Clinical trials: Chronic Ischaemic Heart Disease
Cardiomyopathy, Dilated
Immunoadsorption Therapy for Patients With Non-Ischemic Dilated Cardiomyopathy (DCM)
The purpose of this study is to evaluate the clinical safety and feasibility of Mysorba in patients with chronic non-ischemic dilated cardiomyopathy (DCM).
- Trial name
- NCT01478087
- Testing
- Mysorba
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- Asahi Kasei Medical Co., Ltd.
Coronary Artery Disease, Total Occlusion of Coronary Artery
The Registry Study to Compare the Cardiopulmonary Exercise Test Parameters Before and After Cardiac Rehabilitation in Patients With Chronic Total Occlusion of the Coronary Arteries
The aim of this study is to find strategy for treatment through comparing the cardiopulmonary exercise test parameters before and after cardiac rehabilitation in patients with chronic total occlusion of the coronary arteries.
- Trial name
- NCT03221712
- Testing
- cardiac rehabilitation
- Where
- South Korea
- Volunteers
- 5,000 people
- Sponsor
- Seung-Jung Park
Insomnia, Insomnia Chronic
SHADES Mechanistic Trial
Cardiovascular disease (CVD) is common, deadly, and costly, and adults with insomnia represent a large group of people at elevated risk of developing CVD in the future.
- Conditions
- Insomnia, Insomnia Chronic, Insomnia, Primary, Sleep Disturbance
- Trial name
- SHADES (NCT06041581)
- Testing
- Sleep Healthy Using The Internet (SHUTi), Telephonic CBT-I, Face-to-Face CBT-I
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Indiana University
Thrombosis, Myocardial Infarction
Differential EFfects of Dual antIplatelet and Dual aNtithrombotic thErapy on Hemostasis in Chronic Coronary Syndrome Patients
The investigators will be comparing the effects of two different drug treatment strategies, in patients with history of a heart attack, on different markers of bleeding and clotting risk.
- Trial name
- DEFINE CCS (NCT05116995)
- Testing
- Rivaroxaban, Ticagrelor
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Nova Scotia Health Authority
Ischemic Heart Disease, Coronary Artery Disease
Cell Therapy in Chronic Ischemic Heart Disease
This study was designed to test the hypothesis that direct injection of bone-marrow cells in the heart may increase the number of blood vessels, ameliorating the heart's performance, and relieving patients from symptoms like…
- Trial name
- NCT00362388
- Testing
- Intramyocardial injection of autologous bone marrow cells
- Where
- 6 sites in Brazil
- Volunteers
- 300 people
- Sponsor
- Ministry of Health, Brazil
Chronic Coronary Syndrome, Coronary Artery Disease
Advanced Invasive Diagnosis for Patients With Chronic Coronary Syndromes Undergoing Coronary ANGIOgraphy (AID-ANGIO)
AID-ANGIO is an observational, prospective, single arm, longitudinal study. Its objective is to investigate the diagnostic yield of the systematic use of a diagnostic strategy hierarchically addressing both obstructive and…
- Conditions
- Chronic Coronary Syndrome, Coronary Artery Disease, Microvascular Angina, Coronary Vasospasm
- Trial name
- AID-ANGIO (NCT05635994)
- Testing
- AID strategy
- Where
- 4 sites in Spain
- Volunteers
- 260 people
- Sponsor
- Hospital San Carlos, Madrid
Chronic Total Occlusion of Coronary Artery, Microvascular Coronary Artery Disease
Microvascular Coronary Resistance and Absolute Coronary FLOW in Patients With Percutaneous Intervention of a Chronic Total Occlusion
It is an observational study which objective is to analyze, through a series of invasive parameters, the state of the coronary microvasculature immediately after the successful percutaneous coronary intervention of a chronic…
- Conditions
- Chronic Total Occlusion of Coronary Artery, Microvascular Coronary Artery Disease, Coronary; Ischemic, Coronary Microvascular Dysfunction
- Trial name
- FLOW-CTO (NCT05197361)
- Testing
- Invasive coronary physiology
- Where
- 4 sites in Spain
- Volunteers
- 34 people
- Sponsor
- Parc de Salut Mar
Coronary Artery Disease, Coronary Disease
Sapphire 3 CTO Study
A prospective, open label, multi-center, single arm, observational study designed to evaluate the acute safety and device performance of the Sapphire 3 0.85, 1.0 and 1.25mm diameter coronary dilatation catheter in predilatation…
- Conditions
- Coronary Artery Disease, Coronary Disease, Myocardial Ischemia, Heart Diseases
- Trial name
- NCT06358508
- Testing
- Sapphire 3 Coronary Dilatation Catheter
- Where
- 14 sites in United States, Spain
- Volunteers
- 170 people
- Sponsor
- OrbusNeich
Coronary Occlusion
Decision Aid in Chronic Total Occlusion (CTO) Patients
The aim of this study is to assess the feasibility and validity of patient-level randomization (vs. cluster randomization) in pilot trials of decision aid efficacy.
- Trial name
- NCT02963584
- Testing
- decision aid
- Volunteers
- 160 people
- Sponsor
- The First Affiliated Hospital of Dalian Medical University
Coronary Artery Disease, Chronic Total Occlusion
German Epicardial Collateral CTO Registry
The EPIC registry is an observational multicentre registry evaluating the technical feasibility of retrograde CTO-PCI using epicardial collateral connections.
- Conditions
- Coronary Artery Disease, Chronic Total Occlusion, Percutaneous Coronary Intervention
- Trial name
- EPIC (NCT04533633)
- Testing
- Retrograde Percutaneous Coronary Intervention of Chronic Total Occlusion
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Universitätsmedizin Mannheim
Atrial Fibrillation, Atrial Flutter
Comparison of ATI-5923, a Novel Vitamin K Antagonist, With Warfarin in Patients Requiring Chronic Anticoagulation
The purpose of this research study is to test an experimental drug ATI-5923 vs Coumadin. The study is intended to demonstrate ATI-5923 is superior to Coumadin for keeping INR values in the desired therapeutic range.
- Conditions
- Atrial Fibrillation, Atrial Flutter, Venous Thromboembolic Disease, Myocardial Infarction
- Trial name
- EmbraceAC (NCT00691470)
- Testing
- ATI-5923, Coumadin (warfarin)
- Where
- 41 sites in United States
- Volunteers
- 600 people
- Sponsor
- ARYx Therapeutics
Chronic Heart Failure, Left Ventricular (LV) Systolic Dysfunction
A Study Evaluating an Implantable Cardiac Microcurrent Device in Patients With Chronic Heart Failure
This study evaluates the safety and performance/effectiveness of the C-MIC System, an active implantable medical device designed to treat patients with heart failure with reduced ejection fraction (HFrEF).
- Conditions
- Chronic Heart Failure, Left Ventricular (LV) Systolic Dysfunction, Ischemic and Non-ischemic Cardiomyopathy
- Trial name
- NCT07795359
- Testing
- Subcutaneous cardiac microcurrent treatment
- Volunteers
- 60 people
- Sponsor
- Berlin Heals GmbH
Chronic Stable Angina, Periprocedural Myocardial Damage
MYocardial DAmage AND MIcrobiota STUDY
MYDA-MI study is a randomized, placebo controlled, double blind study performed in San Filippo Neri Hospital, Roma, Italy. The planned study duration is 18 months.
- Trial name
- MYDA-MI (NCT02908776)
- Testing
- Probiotic
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- San Filippo Neri General Hospital
Pain, Cardiac Ischemia
Development and Usability Testing of a Progressive WebApp for Women With Heart Disease
The overall goal of this program of research is to develop and systematically evaluate an integrated smartphone and web-based intervention (at heart [formerly called HEARTPA♀N]) to provide evidence-informed symptom triage and…
- Conditions
- Pain, Cardiac Ischemia, Women, Pain, Chronic
- Trial name
- at heart (NCT03800082)
- Testing
- at heart (changed from HEARTPA♀N during usability testing)
- Where
- Canada
- Volunteers
- 98 people
- Sponsor
- University of Toronto
Arteriosclerosis, Coronary Artery Disease
Comparison of a CrossBoss First Versus Standard Wire Escalation Strategy for Crossing Coronary Chronic Total Occlusion: the "CrossBoss First" Trial
CrossBoss First is a single-blind randomized controlled trial that will randomize 246 patients undergoing clinically-indicated Chronic Total Occlusion Percutaneous Coronary Intervention, to upfront use of the CrossBoss catheter…
- Conditions
- Arteriosclerosis, Coronary Artery Disease, Myocardial Ischemia, Coronary Disease
- Trial name
- NCT02510547
- Testing
- CrossBoss Catheter, Antegrade Wire Escalation Strategy
- Where
- 11 sites in United States
- Volunteers
- 246 people
- Sponsor
- North Texas Veterans Healthcare System
Coronary Occlusion
Single-Arm Study Evaluating Use of the CORA Catheters for the Crossing of Coronary Chronic Total Occlusions
The goal of this clinical trial is to evaluate the safety and effectiveness of the coraFlex, coraForce, and coraCross catheters for crossing chronic total occlusions of the coronary arteries.
- Trial name
- Cora CTO (NCT05848232)
- Testing
- coraFlex Catheter, coraForce Catheter, coraCross Catheter
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- ReFlow Medical, Inc.
COVID-19, Chronic Heart Failure
Analysis of Health Status of Сomorbid Adult Patients With COVID-19 Hospitalised in Fourth Wave of SARS-CoV-2 Infection
Depersonalized multi-centered registry initiated to analyze dynamics of non-infectious diseases after SARS-CoV-2 infection in population of Eurasian adult patients.
- Conditions
- COVID-19, Chronic Heart Failure, Diabetes Mellitus, Chronic Kidney Diseases
- Trial name
- ACTIV4 (NCT05226416)
- Where
- Russia
- Volunteers
- 3,554 people
- Sponsor
- Eurasian Association of Therapists
Hypertension
A Trial of Telmisartan Prevention of Cardiovascular Disease
The present research is conducted as a randomized, parallel-group, controlled, open study (using the PROBE method) to primarily verify the effects on various biomarkers in high-risk hypertensive patients treated with ARB…
- Trial name
- ATTEMPT-CVD (NCT01075698)
- Testing
- Non-ARB (standard therapy), ARB (Telmisartan)
- Where
- Japan
- Volunteers
- 1,228 people
- Sponsor
- Kumamoto University
Chronic Stable Angina
The Effects of Inorganic Nitrate on Cardiac Muscle in Angina
Previous studies have shown that interventions which modestly increase blood nitrite_ improve skeletal muscle function on exercise while sparing oxygen, and have been also shown to open up the blood flow during periods of oxygen…
- Trial name
- NCT02078921
- Testing
- Sodium Nitrate
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- University of Aberdeen
Hypertension, Diabetes Mellitus, Type 2
ENCOMPASS: Expansion Study A, RCT
Some patients living with multiple long-term health conditions have difficulty accessing the services they need, despite available primary care and community resources.
- Conditions
- Hypertension, Diabetes Mellitus, Type 2, Chronic Kidney Diseases, Ischemic Heart Disease
- Trial name
- ENCOMPASS (NCT04790604)
- Testing
- Community Health Navigator Program
- Where
- Canada
- Volunteers
- 96 people
- Sponsor
- University of Calgary