Clinical trials: Chronic Ischaemic Heart Disease
Cardiomyopathy, Coronary Artery Disease
Efficacy and Safety of Implantable Cardioverter-Defibrillator (ICD) Implantation in the Elderly
The overall aim of this trial is to study the safety and efficacy of ICD implantation as a primary prevention strategy of sudden cardiac death in patients 70 years and older.
- Conditions
- Cardiomyopathy, Coronary Artery Disease, Congestive Heart Failure, Myocardial Infarction
- Trial name
- I-70 (NCT02121158)
- Testing
- Implantable Cardioverter Defibrillator, Optimal Medical Therapy
- Where
- 5 sites in United States
- Volunteers
- 167 people
- Sponsor
- VA Office of Research and Development
Decompensated Heart Failure, Ischemic Heart Disease
Clinical and Morphological Characteristics of Chronic Inflammation in the Myocardium in Patients With Decompensated HF With Ischemic Systolic Dysfunction
The purpose of the study is to investigate the clinical and morphological characteristics of chronic subclinical inflammation in the myocardium in patients with decompensated heart failure with ischemic systolic dysfunction.
- Trial name
- FHID (NCT02649517)
- Testing
- Endomyocardial biopsy
- Where
- 2 sites in Russia
- Volunteers
- 60 people
- Sponsor
- Russian Academy of Medical Sciences
Pain, Cardiac Ischemia
Development and Usability Testing of a Progressive WebApp for Women With Heart Disease
The overall goal of this program of research is to develop and systematically evaluate an integrated smartphone and web-based intervention (at heart [formerly called HEARTPA♀N]) to provide evidence-informed symptom triage and…
- Conditions
- Pain, Cardiac Ischemia, Women, Pain, Chronic
- Trial name
- at heart (NCT03800082)
- Testing
- at heart (changed from HEARTPA♀N during usability testing)
- Where
- Canada
- Volunteers
- 98 people
- Sponsor
- University of Toronto
Omega 3 Fatty Acids, Coronary Arterial Disease (CAD)
Investigation of the Effects of Omega-3 Supplementation in Chronic Kidney Disease Patients Diagnosed With Coronary Artery Disease and Dyslipidemia
Chronic kidney disease (CKD) is characterized by the slow, progressive, and irreversible loss of kidney function. Uremic toxins in CKD patients trigger an inflammatory response driven by various cytokines, chemokines, and other…
- Conditions
- Omega 3 Fatty Acids, Coronary Arterial Disease (CAD), Chronic Kidney Disease(CKD)
- Trial name
- NCT07127068
- Testing
- Omega-3 Suplementation, No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- University of Beykent
Congestive Heart Failure
Extracorporeal Shockwave Myocardial Revascularization (ESMR) Therapy For The Treatment of Chronic Heart Failure
Evaluation of non-invasive treatment modality, using low-intensity extracorporeal shockwaves for treatment of subjects diagnosed with Congestive Heart Failure, with ischemic etiology.
- Trial name
- NCT01251185
- Testing
- Cardiospec
- Where
- Israel
- Volunteers
- 9 people
- Sponsor
- Medispec
Acute Coronary Syndrome, Chronic Coronary Syndrome
A Study on the Peripheral Blood in Patients With Acute Coronary Syndrome
The goal of this study is to conduct analyses the changes of cell growth factors, inflammatory factors, metabolites, plasma proteome, etc.
- Trial name
- NCT06955143
- Where
- China
- Volunteers
- 310 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Chest Pain, Chronic Myocardial Ischemia
Stem Cell Study for Patients With Heart Disease
The purpose of this study is to determine if stem cell therapy with your own cells (autologous cells) delivered with a catheter to regions of the heart with poor blood flow will be safe and if it will relieve your chest pain…
- Conditions
- Chest Pain, Chronic Myocardial Ischemia, Coronary Artery Disease, Angina
- Trial name
- NCT00221182
- Testing
- Autologous peripheral blood CD34 positive cell therapy
- Where
- 3 sites in Japan
- Volunteers
- 1 people
- Sponsor
- Foundation for Biomedical Research and Innovation
Coronary Heart Disease
Testosterone and Myocardial Perfusion in Coronary Heart Disease (CHD)
Testosterone has traditionally been regarded as a risk factor for heart disease due to the fact that males have a higher incidence of this disease than women, at least until the menopause.
- Trial name
- NCT00239590
- Testing
- Testosterone undecanoate
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- Imperial College London
Anoxic-Ischemic Encephalopathy
Study for the Improvement of Long-Term Outcome Prediction in Patients in Coma After Cardiac Arrest
The primary objective of HOPE is to improve the accuracy of outcome prediction in anoxic-ischemic encephalopathy following cardiac arrest by bringing under close scrutiny some of the existing methods used for this purpose (e.g.
- Trial name
- HOPE (NCT02231060)
- Where
- 16 sites in Germany
- Volunteers
- 150 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Progression of Atherosclerotic Plaque, Coronary Artery Disease
Coronary Chronic Total Occlusion and Oxidative Balance
The presence of chronic blockage of coronary arteries, which we may accept as the terminal point of atherosclerotic coronary artery disease, is closely associated with a poor prognosis.
- Trial name
- NCT04754880
- Testing
- Comparison of oxidative and antioxidative markers between groups
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Stable Coronary Artery Disease, Obesity
Chronic Inflammatory Activation in Fat Tissue: an Atherogenic Factor in Stable Coronary Artery Disease
Chronic inflammatory activation in fat tissue can be the link between adiposity and an increased risk for atherosclerosis. Aim of the study is to investigate how molecular alterations in fat tissue can be influenced by regular…
- Conditions
- Stable Coronary Artery Disease, Obesity, Impaired Glucose Tolerance
- Trial name
- KFO (NCT00510588)
- Testing
- training, training + metformin, training + glitazon
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- University of Leipzig
Osteoarthritis, Knee, Osteoarthritis, Hip
Personalized Exercise Therapy and Self-management Support for Patients With Multimorbidity
Chronic conditions such as knee or hip osteoarthritis (OA), chronic obstructive pulmonary disease (COPD), heart failure (HF), coronary heart disease (CHD), hypertension, type 2 diabetes mellitus (T2DM) and depression are among…
- Conditions
- Osteoarthritis, Knee, Osteoarthritis, Hip, Heart Failure, Coronary Heart Disease
- Trial name
- MOBILIZE (NCT04645732)
- Testing
- Personalized exercise therapy and self-management support program, Usual care
- Where
- 16 sites in Denmark
- Volunteers
- 228 people
- Sponsor
- University of Southern Denmark
Angina Pectoris
Efficacy and Safety of Lacidipine in Chronic Stable Angina
The aim of this study was to explore whether lacidipine at doses of 2 mg, 4 mg and 6 mg decreased the symptoms of angina, compared to placebo in patients with chronic stable angina
- Trial name
- NCT02232607
- Testing
- Lacidipine, low dose, Lacidipine, medium dose, Lacidipine, high dose
- Volunteers
- 283 people
- Sponsor
- Boehringer Ingelheim
Fibrillation, Atrial, Coronary Artery Disease
Atrial Fibrillation and Non-obstructive Coronary Lesions
Atrial fibrillation (AF) is the most common cardiac arrhythmia associated with excessive risk of ischemic stroke and heart failure as well as reduced life expectancy.
- Conditions
- Fibrillation, Atrial, Coronary Artery Disease, Chronic Kidney Diseases
- Trial name
- AF-CAD (NCT04537507)
- Testing
- Coronary angiography
- Where
- 5 sites in Poland, Russia and 1 more
- Volunteers
- 8,000 people
- Sponsor
- Medical University of Bialystok
Chronic Total Occlusions of Coronary Arteries, Chronic Total Occlusion (CTO)
Clinical Outcomes of Drug-Coated Balloons in the Treatment of Patients With Coronary De Novo Chronic Total Occlusion Lesions
The aim of this study is to evaluate the long-term efficacy and safety of drug-coated balloon (DCB) strategies, including DCB alone or hybrid strategies of DCB and drug-eluting stent (DES), compared to DES-only in patients with…
- Conditions
- Chronic Total Occlusions of Coronary Arteries, Chronic Total Occlusion (CTO), Coronary Artery Disease (CAD)
- Trial name
- DCB-CTO (NCT07463664)
- Testing
- DES Implantation, DCB Angioplasty
- Where
- 18 sites in China
- Volunteers
- 200 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Obstructive Coronary Artery Disease
Coronary Revascularization Versus Conservative Therapy in Patients With Treated Critical Limb Ischemia
The objective of the INCORPORATE trial is to evaluate whether an intentional invasive strategy with ischemia targeted, reasonably complete coronary revascularization and optimal medical therapy is superior as compared to a…
- Trial name
- INCORPORATE (NCT03712644)
- Testing
- FFR-guided coronary revascularization
- Where
- 2 sites in Austria, Hungary
- Volunteers
- 650 people
- Sponsor
- Medical University of Graz
Impaired Health, Disease
The Lolland-Falster Health Study
The study is a epidemiological, cross-sectional study in a mainly rural area of Denmark in Denmark. Life expectancy is shorter, morbidity is higher, and social problems more prevalent than in the urban areas of the country.
- Conditions
- Impaired Health, Disease, Wellbeing, Mental Disorders
- Trial name
- LOFUS (NCT02482896)
- Where
- Denmark
- Volunteers
- 25,000 people
- Sponsor
- Region Sjælland
Atherosclerosis, Stroke
Vascular Inflammation Imaging Using Somatostatin Receptor Positron Emission Tomography
This VISION study aims to investigate the role of inflammation in atherosclerosis using 68Ga- DOTATATE PET, and to validate 68Ga-DOTATATE PET imaging for the detection and quantification of vascular inflammation in the aorta…
- Conditions
- Atherosclerosis, Stroke, Transient Ischemic Attack, Chronic Stable Angina
- Trial name
- VISION (NCT02021188)
- Where
- United Kingdom
- Volunteers
- 42 people
- Sponsor
- University of Cambridge
Acute Coronary Syndrom, Chronic Obstructive Pulmonary Syndrom
Pneumological Acute Coronary Syndrom (ACS) Phenotyping Aachen
In this open, monocentric, observational study acute coronary syndrom (ACS) patients will be characterized by pneumological examination concerning a concomitant chronic obstructive pulmonary disease (COPD).
- Trial name
- PAPA (NCT02587481)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- RWTH Aachen University
Platelet Aggregation, Spontaneous, Coronary Artery Disease
Effect of Low Dose of Colchicine on Platelet Reactivity
Inflammation plays an important role in atherosclerosis and the occurrence of ischemic events. Statins, in addition to their lipid-lowering effect, have also documented anti-inflammatory effect that may partly explain their…
- Trial name
- NCT05956145
- Testing
- Colchicine 0.5 MG
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- University of Sao Paulo