Clinical trials: Chronic Ischaemic Heart Disease
Angina Pectoris, Coronary Artery Disease
Chronic Total Coronary Occlusion Treatment Results 6 Years After Bioresorbable Scaffold Implantation
Aim of the study is to evaluate chronic total coronary occlusion treatment results 6 years after bioresorbable scaffold implantation by quantitative coronary analysis, intravascular ultrasound and optical coherence tomography.
- Conditions
- Angina Pectoris, Coronary Artery Disease, Occlusion, Coronary
- Trial name
- CTO_BVS (NCT06164977)
- Testing
- Percutaneous coronary intervention.
- Where
- Latvia
- Volunteers
- 34 people
- Sponsor
- Pauls Stradins Clinical University Hospital
Covid19, SARS-CoV-2 Infection
Analysis of Chronic Non-infectious Diseases Dynamics After COVID-19 Infection in Adult Patients
Non-commercial depersonalized multi-centered registry study on analysis of chronic non-infectious diseases dynamics after SARS-CoV-2 infection in adults.
- Conditions
- Covid19, SARS-CoV-2 Infection, Pneumonia, Copd
- Trial name
- ACTIV (NCT04492384)
- Testing
- non-interventional
- Where
- Russia
- Volunteers
- 6,396 people
- Sponsor
- Eurasian Association of Therapists
Chronic Stable Angina
The Effects of Inorganic Nitrate on Cardiac Muscle in Angina
Previous studies have shown that interventions which modestly increase blood nitrite_ improve skeletal muscle function on exercise while sparing oxygen, and have been also shown to open up the blood flow during periods of oxygen…
- Trial name
- NCT02078921
- Testing
- Sodium Nitrate
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- University of Aberdeen
Heart Failure, Congestive, Coronary Arteriosclerosis
After Discharge Management of Low Income Frail Elderly
The purpose of this study is to determine whether comprehensive post-hospitalization interdisciplinary care management can be an effective care delivery model to improve outcomes in low-income frail elderly.
- Conditions
- Heart Failure, Congestive, Coronary Arteriosclerosis, Atrial Fibrillation, Cerebrovascular Accident
- Trial name
- NCT00328848
- Testing
- Behavioral
- Volunteers
- 530 people
- Sponsor
- Summa Health System
Contrast-induced Nephropathy, Chronic Kidney Diseases
Continuing or Discontinuing ACE/ARBs in Patients With Chronic Kidney Disease Undergoing Coronary Angiography
Contrast induced nephropathy (CIN) is a well-known possible complication of percutaneous coronary intervention (PCI) with an incidence varies from 3.3% to 14.5% in patients undergoing PCI.
- Conditions
- Contrast-induced Nephropathy, Chronic Kidney Diseases, Ischemic Heart Disease
- Trial name
- NCT05271448
- Testing
- Continue ACEI or ARBs ( Enalapril , Ramipril , Valsartan , Candesartan, Losartan ), Hold ACEI or ARBs
- Where
- Palestinian Territories
- Volunteers
- 600 people
- Sponsor
- An-Najah National University
Coronary Artery Disease, Arterial Stiffness, Blood Pressure
Expanded Studies on the SCAPIS Stockholm Reexamination Cohort
The Swedish CArdioPulmonary bioImage Study (SCAPIS) is a unique, large-scale national research initiative involving 30,000 randomly selected individuals aged 50-64, recruited between 2014 and 2018.
- Conditions
- Coronary Artery Disease, Arterial Stiffness, Blood Pressure, AORTIC VALVE DISEASES, Mitral Valve Stenosis and/or Insufficiency
- Trial name
- SCAPIS-ReEx (NCT07476703)
- Testing
- Coronary computer tomography (CCTA), Echocardiograhy and aortic ultrasound, Liver elastography
- Where
- Sweden
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Danderyd Hospital
Coronary Artery Disease, Acute Coronary Syndromes
Aspirin 50mg vs 100mg Combined With P2Y12 Inhibitor After PCI
This is a randomized, open-label, active-controlled, non-inferiority clinical trial (the ASPIRE-LD trial) conducted in China. It aims to compare the efficacy and safety of low-dose aspirin (50 mg once daily) versus standard-dose…
- Conditions
- Coronary Artery Disease, Acute Coronary Syndromes, Chronic Coronary Syndrome, Percutaneous Coronary Intervention
- Trial name
- ASPIRE-LD (NCT07846462)
- Testing
- Aspirin, P2Y12 inhibitor
- Where
- China
- Volunteers
- 2,640 people
- Sponsor
- Jilin University
Ischemic Heart Disease, Myocardial Ischemia
Quality of Life in Patients With Chronic Ischemic Heart Disease
This study will examine the health-related quality of life in patients being treated for chronic heart disease. Patients 18 years or older with chronic ischemic heart disease and left ventricular dysfunction enrolled in protocols…
- Trial name
- NCT00005671
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Stable Angina, Unstable Angina
COMBO-Stent in Patients on Chronic Anticoagulant Therapy (COSTA) COSTA-Bleed and COSTA-Outcome Trials
Prospective, multi-centre, randomized, open-label, parallel comparisons to evaluate the incidence of bleedings (COSTA-Bleed) and the incidence of ischemic and bleeding events (COSTA-Outcome) following a therapy with the abluminal…
- Conditions
- Stable Angina, Unstable Angina, STEMI, NSTEMI
- Trial name
- COSTA (NCT02723981)
- Testing
- COMBO-Stent, Clopidogrel, Vitamin K Antagonist, Rivaroxaban, Dabigatran, Any drug eluting stent oder bare metal sent
- Where
- 10 sites in Germany
- Sponsor
- IHF GmbH - Institut für Herzinfarktforschung
Coronary Artery Disease, Cerebral Vascular Disease
Pilot Study: Cardiovascular Events in High Risk Orthopedic Surgical Patients
This is a non-randomized, non-interventional pilot observational study designed to follow high-risk patients through their surgical and hospital stay.
- Conditions
- Coronary Artery Disease, Cerebral Vascular Disease, Peripheral Artery Disease, Renal Insufficiency
- Trial name
- NCT01809730
- Where
- United States
- Sponsor
- NYU Langone Health
Coronary Artery Disease
Effect of Grape Seed Extract Plus Ascorbic Acid on Endothelial Function
A pilot study of 15 subjects will be conducted to confirm an acute effect of grape seed extract on endothelial function. We then will perform a a randomized, double blind, placebo controlled crossover study designed to…
- Trial name
- NCT00554242
- Testing
- Grape seed extract and ascorbic acid
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Boston University
Refractory Angina Pectoris
Extracorporeal Shockwave Therapy for the Treatment of Refractory Chronic Angina Pectoris
Low intensity shockwaves have been proven in animal studies to induce local growth of new blood vessels from existing ones. The hypothesis of this study is that shockwave therapy could improve the symptoms of patients with…
- Trial name
- NCT01567644
- Testing
- Cardiac Extracorporeal Shockwave Therapy generator (Cardiospec)
- Where
- Germany
- Volunteers
- 35 people
- Sponsor
- Medispec
Hypertension
A Trial of Telmisartan Prevention of Cardiovascular Disease
The present research is conducted as a randomized, parallel-group, controlled, open study (using the PROBE method) to primarily verify the effects on various biomarkers in high-risk hypertensive patients treated with ARB…
- Trial name
- ATTEMPT-CVD (NCT01075698)
- Testing
- Non-ARB (standard therapy), ARB (Telmisartan)
- Where
- Japan
- Volunteers
- 1,228 people
- Sponsor
- Kumamoto University
Chronic Ischemic Left Ventricular Dysfunction, Myocardial Infarction
The Transendocardial Autologous Cells (hMSC) or (hMSC) and (hCSC) in Ischemic Heart Failure Trial.
Before initiating the full randomized study, a Pilot Safety Phase will be performed. In this phase the composition of cells administered via the Biosense Webster MyoStar NOGA Injection Catheter System will be tested.
- Trial name
- TAC-HFT-II (NCT02503280)
- Testing
- Autologous hMSCs, Autologous Human C-Kit CSCs II, Biosense Webster MyoStar NOGA Injection Catheter System
- Where
- United States
- Sponsor
- Joshua M Hare
Coronary Artery Disease, Type II Diabetes Mellitus
Effect of Metabolic Therapy in Patients With Chronic Ischemic Heart Disease
Patients with coronary artery disease have an abnormal cardiac metabolism. The hypothesis of this study is that shifting cardiac metabolism from free fatty acids to glucose will improve myocardial ischemia
- Trial name
- NCT00282360
- Testing
- Trimetazidine
- Volunteers
- 30 people
- Sponsor
- IRCCS San Raffaele
Myocardial Ischemia
ACT34-CMI -- Adult Autologous CD34+ Stem Cells (Follow-Up Study)
The purpose of this 12-month, observational, follow-up study is to collect additional data (by telephone contact) with which to assess the efficacy, safety, and effects of intramyocardial injections of adult autologous CD34+…
- Trial name
- NCT00545610
- Where
- 23 sites in United States
- Volunteers
- 150 people
- Sponsor
- Lisata Therapeutics, Inc.
Chronic Kidney Diseases, Renal Failure
IntraRenal HEmoDynamics to IntegraTE CA-AKI Risk and Monitor NephroprotectiIoN by ImpElla Support.
the hypothesis is that elevation of the intrarenal resistive index (RI) characterizes patients at elevated risk for subsequent CA-AKI and integrates items of the Mehran AKI risk score into a single, readily obtainable parameter.
- Conditions
- Chronic Kidney Diseases, Renal Failure, Coronary Artery Disease
- Trial name
- NCT06599424
- Testing
- Observational
- Where
- 2 sites in Germany
- Volunteers
- 550 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Acute Coronary Syndrome
TicagRelor Or Clopidogrel in Severe and Terminal Chronic Kidney Disease Patients Undergoing PERcutaneous Coronary Intervention for an Acute Coronary Syndrome.
Ticagrelor is a potent and fast-acting P2Y12-ADP receptor antagonist recommended as first-line agent in ACS (2). This drug was associated with a 20% relative reduction in the rate of MACE in ACS patients undergoing PCI compared…
- Trial name
- TROUPER (NCT03357874)
- Testing
- Clopidogrel, Ticagrelor
- Where
- France
- Volunteers
- 259 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Myocardial Infarction, Diet
Dietary Antioxidants and Chronic Diseases-The Swedish National March Cohort
Dietary antioxidants might protect from the development of chronic diseases by reducing levels of oxidative stress. The investigators therefore investigated the effect of dietary Non Enzymatic Antioxidant Capacity, which measures…
- Conditions
- Myocardial Infarction, Diet, Osteoarthritis
- Trial name
- NCT03350568
- Testing
- Total dietary NEAC assessed at baseline
- Where
- Sweden
- Volunteers
- 43,880 people
- Sponsor
- Karolinska Institutet
Myocardial Infarction, Percutaneous Coronary Intervention
Text Message Intervention to Improve Cardiac Rehab Participation
Cardiac rehabilitation (CR) is strongly recommended for patients with coronary heart disease. However, patient enrollment and completion of cardiac rehabilitation is low.
- Conditions
- Myocardial Infarction, Percutaneous Coronary Intervention, Coronary Artery Bypass Surgery, Heart Valve Repair or Replacement
- Trial name
- NCT03346278
- Testing
- Text Messaging Intervention
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Washington