Clinical trials: Chronic Hypertension
Pulmonary Artery Hypertension
Vascular Subphenotypes of Lung Disease in HIV & COPD
This study is looking for high blood pressure in the lungs (Pulmonary artery hypertension PAH) in HIV and COPD patients.
- Trial name
- VAST (NCT01581086)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pittsburgh
Diabetes, Hypertension
Study of Medical Assistant Health Coaching in Primary Care for Patients With Chronic Conditions
Randomized control trial studying the effect of medical assistant health coaching for patients with diabetes, hypertension and hyperlipidemia within two San Francisco primary care community clinics, Mission Neighborhood Health…
- Conditions
- Diabetes, Hypertension, Hyperlipidemia
- Trial name
- HCPC (NCT01220336)
- Testing
- Health coaching by medical assistants in primary care
- Where
- 2 sites in United States
- Volunteers
- 441 people
- Sponsor
- University of California, San Francisco
Chronic Thromboembolic Pulmonary Hypertension
Iodine Subtraction Mapping in the Diagnosis of Chronic Pulmonary Thromboembolic Disease
Chronic thromboembolic pulmonary hypertension (CTEPH) is a severe but treatable disease that is commonly underdiagnosed. Computed tomography lung subtraction iodine mapping (CT-LSIM) in addition to standard CT pulmonary…
- Trial name
- INSPIRE (NCT03806907)
- Testing
- Computed tomography lung subtraction iodine mapping
- Volunteers
- 100 people
- Sponsor
- University of Sheffield
Pulmonary Hypertension, Chronic Pulmonary Disease
Clinical, Radiological, Tissue and Biological Phenotyping for the Analysis of the Transition From Physiology to Pathology in Pulmonary Diseases With Pulmonary Hypertension
This is a monocentric, case-control, comparative study aiming at investigating the transition from physiological to pathological pulmonary circulation in patients with pulmonary hypertension (PH) and chronic lung diseases.
- Trial name
- PHENOPULM (NCT07184671)
- Testing
- blood sampling, broncho-alveolar lavage sampling, lung parenchyma sampling
- Volunteers
- 105 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Right Heart Function, Chronic Obstructive Pulmonary Disease
Effect of Acetazolamide on Right Heart Function at Rest in Lowlanders With COPD Traveling to High Altitude
The purpose of this randomized, placebo-controlled double-blind trial is to evaluate the effect of acetazolamide on right heart function at rest in lowlanders with chronic obstructive pulmonary disease (COPD) traveling to high…
- Conditions
- Right Heart Function, Chronic Obstructive Pulmonary Disease, Altitude Sickness
- Trial name
- NCT04915365
- Testing
- Acetazolamide
- Where
- Kyrgyzstan
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Infection, Heart Failure
Prediction of 30-Day Readmission Using Machine Learning
This is a retrospective observational study drawing on data from the Brigham and Women's Home Hospital database. Sociodemographic and clinic data from a training cohort were used to train a machine learning algorithm to predict…
- Conditions
- Infection, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT04849312
- Where
- 2 sites in United States
- Volunteers
- 372 people
- Sponsor
- Brigham and Women's Hospital
Cirrhosis, Portal Hypertension
Spironolactone on Fibrosis Progrssion-Portal Hypertension(FP-PH)in Cirrhosis
The aim of this study is to investigate the effects of spironolactone on liver fibrosis progression and portal pressure gradient in patients with advanced chronic liver disease.
- Trial name
- FP-PH (NCT02907749)
- Testing
- Spironolactone and carvedilol, Carvedilol
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Changqing Yang
Chronic Kidney Diseases
Physical Activity in Renal Disease (PAIRED): The Effect on Hypertension
Background and importance: Hypertension is highly prevalent among Canadians with non-dialysis dependent chronic kidney disease (CKD). It is a modifiable risk factor for both cardiovascular (CV) events and CKD progression.
- Trial name
- NCT03551119
- Testing
- Exercise, Enhanced usual care
- Where
- 3 sites in Canada
- Volunteers
- 44 people
- Sponsor
- University of Alberta
Hypertensive Emergency-associated Hemolytic Uremic Syndrome
Eculizumab in Hypertensive Emergency-associated Hemolytic Uremic Syndrome
Hemolytic and uremic syndrome (HUS) is a clinic-biological syndrome related to thrombotic microangiopathy affecting predominantly the kidney.
- Trial name
- HYPERSHU (NCT05726916)
- Testing
- Soliris®, Renin angiotensin system blockers
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Osteo Arthritis, Osteoporosis
Determining the Feasibility of Implementing a Combined Cognitive and Exercise Training Program for Older Adults in a Community Setting.
The overarching aim of this project is to implement and evaluate a proven cognitive training regimen in combination with a community exercise program among older adults who attend wellness exercise programs at the YMCA.
- Conditions
- Osteo Arthritis, Osteoporosis, Joint Replacement, Fibromyalgia
- Trial name
- NCT04515758
- Testing
- Exercise and Cognitive Training, Exercise Training Only
- Where
- Canada
- Volunteers
- 43 people
- Sponsor
- University of Waterloo
Pulmonary Hypertension, Pulmonary Hypertension Due to Lung Diseases
Bioenergetic Effect of Pioglitazone in CLD-PH
The goal of this clinical trial is to learn about the safety and efficacy of Pioglitazone in people with Pulmonary Hypertension (PH) due to Chronic Lung Disease (CLD).
- Trial name
- NCT06336798
- Testing
- Pioglitazone 30mg, Labs
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Emory University
Cirrhosis, Chronic Liver Disease
The Association With Peptic Ulcer Disease and Hepatic Vein Pressure Gradient
The aim of this study is to assess the role of portal hypertension of peptic ulcer disease in liver cirrhosis and chronic hepatitis.
- Trial name
- NCT01944878
- Where
- South Korea
- Volunteers
- 455 people
- Sponsor
- Chuncheon Sacred Heart Hospital
ESRD, Extracellular Fluid Alteration
Using Intradialytic Blood Pressure Slopes to Guide Ultrafiltration
This study is an open label randomized clinical trial that comparing intradialytic blood pressure slope-based ultrafiltration prescriptions to standard care in the chronic fluid management of maintenance hemodialysis patients.
- Conditions
- ESRD, Extracellular Fluid Alteration, Hypertension
- Trial name
- IBPS (NCT03303391)
- Testing
- Intradialytic Blood Pressure Slope Based Ultrafiltration
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Texas Southwestern Medical Center
Hypertension, Vascular Diseases
SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN
The purpose of this single-arm interventional study is to evaluate the long-term safety, efficacy, and durability of the Symplicity Spyral system in subjects treated with renal denervation.
- Conditions
- Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases
- Trial name
- NCT05198674
- Testing
- Renal Denervation (Symplicity Spyral™)
- Where
- 97 sites in United States, Australia and 9 more
- Volunteers
- 1,899 people
- Sponsor
- Medtronic Vascular
Pulmonary Hypertension
Sildenafil and Pulmonary Artery Pressure
The purpose of the study is to see if the administration of sildenafil (Viagra) in patients with portopulmonary hypertension could be a safe and effective treatment.
- Trial name
- NCT00145938
- Testing
- sildenafil
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Chicago
Chronic Kidney Disease Patients
Bedtime Potassium Losartan on CKD With Nocturnal Hypertension Patients With Nondipping Blood Pressure Pattern
Nondipping blood pressure (BP) pattern is a potential independent risk factor for chronic kidney disease (CKD). Whether bedtime administration of potassium losartan has benefit for anti-hypertension and the prognosis of CKD…
- Trial name
- NCT03603938
- Testing
- potassium losartan
- Where
- China
- Volunteers
- 189 people
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
End Stage Renal Disease, Hypertension
Electronic Decision Support for Deprescribing in Patients on Hemodialysis
Dialysis patients are prescribed an average of 10-12 medications per day, from up to 4-5 different clinicians and have the heaviest pill burden of all chronic conditions given their degree of comorbidity.
- Conditions
- End Stage Renal Disease, Hypertension, Diabete Type 2, Renal Failure Chronic
- Trial name
- MedSafer-HD (NCT05585268)
- Testing
- Medication reconciliation supplemented with MedSafer and deprescribing brochures
- Where
- Canada
- Volunteers
- 195 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Essential Hypertension
Heat Therapy in Older Hypertensive Women
The prevalence of hypertension is greater in older women than men, while the blood pressure (BP) control rate is lower in older women in US. Uncontrolled hypertension is a major risk factor for cardiovascular morbidity/mortality.
- Trial name
- NCT03857490
- Testing
- Lower leg heat therapy
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- University of Texas Southwestern Medical Center
Hypertension, High Blood Pressure
Efficient Self-management of Chronic Disease Using Health Information Technology - a Study on Hypertension
Background: Hypertension is an increasing global problem and measures are needed against the emerging hypertensive burden. Management of the risk factor hypertension consists of medical treatment in conjunction with lifestyle…
- Trial name
- PERHIT (NCT03554382)
- Testing
- system to support self-management of hypertension
- Where
- 4 sites in Sweden
- Volunteers
- 971 people
- Sponsor
- Region Skane
Essential Hypertension, Cardiovascular Disease
Prognostic Value of the Circadian Pattern of Ambulatory Blood Pressure for Multiple Risk Assessment
The HYGIA study was designed to investigate prospectively 1. the prognostic value of ambulatory blood pressure (BP) monitoring among subjects primarily evaluated at primary care settings 2.
- Conditions
- Essential Hypertension, Cardiovascular Disease, Stroke, Chronic Kidney Disease
- Trial name
- HYGIA (NCT00741585)
- Testing
- Any antihypertensive medication alone or in combination, Ambulatory blood pressure monitoring
- Where
- 20 sites in Spain
- Volunteers
- 21,983 people, healthy volunteers welcome
- Sponsor
- University of Vigo
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