Clinical trials: Chronic Hypertension
Hypertension, Diabete Mellitus
Randomized Controlled Trial of the Smart O2O Model Development for Chronic Diseases Management Through Digital Health
Objectives The aim of this intervention is to assess how well and how efficiently the O2O Service Model works in delivering primary healthcare and managing chronic diseases for patients living in Pyeongchang-gun at the local…
- Trial name
- NCT06150508
- Testing
- O2O digital healthcare service
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Type 2 Diabetes, Hypertension
NUTRITION MATTERS: A Food is Medicine Intervention for African-American Adults With Multiple Chronic Conditions
African Americans have higher rates of diabetes, obesity, heart disease, and high blood pressure. In addition, middle-aged non-Hispanic Black adults develop multiple chronic conditions (MCCs) at an earlier age, which share most…
- Conditions
- Type 2 Diabetes, Hypertension, Obesity and Obesity-related Medical Conditions, Heart Disease
- Trial name
- NCT06933940
- Testing
- Nutrition Matters
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Winston Salem State University
Chronic Kidney Disease, Hypertension
ADMA Levels in End-Stage Renal Disease
Asymmetric dimethylarginine, ADMA, in plasma, is significantly elevated in patients with renal disease and associated with cardiovascular morbidity and mortality.
- Trial name
- NCT00350974
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Hypertension, Diabetes
Development and Evaluation of mHealth Solutions to Monitor and Involve Cardiometabolic Patients in Self-care
To develop, using barcode systems and virtual pillbox (TuMedicina and Alice), an App aimed at patients and carers of patients with cardiometabolic diseases as the main diagnosis, over 45 years of age, who have one or more…
- Conditions
- Hypertension, Diabetes, Heart Failure, Copd
- Trial name
- NCT04159558
- Testing
- Mobile application
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Universidad Miguel Hernandez de Elche
Arthritis, Asthma
Mobility Assessment in Multi-morbidity
Multimorbidity (the presence of two or more coexisting long-term conditions) is a significant challenge facing the NHS, especially given UK's ageing population and the association with high levels of illness burden and healthcare…
- Conditions
- Arthritis, Asthma, Atrial Fibrillation, Bronchiectasis
- Trial name
- Multi-mobility (NCT06473168)
- Volunteers
- 55 people
- Sponsor
- Northumbria University
Hyperlipidemia, Hypertension
Renal Hemodynamic Effects of the HMG-CoA Reductase Inhibitors in Normal Volunteers and in Patients With Chronic Renal Failure
This study was done to determine whether Simvastatin (a medication commonly used to treat patients with high cholesterol levels in the blood increases blood flow to the kidneys and improves renal function in normal volunteers and…
- Conditions
- Hyperlipidemia, Hypertension, Chronic Renal Failure
- Trial name
- NCT02511418
- Testing
- Simvastatin
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic
End Stage Kidney Disease (ESKD), Hypertension (HTN)
Guiding Optimal Blood Pressure Management in Peritoneal Dialysis Pilot Trial
The GOAL-BP pilot study will help determine whether a study comparing two blood pressure goals can be carried out in adults with end-stage kidney disease and high blood pressure who receive peritoneal dialysis.
- Conditions
- End Stage Kidney Disease (ESKD), Hypertension (HTN), Peritoneal Dialysis (PD)
- Trial name
- GOAL-BP (NCT07910773)
- Testing
- Target systolic blood pressure <120 mmHg., Target systolic blood pressure <140 mmHg
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of California, San Francisco
Diabetes Mellitus, Metabolic Syndrome
Food is Medicine vs Lifestyle Medicine For Cardiovascular Kidney Metabolic (CKM) Syndrome
The investigators are piloting a 3 month community-based lifestyle medicine program that incorporates experiences and education in urban agriculture, nutrition, culinary arts, and physical fitness to test the hypothesis whether…
- Conditions
- Diabetes Mellitus, Metabolic Syndrome, Obesity, Hypertension,Essential
- Trial name
- FiLMED (NCT06461273)
- Testing
- Lifestyle Medicine Program, Medically Tailored Groceries
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Rutgers, The State University of New Jersey
Hypertension
Milk Proteins, Ambulatory Blood Pressure and Vascular Function
Epidemiological studies demonstrated an inverse associations between cardiovascular events and milk and dairy product consumption.
- Trial name
- NCT02090842
- Testing
- Ca-caseinate, Maltodextrin, Whey protein isolate
- Where
- United Kingdom
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Reading
Chronic Kidney Disease
Effects of a Reduction in Kidney Function on Cardiovascular Structure and Function: A Prospective Study of Kidney Donors
Studies of patients with established kidney disease, even when this is mild, appear to show that they are at high risk of heart failure, stroke and sudden cardiac death.
- Trial name
- NCT01028703
- Where
- United Kingdom
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Diabetes Mellitus, Type 2, Hypertension
EMPOWERing Patients With Chronic Diseases Through Smartphone App, Health Coaching and Shared Decision Making
Chronic diseases are the leading cause of deaths in Singapore. The rising prevalence in chronic diseases with age and Singapore's rapidly aging population calls for new models of care to effectively prevent the onset and delay…
- Trial name
- NCT05486390
- Testing
- Nudge, health coaching and shared decision-making
- Where
- 3 sites in Singapore
- Volunteers
- 320 people
- Sponsor
- Singapore General Hospital
COPD Exacerbation (AECOPD), Pulmonary Hypertension
Dynamic Changes in Right Ventricle and Pulmonary Artery Coupling Among COPD Patients With Acute Exacerbation
Chronic obstructive pulmonary disease (COPD) is a common, preventable, and manageable disease characterized by persistent respiratory symptoms and airflow limitation.
- Trial name
- NCT07694713
- Testing
- Echocardiography assessment
- Where
- Egypt
- Volunteers
- 115 people
- Sponsor
- Assiut University
Pulmonary Hypertension, Rheumatic Valvular Heart Disease
Sildinafil in Pulmonary Hypertension-Rheumatic Chronic Valvular Disease(RCT)
Pulmonary hypertension secondary to left heart disease is associated with increased morbidity and mortality, particularly in patients with rheumatic chronic valvular heart disease, which remains highly prevalent in low- and…
- Trial name
- SERIES (NCT07462260)
- Testing
- Sildenafil 25 MG
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Sindh Institute of Cardiovascular Diseases
Chronic Obstructive Pulmonary Disease
Inhaled Iloprost for Disproportionate Pulmonary Hypertension in Chronic Obstructive Pulmonary Disease (COPD)
Pulmonary hypertension is frequently present in COPD and it is generally limited to a mild increase in mean pulmonary artery pressure.
- Trial name
- COPDVEN (NCT01116063)
- Testing
- Inhaled iloprost
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Carmel Medical Center
Hypertension (HTN), Hypertension Arterial
Chronic Effect of Isometric Exercise on Blood Pressure in Patients With Hypertension
International recommendations support dynamic or isometric strength training as an adjunct to aerobic exercise. Given the lack of consensus, this study aims to evaluate the chronic effects of isometric exercise, performed through…
- Trial name
- NCT07147595
- Testing
- Isometric handgrip exercise, Isometric knee extension exercise
- Where
- Brazil
- Volunteers
- 66 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Heart Failure, Pulmonary Hypertension
Sildenafil Versus Placebo in Chronic Heart Failure
This protocol describes a 2-arm randomised controlled pilot study assessing the tolerance, safety and efficacy of sildenafil compared to control.
- Trial name
- SilHF (NCT01616381)
- Testing
- Sildenafil
- Where
- 6 sites in Israel, Italy and 2 more
- Volunteers
- 75 people
- Sponsor
- Helse Stavanger HF
Hypertension Treated With Antihypertensive Drugs, Chronic Kidney Disease, 3B and 4
LOw DosE Spironolactone, chlorThAlidone oR Combination in CKD Trial
The purpose of this research is to gather information on the safety and effectiveness of spironolactone and chlorthalidone for treatment of high blood pressure in patients with moderate to advanced CKD.
- Trial name
- LODESTAR (NCT07645300)
- Testing
- phase 2A Chlorthalidone, phase 2A Spironolactone, phase 2A Chlorthalidone + Spironolactone
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- VA Office of Research and Development
Children, Chronic Renal Failure
Effect of Strict Blood Pressure Control and ACE-Inhibition on Progression of Chronic Renal Failure in Pediatric Patients
In children with chronic kidney disease, progression to end-stage renal failure is associated with high patient morbidity and poor quality of life.
- Conditions
- Children, Chronic Renal Failure, Hypertension, Acquired Kidney Disease
- Trial name
- ESCAPE (NCT00221845)
- Testing
- ACE Inhibition, Intensified Blood Pressure Control, Add-on Angiotensin Receptor Blockade
- Where
- 33 sites in Czechia, France and 10 more
- Volunteers
- 400 people
- Sponsor
- Heidelberg University
Diabetes, Heart Disease
The CREATE Wellness Study
Cardiovascular disease (CVD) is the leading cause of death in the U.S. Efforts to improve CVD risk factors often fall short in complex patients with multiple co-morbid conditions, a growing, expensive, and high-risk segment of…
- Conditions
- Diabetes, Heart Disease, Hypertension, Dyslipidemia
- Trial name
- NCT02302612
- Testing
- CREATE Wellness, Usual Care Control
- Where
- United States
- Volunteers
- 647 people
- Sponsor
- Kaiser Permanente
Bronchopulmonary Dysplasia, Bronchopulmonary Dysplasia Associated Pulmonary Hypertension
Enteral L Citrulline Supplementation in Preterm Infants - Safety, Efficacy and Dosing
Oral L-citrulline supplementation may prevent and/or decrease the severity of chronic lung disease associated with pulmonary hypertension in preterm infants.
- Conditions
- Bronchopulmonary Dysplasia, Bronchopulmonary Dysplasia Associated Pulmonary Hypertension, Pulmonary Hypertension, Premature Birth
- Trial name
- NCT03649932
- Testing
- Enteral L-citrulline
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- The University of Texas Medical Branch, Galveston
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