypertension and Advanced Chronic Kidney Disease
This is a Phase 2 randomized, double-blind, placebo-controlled, multi-center study to assess the efficacy, safety, and pharmacokinetics of KBP-5074 in patients with moderate-to-severe chronic kidney disease and uncontrolled…
- Trial name
- BLOCKCKD (NCT03574363)
- Testing
- KBP-5074 0.25 mg tablet, KBP-5074 0.5 mg tablet
- Where
- 2 sites in United States
- Volunteers
- 162 people
- Sponsor
- KBP Biosciences
Infection, Heart Failure
Serum Potassium Prediction Using Machine Learning and Single-lead ECG
This is a retrospective study drawing on data from the Brigham and Women's Hospital Home Hospital Program's Database. Sociodemographic and clinical data from a training cohort were used to train a machine learning algorithm to…
- Conditions
- Infection, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT07493798
- Testing
- Potassium estimation algorithm
- Where
- 2 sites in United States
- Sponsor
- Brigham and Women's Hospital
Hypertension
Predisposition and Transition Mechanisms From Arterial Hypertension to Heart Failure
This project aims at investigating the genetic, genomic and proteomic basis of hypertension and susceptibility to hypertension-related end organ damage (renal damage and heart failure).
- Trial name
- Hypercare (NCT02430805)
- Testing
- dna extraction and genotyping
- Where
- 2 sites in France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Infection, Heart Failure
Rural Home Hospital: Proof of Concept
This study examines the implications of providing hospital-level care in rural homes.
- Conditions
- Infection, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT04531280
- Testing
- Home hospital care
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Brigham and Women's Hospital
Hypertension, Nursing
Effectiveness of Telenursing on Self-Care and Blood Pressure Control in Adults With Hypertension
This quasi-experimental study aims to evaluate the effectiveness of a structured telenursing program in improving self-care practices and blood pressure control among adults with chronic hypertension in Türkiye.
- Conditions
- Hypertension, Nursing, Telenursing
- Trial name
- TELENURSING-HT (NCT07056530)
- Testing
- Telenursing Counseling
- Where
- Turkey (Türkiye)
- Volunteers
- 151 people
- Sponsor
- Dursun Alper YILMAZ
Coronary Artery Disease, Cerebral Vascular Disease
Pilot Study: Cardiovascular Events in High Risk Orthopedic Surgical Patients
This is a non-randomized, non-interventional pilot observational study designed to follow high-risk patients through their surgical and hospital stay.
- Conditions
- Coronary Artery Disease, Cerebral Vascular Disease, Peripheral Artery Disease, Renal Insufficiency
- Trial name
- NCT01809730
- Where
- United States
- Sponsor
- NYU Langone Health
Hypertension, Renal Failure Chronic Requiring Hemodialysis
Blood Pressure in Dialysis Patients
Hypertension is a major cause of cardiovascular (CV) morbidity and mortality. Although studies in the general population have demonstrated a continuous reduction in CV risk with each mmHg drop in systolic blood pressure (SBP)…
- Conditions
- Hypertension, Renal Failure Chronic Requiring Hemodialysis, Blood Pressure, Dialysis
- Trial name
- BID (NCT01421771)
- Testing
- Antihypertensive Agents, Dry weight Challenge, Extend dialysis treatment time and re-challenge estimated dry weight
- Where
- 21 sites in United States
- Volunteers
- 126 people
- Sponsor
- University of New Mexico
Food Insecurity, Diabetes in Adults
RUSH Food is Medicine Veggie Rx - GusNIP Produce Prescription
The goal of this clinical trial is to assess nutrition incentives and produce vouchers to measure the impacts of food insecurity-related chronic health conditions in adults with hypertension and/or diabetes.
- Conditions
- Food Insecurity, Diabetes in Adults, Hypertension (HTN)
- Trial name
- NCT07376044
- Testing
- Food is Medicine
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Rush University Medical Center
Hypertension
The Chronic Effects of Beetroot Juice in Hypertensive Subjects
We are interested in the effect of diet on blood pressure. Our previous research has shown that beetroot juice lowers blood pressure in healthy people.
- Trial name
- NCT01405898
- Testing
- beetroot juice, Nitrate-free beetroot juice
- Where
- United Kingdom
- Volunteers
- 68 people
- Sponsor
- Queen Mary University of London
Hypertension, Pulmonary
Simvatstatin Used to Treat Pulmonary Hypertension
we try to use simvastatin in the treatment of advanced pulmoary hypertension secondary to congenital heart disease or chronic pulmonary embolism before and after the operation.
- Trial name
- NCT00538044
- Testing
- simvastatin
- Where
- China
- Sponsor
- Capital Medical University
Hypertension in Pregnancy
L-arginine Effects on Chronic Hypertension in Pregnancy
The purpose of this study is to evaluate the effects of oral L-arginine administration on pregnant women at second trimester of gestation with chronic hypertension, respect with placebo.
- Trial name
- NCT00974714
- Testing
- L-arginine
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- University of Modena and Reggio Emilia
Hypertension
A Trial of Telmisartan Prevention of Cardiovascular Disease
The present research is conducted as a randomized, parallel-group, controlled, open study (using the PROBE method) to primarily verify the effects on various biomarkers in high-risk hypertensive patients treated with ARB…
- Trial name
- ATTEMPT-CVD (NCT01075698)
- Testing
- Non-ARB (standard therapy), ARB (Telmisartan)
- Where
- Japan
- Volunteers
- 1,228 people
- Sponsor
- Kumamoto University
Chronic Venous Hypertension With Ulcer
Transforming Nanoparticle Dressing For Management of Chronic Venous Ulcers
The present randomized controlled study aims to evaluate the role of transforming nanoparticle dressing n management of chronic venous ulcers.
- Trial name
- NCT04793074
- Testing
- Transforming nanoparticle dressing, Conventional compression dressing
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Egyptian Biomedical Research Network
Liver Cirrhosis, Acute-On-Chronic Liver Failure
Characterization and Pathogenesis of ACLF
This single-center prospective observational study aims at characterization of pathogenesis of ACLF. There will be three different cohorts investigated with the main endpoint mortality in these groups. 1.
- Conditions
- Liver Cirrhosis, Acute-On-Chronic Liver Failure, Portal Hypertension
- Trial name
- ACLF-I (NCT04975490)
- Where
- Germany
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Healthy Volunteers
A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Efficacy of BC 007 in Healthy Subjects
Berlin Cures develops BC 007 to treat patients suffering from diseases (chronic heart failure, pulmonary hypertension, chronic fatigue syndrome etc.) which are associated with functional autoantibodies (AAB) directed against…
- Trial name
- NCT02955420
- Testing
- BC 007, NaCl 0.9 %
- Where
- Germany
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Berlin Cures GmbH
Hypertension, Diabetes Mellitus
Comparison of Intensive Versus Standard Care & Education for Dyslipidemia in Hypertension and Diabetes Patients
The prevalence of dyslipidemia is high among patients with hypertension and diabetes mellitus, which increases the risk of cardiovascular disease.
- Conditions
- Hypertension, Diabetes Mellitus, Dyslipidemia, Primary Prevention
- Trial name
- NCT07045623
- Testing
- centralized management and education group
- Where
- South Korea
- Volunteers
- 348 people
- Sponsor
- Saint Vincent's Hospital, Korea
Heart Failure，Congestive, Mental Health (Depression)
Evaluation of Nurse-led Integrated Care of Complex Patients Facilitated By Telemonitoring: The SMaRT Study
In Canada, 3 out of 4 Canadians aged 65 and older have at least one chronic condition, while 1 in 4 seniors reported having three or more.
- Conditions
- Heart Failure，Congestive, Mental Health (Depression), Diabetes Mellitus, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT05543720
- Testing
- Medly
- Where
- 4 sites in Canada
- Volunteers
- 350 people
- Sponsor
- University Health Network, Toronto
Hypertension, Dyslipidemia
Improved Delivery of Cardiovascular Care Through Outreach Facilitation
The aim of the proposed study is to implement and evaluate Outreach Facilitation as a means to increase the uptake of evidence-based practice for secondary prevention and management of patients with established CVD and…
- Conditions
- Hypertension, Dyslipidemia, Diabetes, Chronic Kidney Disease
- Trial name
- IDOCC (NCT00574808)
- Testing
- Outreach Facilitation implementing elements of the Chronic Care Model
- Where
- Canada
- Volunteers
- 194 people
- Sponsor
- C. T. Lamont Primary Care Research Centre
CTEPH, Pulmonary Embolism
Symptom-related Screening for Early Detection of CTEPH.
Routine screening for Chronic thromboembolic pulmonary hypertension (CTEPH) i after PE is not supported by current evidence and guidelines.
- Conditions
- CTEPH, Pulmonary Embolism, Symptoms and Signs, Dyspnea
- Trial name
- NCT03953560
- Testing
- dyspnea grade ≥ II according NYHA-WHO
- Where
- 16 sites in Spain
- Volunteers
- 646 people
- Sponsor
- Luis Jara-Palomares, MD
Chronic Renal Failure, Hypertension
Low Sodium Dialysate and Ambulatory Blood Pressure Measurement Parameters
End stage renal disease (ESRD) is related with increased cardiovascular mortality and morbidity. Hypertension (HT) is an important risk factor for cardiovascular disorder among hemodialysis (HD) patients.
- Trial name
- NCT02621450
- Testing
- standart dialysis, low sodium dialysis
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
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