Clinical trials: Chronic Hypertension
Sleep Apnea, Obstructive, Pregnancy
OSA in Pregnant Women With Chronic HTN
The purpose of this study is to identify whether pregnant women with chronic hypertension are at significantly higher risk of having undiagnosed OSA and should be routinely screened with home sleep tests.
- Conditions
- Sleep Apnea, Obstructive, Pregnancy, Hypertension
- Trial name
- OSA-CHTN (NCT03230110)
- Testing
- WP200U home sleep study device
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Duke University
Hyperlipidemias, Diabetes
Social Needs Screening and Chronic Diseases Study (WE CARE)
The goal of this clinical trial is to learn if the implementation of the WE CARE social determinants of health (SDOH) screening and referral intervention with an antiracist lens in primary care settings can lead to a meaningful…
- Conditions
- Hyperlipidemias, Diabetes, Depression, Pediatric Asthma
- Trial name
- NCT06903897
- Testing
- WE CARE SDOH System, Standard Pediatric Care
- Where
- 3 sites in United States
- Volunteers
- 68,000 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Diabete Mellitus, Dyslipidaemia
Prevalence and Associated Factors of High BMI and Periodontitis in Thai Adults Aged Under 60 Years
Overweight and obesity, as well as periodontitis, are common public health problems with increasing prevalence. Both conditions may be linked through shared mechanisms involving chronic low-grade systemic inflammation.
- Conditions
- Diabete Mellitus, Dyslipidaemia, Chronic Kidney Disease, Psychiatric Disorder
- Trial name
- NCT07880717
- Testing
- Periodontal Examination, Questionnaire interview, Anthropometric measurements
- Where
- Thailand
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Chronic Periodontitis, Hypertension
Influence of Periodontal Diseases on Vascular Parameters in Patients Suffering of Hypertension
The aim of this study is to assess the influence of the severity of chronic periodontitis on hemodynamic parameters in hypertensive patients.Secondary purposes of this protocol is to identify evolution of several biomarkers and…
- Trial name
- NCT02394860
- Testing
- echo Doppler lower limbs
- Where
- France
- Volunteers
- 76 people
- Sponsor
- University Hospital, Strasbourg, France
Chronic Kidney Diseases, Hypertension
Pilot to Examine Risk and Feasibility of Remote Management of BP From Childhood Into Early Adulthood
Hypertension is an increasingly common problem in children, especially among those who are obese or with diabetes and chronic kidney disease.
- Conditions
- Chronic Kidney Diseases, Hypertension, Blood Pressure
- Trial name
- PERFORMANCE2 (NCT03691701)
- Testing
- strict blood pressure control
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Chronic Kidney Disease, Bloodpressure
Pilot to Examine Risk and Feasibility of Remote Management of BP From CKD Through ESRD
The transition from chronic kidney disease (CKD) to end-stage renal disease ESRD is a vulnerable and challenging period of time for patients and providers.
- Conditions
- Chronic Kidney Disease, Bloodpressure, Hypertension
- Trial name
- PERFORMANCE (NCT02975505)
- Testing
- Strict blood pressure control
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- University of California, San Francisco
Pulmonary Hypertension
Frespaciguat (MK-5475) in Participants With Pulmonary Hypertension Associated With Chronic Obstructive Pulmonary Disease (PH-COPD) (MK-5475-006)
The primary objectives of this study are to assess the safety/tolerability and efficacy (by evaluating changes in pulmonary vascular resistance [PVR] and pulmonary blood volume [PBV]) of frespaciguat in participants with…
- Trial name
- NCT04370873
- Testing
- Frespaciguat
- Where
- 9 sites in United States, Israel and 1 more
- Volunteers
- 22 people
- Sponsor
- Merck Sharp & Dohme LLC
Pulmonary Hypertension
Bosentan in Patients With Inoperable Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
The present trial investigates the long-term safety, tolerability and efficacy of bosentan in patients with inoperable CTEPH.
- Trial name
- BENEFIT OL (NCT00319111)
- Testing
- bosentan
- Volunteers
- 151 people
- Sponsor
- Actelion
Type 2 Diabetes Mellitus (T2DM), Type 2 Diabetes
Osaka Cardiometabolic Epidemiological Study: Ohtori Study Part 2
The aim of this study is to investigate the relationship between body fat distribution measured by CT scan and related risk factors with the risk of incident metabolic and cardiovascular disease in a prospective cohort study of…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Type 2 Diabetes, Diabetes Mellitus, Hypertension
- Trial name
- OCES-2 (NCT06694012)
- Where
- Japan
- Volunteers
- 2,000 people
- Sponsor
- Osaka Metropolitan University
Idiopathic Intracranial Hypertension (IIH)
Intracranial Venous Stenting Evaluation in Patients With Idiopathic Intracranial Hypertension in the Early Phase
This study is aimed at patients suffering from recently discovered intracranial hypertension, caracterized by visual loss, chronic headache and/or tinnitus.
- Trial name
- DIVE IIN EARLY (NCT06919744)
- Testing
- Best medical care, Intervention (stenting)
- Where
- 3 sites in France
- Volunteers
- 114 people
- Sponsor
- University Hospital, Montpellier
Chronic Myeloproliferative Disorders
Study of Pulmonary Hypertension in Patients With Chronic Myeloproliferative Disorders at Sohag University Hospital
Pulmonary hypertension (PH) is a complex condition that may be related to many clinical conditions. It is a serious disorder with a high morbidity and mortality rates.
- Trial name
- NCT04843475
- Testing
- Echocardiography
- Volunteers
- 150 people
- Sponsor
- Sohag University
Preeclampsia
sFlt-1:PlGF Ratio in Diagnosing Superimposed Preeclampsia
Preeclampsia: associated with poor placentation, incomplete uteroplacental spiral arteries remodeling. Result: ischemia, re-perfusion injury, oxidative stress.
- Trial name
- NCT03441711
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- University of Tennessee
Diabetes Mellitus, Type 2, Hypertension
Expanding Technology-Enabled Nurse Delivered Chronic Disease Care
The purpose of this study is to investigate whether the self-management of diabetes and hypertension can be improved with the use of mobile monitoring devices and nursing support.
- Trial name
- EXTEND (NCT05120544)
- Testing
- EXTEND Plus, EXTEND
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Duke University
COPD, Pulmonary Hypertension
Prevalence of Pulmonary Hypertension in COPD Patients
The prevalence of an increased pulmonary blood pressure amongst patients with chronic obstructive pulmonary disease (COPD)is unclear. So is the impact of abnormal pulmonary blood pressure on symptoms.
- Trial name
- NCT00614900
- Where
- Denmark
- Volunteers
- 117 people
- Sponsor
- University of Aarhus
Human Immunodeficiency Virus, Diabetes Mellitus, Type 2
Impact of Integrated HIV/NCD Screening on HIV Testing Uptake and Engagement in HIV Care in Kisarawe, Tanzania
This study focuses on the integration of HIV and NCD screening and care. The investigators will conduct a randomized controlled trial examining the efficacy and cost-effectiveness of the intervention strategy in Kisarawe…
- Conditions
- Human Immunodeficiency Virus, Diabetes Mellitus, Type 2, Hypertension
- Trial name
- NCT03098654
- Testing
- Blood glucose and blood pressure testing, Diet and lifestyle counseling, DM/HTN medications as needed
- Where
- Tanzania
- Volunteers
- 214 people
- Sponsor
- Medical University of South Carolina
Resistant Hypertension, Kidney Failure, Chronic
Low-Dose Spironolactone in Hemodialysis Patients With Resistant Hypertension
Many patients on hemodialysis have high blood pressure that does not respond to three or more drugs (resistant hypertension). This pilot study gave a low dose of spironolactone (12.5 mg once daily) for 6 weeks to adults on…
- Conditions
- Resistant Hypertension, Kidney Failure, Chronic, Hemodialysis
- Trial name
- NCT07888504
- Testing
- Spironolactone
- Where
- Indonesia
- Volunteers
- 21 people
- Sponsor
- Universitas Sebelas Maret
Renal Replacement Therapy, Renal Dialysis
A Clinical Trial of IntensiVE Dialysis
This study will assess clinical outcomes of extended weekly hours of haemodialysis (>= 24 hours per week) compared with standard hours of haemodialysis (<=18 hours/week) in people with ESKD.
- Conditions
- Renal Replacement Therapy, Renal Dialysis, End Stage Kidney Disease, End Stage Renal Disease
- Trial name
- ACTIVE (NCT00649298)
- Testing
- haemodialysis
- Where
- 40 sites in Australia, Canada and 2 more
- Volunteers
- 200 people
- Sponsor
- The George Institute
Chronic Hypertension Complicating Pregnancy, Pre-Eclampsia
Chronic Hypertension and Acetyl Salicylic Acid in Pregnancy
A randomized clinical trial to assess the efficiency of acetylsalicylic acid (aspirin) 150 mg/day started before 20 weeks of gestation in the prevention on maternal and fœtal complications in pregnant women with chronic…
- Conditions
- Chronic Hypertension Complicating Pregnancy, Pre-Eclampsia, Intrauterine Growth Restriction, Aspirin
- Trial name
- CHASAP (NCT04356326)
- Testing
- Aspirin 150 mg
- Where
- 20 sites in France
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Hypertension
26-week Open Study of telmisartan40mg+amlodipine10mg or telmisartan80mg+amlodipine10 mg in Hypertension
The primary objective of this trial is to assess the efficacy and safety of the fixed dose combinations telmisartan 40mg/amlodipine 10mg (T40/A10) or telmisartan 80mg/amlodipine 10mg (T80/A10) during open-label treatment for at…
- Trial name
- NCT00624052
- Testing
- fixed-dose combination of telmisartan 40mg+amlodipine 10mg, fixed-dose combination of telmisartan 80mg+amlodipine10mg
- Where
- 92 sites in Australia, Austria and 10 more
- Volunteers
- 838 people
- Sponsor
- Boehringer Ingelheim
Acute Exacerbation of COPD
Copd Exacerbation and Pulmonary Hypertension Trial
This trial will investigate whether patiens admitted with an acute exacerbation of chronic obstructive lung disease and pulmonary hypertension will benefit from a targeted pharmacological treatment.
- Trial name
- CODEX-P (NCT04538976)
- Testing
- Sildenafil
- Where
- 5 sites in Denmark
- Volunteers
- 250 people
- Sponsor
- Chronic Obstructive Pulmonary Disease Trial Network, Denmark
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