Clinical trials: Chronic Hypertension
Renal Dialysis
Transdermal Clonidine in Chronic Hemodialysis Patients
The majority of chronic hemodialysis patients need a combination of several antihypertensive drugs for adequate BP control. The primary objective of this study is to evaluate whether transdermal clonidine can improve blood…
- Trial name
- NCT02545530
- Testing
- transdermal clonidine
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Peking University People's Hospital
Hypertension, Chronic Kidney Disease
Efficacy and Safety of the DASH Diet in Adults With Moderate Chronic Kidney Disease: Pilot Study
More than two-thirds of US adults with chronic kidney disease (CKD) have uncontrolled hypertension. Both hypertension and CKD are major independent risk factors for cardiovascular disease, which is the leading cause of death in…
- Trial name
- NCT02059811
- Testing
- DASH Diet, Control Diet
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Duke University
Chronic Kidney Diseases, Hypertension
Green Propolis Extract and Royal Jelly in Hypertensive Patients and/or With Chronic Kidney Disease
This work aims to evaluate the effects of the association of green propolis extract with royal jelly on inflammation and oxidative stress in participants with chronic kidney diseases (CKD) and Systemic arterial hypertension…
- Conditions
- Chronic Kidney Diseases, Hypertension, Cardiovascular Diseases
- Trial name
- NCT06288204
- Testing
- Propolis associated with Royal Jelly, Royal Jelly
- Where
- 2 sites in Brazil
- Volunteers
- 153 people
- Sponsor
- Universidade Federal Fluminense
Pre-Eclampsia, Fetal Growth Retardation
Antepartum Chronic Epidural Therapy (ACET) to Improve Blood Flow to the Uterus, Placenta and Baby in Pre-Eclampsia and Intrauterine Growth Restriction
Pre-eclampsia (PE) and intrauterine growth restriction (IUGR) are common and important disorders of pregnancy. Both disorders are associated with an impairment of uteroplacental blood flow (UPBF).
- Trial name
- NCT00197340
- Testing
- Epidural ropivacaine
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Hadassah Medical Organization
Hypertension, End Stage Renal Disease
Study of the Effect of Intradialytic Vasopressin on Chronic Hypertension in Patients With End Stage Renal Disease
The death rate of patients with endstage renal disease (ESRD) on dialysis each year is 20%, with diseases related to the heart and blood vessels causing about half.
- Trial name
- NCT01247090
- Testing
- Vasopressin - Very Low Dose, Vasopressin - Low Dose
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Columbia University
Chronic Thromboembolic Pulmonary Hypertension
N-acetyl Cysteine in Post-reperfusion Pulmonary Injury in Chronic Thromboembolic Pulmonary Hypertension.
This study will evaluate the use of N-acetyl cysteine in post-reperfusion pulmonary injury in patients with chronic thromboembolic pulmonary hypertension undergoing pulmonary balloon angioplasty and pulmonary endarterectomy.
- Trial name
- NAC-PostRep (NCT04081012)
- Testing
- N-acetyl cysteine
- Where
- Mexico
- Volunteers
- 34 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Cardio Vascular Disease, Cerebro Vascular Disease
Qungasvik (Toolbox)-Healthy Hearts: A Cultural Approach to Reducing Chronic Disease Risk
Due to the extreme remoteness, transportation challenges, and lack of access to clinical care, the delivery of preventative health interventions in rural Alaska Native communities is a top tribal priority.
- Conditions
- Cardio Vascular Disease, Cerebro Vascular Disease, Mental Health, Chronic Disease (Physical)
- Trial name
- AK CEAL EI (NCT07829341)
- Testing
- Qungasvik-Healthy Hearts
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Alaska Fairbanks
Chronic Hypertension Complicating Pregnancy (Diagnosis), Preeclampsia
Impedance Cardiography to Decrease the Risk of Preeclampsia
To determine if the use of impedance cardiography can identify appropriate medications for use in treating chronic hypertensive patients to decrease the risk of preeclampsia.
- Trial name
- NCT03245970
- Testing
- Labetalol Hydrocholoride 200 mg orally every 12 hours, Nifedipine 60 mg orally daily, Atenolol 25 mg daily
- Where
- United States
- Sponsor
- University of Tennessee Medical Center
Atherosclerosis, Chronic Kidney Disease
Revascularization of Renal Artery Stenosis Versus Medical Therapy for the Treatment of Ischemic Nephropathy
The aim of the study is to value, in patients with chronic kidney disease and hypertension, whether medical therapy plus interventional renal artery revascularization is superior to medical therapy alone for the treatment of…
- Conditions
- Atherosclerosis, Chronic Kidney Disease, Hypertension, Renovascular, Ischemic Nephropathy
- Trial name
- NITER (NCT01023373)
- Testing
- Medical treatment, PTRS, renal artery stent
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Azienda Unita Sanitaria Locale di Piacenza
Hypertension, Type 2 Diabetes
Assessing the Efficacy of Targeted Home Visits in the Management of Chronic Conditions
The purpose of study is to evaluate whether home visit programs are an effective method for HTN and T2DM management as compared to standard of care clinic visits.
- Trial name
- NCT05168605
- Testing
- Home visit
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Texas Southwestern Medical Center
Hypertension, Chronic Heart Failure
Tolerability, Pharmacokinetics and Dopamine ß-hydroxylase (DßH) Inhibition Profile of BIA 5-453
The purpose of this study is to assess the safety and tolerability of BIA 5-453 after single oral doses
- Trial name
- NCT02845037
- Testing
- BIA 5-453
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Leukemia, Chronic Lymphatic, Mantle Cell Lymphoma
Atrial Fibrillation in Patients Receiving Ibrutinib
Ibrutinib (a tyrosine kinase inhibitor targeting Bruton) is a standard of treatment in haematology. According to retrospective data, atrial fibrillation and systemic hypertension are common ibrutinib-related advserse events.
- Trial name
- FABRIC (NCT04407845)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- European Georges Pompidou Hospital
Atherosclerosis, Cardiovascular Disease
A Study of Clazakizumab (LY5724886) in Adults With Elevated hsCRP and at Increased Risk for Cardiovascular Event
The purpose of this study is to measure the change in high-sensitivity C-reactive protein (hsCRP), a marker of inflammation in the body, with clazakizumab compared with placebo in adults who have elevated hsCRP and at increased…
- Conditions
- Atherosclerosis, Cardiovascular Disease, Obesity, Hypertension
- Trial name
- CLARITY-CRP (NCT07783802)
- Testing
- Clazakizumab
- Where
- 46 sites in United States, Argentina and 2 more
- Volunteers
- 120 people
- Sponsor
- Eli Lilly and Company
Cardiovascular Disease (CVD), Heart Failure
Study of the Progression of Chronic Cardiovascular Conditions
This study will collect physiologic data in patients with cardiovascular conditions and observe the natural history of those conditions for research purposes.
- Conditions
- Cardiovascular Disease (CVD), Heart Failure, Aortic Stenosis, Aortic Stenosis Disease
- Trial name
- OCORO (NCT07420907)
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Prolaio
Multimorbidity, Multiple Chronic Conditions
Effect of Aerobic Training on the Health Parameters of Postmenopausal Women With Multimorbidity
People affected by multiple chronic diseases have a greater chance of hospitalization, longer hospital stays, worse general health, worse physical and mental function and lower functional capacity, with an average risk of 50% of…
- Conditions
- Multimorbidity, Multiple Chronic Conditions, Hypertension, Dyslipidemias
- Trial name
- NCT05075902
- Testing
- Aerobic training
- Where
- Brazil
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Federal University of Uberlandia
Arterial Hypertension, Atherosclerosis Occlusive Disease
Gut Microbiota in Chronic Noncommunicable Diseases
It is an observational study in patients with chronic noncommunicable diseases (i.e. cardiovascular diseases, diabetes mellitus, non-alcoholic fatty liver disease, chronic obstructive pulmonary disease and asthma ) and control…
- Conditions
- Arterial Hypertension, Atherosclerosis Occlusive Disease, Heart Failure With Preserved Ejection Fraction, Heart Failure With Reduced Ejection Fraction
- Trial name
- NCT04820556
- Where
- 2 sites in Russia
- Volunteers
- 1,084 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Chronic Liver Disease, Esophageal Varices
Blood Ammonia as Predictor for Esophageal Varices and Risk of Bleeding
Assessment of blood ammonia level as a non-invasive predictor for presence of EV and risk of bleeding
- Trial name
- EV (NCT03212872)
- Testing
- Endoscopy
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Tanta University
Advanced Chronic Liver Disease, Portal Hypertension
Zinc Supplementation to Improve Prognosis in Patients With Compensated Advanced Chronic Liver Disease.
Zinc homeostasis could play a role in advanced chronic liver disease (cACLD) and its supplementation has been linked with improvement in liver function, decrease of hepatic complications and reduction in hepatocellular carcinoma…
- Conditions
- Advanced Chronic Liver Disease, Portal Hypertension, Hepatocellular Carcinoma
- Trial name
- NCT06434753
- Testing
- Zinc Acexamate
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Airway Obstruction, Hypertension
Epidemiological Study on the Relationship Between Respiratory Health and Air Pollution From Industrial Sources
The ELISABET STUDY is across sectional Survey on a representative sample of two urban area conduct on a representative sample. The main objective of the project is to compare the prevalence of the obstructive ventilatory…
- Conditions
- Airway Obstruction, Hypertension, Diabetes Mellitus, Dyslipidemias
- Trial name
- ELISABET (NCT02490553)
- Testing
- heteroevaluation scale by a nurse or doctor
- Volunteers
- 3,276 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Chronic Obstructive Pulmonary Disease, Pulmonary Hypertension
Do Phosphodiesterase 5A Inhibitors Improve Exercise Capacity in Patients With Chronic Obstructive Pulmonary Disease (COPD) and Pulmonary Hypertension?
The investigators hypothesise that phosphodiesterase 5A inhibitors will improve exercise capacity in those with Chronic Obstructive Pulmonary Disease and secondary pulmonary hypertension.
- Trial name
- NCT01197469
- Testing
- Tadalafil
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University of Dundee
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